• This report presents the recommendations of the Advisory Committee on Immunization Practices (ACIP) for use of two rotavirus vaccines among U.S. infants: RotaTeq® (RV5) (Merck and Company, Whitehouse Station, New Jersey), which was licensed by the Food and Drug Administration (FDA) in February 2006 ( 10 ) and Rotarix® (RV1) (GlaxoSmithKline [GSK] Biologicals, Rixensart, Belgium), which was licensed by FDA in April 2008 ( 11 ). (cdc.gov)
  • Rotavirus live- attenuated vaccines , both mono- and pentavalent, generate broadly heterotypic protection . (bvsalud.org)
  • IMPORTANCE Rotavirus live- attenuated vaccines generate broadly heterotypic protection , and B- cells isolated from adults encode antibodies that are broadly protective in mice . (bvsalud.org)
  • Ebola monoclonal antibodies may interfere with immune response of live vaccines. (medscape.com)
  • Vaccines (eg, rotavirus) can help increase resistance to infection. (medscape.com)
  • The information may be useful in designing a new generation of rotavirus vaccines that could be easier to store and administer than current vaccines, said the researchers. (sciencedaily.com)
  • Meanwhile, it also provides guidance and insights for developing Omicron antibodies and vaccines. (nature.com)
  • Lower type 1 and type 3 polio antibody levels were found in children who received oral polio and rotavirus vaccines than those who received oral polio vaccine and placebo but differences between the two groups were not statistically significant. (gla.ac.uk)
  • Background: Neutralizing antibodies in breast milk may adversely influence the immune response to live oral vaccines. (uib.no)
  • REHOVOT, ISRAEL-March 4, 2019-Only a few vaccines - for example, polio and rotavirus - can be given orally. (weizmann-usa.org)
  • The estimated effect of cholera, shigella, Enterotoxigenic Escherichia coli (ETEC) and rotavirus vaccines was determined by applying the standard Child Health Epidemiology Reference Group (CHERG) rules. (biomedcentral.com)
  • Based on the evidence, we propose a 74% mortality reduction in rotavirus specific mortality, 52% reduction in cholera incidence due to their respective vaccines. (biomedcentral.com)
  • Vaccines for rotavirus and cholera have the potential to reduce diarrhea morbidity and mortality burden. (biomedcentral.com)
  • Researchers at Washington University School of Medicine in St. Louis have found a creative way to make a vaccine for norovirus, the leading cause of foodborne infections, by piggybacking on rotavirus, an unrelated virus for which there are already several highly effective vaccines. (medicalxpress.com)
  • A new study at Washington University School of Medicine in St. Louis describes a creative way to make a vaccine against norovirus by piggybacking on the highly effective vaccines for rotavirus, an unrelated virus that also causes diarrhea. (medicalxpress.com)
  • The rotavirus vaccines work really well, and there are already global distribution systems set up for them, so based on that, we saw an opportunity to finally make some headway against norovirus. (medicalxpress.com)
  • Before the first rotavirus vaccines were rolled out in 2006, half a million children around the world died every year of diarrhea caused by rotavirus infection. (medicalxpress.com)
  • Four rotavirus vaccines are in use around the world. (medicalxpress.com)
  • All are live-virus vaccines, meaning they are based on weakened forms of rotavirus capable of triggering an immune response but not of making people sick. (medicalxpress.com)
  • It doesn't infect mice or rats or any other ordinary lab animals, so the kinds of experiments that led to the development of rotavirus vaccines have been impossible to replicate with norovirus. (medicalxpress.com)
  • They worked with a laboratory strain of rotavirus as a stand-in for one of the approved rotavirus vaccines, which are proprietary. (medicalxpress.com)
  • Then, they administered the modified rotavirus to immunocompromised infant mice by mouth, the same way rotavirus vaccines are given to children. (medicalxpress.com)
  • New combination vaccines should induce similar or superior levels of neutralizing antibody in serum for individual protection against paralytic disease and mucosal immunity that effectively decreases viral replication in the intestine and pharynx for population protection against transmission of poliovirus. (who.int)
  • Rotavirus is the most common cause of severe gastroenteritis in infants and young children worldwide. (cdc.gov)
  • Before initiation of the rotavirus vaccination program in the United States in 2006, approximately 80% of U.S. children had rotavirus gastroenteritis by age 5 years. (cdc.gov)
