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  • Derris
  • 3. PHYSICO-CHEMICAL PROPERTIES 3.1 Origin of the substance Rotenone is extracted from plants, particularly from Derris spp grown in Malaya, East Indies, and South America, and Lonchocarpus also known as "cub ", grown in Central and South America. (inchem.org)
  • In 1902 Japanese chemist Nagai Nagayoshi isolated a pure crystalline compound from Derris elliptica which he called rotenone, after the Japanese name of the plant, roten. (wikipedia.org)
  • Rotenone is produced by extraction from the roots and stems of several tropical and subtropical plant species, especially those belonging to the genera Lonchocarpus and Derris. (wikipedia.org)
  • Rotenone, isolated from roots of derris plant, has been shown to possess various biological activities, which lead to attempting to develop a potent drug against several diseases. (sigmaaldrich.com)
  • Derris root, when crushed, releases rotenone. (wikipedia.org)
  • Isolation of rotenone from Derris elliptica in 1902. (wikipedia.org)
  • dopaminergic
  • Moreover, MCE treatment significantly augments the levels of anti-apoptotic Bcl2 and blocks the release of cytochrome c, thereby alleviating the rotenone-induced dopaminergic neuronal loss, as evidenced by tyrosine hydroxylase (TH) immunostaining in the striatum . (medchemexpress.com)
  • Here we report that rotenone-induced apoptosis in human dopaminergic SH-SY5Y cells is attenuated by pretreatment with several growth factors, most notably basic fibroblast growth factor (bFGF). (jneurosci.org)
  • These data suggest that rotenone-induced dopaminergic cell death requires BAD and identify bFGF and its activation of ERK1/2 and PI3-kinase signaling pathways as novel intervention strategies to block cell death in the rotenone model of Parkinson's disease. (jneurosci.org)
  • In this study, using primary mesencephalic cultures, we observed that nontoxic or minimally toxic concentrations of the pesticide rotenone (0.5 n m ) and the inflammogen lipopolysaccharide (LPS) (0.5 ng/ml) synergistically induced dopaminergic neurodegeneration. (jneurosci.org)
  • induce
  • 2.4 First-aid measures and management principles Ingestion: Induce vomiting unless the product vehicle is a petroleum distillate (see the treatment protocol on decontamination procedures) Gastric lavage may be performed if a large amount of rotenone was ingested even if it is dissolved in kerosene or a related petroleum distillate. (inchem.org)
  • However, recent studies have demonstrated that rotenone has the potential to induce several adverse effects such as a neurodegenerative disease. (sigmaaldrich.com)
  • NSC34 motor neuron cells were pretreated with 2.5 μg/mL BV and stimulated with 10 μM rotenone to induce cell toxicity. (nih.gov)
  • Third and most importantly, rotenone and LPS failed to induce the synergistic neurotoxicity as well as the production of superoxide in cultures from NADPH oxidase-deficient animals. (jneurosci.org)
  • Feng
  • Based on these findings, we believe that microtubules are a critical target of PD environmental toxins such as rotenone," said Feng. (rxpgnews.com)
  • COMPOUND
  • Radiolytic transformation of the rotenone with gamma-irradiation created a new product, named rotenoisin B. The present work was designed to investigate the anticancer activity of rotenoisin B with low toxicity and its molecular mechanism in hepatic cancer cells compared to a parent compound, rotenone. (sigmaaldrich.com)
  • invasive species
  • But as I re-enter my brain into my job, I noticed this Chicago Tribune story about plans to apply Rotenone to deal with Asian Carp - an invasive species in the Great Lakes region. (scpr.org)
  • cellular
  • Methods: In this study, we aimed at exploring the role of autophagy in the pathogenesis of rotenone-induced cellular and animal models for PD. (harvard.edu)
  • Typically, rotenone-containing plants in the Fabaceae family of legumes are crushed and introduced into a body of water, and as rotenone interferes with cellular respiration, the affected fish rise to the surface in an attempt to gulp air, where they are more easily caught. (wikipedia.org)
  • Pre-treatment with BV significantly enhanced cell viability and ameliorated mitochondrial impairment in rotenone-treated cellular model. (nih.gov)
  • vivo
  • Moreover, the number of autophagic vacuoles was increased in rotenone-based PD models in vitro and in vivo. (harvard.edu)
  • poison
