• Expressions of ryanodine receptor 2 (RyR2), sarcoplasmic reticulum Ca 2+ -2ATPase (SERCA) and Na + /Ca 2+ exchanger (NCX1) were decreased, together with quantitative alterations in Ca 2+ regulatory proteins, FKBP12.6 and phospholamban progressively and respectively in the diabetic rats. (biomedcentral.com)
  • 7 ] found that the SR Ca 2+ release rate and Ca 2+ stores were depressed in the cardiomyocytes of type 1 diabetic rats. (biomedcentral.com)
  • The aim of the current investigation was to scrutinize the protective effect of luteolin against the STZ induced Diabetic Cardiomyopathy (DCM) in rats. (alliedacademies.org)
  • Given that diabetic cardiomyopathy's definition excludes concomitant atherosclerosis or hypertension, there are no changes in perfusion or in atrial natriuretic peptide levels up until the very late stages of the disease, when the hypertrophy and fibrosis become very pronounced. (wikipedia.org)
  • As shown in a previous study, the ability of Ca 2+ current to trigger SR Ca 2+ release is decreased significantly in diabetic cardiomyocytes. (biomedcentral.com)
  • 8 ] the maximal amplitude of Ca 2+ sparks was not significantly changed, but the spontaneous Ca 2+ spark frequency was elevated in diabetic cardiomyocytes, compared with control cells. (biomedcentral.com)
  • However, as discussed by Feuvray and Lopaschuk 3 and Paulson, 4 there has been considerable debate regarding the sensitivity of the diabetic heart to ischemic injury. (ahajournals.org)
  • The existence of DCM is supported by population-based studies ( 4 ) and by observations that in comparison with age-matched individuals, diabetic subjects have an increased frequency of HF that persists even after adjustment for CAD ( 1 ). (onlinejacc.org)