  • In February 2006, a live, oral, human-bovine reassortant rotavirus vaccine (RotaTeq® [RV5]) was licensed as a 3-dose series for use among U.S. infants for the prevention of rotavirus gastroenteritis, and the Advisory Committee on Immunization Practices (ACIP) recommended routine use of RV5 among U.S. infants (CDC. (cdc.gov)
  • This report updates and replaces the 2006 ACIP statement for prevention of rotavirus gastroenteritis. (cdc.gov)
  • severe dehydrating gastroenteritis caused by rotavirus occurred primarily among children aged 4-23 months ( 13--15 ). (cdc.gov)
  • Rotavirus was detected in 1844 (32.8%) of 5627 children with acute diarrhea that had stool specimens collected, and 93% of positive cases of rotavirus gastroenteritis were between 3 and 23 months of age, with highest prevalence in children 6-11 months of age. (lww.com)
  • A four-layer solid phase enzyme-immunoassay (EIA) with antisera against Nebraska calf diarrhoea virus (NCDV) as immunoreagents was developed to detect human rotavirus antigens from stool specimens of patients with acute rotavirus gastroenteritis. (bmj.com)
  • The difficulties in cultivating human rotavirus in vitro for immunisation and the relative ease of growing NCDV in widely-used continuous cell lines make NCDV a good alternative in the preparation of the highly specific and sensitive rotavirus antisera required in immunoassays, and facilitate the setting-up methods for the routine diagnosis of rotavirus gastroenteritis by EIA or RIA in diagnostic virus laboratories. (bmj.com)
  • Rotavirus gastroenteritis (RVGE) is the most common cause of severe childhood diarrhea worldwide. (biomedcentral.com)
  • Rotavirus infections are a common weeks' gestation by vaginal delivery after showed pH 7.3, HCO 7.5 mmol/L, 3 cause of gastroenteritis in infants a twin pregnancy. (who.int)
  • Serum electrolytes, though rotavirus gastroenteritis is of age and ACTH therapy had been liver and renal function tests and urine usual y self-limiting in healthy infants, initiated at that time. (who.int)
  • Clinical sepsis and disseminated in- tion during rotavirus gastroenteritis is rate 120 beats/min. (who.int)
  • and body tempera- based on the presence of leukocytosis, ative bacteraemia as a complication ture 36.4 °C. Neurological examina- thrombocytopaenia, metabolic acido- of rotavirus-associated gastroenteritis tion showed developmental delay, mild sis, increased serum CRP level, pro- has been reported in healthy children hypotonia and increased leg muscle longed PT, PTT and increased level of (2) . (who.int)
  • In April 2008, a live, oral, human attenuated rotavirus vaccine (Rotarix® [RV1]) was licensed as a 2-dose series for use among U.S. infants, and in June 2008, ACIP updated its rotavirus vaccine recommendations to include use of RV1. (cdc.gov)
  • Live attenuated rotavirus vaccine. (mims.com)
  • We have mapped the epitope of one such antibody by determining the high-resolution cryo-EM structure of its antigen -binding fragment (Fab) bound to the virion of a candidate vaccine strain , CDC -9. (bvsalud.org)
  • In simple terms, it takes time to either identify existing or develop a new antibody that is specific to an antigen on the surface of an invading pathogen and then to synthesize it on a sufficient scale. (adpi.org)
  • The latter process involves segments of the antibody (immunoglobulin) genes undergoing recombination, generating an enormous repertoire of antigen-binding sites segments (the variable region) of the immunoglobulin molecule. (adpi.org)
  • Procedure -Intranasal BCV antigen concentration and antibody titer against BCV were measured on entry to a feedlot. (avma.org)
  • Human IgG antibody Laboratories manufactures the rotavirus antigen elisa reagents distributed by Genprice. (influenza-x.org)
  • The Rotavirus Antigen Elisa reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (influenza-x.org)
  • Description: Enzyme-linked immunosorbent assay kit for quantification of Goat rotavirus (RV) antigen (Ag) in samples from serum, plasma, tissue homogenates and other biological fluids. (influenza-x.org)
  • Human rotavirus antigen detection by enzyme-immunoassay with antisera against Nebraska calf diarrhoea virus. (bmj.com)
  • Rotavirus antigen raphy showed a small amount of fluid only 2 reported cases of secondary was detected in the stool specimen by retention in the intestinal loops. (who.int)
  • The resulting purple-coloured extracts from these fruits contain high levels of recombinant anti-rotavirus neutralizing human IgA in combination with increased amounts of health-promoting anthocyanins. (upv.es)
  • Another possibility is that Gambian breast milk contains anti-rotavirus antibody or nonantibody factors which inhibited the vaccine response. (gla.ac.uk)
