• Clonus Migraine Epilepsy Pathologic nystagmus Physiologic nystagmus Psychogenic non-epileptic seizures Saccade Ocular flutter Venes, Donald (2009). (wikipedia.org)
  • Two phases of eye movements associated with blinking can be distinguished: an initial dynamic ocular rotation that occurs with every blink and a subsequent sustained phase 1 that occurs only when closure of the eyelid is prolonged. (arvojournals.org)
  • To investigate the three-dimensional ocular kinematics during the initial phase of blinks, we recorded eye movements in healthy human subjects with dual search coils that were modified to exclude torsional artifacts. (arvojournals.org)
  • Binocular diplopia resolves with either eye being closed and indicates ocular misalignment as an underlying problem. (eyewiki.org)
  • 17. Which ocular diagnoses involving the anterior segment of the eye should be considered when a patient complains of transient monocular blurring of vision? (stanford.edu)
  • We explored the characteristics of her ocular tremor during voluntary eye movements, seeking insight on the role of the cerebellum on tremorogenesis. (biomedcentral.com)
  • Nystagmus is defined as the involuntary, periodic rhythmic ocular oscillation of the eyes that can either be physiologic (may not affect vision) or pathologic. (medscape.com)
  • Many forms of acquired nystagmus may also be caused by disruptions of visual fixation, the vestibulo-ocular reflex and the mechanism that makes it possible to hold the gaze at eccentric eye positions. (medscape.com)
  • Three mechanisms are involved in maintaining foveal centration of an object of interest: fixation, the vestibulo-ocular reflex, and the neural integrator (which allows for gaze holding in extreme, or eccentric, eye positions). (medscape.com)
  • A disorder affecting any of the three components involved in maintaining the steady positioning of the eyes (ie, visual fixation, the vestibulo-ocular reflex or the neural integrator) may result in nystagmus. (medscape.com)
  • Inspired by the visual ocular smooth-pursuit system, several studies have used eye movements to track moving sounds, but obtained poor pursuit performance, which led to the idea that the auditory system lacks sensitivity to sound velocity. (eneuro.org)
  • After the functional binocular vision exam, I look at the closely linked vestibular system, for which, intact binocular visual function is necessary, I look at the athlete's gaze stability or vestibular ocular reflex (VOR), or ability to keep an image centered on the fovea during horizontal and vertical head motion. (neurosync.health)
  • Parkinsons can also affect your visual performance, mainly in two parts of your eyes: the tear film and the ocular muscles. (parkinsonsinfoclub.com)
  • Quantitative characterization of saccade parameters, saccadic intrusions (SI), and nystagmus was performed. (unisi.it)
  • Horizontal and vertical spontaneous jerk nystagmus, gaze-evoked, and rebound nystagmus were evident. (unisi.it)
  • Conclusion: Slow eye movements accompanying saccades, SI, and cerebellar nystagmus are frequently seen in AT patients, additionally our ATLD patients showed the presence of fast and hypermetric saccades suggesting damage of granule cell-parallel fiber-Purkinje cell synapses of the cerebellar vermis. (unisi.it)
  • Efferent visual pathway lesions can create a perception of oscillopsia, a visual disturbance in which objects appear to jiggle or move owing to nystagmus (involuntary eye movements). (medscape.com)
  • [ 1 ] Nystagmus typically includes two movements: a slow first movement of the eye away from the visual target followed by a second, corrective movement that brings the eye back to the visual target. (medscape.com)
  • [ 1 ] Conversely, if the second corrective movement is slow, the nystagmus is termed pendular nystagmus and is commonly characterized with sinusoidal oscillations that are approximately of equal amplitude and velocity. (medscape.com)
  • To understand the mechanisms by which nystagmus may occur, it is important to discuss the means by which the nervous system maintains steady position of the eyes. (medscape.com)
  • Methods: Saccade dynamics, metrics, and visual fixation deficits were investigated in two Italian adult siblings with genetically confirmed ATLD. (unisi.it)
  • It is important to know that previous research indicates that experts have overall less fixations and larger saccadic amplitudes, this means, their saccades cover larger areas before a new fixation occurs. (mere.st)
  • Fixation in the primary position involves the visual system's ability to detect drift of a foveating image and signal an appropriate corrective eye movement to refoveate the image of regard (ie, move the image to the central 1-2º of the visual field where visual acuity is highest). (medscape.com)
