Salamanders and newts regenerative newt limb blastema. Medical search. Frequent questions

Limited regeneration of limbs occurs in most fishes and salamanders, and tail regeneration takes place in larval frogs and toads (but not adults). (wikipedia.org)

Many arthropods can regenerate limbs and other appendages following either injury or autotomy. (wikipedia.org)

Gene over-expression analyses in Xenopus limb and tail regeneration have indicated that successful regeneration requires the re-activation of developmental FGF or BMP signalling pathways [ 8 - 12 ]. (biomedcentral.com)

Using Affymetrix Gene Chip analysis, we have identified genes linked to regenerative success downstream of BMP signalling, including the BMP inhibitor Gremlin and the stress protein Hsp60 ( no blastema in zebrafish). (biomedcentral.com)

salamanders and newts), an order of tailed amphibians, is possibly the most adept vertebrate group at regeneration, given their capability of regenerating limbs, tails, jaws, eyes and a variety of internal structures. (wikipedia.org)

Xenopus tadpoles can regenerate their tails, limb buds and the lens of the eye, although the ability of the latter two organs to regenerate diminishes with advancing developmental stage. (biomedcentral.com)

Epimorphic regeneration is the process by which complete regeneration of a complex structure such as a limb occurs through production of a proliferating blastema. (biomedcentral.com)

After the limb or tail has been autotomized, cells move into action and the tissues will regenerate. (wikipedia.org)
Many of the genes that are involved in the original development of tissues are reinitialized during the regenerative process. (wikipedia.org)
Once the wound is healed, the cells of the stump must mobilise under the wound epidermis and begin the process of replacing lost tissues, by forming a proliferating blastema. (biomedcentral.com)

While all vertebrates are capable of some types of tissue regeneration, most, including humans, have lost the ability to regenerate whole structures such as limbs ( epimorphic regeneration ), [ 1 ]. (biomedcentral.com)

In some cases a shed limb can itself regenerate a new individual. (wikipedia.org)

salamanders and newts), an order of tailed amphibians, is possibly the most adept vertebrate group at regeneration, given their capability of regenerating limbs, tails, jaws, eyes and a variety of internal structures. (wikipedia.org)
Limited regeneration of limbs occurs in most fishes and salamanders, and tail regeneration takes place in larval frogs and toads (but not adults). (wikipedia.org)
Understanding how these mechanisms impact on regenerative processes is essential to devise therapeutic approaches to improve tissue regeneration and extend healthspan. (mdpi.com)
It focuses on established models of mammalian regeneration as well as on models in which regenerative abilities do not decline with age, as these can deliver valuable insights for our understanding of the interplay between regeneration and aging. (mdpi.com)
Previous studies indicated that macrophages play a role during lens regeneration in newts, but their function has not been tested experimentally. (bvsalud.org)
Next, we used clodronate liposomes to deplete macrophages, which inhibited lens regeneration in both newt species. (bvsalud.org)

The case of autotomy, for example, serves as a defensive function as the animal detaches a limb or tail to avoid capture. (wikipedia.org)

The mechanisms responsible for this decay are both cell intrinsic, such as cellular senescence, as well as cell-extrinsic, such as changes in the regenerative environment. (mdpi.com)
Together, our findings highlight the importance of macrophages in facilitating a pro-regenerative environment in the newt eye, helping to resolve fibrosis, modulating the overall inflammatory landscape and maintaining the proper balance of early proliferation and late apoptosis. (bvsalud.org)