  • 20 U/ml (by ELISA)) with serum anti-rotavirus IgA antibody titers ≥ 20U/ml one or two months after the second dose of vaccine or placebo ranges from 77.9% to 100% and from 0% to 17.1% respectively. (mims.com)
  • In a proof-of-concept study in healthy adult men, scientists in the Netherlands found that microbiome manipulation with antibiotics influenced response to oral rotavirus vaccine. (sciencedaily.com)
  • Objective -To measure antibody titers against bovine coronavirus (BCV), determine frequency of BCV in nasal swab specimens, and compare calves treated for bovine respiratory tract disease (BRD) between those given an intranasally administered vaccine and control calves. (avma.org)
  • Results -Intranasal BCV (125/407 [31%]) and serum antibody titers ≥ 20 against BCV (246/396 [62%]) were identified in calves entering the feedlot. (avma.org)
  • Furthermore, determination of hepatitis B antibody titers could be useful in newly diagnosed CD subjects regardless of age at diagnosis. (mdpi.com)
  • In order to study the immune escape of Omicron in more detail, we comprehensively and systematically studied the interaction between the antibodies reported in PDB and current Omicron strains. (nature.com)
  • P typing results from a global collection of rotavirus strains: implications for vaccine development. (microbiologyresearch.org)
  • Based on the antigenic sites located on the VP6 protein of the inner capsid, rotavirus strains are classified into five main (A, B, C, D, E) and two additional tentative (F, G) serotype groups, which are also known as serogroups. (news-medical.net)
  • The rotavirus strains classified into serogroups A, B, and C are pathogenic for humans and various animal species. (news-medical.net)
  • Canine rotaviruses appear to group together with the G3P[3] rotavirus strains. (news-medical.net)
  • Results of serological assays and nucleotide chain recognition methods have shown that many strains of rotaviruses isolated from mammalian species have the ability to infect humans. (news-medical.net)
  • Phylogenetic analyses of the rotavirus genome expose repeated intersections between the evolution of human and animal rotavirus strains, possibly as a consequence of multiple events of transmission between various animal species. (news-medical.net)
  • Rotaviruses are ubiquitous in the animal kingdom, and therefore, interspecies transmission and more importantly, exchange of genetic material between animal and human strains through re-assortment can lead to the emergence of novel rotavirus strains of epidemiological significance [ 9 ]. (biomedcentral.com)
  • Rotavirus diarrhoea was more severe than diarrhoea due to all other causes and clinical rotavirus infection was associated with weight loss in the post-infection period. (gla.ac.uk)
  • The deduced amino acid sequences of the outer capsid protein, VP7, of serotype G1 rotavirus clinical isolates collected over a 6 year period (1990-1995) in Melbourne, Australia, were examined. (microbiologyresearch.org)
  • The severity of the young pigs' clinical presentation depends on the dose ingested and the number of protective antibodies present in the dam's colostrum and milk. (news-medical.net)
  • A much more promising strategy is to use recombinant monoclonal antibodies (mAbs) against influenza and several are currently in clinical development ( 9 - 13 ). (frontiersin.org)
  • The enteric Gram-negative bacteraemia in the ABON® immunochromatographic blood culture of the patient at the time infants with rotavirus infection who test (Abon Biopharm Ltd). of clinical deterioration (on day 8) were treated with corticosteroids for yielded E. cloaca . (who.int)
  • Two days later, on we report the case of a patient with no- day 8 of her hospitalization, the patient sensitive to ceftriaxone, meropenem, socomial rotavirus-associated gastro- showed deterioration of clinical signs, amikacin, ciprofloxacin, but resistant to enteritis complicated by Enterobacter with lethargy, fever (39 °C), tachy- amoxicillin-clavulanic acid and cefuro- cloacae bacteraemia who was treated cardia (170 beats/min. (who.int)
  • Any detectable titer of neutralizing antibody against poliovirus is considered protective against clinical paralytic diseases. (who.int)
  • The structure of an attenuated human rotavirus isolate ( CDC -9) bound with the Fab fragment of a broadly heterotypic protective antibody shows that protection is probably due to inhibition of the conformational transition in the viral spike protein (VP4) critical for viral penetration, rather than to inhibition of receptor binding. (bvsalud.org)
  • In the new experiments, Howard Hughes Medical Institute (HHMI) researchers have mapped the structure of an antiviral antibody clamped onto a protein called VP7 that stipples the surface of rotavirus. (sciencedaily.com)