  • Using a wand or flashlight or other fixation targets, the clinician moves the fixation target to different points in the patient's field of vision asks the patient to follow the target with just the eyes . (seevividly.com)
  • Red dots show fixations and yellow lines depict saccadic eye movements from one fixation to another. (scholarpedia.org)
  • In five healthy human subjects, eye movements about all principal axes of rotation (horizontal, vertical, and torsional) were recorded during voluntary blinks of different durations (as short as possible, 0.83 seconds, and 1.67 seconds) in straight-ahead gaze. (arvojournals.org)
  • 3 measured horizontal and vertical eye movements during blinks at different gaze positions within 10° from straight-ahead gaze. (arvojournals.org)
  • Possible PSP requires the presence of a gradually progressive disorder with onset at age 40 or later, either vertical supranuclear gaze palsy or both slowing of vertical saccades and prominent postural instability with falls in the first year of onset, as well as no evidence of other diseases that could explain these features. (neurology.org)
  • Probable PSP requires vertical supranuclear gaze palsy, prominent postural instability, and falls in the first year of onset, as well as the other features of possible PSP. (neurology.org)
  • [ 3 ] Versions are movements of both eyes in the same direction (eg, right gaze in which both eyes move to the right). (medscape.com)
  • Yoke muscles are the primary muscles in each eye that accomplish a given version (eg, for right gaze, the right lateral rectus and left medial rectus muscles). (medscape.com)
  • Each extraocular muscle has a yoke muscle in the opposite eye to accomplish versions into each gaze position. (medscape.com)
  • Such gaze shifts are themselves a source of powerful retinal stimulation, and so the visual system appears to have evolved mechanisms to maintain perceptual stability during movements of the eyes in space. (jneurosci.org)
  • The third mechanism is the neural integrator, which is required to maintain a steady gaze in extreme or eccentric eye positions. (medscape.com)
  • Saccades are jumping eye movements, so to test the saccadic system, the patient may be asked to quickly switch gaze between two targets. (seevividly.com)
  • People with neglect may also have no weakness of their eye or limb muscles, yet fail to direct their gaze or hands to explore contralesional space (e.g. (scholarpedia.org)
  • Saccadic rapid eye movements direct us to gaze at a specific object or to read lines of print. (parkinsonsinfoclub.com)
  • An understanding of gaze promotes the development of both saccades and pursuits that allow individuals to participate in their activities of daily life. (carrickinstitute.com)
  • Key structures involved in horizontal and vertical gaze allow the clinician to physiologically test specific areas of the integrated nervous system with direction towards clinical applications. (carrickinstitute.com)
  • Here, we show that frontal eye field delay activity (particularly in visuomovement neurons) shows a progressive transition through intermediate target-gaze codes, with a further jump to coding the intended gaze position in movement neurons with no delay response. (eneuro.org)
  • Adaptive shortening of a saccade influences the metrics of other saccades withina spatial window around the adapted target. (pisavisionlab.org)
  • I decided to run a few short experiments that could test the basic eye-tracking metrics: point-of-regard estimation accuracy and precision, saccade trajectory and velocity, and changes pupil size. (pygaze.org)
  • Over the last four decades, ISCAN has pioneered eye tracking instrumentation to provide metrics which have a major bearing on this knowledge. (iscaninc.com)
  • Eye tracking allows these metrics to be gathered and compared for different contexts and preliminary designs, hopefully making the final implementation more effective. (iscaninc.com)
  • 2001)⁠. Whisking is coordinated with head and body movements, which enables rapid sampling of the proximal environment during spatial exploration. (scholarpedia.org)
  • spatial resolution = 0.1 deg and temporal resolution = 60 Hz) was used to non-invasively measure horizontal and vertical eye movements in our patient. (biomedcentral.com)
  • It records eye movement in relation to a simple, circular visual stimulus and produces immediate results showing variability in spatial and temporal prediction. (neurosync.health)
  • Abstract Recent research on spatial number representations suggest that the number space is not necessarily horizontally organized and might also be affected by acquired associations between magnitude and sensory experiences in vertical space. (researchgate.net)
  • The present study now aims to compare vertical and horizontal spatial associations in mental arithmetic. (researchgate.net)