  • The earliest record of the now-known rotenone-containing plants used for killing leaf-eating caterpillars was in 1848, and for centuries, the same plants were used to poison fish. (wikipedia.org)
  • dose-dependent
  • Results: Reactive oxygen species over-generation, mitochondrial membrane potential reduction or apoptosis rate elevation occurred in a dose-dependent fashion in rotenone-treated human neuroblastoma cell line SH-SY5Y. (harvard.edu)
  • Rotenone (1.5, 2, or 2.5 mg/kg) causes a dose-dependent increase in α-synuclein in the substantia nigra. (medchemexpress.com)
  • cells
  • Interestingly, rotenoisin B showed low toxic effects on normal cells compared to rotenone. (sigmaaldrich.com)
  • Pretreatment with 2.5 μg/mL BV had a neuroprotective effect against 10 μM rotenone-induced cell death in NSC34 motor neuron cells. (nih.gov)
  • Moreover, BV treatment inhibited the activation of JNK signaling and cleaved caspase-3 related to cell death and increased ERK phosphorylation involved in cell survival in rotenone-treated NSC34 motor neuron cells. (nih.gov)
  • A) NSC34 cells were treated with 10 µM rotenone for 0, 3, 6, 12, and 24 h and cell viability was determined using MTT assay. (nih.gov)
  • B) NSC34 cells were treated with 2.5 µg/mL BV prior to stimulation with 10 µM rotenone for 24 h. (nih.gov)
  • BV pretreatment prevented 10 µM rotenone-induced cytotoxicity in NSC34 cells. (nih.gov)
  • To examine the cytotoxicity of NSC34 cells after rotenone treatment, we incubated NSC34 motor neuron cells with 10 μM rotenone for various time periods (0, 3, 6, 12, and 24 h). (nih.gov)
  • Compared to untreated NSC34 cells, 10 μM rotenone treatment for 24 h resulted in a 37% decrease in cell viability. (nih.gov)
  • To investigate whether BV attenuates rotenone-induced cytotoxicity, we performed a cell viability test on the cells treated with 10 μM rotenone for 24 h with or without 2.5 µg/mL BV pretreatment. (nih.gov)
  • BV pretreatment prevented cell death induced by 10 μM rotenone, with about 29% protection for a dose of 2.5 µg/mL BV compared to rotenone-treated cells (Figure 1B). (nih.gov)
  • Reducing the expression of the proapoptotic protein Bcl-2-associated death protein (BAD) by small interfering RNA rendered SH-SY5Y cells resistant to rotenone, implicating BAD in rotenone-induced cell death. (jneurosci.org)
  • lakes
  • 2. The Washington State Office of Financial Management eliminated the funds in the WDFW budget for treating lakes with rotenone. (washingtonflyfishing.com)
  • You need to tell the legislators from your district that treating lakes with rotenone is very important and must be left in the budget for the WDFW. (washingtonflyfishing.com)
  • Rotenone has been used by government agencies to kill fish in rivers and lakes in the United States since 1952. (wikipedia.org)
  • free radical
  • So the aim of this research is to study the changes of free radical oxidation processes depending on time in rat tissues (different parts of brain, liver, and heart) via rotenone model. (scirp.org)
  • Second, rotenone and LPS synergistically stimulated the NADPH oxidase-mediated release of the superoxide free radical. (jneurosci.org)
  • Environmental
  • The study does not directly suggest rotenone exposure is responsible for PD in humans, but is consistent with the belief that chronic exposure to environmental toxins increases the likelihood of the disease. (wikipedia.org)
  • humans
  • Rotenone is also used in powdered form to treat scabies and head lice on humans, and parasitic mites on chickens, livestock, and pet animals. (wikipedia.org)
  • readily
  • Rotenone is readily racemised by alkali and readily oxidized especially in the presence of light and alkali. (inchem.org)
  • electron
  • Morphological characterization by transmission electron microscopy (TEM) and atomic force microscopy (AFM) provide visualization of the differences in the aggregated α-synuclein species developing during the early kinetics of the fibrillation process in the absence and presence of rotenone. (mdpi.com)
  • Rotenone works by interfering with the electron transport chain in mitochondria. (wikipedia.org)
  • study
  • In this study, the biophysical properties and fibrillation kinetics of α-synuclein in the presence of rotenone were investigated and, more specifically, the effects of rotenone on the early-stage misfolded forms of α-synuclein were considered. (mdpi.com)
  • data
  • We believe that these data provide useful information for a better understanding of the molecular basis of rotenone-induced misfolding and aggregation of α-synuclein. (mdpi.com)