  • The structural map reveals intimate new details about how the antibody interferes with VP7, a protein that helps the virus infect cells. (sciencedaily.com)
  • Rotavirus does not have an envelope covering its protein shell. (sciencedaily.com)
  • The new research shows that as rotavirus matures inside an infected cell, it assembles a kind of "armor" coating made principally of VP7 and a "spike" protein called VP4. (sciencedaily.com)
  • By rotating the crystallized protein complexes through multiple exposures, the researchers could record enough data to calculate three-dimensional models, which exposed the underlying architecture of VP7 and the antibody fragment. (sciencedaily.com)
  • The resulting detailed structural map of the VP7-antibody protein complex revealed that the antibody neutralizes the virus by preventing the VP7 proteins from dissociating, said Harrison. (sciencedaily.com)
  • In this work, we carried out a systematic and comprehensive analysis of the reported spike protein antibodies, counting the epitopes and genotypes of these antibodies. (nature.com)
  • Our results showed that Omicron mutations affected the epitopes of most of the existing antibodies in Protein Data Bank (PDB). (nature.com)
  • Rotavirus was tested without protein load. (springer.com)
  • The researchers created an experimental rotavirus-norovirus combo vaccine by adding a key protein from norovirus to a harmless strain of rotavirus. (medicalxpress.com)
  • The researchers inserted the gene for the protein that forms the outer surface of human norovirus into the genome of the rotavirus lab strain. (medicalxpress.com)
  • The protective efficacy of Rotarix lyophilised formulation against any and severe rotavirus gastro-enteritis was evaluated in Europe, Latin America, Africa and Asia. (mims.com)
  • The immunologic mechanism by which ROTARIX protects against rotavirus gastro-enteritis is not entirely understood. (vaccineriskawareness.com)
  • Ingredients: ROTARIX is a liquid suspension of the live attenuated RIX4414 strain of human rotavirus of the G1P[8] type for use in the prevention of rotavirus gastro-enteritis. (vaccineriskawareness.com)
  • In the team's earlier field work in children in Ghana and Pakistan, they found that infants with good immunity to the rotavirus vaccine had specific bacteria in their intestine. (sciencedaily.com)
  • Virtually every child in the world becomes infected with rotaviruses before developing natural immunity. (sciencedaily.com)
  • Both natural and vaccine-induced immunity occur only after the immune system has "seen" the virus and generates neutralizing antibodies. (sciencedaily.com)
  • As the infant plays no part in the synthesis of these antibodies, their receipt by the infant from the mother is described as passively-acquired adaptive immunity. (adpi.org)
  • This study aimed to verify whether LNT administration could relieve diarrhea via improving gut immunity in rotavirus (RV)-challenged weaned pigs. (biomedcentral.com)
  • Rotavirus VP4 Epitope of a Broadly Neutralizing Human Antibody Defined by Its Structure Bound with an Attenuated-Strain Virion. (bvsalud.org)
  • Transgenic tomato plants expressing a recombinant human immunoglobulin A (hIgA_2A1) selected against the VP8* peptide of rotavirus SA11 strain were obtained. (upv.es)
  • 1 dose (1.5 ml) contains: Live attenuated human rotavirus RIX4414 strain not less than 10 6.0 CCID 50 . (mims.com)
  • A pooled analysis of four efficacy studies, showed a 71.4% (95% CI: 20.1;91.1) efficacy against severe gastro-enteritis (Vesikari score ≥11) caused by rotavirus G2P[4] strain. (mims.com)
  • PVP-I was tested against Klebsiella pneumoniae and Streptococcus pneumoniae according to bactericidal quantitative suspension test EN13727 and against severe acute respiratory syndrome and Middle East respiratory syndrome coronaviruses (SARS-CoV and MERS-CoV), rotavirus strain Wa and influenza virus A subtype H1N1 according to virucidal quantitative suspension test EN14476. (springer.com)
  • There is now increasing evidence that animal rotaviruses can infect humans, either through direct transmission of the virus or by contributing one or several genes to reassortants with essentially a human strain genetic background. (news-medical.net)
  • Description: RotaVirus (Strain SA-11), whole cell sonicate, inactivated using Photochemical. (influenza-x.org)
  • Description: RotaVirus (Strain SA-11) inactivated by UV and verified by infectivity testing. (influenza-x.org)
  • Scientists in the US have identified a particular bacterial strain, Segmented filamentous bacteria (SFB), that can prevent and cure rotavirus in mice. (drugtargetreview.com)