  • The analysis of the problem solving performances revealed a motion-arithmetic compatibility effect for spatial actions along both the horizontal and vertical axes. (researchgate.net)
  • Here, we tracked FEF spatial codes through time using a novel analytic method applied to the classic memory-delay saccade task. (eneuro.org)
  • Eye movement abnormalities included slow eye movements that preceded the initial saccade. (unisi.it)
  • The presence of characteristic saccadic abnormalities can be enormously helpful in guiding diagnosis in the outpatient clinic. (hmto-hnas.com)
  • We present a simplified review the anatomy of horizontal and vertical saccades, discuss practical aspects of their examination, and review saccadic abnormalities in hyperkinetic and hypokinetic movement disorders. (hmto-hnas.com)
  • Further, we provide an algorithm illustrating the value of saccadic abnormalities in the differential diagnosis of the movement disorders patient. (hmto-hnas.com)
  • We performed video-oculography to evaluate vergence eye movement abnormalities in students diagnosed clinically with vergence disorders. (arvojournals.org)
  • Here, we show that the magnitude of perceptual compression for a wide variety of probe stimuli and saccade amplitudes is quantitatively predicted by a simple heuristic model based on the geometry of retinotopic representations in the primate brain. (jneurosci.org)
  • Fixations and saccades. (mere.st)
  • One of them lasts about 250 ms. Saccades are the very fast eye movements between fixations lasting about 55ms. (mere.st)
  • Eye movement analysis can also happen on a more finegrained and derived level, but they are all based on fixations and saccades. (mere.st)
  • Eye fixations can clearly indicate if a package on a store shelf, a logo marking, an ad in a website or a billboard on the highway are noticed. (iscaninc.com)
  • It can also be caused by a lesion in the omnipause neurons which tonically inhibit initiation of saccadic eye movement (until signaled by the superior colliculus) by blocking paramedian pontine reticular formation (PPRF) burst neurons in the pons. (wikipedia.org)
  • We previously showed that macaque caudal intraparietal (CIP) area neurons possess robust 3D visual representations, carry choice- and saccade-related activity, and exhibit experience-dependent sensorimotor associations (Chang et al. (elifesciences.org)
  • Saccades are one of the most useful types of eye movements in the evaluation of the movement disorders patient. (hmto-hnas.com)
  • The goal is to provide a practical guide to bedside evaluation of saccades in the context of the movement disorders patient. (hmto-hnas.com)
  • Affected individuals may experience problems with how they see the world (afferent visual pathway symptoms) and/or how smoothly and synchronously their eyes move together (efferent visual pathway disorders). (medscape.com)
  • Because patients with MS and other CNS inflammatory disorders who have visual symptoms often seek ophthalmic attention, eye care experts play a vital role in the localization and diagnosis of these conditions. (medscape.com)
  • A clinician often performs a number of vision tests on a patient with suspected amblyopia (lazy eye) or other binocular vision disorders. (seevividly.com)
  • Among disorders of binocular function, vergence insufficiency is the inability to converge or diverge the eyes smoothly and effectively to the object of interest and/or inability to maintain the vergence angle. (arvojournals.org)
  • This clinical applications series is an advanced clinical experience that expands the clinicians ability to utilize eye movements to understand, diagnose and treat disorders of the nervous system. (carrickinstitute.com)
  • Neurodegenerative diseases (NDDs) are devastating disorders which impair memory, cognition, movements, and general functioning. (aao.org)
  • This reflex allows a stable image to be maintained on the retina during rapid head movements by rotating eyes in the opposite direction of the head movement, with a velocity that is equal to the head movement velocity. (medscape.com)
  • Visual feedback provides the positional error and retinal slip velocity, needed to realign the fovea with the target through corrective saccades and smooth pursuit. (eneuro.org)
  • Wemeasured localization judgements by asking subjects to localize a probe flashedbefore saccade onset. (pisavisionlab.org)
  • Sensorimotor associations between 3D orientation and saccade direction preferences were stronger in CIP than V3A, and moderated by choice signals in both areas. (elifesciences.org)
  • The frontal eye fields (FEFs) participate in both working memory and sensorimotor transformations for saccades, but their role in integrating these functions through time remains unclear. (eneuro.org)
  • It is also referred to as saccadomania or reflexive saccade. (wikipedia.org)
  • 2 described the horizontal and vertical trajectories of the human eye during the entire period of voluntary and reflexive blinks. (arvojournals.org)
