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  • RyRs
  • The modification in the response of RyRs to luminal Ca(2+) was not observed with heat-inactivated trypsin, indicating that digestion of luminal sites on the RyR channel complex was responsible. (ox.ac.uk)
  • congenital
  • The current studies of calcium mobilization began with our search for a conceptual framework for thinking about the origin of a series of congenital myopathies. (utah.edu)
  • affinity
  • At high NaCl concentrations, propranolol increased the number of ryanodine-binding sites (B max ) with no effect on the binding affinity. (biochemj.org)
  • mechanism
  • Specifically, the decline of intra-SR [Ca 2+ ] that accompanies the Ca 2+ -release process contributes to Ca 2+ -release termination, a mechanism referred to as luminal Ca 2+ -dependent deactivation. (ahajournals.org)
  • Alessandri-Haber N, Dina OA, Joseph EK, Reichling D, Levine JD (2006) A transient receptor potential vanilloid 4-dependent mechanism of hyperalgesia is engaged by concerted action of inflammatory mediators. (springer.com)
  • The mechanism controlling [Ca2+]i primarily involves agonist-induced release of Ca2+ from internal stores to generate Ca2+ oscillations. (umassmed.edu)
  • modulators
  • Modulators of the RyR that are known to alter its conformational states, such as adenine nucleotides, Ca 2+ concentration and pH, modified the effect of propranolol on ryanodine binding. (biochemj.org)
  • depolarization
  • Voltage-gated Ca 2+ (Ca V 1.1) channels, found in tubules or plasmalemma, form symmetric complexes called Ca V tetrads that associate with and activate underlying RYR tetramers during membrane depolarization by conveying a conformational change. (rupress.org)
  • regulation
  • Cardiomyocytes have been shown to express in different conditions all types of nitric oxide synthases (NOS), but the role of NO in the regulation of calcium current remains controversial. (semanticscholar.org)