Ex vivo culture assays on PBMCs and primary salivary gland epithelial cell (pSGEC) lines were performed to model changes in target tissues before and after JAKi. (bvsalud.org)
January and April 2017) to assess the canine humoral immune response to whole salivary gland homogenate (SGH) and to the single salivary 43 kDa yellow-related recombinant protein (rSP03B) of Phlebotomus perniciosus , a proven vector of L. infantum naturally present in this region. (biomedcentral.com)
Blood4
This species is of interest because of the pathogens it carries, and its salivary apyrases which prevent platelet activation and aggregation, that is, blood-clotting. (wikipedia.org)
Methods: Human minor salivary glands (MSGs) and peripheral blood mononuclear cells (PBMCs) were investigated using bulk or single cell (sc) RNA sequencing (RNAseq), immunofluorescence microscopy (IF), and flow cytometry. (bvsalud.org)
Haematophagous animals use the blood of vertebrates as their sole source of nutrition and have evolved many salivary constituents to counteract the haemostatic response of their prey. (biosciencehorizons.com)
The animals studied all tend to possess an anticoagulant and a form of apyrase (PAgI) to assist with blood feeding. (biosciencehorizons.com)
Platelet5
This species is of interest because of the pathogens it carries, and its salivary apyrases which prevent platelet activation and aggregation, that is, blood-clotting. (wikipedia.org)
Aegyptin, a secreted salivary protein from Aedes aegypti, binds collagen and inhibits platelet aggregation and adhesion. (ox.ac.uk)
Reductions of Aegyptin did not affect salivary ADP-induced platelet aggregation inhibition or disturb anticlotting activities. (ox.ac.uk)
Our results demonstrate the relevance of Aegyptin for A. aegypti blood feeding, providing further support for the hypothesis that platelet aggregation inhibition is a vital salivary function in blood feeding arthropods. (ox.ac.uk)
It has been suggested that the multiple mosquito salivary components mediating platelet aggregation (i.e. (ox.ac.uk)
Proteins5
Background Certain salivary proteins of phlebotomine sand flies injected into the host skin during blood-feeding are highly antigenic and elicit strong antibody-mediated immune responses in repeatedly-exposed hosts. (meganhardenfitness.com)
Large-scale screening for anti-sand fly saliva antibodies requires replacement of SGH with recombinant salivary proteins. (meganhardenfitness.com)
Recombinant apyrase rPorSP15, yellow-related protein rPorSP24, ParSP25-like protein rPorSP65, D7-related protein rPorSP67, and antigen 5-related protein rPorSP76 were tested using ELISA with sera of domestic animals from L. donovani foci in Ethiopia where Ph. (meganhardenfitness.com)