  • Cranial nerve 3: The oculomotor nerve controls pupil response and other motions of the eye, and branches out from the area in the brainstem where the midbrain meets the pons. (safehubcollective.org)
  • Trained monkeys performed a two-choice perceptual decision-making task in which they reported the perceived orientation of a dynamic Glass pattern, before and after unilateral, reversible, inactivation of a brainstem area-the superior colliculus (SC)-involved in preparing eye movements. (nature.com)
  • Structures that are critical for eye-movement control are located in the medulla and promote integration from the vestibular system and from the complex inferior olivary nuclear system. (carrickinstitute.com)
  • The clinician should inquire about prior strabismus, a ''lazy" or amblyopic eye, patching as a child, childhood eye surgery, and any abnormal head positions. (eyewiki.org)
  • The magnitude of innervation is determined by the fixating eye, which means that the angle of deviation between eyes ( strabismus ) may vary depending on which eye is fixating. (medscape.com)
  • strabismus often increases in the field of action of a weak eye muscle. (medscape.com)
  • Suppression helps eliminate confusing visual images such as a single blurry image (from amblyopia /lazy eye) or a double image from a turned eye (strabismus). (seevividly.com)
  • We investigated the saccadic adaptation field andassociated localization changes for saccade lengthening, or outward adaptation. (pisavisionlab.org)
  • 13. A patient complains of loss of visual field in one eye, what should be ruled-out on examination? (stanford.edu)
  • This is actually one of the most important tests in a vision exam, as is probably the one test most patients associate with an eye examination. (seevividly.com)
  • The entire process of collecting eye tracking data for each athlete takes about one minute, but its quick post-eye tracking analysis and easy to interpret numeric and graphed performance scores makes it the most important minute of the examination. (neurosync.health)
  • This 25-hour clinical program is a comprehensive overview of the brain and eye movements highlighting hands-on examination and treatment protocols. (carrickinstitute.com)
  • A mastery of clinical examination procedures to quantify brain function and eye movements is necessary in the treatment of traumatic brain injuries and neurodegenerative diseases. (carrickinstitute.com)
  • It increased with increases of the horizontal component of the saccade andremained largely constant with deviation of the vertical component of the saccade.Mislocalization of probes inside the adaptation field was correlated with the amountof adaptation of saccades to the probe location. (pisavisionlab.org)
  • Under such conditions, there is a systematic misperception of the probes toward the saccade end point. (jneurosci.org)
  • The earliest eye movement during blinks consisted of a pulselike trajectory in a direction that was always extorsional, downward, and inward, regardless of the duration of eyelid closure. (arvojournals.org)
  • Together, the results explicate parallel representations, hierarchical transformations, and functional associations of visual and saccade-related signals at a key juncture in the 'where' pathway. (elifesciences.org)
  • Convergence is movement of both eyes nasally, and divergence is movement of both eyes temporally. (medscape.com)
  • Intriguingly, the time course of saccade-related activity in CIP aligned with the temporally integrated V3A output. (elifesciences.org)
  • [ 4 , 5 , 6 ] Fusional convergence and divergence are optomotor reflexes that are designed to position the eyes such that the image of regard falls on the fovea of each eye. (medscape.com)
  • The primary deviation is misalignment, with the normal eye fixating. (medscape.com)
  • If the paretic eye fixates, the ensuing secondary deviation is typically larger than the primary deviation. (medscape.com)
  • Monocular diplopia persists when the unaffected eye is closed, but will resolve when the affected eye is closed. (eyewiki.org)
  • Thus, the key and differentiating question between monocular and binocular diplopia is: "Does the double vision resolve with closing EITHER eye? (eyewiki.org)
  • because if the patient happens to close the affected (monocular diplopia) eye then the response might lead the examiner to conclude that the diplopi is binocular when in fact it is monocular. (eyewiki.org)
  • Ductions are monocular eye movements. (medscape.com)
  • 20. What should be considered in a patient who has eye or brow pain with transient monocular vision loss? (stanford.edu)
  • Under this assumption, the psychophysical data on perisaccadic compression can be appreciated intuitively by imagining that, around the time of a saccade, the brain confounds nearby oculomotor and sensory signals while attempting to localize the position of objects in visual space. (jneurosci.org)
