The S100 calcium binding protein B (S100B) implicated in brain inflammation acts via the receptor of advanced glycation end products (RAGE) and is also secreted from adipocytes. (nih.gov)
Secondary outcomes evaluated stress and inflammatory indices using the Perceived Stress Scale (PSS), S100 calcium-binding protein B (S100B), and C-reactive protein (CRP). (nih.gov)
La elevación de la concentración de S100B en el tejido cerebral se correlaciona con su papel en trastornos neurológicos. (bvsalud.org)
S100 calcium-binding protein B (S100B) is a protein of the S-100 protein family. (assaysolution.com)
S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. S100A is composed of an alpha and beta chain whereas S100B is composed of two beta chains. (scytek.com)
Antibody13
Antibody to S100 stains Schwannomas, ependymomas, astrogliomas, almost all benign and malignant melanomas and their metastases. (scytek.com)
This antibody reacts with alpha and beta subunits of human S-100 protein (21-24 kD). (abcam.cn)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Defensin Beta 1 (DEFb1) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (jsce-ip.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Defensin Beta 1 (DEFb1) in samples from Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (jsce-ip.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse EGF Like Domain Protein, Multiple 7 (EGFL7) in serum, plasma, tissue homogenates and other biological fluids. (gkts.net)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse EGF Like Domain Protein, Multiple 7 (EGFL7) in samples from Serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (gkts.net)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Dickkopf Related Protein 4 (DKK4) in serum, plasma and other biological fluids. (gkts.net)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Calpain 1, Large Subunit (CAPN1) in samples from Tissue homogenates, cell lysates and other biological fluids. (clinical-trial-logistics.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Myelin Proteolipid Protein Like Protein (PLPL) in samples from Tissue homogenates and other biological fluids. (operatiebrp.nl)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Surfactant Associated Protein D (SPD) in serum, plasma, lung lavage fluid and other biological fluids. (2sars.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Surfactant Associated Protein D (SPD) in samples from serum, plasma, lung lavage fluid and other biological fluids with no significant corss-reactivity with analogues from other species. (2sars.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Patatin Like Phospholipase Domain Containing Protein 2 (PNPLA2) in tissue homogenates, cell lysates and other biological fluids. (resourcerecovery.be)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Patatin Like Phospholipase Domain Containing Protein 2 (PNPLA2) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (resourcerecovery.be)
Neuron-specifi1
Additionally, markers of early signs of neuronal damage were determined in 10 patients: neuroglial protein S100 and neuron-specific enolase NSE. (edu.ua)
Genes3
S100 genes include at least 19 members which are located as a cluster on chromosome 1q21. (wikipedia.org)
Mapping of the genes encoding human protein matches to pathways point to targets that could explain the observed presentation of symptoms in COVID-19 disease. (danielsolis.cz)
185 genes in signature reported in the publication with PubMedID mRNA_KAT5_22196727 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. (maayanlab.cloud)
Kinase4
This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. (wikipedia.org)
The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. (cancerindex.org)
Cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) interacts with CDK2AP2, modulates the actions of transforming growth factor-B1, cyclin-dependent kinase 2 and retinoblastoma protein, and closely interacts with micro-RNA21 and micro-RNA25. (cancerindex.org)
Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. (abcam.cn)
Specificity1
Specificity: Recognizes proteins of 21-24kDa, identified as the A and B subunits of S100 protein. (scytek.com)
ELISA12
This Human S100A1 ELISA Kit was designed for the quantitative measurement of Human S100A1 protein in serum, plasma, tissue homogenates. (cusabio.com)
Description: A sandwich quantitative ELISA assay kit for detection of Human Defensin Beta 1 (DEFb1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (jsce-ip.com)
Description: A sandwich ELISA kit for detection of EGF Like Domain Protein, Multiple 7 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (gkts.net)
Description: A sandwich quantitative ELISA assay kit for detection of Human EGF Like Domain Protein, Multiple 7 (EGFL7) in samples from serum, plasma, tissue homogenates or other biological fluids. (gkts.net)
Description: A sandwich quantitative ELISA assay kit for detection of Human Dickkopf Related Protein 4 (DKK4) in samples from serum, plasma or other biological fluids. (gkts.net)
Description: A sandwich quantitative ELISA assay kit for detection of Human Calpain 1, Large Subunit (CAPN1) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (clinical-trial-logistics.com)
Description: A competitive ELISA for quantitative measurement of Human Myelin proteolipid protein(PLP1) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (operatiebrp.nl)
Description: A sandwich quantitative ELISA assay kit for detection of Human Proteolipid Protein 1, Myelin (PLP1) in samples from tissue homogenates, cell lysates or other biological fluids. (operatiebrp.nl)
Description: A competitive ELISA for quantitative measurement of Human AN1 type zinc finger protein 6(ZFAND6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (operatiebrp.nl)
