S6 ribosomal protein ribosomal protein s6. Medical search. Frequent questions

Studies show that the p70 ribosomal protein S6 kinases (S6K1 and S6K2) and p90 ribosomal protein S6 kinases (RSK) both phosphorylate eS6 and that S6K1 and S6K2 predominate this function. (wikipedia.org)
We now provide evidence that two growth-regulated, nucleus- and cytoplasm-localized protein kinases, 90-kDa ribosomal S6 kinase (RSK) and mitogen-activated protein kinase (MAP kinase), contribute to the serum-induced phosphorylation of c-Fos. (nih.gov)
Ribosomal Protein S6 Kinases, 90-kDa" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
A family of ribosomal protein S6 kinases that are structurally distinguished from RIBOSOMAL PROTEIN S6 KINASES, 70-KDA by their apparent molecular size and the fact they contain two functional kinase domains. (uams.edu)
Although considered RIBOSOMAL PROTEIN S6 KINASES, members of this family are activated via the MAP KINASE SIGNALING SYSTEM and have been shown to act on a diverse array of substrates that are involved in cellular regulation such as RIBOSOMAL PROTEIN S6 and CAMP RESPONSE ELEMENT-BINDING PROTEIN. (uams.edu)
This graph shows the total number of publications written about "Ribosomal Protein S6 Kinases, 90-kDa" by people in UAMS Profiles by year, and whether "Ribosomal Protein S6 Kinases, 90-kDa" was a major or minor topic of these publications. (uams.edu)
Below are the most recent publications written about "Ribosomal Protein S6 Kinases, 90-kDa" by people in Profiles over the past ten years. (uams.edu)
It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. (genetex.com)
Protein kinases are one of the largest and most influential of gene families: constituting some 2% of the proteome, they regulate almost all biochemical pathways and may phosphorylate up to 30% of the proteome. (wormbook.org)
Protein kinases constitute one of the largest and most important of protein families, accounting for ~2% of genes in a variety of eukaryotic genomes. (wormbook.org)
By phosphorylating substrate proteins, kinases modify the activity, location and affinities of up to 30% of all cellular proteins, and direct most cellular processes, particularly in signal transduction and co-ordination of complex pathways. (wormbook.org)
Most protein kinases share a common ePK (eukaryotic protein kinase) catalytic domain, and can be identified by sequence similarity with Blast or profile hidden Markov models (HMMs). (wormbook.org)
The remaining atypical protein kinases (aPK) belong to several families, some of which have structural, but not sequence similarity to ePKs. (wormbook.org)
We identified 438 protein kinase genes, including 20 atypical kinases, and an additional 25 kinase fragments or pseudogenes. (wormbook.org)
A family of protein serine/threonine kinases which act as intracellular signalling intermediates. (bvsalud.org)
Ribosomal protein S6 kinases are activated through phosphorylation in response to a variety of HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. (bvsalud.org)
Although specific for RIBOSOMAL PROTEIN S6 members of this class of kinases can act on a number of substrates within the cell. (bvsalud.org)
The immunosuppressant SIROLIMUS inhibits the activation of ribosomal protein S6 kinases. (bvsalud.org)

Phosphorylation of ribosomal protein S6 (RPS6) on ser235/236 and ser240/244 in the pancreatic beta cell increases cell size and insulin content and influences systemic glucose homeostasis. (diabetesjournals.org)
Phosphorylation of RIBOSOMAL PROTEIN S6 by enzymes in this class results in increased expression of 5' top MRNAs. (bvsalud.org)