  • By additionally measuring rotation about the torsional axis, the authors investigated whether the three-dimensional rotation of the eye during the early phase of eyelid closure could be assigned to the action of a single extraocular muscle. (arvojournals.org)
  • Eye movements during blinks are associated with a co-contraction of most of the extraocular muscles, 3 4 5 6 7 which in turn leads to a retraction of the eyeball. (arvojournals.org)
  • Vertical diplopia (images displaced vertically) can be due to involvement of extraocular muscles, neuromuscular junction (e.g., myasthenia gravis), or cranial nerves (e.g. (eyewiki.org)
  • The field of action of an extraocular muscle is the direction of rotation of the eye when that muscle contracts. (medscape.com)
  • This is actually evaluating 3 cranial nerves - the third cranial nerve (CNIII), the fourth cranial nerve (CNIV), and the sixth cranial nerve (CNVI) which control all the possible movements of the 6 extraocular muscles responsible for eye movement. (seevividly.com)
  • The mechanisms underlying this perceptual stability can be probed in the laboratory by briefly presenting a stimulus around the time of a saccadic eye movement and asking subjects to report its position. (jneurosci.org)
  • Interestingly, the auditory pursuit responses adapted to the covert movement spectrum of the stimulus ensemble, from which we infer that the system may optimize a trade-off between movement speed and effort. (eneuro.org)
  • Binocular horizontal diplopia (images displaced horizontally) is usually due to disease of the medial or lateral rectus muscle, the neuromuscular junction, or the nerves supplying these muscles (e.g., cranial nerves III or VI). (eyewiki.org)
  • Diplopia worse with distance is more typical of sixth nerve palsy because of difficulty with divergence at distance of the eyes while diplopia worse at near is more suggestive of medial rectus palsy because of the need for convergence of the eyes at near. (eyewiki.org)
  • However, if there is muscle restriction (e.g., thyroid eye disease, orbital fracture, orbital myositis) then the diplopia may be worse in the opposite field of action of the restricted muscle. (eyewiki.org)
  • Because eye movement is very precisely controlled and intergrated with visual processing, vision loss or eye movement abnormality both lead to impairment of visuo-motor behavior, leading to debilitating symptoms such as eye strain, dizziness ,and headache during activities of daily living. (stanford.edu)
  • Dr. Liao uses noninvasive infrared eye trackers (sampling up to 1000 times per second) to perform recordings of visuo-motor behavior in the Stanford Eye Clinic. (stanford.edu)
  • By recording and studying eye behavior, Dr. Liao's team can decipher the most important contributors to visual disability, which will her her design the most appropriate treatment and visual rehabilitation for each patient. (stanford.edu)
  • We here demonstrate accurate head-pursuit of sounds, moving along unpredictable trajectories in the horizontal plane. (eneuro.org)
  • Adaptation and mislocalization fields for saccadic outward adaptation in humans,Journal of Eye Movement Research, 4 (3), 1-18. (pisavisionlab.org)
  • Within this adaptation field visualstimuli presented before an adapted saccade are mislocalized in proportion to thechange of the saccade metric. (pisavisionlab.org)
  • Wemeasured the adaptation field for two different saccade adaptations (14 deg to 20deg and 20 deg to 26 deg) by testing transfer to 34 different target positions. (pisavisionlab.org)
  • As you can see, I have been investigating questions about the Framing of Gameplay Experience in Games with Eye Movement Based Adaptation. (mere.st)
  • I look at eye teaming skills (convergence and divergence), eye focusing skills (accommodation) and eye tracking skills. (neurosync.health)
  • On eyelid opening, a consistent pulselike movement in the intorsional, upward, and outward direction occurred. (arvojournals.org)
  • We here demonstrate that human subjects faithfully track a sound's unpredictable movements in the horizontal plane with smooth-pursuit responses of the head. (eneuro.org)
  • Separate, causal roles of the caudate in saccadic choice and execution in a perceptual decision task. (nature.com)
  • In most cases, details that cannot be perceived by the human eye are regarded as irrelevant and referred to as perceptual redundancy. (informit.com)
  • The goal of normal disconjugate eye movements is to direct the corre- sponding retinal points of the two eyes to a visual object that is nearer or farther than the previous object. (safehubcollective.org)
  • When these estimates are informed by vision, the brain must combine retinal information with extraretinal signals that encode the position of the eye, head, and body to obtain accurate representations of objects in space. (jneurosci.org)
