The 37/67-kDa laminin receptor (LAMR/RPSA) was originally identified as a 67-kDa binding protein for laminin, an extracellular matrix glycoprotein that provides cellular adhesion to the basement membrane. (nih.gov)
LAMR has evolutionary origins, however, as a 37-kDa RPS2 family ribosomal component. (nih.gov)
LamR11
Cell-adhesive protein LAMR1 plays an important role in the processes of cancer proliferation, invasion and metastasis. (nih.gov)
Extracellular matrix1
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. (wikipedia.org)
Probe Set ID Ref Seq Protein ID Signal Strength Name Gene Symbol Species Function Swiss-Prot ID Amino Acid Sequence 1367452_at NP_598278 7.9 small ubiquitin-related modifier 2 precursor Sumo2 Rattus norvegicus " Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. (nih.gov)
Ribosomal6
40S ribosomal protein SA is a ribosomal protein that in humans is encoded by the RPSA gene. (wikipedia.org)
The RPSA gene encodes a multifunctional protein, which is both a ribosomal protein and a high-affinity, non-integrin laminin receptor. (wikipedia.org)
Ribosomal protein SA and RPSA are the approved name and symbol. (wikipedia.org)
The N-domain of RPSA is homologous to the ribosomal protein S2 (RPS2) of prokaryotes. (wikipedia.org)
RPSA is a ribosomal protein which has acquired the function of laminin receptor during evolution. (wikipedia.org)
i) Yeast two-hybrid screens have shown that RPSA binds to Ribosomal protein S21 of the 40S small ribosomal subunit. (wikipedia.org)
Binds5
RPSA binds to proteins that are involved in the translation of the genetic code. (wikipedia.org)
iii) Studies that were based on nuclear magnetic resonance spectroscopy (NMR), have shown that the anticodon binding domain of Lysyl-tRNA synthetase binds directly to the C-domain of RPSA. (wikipedia.org)
Heparin binds in vitro to the N-domain of RPSA but not to its C-domain. (wikipedia.org)
i) RPSA binds aflatoxin B1 both in vivo and in vitro. (wikipedia.org)
The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. (nih.gov)
Ribosome2
and p40 ribosome-associated protein. (wikipedia.org)
ii) Serial deletions of RPSA have shown that the segment of residues 236-262, included in the C-domain, is involved in the interaction between RPSA and the 40S subunit of ribosome. (wikipedia.org)
RPS22
Expressed in all domains of life, RPS2 proteins have been shown to have remarkably diverse physiological roles that vary across species. (nih.gov)
The structure of the N-domain of RPSA is similar to those of prokaryotic RPS2. (wikipedia.org)
Cellular3
The folding intermediate is predominant at 37 °C. Several interactions of RPSA that had originally been discovered by methods of cellular biology, have subsequently been confirmed by using recombinant derivatives and in vitro experiments. (wikipedia.org)
RPSA is a potential cellular receptor for several pathogenic Flaviviruses, including the dengue virus (DENV), and Alphaviruses, including the Sindbis virus (SINV). (wikipedia.org)
This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. (nih.gov)
Residues2
RPSA can be sub-divided in two main domains: an N-domain (residues 1-209), which corresponds to exons 2-5 of the gene, and a C-domain (residues 210-295), which corresponds to exons 6-7. (wikipedia.org)
The N-domain also includes weak binding sites for recombinant domain 3 (ED3, residues 296-400) from the envelope proteins of two Flaviviruses, West-Nile virus and serotype 2 of DENV. (wikipedia.org)
Colon1
It has been observed that the level of RPSA transcript is higher in colon carcinoma tissue and lung cancer cell lines than their normal counterparts. (wikipedia.org)
Processes1
It also acts as a cell surface receptor, in particular for laminin, and is involved in several pathogenic processes. (wikipedia.org)
Functions2
The latter have shown that the folded N-domain and disordered C-domain of RPSA have both common and specific functions. (wikipedia.org)
Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity). (nih.gov)
Highly1
Moreover, the C-domain of RPSA and heparin compete for binding to laminin, which shows that the highly acidic C-domain of RPSA mimicks heparin (and potentially heparan sulfates) for the binding to laminin. (wikipedia.org)
Small1
RPSA is also a receptor for small molecules. (wikipedia.org)
Family1
These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. (wikipedia.org)