Ribosomal protein S6 (rpS6 or eS6) is a component of the 40S ribosomal subunit and is therefore involved in translation. (wikipedia.org)
Our phosphoproteomic analysis identified the protein phosphatase, PPm1K, as a novel regulator of RPS6 phosphorylation. (diabetesjournals.org)
PPm1K knockdown did not increase phosphorylation of p70 S6 Kinase (S6K) or the mammalian target of rapamycin (mTOR) upstream of RPS6 suggesting that PPm1K regulates RPS6 phosphorylation in an mTOR-S6K independent manner. (diabetesjournals.org)
The effects of siRNA-mediated PPm1K knockdown on RPS6 phosphorylation were accompanied by a 1.5 fold increase in protein translation and the induction of an unfolded protein response as determined by an increase in XBP-1 splicing, and BiP expression. (diabetesjournals.org)
Together our data identify a new role for the phosphatase PPm1K as a glucose sensitive modulator of RPS6 phosphorylation and protein translation that impacts beta cell insulin content and secretion. (diabetesjournals.org)
Results: The MS/TCAGE association was replicated and rationalized to a single marker, ribosomal protein S6 (RPS6). (edu.au)
Recombinant protein encompassing a sequence within the center region of human RPS6. (genetex.com)
RPS6 antibody detects RPS6 protein at cytoplasm and nucleus by immunofluorescent analysis. (genetex.com)
RPS6 is a protein with 28 kDa. (msgp.pt)

Active mTORC1 phosphorylates the eukaryotic initiation factor 4E-binding protein-1 (4E-BP1) and 40S ribosomal protein S6 kinase 1 (S6K1) to promote protein synthesis [ 3 , 4 ]. (springer.com)
PI3KCA E545K expression conferred resistance to MEKi plus CDK4i in NRAS-mutant melanoma cell lines and increased phosphorylation of S6 and its upstream kinase S6K1. (aacrjournals.org)
S6 is activated downstream of mTOR, and additional inhibition of mTOR or S6K1 reduced S6 phosphorylation and resensitized PI3KCA E545K cells to MEKi plus CDK4i. (aacrjournals.org)

For instance, it can be activated by oncogenic mutations of PTEN, VHL, the RAS/mitogen-activated protein kinase (MAPK) pathway and the phosphorylation of phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway. (spandidos-publications.com)

This compound markedly decreased the hypoxia-induced accumulation of HIF-1α protein dose-dependently, whereas it did not affect the expressions of HIF-1β and topoisomerase-I (topo‑I). Furthermore, celastrol prevented hypoxia-induced expression of HIF-1 target genes for vascular endothelial growth factor (VEGF) and erythropoietin (EPO). (spandidos-publications.com)
As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. (genetex.com)
Briefly, miRNAs are expected to account for 1-5% of the human genome and to interfere with at least 30% of the protein-coding genes ( 4 , 5 ). (frontiersin.org)

Pathways leading to the induction of human eS6 phosphorylation have been found to enhance IL-8 protein synthesis. (wikipedia.org)
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. (ebiocell.com)
Similarly, primary cilia have been implicated in regulation of mTOR signaling, in which Tuberous Sclerosis Complex proteins 1 and 2 (TSC1/2) negatively regulate protein synthesis by inactivating the mTOR complex 1 (mTORC1) at energy limiting states. (springer.com)
In the presence of nutrients, mTORC1 is activated and promotes cell growth, including protein synthesis and energy storage. (springer.com)
Further analysis revealed that celastrol inhibited HIF-1α protein synthesis, without affecting the expression level of HIF-1α mRNA or degradation of HIF-1α protein. (spandidos-publications.com)
Insulin reduces blood amino acid concentrations by limiting the release of amino acids into the bloodstream from skeletal muscle 18 , 20 and promoting protein synthesis in the liver and other tissues 3 . (biorxiv.org)
It plays a key role in cell growth and proliferation by regulating INS sensitivity, metabolism, protein synthesis, and cell cycle. (ptglab.com)
Supplementing with BCAAs has been shown to increase protein synthesis and decrease muscle breakdown. (ironmagazine.com)
While many amino acids play a role in building muscle tissue, leucine is the only amino acid that is proven to be anabolic by directly increasing protein synthesis. (ironmagazine.com)
Leucine is unique in its ability to stimulate protein synthesis. (ironmagazine.com)
Leucine has an impact on protein synthesis that is up to ten times greater than any other amino acid! (ironmagazine.com)
mTor is one of the body's protein synthesis regulators and energy sensors. (ironmagazine.com)
mTor increases protein synthesis in two different ways. (ironmagazine.com)
This protein increases the synthesis of components of the protein synthesis pathway. (ironmagazine.com)
So, not only does mTor increase protein synthesis, it also increases the capacity for protein synthesis. (ironmagazine.com)
mTor also inactivates the binding protein 4E-BP1, and this allows the eIF4E*eIF4G complex to form, which is crucial for allowing protein synthesis to take place. (ironmagazine.com)
Though it's not known how exactly leucine activates mTor, it's known that mTor is very sensitive to leucine concentrations, and mTor is critical for an increase in protein synthesis, which equates to more muscle growth. (ironmagazine.com)
Ingesting leucine at particular times is critical to increase protein synthesis and to slow muscle degradation. (ironmagazine.com)
High levels of ATP activate mTor, and AMP kinase halts the activation of mTor and protein synthesis. (ironmagazine.com)
When ample amounts of leucine are present during training, it keeps the protein synthesis pathway from being shutdown. (ironmagazine.com)
This is a period of time when muscle cells are primed for protein synthesis, but only if the right nutrition is consumed. (ironmagazine.com)
When there isn't enough leucine present, mTor is signaled that there isn't enough building blocks to build muscle tissue and protein synthesis it shut off. (ironmagazine.com)
mTor uses leucine as the standard amino acid to turn protein synthesis on or off, so this amino acid should be a staple post workout. (ironmagazine.com)

