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  • complexes
  • In previous studies, ruthenium complexes have shown good anti-AChE activity and anti-GST activity and possible therapeutic applications in the treatment of Alzheimer's disease and cancer, where they can act as multitarget drugs. (uniri.hr)
  • Therefore, we have tested 32 newly synthesized ruthenium complexes and their precursors for inhibition of the above mentioned enzymes. (uniri.hr)
  • Results of this study have shown that ruthenium complexes have good inhibitory activity on enzymes, moreover some of the complexes have inhibited all of the three tested enzymes, which makes them potential multitarget drugs. (uniri.hr)
  • aromatic
  • More specifically, this invention relates to a process for forming organometallic compounds in which an aromatic-metal-cyclopentadienyl compound is reduced to form a compound in which both an aromatic molecule and a cyclopentadiene molecule are bonded to the metal atom. (google.com)
  • A furtherobject is to provide a new process in which an aromaticmetalscyclopentadienyl compound, either neutral orionic, is reacted with reducing agent to form compounds (in which both an aromatic molecule and a cyclopentadiene molecule are bonded to a single metal atom. (google.com)
  • This invention involves the formation of organometallic compounds in which an aromatic molecule and a cyclopentadiene molecule are coordinated with a single metal atom. (google.com)
  • The compounds produced byour process contain an aromatic molecule and a cyclopentadiene molecule which are both coordinated with a single metal atom selected from the above group. (google.com)
  • For best results, the preferred aromatic molecule coordinatedwith the metal atom, is a compound containing an isolated benzene nucleus, especially those which are free of aliphatic unsaturation on a carbon atom adjacent the benzene ring. (google.com)
  • reducing agent
  • This involves a process in which an aromaticmetal-cyclopentadienyl compound, either neutral or ionic, is reacted with a reducing agent. (google.com)
  • cytotoxicity
  • Compounds 1 , 2 , and 3 showed much higher cytotoxicity than the cisplatin against human leukaemia cancer cells (HL-60 cells). (hindawi.com)
  • In cell-free experiments, these classes of compounds inhibit the activity of cdk2/cyclin E, but the much higher cytotoxicity and stronger cell cycle effects of indoloquinolines L 1 and 7 are not paralleled by a substantially higher kinase inhibition compared with indolobenzazepines L 4 and 11 , arguing for additional targets and molecular effects, such as intercalation into DNA. (springer.com)
  • The compounds shown in Structure 2 were tested for cytotoxicity at the US National Cancer Institute in a panel of about 60 human cancer cell lines. (springer.com)
  • organic
  • Class 987 provides an ANCILLARY and totally OPTIONAL search for subject matter relating to certain types of ORGANIC COMPOUNDS found under official Class 532. (uspto.gov)
  • 40°C. The organic Ru compound is produced in high yield, has excellent thermal decomposition properties, high sintering ability, and can be used to form an ink for preparing a film resistor at low temperature. (matthey.com)
  • Molecular
  • In this study, we used a potent ruthenium (II)-derived compound, [Ru(η6-cymene)2-(1H-benzoimidazol-2-yl)-quinoline Cl]BF4 (TQ-6), to investigate the molecular mechanisms underlying the anti-inflammatory effects against lipopolysaccharide (LPS)-induced macrophage activation and liver injury in mice. (mdpi.com)
  • atoms
  • Most ruthenium atoms were retained in the nuclear compartment, particularly in HCC1937 cells, after 24 h of incubation, and produced a significant block at the G2/M phase. (biomedcentral.com)
  • Uptake
  • It has been hypothesised that transferrin-mediated uptake by transferrin receptor expressing tumour cells may in part explain the apparent tumour selectivity of this compound. (rsc.org)
  • KP1019
  • Circular dichroism spectroscopy and electrospray ionisation mass spectrometry studies demonstrate that two equivalents of KP1019 bind specifically to human apotransferrin , while additional amounts of the ruthenium complex bind unspecifically. (rsc.org)
  • Cell fractionation experiments demonstrated that after a 2 h treatment of human colon cancer cells with 10 µM KP1019 on average 55% of the intracellular ruthenium is located in the cellular nucleus , while 45% remain in the cytosol and other cellular components. (rsc.org)
  • KP1019 comprises a class of ruthenium compounds having promising anticancer activity. (yeastgenome.org)
  • derivatives
  • Moreover, although the library of compounds created is remarkable, it lacks metal-based derivatives, and the effect of metal coordination of indolo[3,2- c ]quinolines on the antiproliferative activity and biological mechanisms involved remained unexplored. (springer.com)
  • bismuth
  • ceramics are lead oxide (PbO), ruthenium dioxide (RuO 2 ), bismuth ruthenate (Bi 2 Ru 2 O 7 ), and bismuth iridate (Bi 2 Ir 2 O 7 ). (britannica.com)
  • cancers
  • It was some 50 years ago that Barnett Rosenberg and coworkers published their studies on unusual patterns of bacterial growth that led to the identification of platinum compounds as highly effective agents against some cancers, particularly those of genitourinary origin. (matthey.com)
  • Our results could provide an alternative approach to finding effective therapeutic ruthenium-based agents with promising anticancer activity, and demonstrated that the BRCA1 RING domain protein was a promising therapeutic target for breast cancers. (biomedcentral.com)
  • drugs
  • All this indicates that this family of compounds is worth investigating further as potential antitumor drugs. (springer.com)
  • Scientists working with similar elements, such as ruthenium, hope to develop effective, less toxic alternative chemotherapy drugs. (uta.edu)
  • activity
  • More importantly, we show that blocking reactive oxygen species production or caspase 8 activity reduces significantly the activity of the compounds. (univoak.eu)
  • Changes in the conformation and binding constants of ruthenium-BRCA1 adducts were observed, causing inactivation of the RING heterodimer BRCA1/BARD1-mediated E3 ubiquitin ligase activity. (biomedcentral.com)
  • CARBON
  • For best results, the preferred aromatic molecule coordinatedwith the metal atom, is a compound containing an isolated benzene nucleus, especially those which are free of aliphatic unsaturation on a carbon atom adjacent the benzene ring. (google.com)
  • Reaction
  • These conditions do not permit a subtle control of the reaction stoichiometry nor is it possible to synthesize thermally labile or metastable compounds [ 2 ]. (mdpi.com)
  • class
  • We have previously described a class of ruthenium(II) compounds with interesting anticancer properties. (univoak.eu)
  • Altogether our data suggest that water-soluble ruthenium(II)-derived compounds represent an interesting class of molecules that, depending on their structures, can target several pro-apoptotic signaling pathways leading to reactive oxygen species production and caspase 8 activation. (univoak.eu)
  • The general hierarchy of the Class 532 series has not been followed and the above compounds include heterocyclic rings when present together with the required elements of this class. (uspto.gov)
  • cells
  • Ruthenium treatment upregulated the marker genes involved in apoptosis and cell cycle progression while it downregulated BRCA1 mRNA and replication of HCC1937 cells. (biomedcentral.com)
  • Inhibition of adhesion, migration and of α5β1 integrin in the HCT-116 colorectal cancer cells treated with the ruthenium drug NAMI-A. (nih.gov)
  • active
  • PQQ-dependent glucose dehydrogenase is more active than FAD-dependent glucose oxidase in the process of D-glucose oxidation by ruthenium(III) compounds, this being due to the different catalytic mechanisms of these enzymes. (ebscohost.com)
  • Drug
  • Influence of components of tumour microenvironment on the response of HCT-116 colorectal cancer to the ruthenium-based drug NAMI-A. (nih.gov)