Description: A competitive ELISA for quantitative measurement of Rat AN1 type zinc finger protein 6(ZFAND6) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (operatiebrp.nl)
Description: A sandwich quantitative ELISA assay kit for detection of Human Surfactant Associated Protein D (SPD) in samples from serum, plasma, tissue homogenates, cell lysates, lung lavage fluid, cell culture supernates or other biological fluids. (2sars.com)
Description: A sandwich ELISA for quantitative measurement of Mouse Alpha hemoglobin stabilizing protein(ERAF) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (scalegen.com)
S100 protein is highly soluble and may be eluted from frozen tissue during staining. (scytek.com)
Alpha1
This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. (cancerindex.org)
Symbol1
with Pubmed ID, gene symbol/accession number and viral interacting protein. (polygenicpathways.co.uk)
Receptor3
Binding of these ligands to RAGE does not accelerate clearance or degradation but rather begins a sustained period of cellular activation mediated by receptor-dependent signaling. (jci.org)
Herein, we investigate how inflammatory mediators, including microglia, interleukin 1 beta (IL1β), and signaling through interleukin 1 receptor type 1 (IL-1R1), influence the survival of retinal neurons in response to excitotoxic damage. (biomedcentral.com)
Antigen1
S100 protein is also expressed in the antigen presenting cells such as the Langerhans cells in skin and interdigitating reticulum cells in the paracortex of lymph nodes. (scytek.com)
Cytoplasm1
S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. (wikipedia.org)
Intracellular2
In a rat model of myocardial infarction, intracoronary S100A1 adenoviral gene transfer restored sarcoplasmic reticular calcium transients and load, normalized intracellular sodium concentrations, reversed the pathologic expression of the fetal gene program, restored energy supply, normalized contractile function, preserved inotropic reserve, and reduced cardiac hypertrophy 1 week post-myocardial infarction. (wikipedia.org)
In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes. (cusabio.com)
Motifs1
S100A1 contains 4 EF-hand calcium-binding motifs in its dimerized form, and can exist as either a hetero or homodimer. (wikipedia.org)
Family5
S100A1 is a member of the S100 family of proteins expressed in cardiac muscle, skeletal muscle and brain, with highest density at Z-lines and sarcoplasmic reticulum. (wikipedia.org)
These biophysical properties seem to be well conserved across the S100 family of proteins. (wikipedia.org)
The purpose of this study was to find and analyze the differentially expressed proteins between PNKD patients and their healthy family members with matched age and gender, thus providing potential biomarkers for early diagnosis of patients with PNKD. (jneuropsychiatry.org)
Isobaric tags for relative and absolute quantitation (iTRAQ) coupled with LC-MS/MS were used to identify the differential proteins obtained from CSF and plasma of PNDK patients and healthy family members. (jneuropsychiatry.org)
The numbers of proteins that were differentially expressed between PNKD patients and their healthy family members were 42 in CSF and 57 in plasma respectively. (jneuropsychiatry.org)
Interactions2
This conformational change exposes a large hydrophobic pocket between helix 3, 4, and the hinge region of S100A1 that is involved in virtually all calcium-dependent target protein interactions. (wikipedia.org)
These changes allow interactions with specific target proteins and modulate their activity. (cusabio.com)
S100A1
S100A1 has been shown to interact with the PEVK region of Titin in a calcium-dependent manner, and its binding reduces the force in an in vitro motility assay, suggesting that S100A may modulate Titin-based passive tension prior to systole. (wikipedia.org)
Extracellular1
Extracellular S-100 beta from normal C6 cells may function as a growth factor on sprouting serotonergic fibers. (ox.ac.uk)
Nuclear protein2
nuclear protein 1, transcriptional regula. (gsea-msigdb.org)
and amphoterin, a nuclear protein sometimes found in the ECM (Table 1 ). (jci.org)
Dissociation1
one in the N-terminus and a canonical EF hand in the C-terminus having higher calcium affinity (dissociation constant of roughly 20 micromolar). (wikipedia.org)
Accession1
The most accurate high-resolution solution structure of human apo-S100A1 protein (PDB accession code: 2L0P) has been determined by means of NMR spectroscopy in 2011. (wikipedia.org)
Plasma4
Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. (gsea-msigdb.org)
A total of 1242 and 512 unique proteins were identified in CSF and plasma respectively. (jneuropsychiatry.org)
Two differentially expressed proteins in the CSF, CALML5 and PDGFA, and one in the plasma, ACTB, showed close links with the PNKD protein in the protein-protein interaction network. (jneuropsychiatry.org)
In this case, plasma, which contains thousands of proteins available for potential biomarker evaluation, offers a promising alternative choice for PNKD biomarker screening [ 12 ]. (jneuropsychiatry.org)
Viral1
Homology between human and viral proteins is an established factor in viral- or vaccine-induced autoimmunity. (danielsolis.cz)
Dependent3
Helix 3, 4, and the hinge region are the most divergent areas between individual S100 proteins, and so it is likely that the sequence of these regions is pivotal in fine-tuning calcium-dependent target binding by S100 proteins. (wikipedia.org)
Whereas DNMT1 is the key maintenance methyltransferase, DNMT3A and DNMT3B represent the main de novo methyltransferases, as they can bind unmethylated DNA and establish novel DNA methylation marks not only during early development but also in differentiated cells in a signal-dependent manner 9 . (nature.com)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
Biological1
Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation. (cusabio.com)