The protein belongs to the S6E family of ribosomal proteins. (genetex.com)

This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. (genetex.com)

The specificity of mAb N5-676 was confirmed by western blot analysis using unconjugated Mouse anti-S6 (pS244) antibody on lysates from untreated (lane 1) or PMA-treated (lane 2) PBMC. (bdbiosciences.com)

Autophagy is either positively mediated by the adenosine 5′-monophosphate (AMP) activated protein kinase (AMPK) pathway [ 12 ], or negatively mediated by the mammalian target of rapamycin (mTOR) pathway [ 13 ]. (hindawi.com)
Markedly, we found that suppression of HIF-1α accumulation by celastrol correlated with strong dephosphorylation of mammalian target of rapamycin (mTOR) and its effectors, ribosomal protein S6 kinase (p70S6K) and eukaryotic initiation factor 4E (eIF4E) and extracellular signal-regulated kinase (ERK), pathways known to regulate HIF-1α expression at the translational level. (spandidos-publications.com)

The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. (genetex.com)
Application of unidirectional pulsatile shear stress to human umbilical vein endothelial cells (HUVECs) decreased PDCD4 protein but not mRNA level. (plos.org)
Specifically, the PDCD4 protein combines directly with the mRNA coding region of the target gene ( MYB/c-MYB ) to block translation [2] . (plos.org)

Conversely, during starvation mTORC1 is inhibited and autophagy is induced by AMP-activated protein kinase (AMPK), leading to generation of intracellular nutrients and energy during degradation of non-functional or non-essential organelles or protein aggregates [ 4 , 6 ], in turn contributing to cell survival. (springer.com)
Autophagy is the "self-eating" process of degrading damaged proteins and organelles, as well as recycling intracellular energy to maintain cellular homeostasis under stress conditions. (hindawi.com)
These result in imbalances in the connectivity of neuronal circuitry, and also negatively impact the intracellular connectivity of neuronal proteins and protein pathways, contributing to cognitive decline associated with AD 6 . (nature.com)

Our results establish a chemistry-based framework for engineering sustained covalent inhibition without accumulating permanently modified proteins and peptides. (rcsb.org)

The phosphorylated form of 40S ribosome protein S6 is thus a marker for mTORC1 activity. (springer.com)

Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. (genetex.com)

Ribosomal+Protein+S6 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Overview of all the structural information available in the PDB for UniProt: P62753 (Human 40S ribosomal protein S6) at the PDBe-KB. (wikipedia.org)

Confocal immunofluorescent analysis of HeLa cells, insulin-treated (left) and LY294002-treated (#9901, right), using Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP ® Rabbit mAb (Alexa Fluor 488 ® Conjugate) (green). (cellsignal.com)

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine. (reactome.org)

2017. Cytoplasmic poly (A) binding protein (PABPC2) critically regulates epidermal maintenance and turnover in planarian Schmidtea mediterranea. . (ncbs.res.in)

Both proteins were localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. (nih.gov)