  • For example, visuospatial attention engages a frontoparietal network including the frontal eye fields (FEFs), which modulate activity in visual sensory areas to enhance the representation of an attended visual object. (frontiersin.org)
  • Accommodative convergence is convergence of the eyes stimulated by accommodating or focusing on a near target. (medscape.com)
  • Processing in the midline regions targets movements of the axial musculature, whereas the lateral regions target movements of the appendicular musculature. (foobrdigital.com)
  • We used a novel Vergence double-step (Vd-s) protocol: the target stepped to a second position before the vergence movement completion. (arvojournals.org)
  • Vertical vergence movements may also occur (ie, one eye moving upward or the other eye moving downward relative to the contralateral eye). (medscape.com)
  • Performances in additions was impaired while making downward compared to upward movements as well as when moving left compared to right and vice versa in subtractions. (researchgate.net)
  • The midline regions of the cerebellum, the vermis and flocculonodular lobe , are involved in comparing visual information, equilibrium, and proprioceptive feedback to maintain balance and coordinate movements such as walking, or gait , through the descending output of the red nucleus (Figure 16.15). (foobrdigital.com)
  • and does not necessarily respect (align with) the vertical midline or meridian (Fig. 3). (scholarpedia.org)
  • The EyeLink 1000 is a powerhouse that sports a 1000 Hz sampling rate and a high accuracy and precision, arguably the best video-based eye tracker out there. (pygaze.org)
  • For patient education information, see the Eye and Vision Center , as well as Anatomy of the Eye . (medscape.com)
  • The primary muscle that moves an eye in a given direction is known as the agonist. (medscape.com)
  • A muscle in the same eye that moves the eye in the same direction as the agonist is known as the synergist, while a muscle in the same eye that moves the eye in the opposite direction of the agonist is the antagonist. (medscape.com)
  • Such vergence movements can also be smooth when the object of interest moves slowly in depth. (safehubcollective.org)
  • A small prism is briefly held in front of one eye, which moves the image of a light or object the patient is fixating on slightly away from central vision. (seevividly.com)
  • The clinician moves a paddle or similar object between the two eyes to disrupt fusion and observes how the eye move. (seevividly.com)
  • Pursuit eye movements allow us to follow an object as it moves. (parkinsonsinfoclub.com)
  • The default mode network RSFC strength was significantly correlated with the PFV, near point of convergence, and difference between the horizontal phoria at near compared with far (P (bvsalud.org)
  • This case is an unusual presentation of a cat's eye Adie-like pupil as the harbinger for ICE syndrome. (stanford.edu)
  • The human eye is sensitive to the range of wavelengths between 380 nm (blue end of the visible spectrum) and 780 nm (red end of the visible spectrum). (informit.com)
  • particularly when we have baseline scores available and they can watch their Eye Sync® scores inching closer to baseline. (neurosync.health)
  • 2005)⁠, in conjunction with head and body movements (Mitchinson et al. (scholarpedia.org)
  • In Experiment 2, instead of instructing to perform active body movements, participants calculated while the problems moved in one of the four relative directions on the screen. (researchgate.net)
  • How are glissades produced in the saccadic system? (safehubcollective.org)
  • If this movement is noticed by the vision system, a quick, small eye movement occurs. (seevividly.com)
  • Any computer-oriented task can be presented and executed on the subject's workstation, while the MegaView system calculates and records precisely where the eyes are directed in display-oriented coordinates. (iscaninc.com)
  • The MegaView system calculates and records precisely where the eyes are directed in display-oriented coordinates. (iscaninc.com)
  • During the initial phase of voluntary eyelid closure, the eyes move in a three-dimensional direction that is consistent with a pulselike innervation of the inferior rectus muscle. (arvojournals.org)
  • Therefore, we hypothesized that a transient net force along the pulling direction of this muscle could explain why the initial movement of the eyeball is downward and nasalward. (arvojournals.org)
  • As opposed to versions (in which both eyes move in the same direction), vergences are movements of the eyes in opposite directions. (medscape.com)
  • Both areas contained saccade-related activity that predicted the direction/timing of eye movements. (elifesciences.org)