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  • cycles
  • Store lyophilized protein at -20°C. Lyophilized protein remains stable until the expiry date when stored at -20°C. Aliquot reconstituted protein to avoid repeated freezing/thawing cycles and store at -80°C for long term storage. (abcam.com)
  • identical
  • Four of the variants contain the three-exon structure with the coding sequences in exon 2 and exon 3, while also sharing identical protein sequences only differing in their untranslated 5' region (Wolf et al. (atlasgeneticsoncology.org)
  • This protein has a Ca2+ affinity 20- to 100-fold higher than the other S100 proteins studied under identical conditions. (mybiosource.com)
  • proteome
  • Proteins isolated from the TCL were subjected to two-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS) in order to profile the TCL proteome, identifying in particular those proteins associated with host-defence. (biomedcentral.com)
  • Identification of metastasis candidate proteins among HCC cell lines by comparative proteome and biological function analysis of S100A4 in metastasis in vitro. (emjreviews.com)
  • actin
  • May function by interacting with other proteins and indirectly play a role in the reorganization of the actin cytoskeleton and in cell motility. (mybiosource.com)
  • Products
  • Here we found that in response to hyperglycemia, neutrophil-derived S100 calcium-binding proteins A8/A9 (S100A8/A9) interact with the receptor for advanced glycation end products (RAGE) on hepatic Kupffer cells, resulting in increased production of IL-6, a pleiotropic cytokine that is implicated in inflammatory thrombocytosis. (jci.org)
  • composition
  • The bovine teat canal provides the first-line of defence against pathogenic bacteria infecting the mammary gland, yet the protein composition and host-defence functionality of the teat canal lining (TCL) are not well characterised. (biomedcentral.com)
  • However, to date the identity of these cationic proteins is still to be established, and the detailed protein composition of the TCL has not been characterised. (biomedcentral.com)
  • In an attempt to better understand the host-defence capacity of the teat canal we characterised the protein composition of the TCL collected from healthy lactating dairy cows. (biomedcentral.com)
  • Function
  • This protein function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. (creativebiomart.net)
  • identification
  • Tears from another five pterygium patients were used for subsequent protein identification experiments using nanoLC coupled with nano-electrospray tandem mass spectrometry (nano-ESI-MS/MS). (arvojournals.org)
  • Modern protein separation and identification technologies allow a much more detailed characterisation of the TCL proteins than has been previously reported. (biomedcentral.com)
  • cell
  • Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. (abcam.com)
  • variants
  • The S100A2 gene has a total length of 4723 bp and seven splice variants, which can be categorized into five variants with protein product and two transcripts without an open-reading frame. (atlasgeneticsoncology.org)
  • inflammatory
  • In this study we have determined that the inflammatory nature of pterygium is reflected in the protein components of the tears. (arvojournals.org)
  • 1 The S100 proteins have been reported to be implicated in the inflammatory response process, as well as in the metastatic development of several cancers. (emjreviews.com)
  • activity
  • Four of the six identified S100 proteins have been reported to have antimicrobial activity, suggesting that the TCL has additional functionality beyond being a physical barrier to invading microorganisms. (biomedcentral.com)