2018. FMRP Interacts with C/D Box snoRNA in the Nucleus and Regulates Ribosomal RNA Methylation. . (ncbs.res.in)

A database of ligand-responsive protein sequences. (guidetopharmacology.org)

In vivo studies further confirmed the inhibitory effect of celastrol on the expression of HIF-1α proteins, leading to a decreased growth of Hep3B cells in a xenograft tumor model. (spandidos-publications.com)
Experimental research found a markedly decreased expression of autophagy-related proteins such as Beclin-1, Atg12-Atg5, and LC3-II in a diabetic mouse model and in a high glucose-induced podocyte injury model [ 4 ]. (hindawi.com)
HSP90 inhibition may also enhance synaptic protein expression via activation of heat shock factor 1 (HSF-1) transcriptional regulation 16 . (nature.com)
This is accomplished by increasing both the interaction strength and number of interactions among participant proteins, which is not necessarily accompanied by a change in expression levels. (nature.com)

Incorporation of these electrophiles into a noncovalent kinase-recognition scaffold produced slowly dissociating, covalent inhibitors of the p90 ribosomal protein S6 kinase RSK2. (rcsb.org)

S6 Ribosomal Protein Mouse Monoclonal Antibody detects endogenous levels of S6 Ribosomal Protein protein. (ebiocell.com)

2022. Ribosomal protein S6 kinase beta-1 gene variants cause hypertrophic cardiomyopathy. . (ncbs.res.in)
Genome-wide association studies (GWASs) have linked RRBP1 (ribosomal-binding protein 1) genetic variants to atherosclerotic cardiovascular diseases and serum lipoprotein levels. (biomedcentral.com)

Autophagy is a self-protective pathway of cell catabolism that allows cells to degrade misfolded proteins or damaged organelles, providing energy for cells and maintaining their homeostasis [ 10 , 11 ]. (hindawi.com)

The heterodimeric TSC complex negatively regulates mTORC1 activity via the GTPase activity of TSC2, towards the small G-protein RHEB (Ras homologue enriched in brain) [ 5 ]. (springer.com)

RPS6KB1(Ribosomal protein S6 kinase beta-1) is also named as STK14A, p70 S6KA and belongs to the S6 kinase subfamily. (ptglab.com)
RPS6KB1 is a 70 kDa protein and has 5 isoforms with the calculated molecular mass of 51-59 kDa produced by alternative initiation. (ptglab.com)

It mainly forms the catalytic subunits of two protein complexes, including mTOR complex 1 (mTOR complex1, mTORC1) and mTOR complex 2 (mTOR complex2, mTORC2). (hindawi.com)

Pertinent to AD pathophysiology, heat shock protein 90 (HSP90)/co-chaperone complex folds tau or hyperphosphorylated tau, whereas heat shock protein 70-carboxyl-terminus of HSP70 Interacting protein (HSP70-CHIP) complex mediates degradation 13 , 14 . (nature.com)

Full length recombinant protein of human Proteasome 19S S3 (NP_002800) produced in HEK293T cells. (novusbio.com)
Analysis of S6 (pS244) in activated human peripheral blood mononuclear cells (PBMC). (bdbiosciences.com)
Unless otherwise stated all data on this page refer to the human proteins. (guidetopharmacology.org)

Herein, we showed that glibenclamide promoted insulin release and further activated autophagy through the adenosine 5′-monophosphate (AMP) activated protein kinase (AMPK) pathway in MIN-6 cells. (hindawi.com)

Anatomy15

Organisms8

Diseases2

Chemicals and Drugs74

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Phenomena and Processes41

Information Science4

Kinases18

Phosphorylation of ribosomal pr2

RpS69

S6K13

Mitogen-activa1

Genes3

Synthesis23

Family of ribosomal1

Subunit1

Specificity1

Mammalian target of2

MRNA3

Intracellular3

Peptides1

Ribosome1

Structurally1

P627531

Ser2401

Serine1

Cytoplasmic1

Cytoplasm1

Nucleus1

Sequences1

Expression4

Inhibitors1

Detects1

Variants2

Organelles1

Regulates1

RPS6KB12

MTOR complex1

Degradation1

Human3

Pathway1