  • Intestinal cells (nuclei shown in blue) are infected with a strain of rotavirus genetically modified to carry a gene from norovirus (green). (medicalxpress.com)
  • Rotavirus Prevalence and Genotypes Among Children Younger Th. (lww.com)
  • Rotavirus causes an estimated 215,000 deaths worldwide in children younger than five years old, according to the Centers for Disease Control and Prevention. (drugtargetreview.com)
  • Dr Zhenda Shi , the study's first author who conducted the study in the Institute for Biomedical Sciences at Georgia State and has begun working at the Centers for Disease Control and Prevention's rotavirus branch, is now investigating whether or not gut microbiota can explain differences in sensitivity to rotavirus infection in humans. (drugtargetreview.com)
  • For more information, see the Centers for Disease Control and Prevention's (CDC) Rotavirus vaccine information statement . (msdmanuals.com)
  • Twenty-two (17.3 %) patients were positive for anti-HCV antibodies, ranging from 0 % to 52.9 % in different centers. (bvsalud.org)
  • Passive transfer of serum antibodies from convalescent patients has been used in the past ( 7 , 8 ), however, this approach is of limited use in a global pandemic emergency. (frontiersin.org)
  • Perhaps certain bacteria help the rotavirus replicate or antibiotics alter bacteria and thereby trigger immune responses that are favorable or unfavorable for a virus. (sciencedaily.com)
  • Harris emphasizes that this work does not advocate for antibiotic use in infants or children to boost rotavirus responses. (sciencedaily.com)
  • These two proteins elicit neutralizing antibody responses and therefore, protection from infection and disease is believed to be type-specific [ 9 ]. (biomedcentral.com)
  • But each year an estimated two million children are hospitalized because rotavirus infection results in severe dehydration caused by diarrhea and vomiting. (sciencedaily.com)
  • Rotavirus is a viral infection of the digestive tract that can cause severe dehydration. (msdmanuals.com)
  • No effect from the concurrent administration of oral polio vaccine on the immune response to rotavirus vaccine was observed. (gla.ac.uk)
  • In addition, naturally circulating enteroviruses may have interfered with the immune response to the rotavirus vaccine. (gla.ac.uk)
  • Traditionally, vaccine studies have focused on the antibody response in the blood, because we understand that part of the immune response the best," Ding said. (medicalxpress.com)
  • Avian rotaviruses represent a diverse group of intestinal viruses, which may induce subclinical manifestations. (news-medical.net)
  • We have previously described R1a-B6, an alpaca-derived single domain antibody (nanobody), that is capable of potent cross-subtype neutralization in vitro of H1N1, H5N1, H2N2, and H9N2 influenza viruses, through binding to a highly conserved epitope in the influenza hemagglutinin stem region. (frontiersin.org)
  • Since integrins also serve as cellular entry points for viruses such as adenovirus, foot-and-mouth disease virus and rotavirus, they systematically inhibited each integrin with a different antibody. (drugdiscoverynews.com)
  • Even better, some of the antibodies from the blood and the intestines were able to neutralize both viruses in human "mini-gut" cultures in a dish. (medicalxpress.com)
  • But norovirus and rotavirus are gut viruses, so antibodies in the blood are less important than the ones in the intestines in terms of fighting off these viruses. (medicalxpress.com)
  • Globally, viruses carrying either G1, G2, G3, G4, G9 and P[4] or P[8] are the most common causes of rotavirus disease in humans. (biomedcentral.com)
  • Rotaviruses replicate mainly in the gut, where they infect cells in the small intestine. (sciencedaily.com)
  • The vaccine efficacy against severe rotavirus gastro-enteritis during the first year of life was 61.2% (95% CI: 44.0;73.2). (mims.com)
  • The protective vaccine efficacy observed against any and severe rotavirus gastro-enteritis is presented in Table 3. (mims.com)
  • Rotavirus is the most common cause of severe dehydrating diarrhea in young children globally accounting for an estimated 527,000 (475 000-580 000) deaths each year, mostly in children under the age of two years [ 2 ]. (biomedcentral.com)
  • Igg Antibody Laboratories manufactures the igg genova kit reagents distributed by Genprice. (chipab.com)
  • While the results from this study are limited since rotavirus is a childhood disease and the microbiome of infants and children is different in adults, the researchers are buoyed that their microbiome/vaccine response theory deserves further study. (sciencedaily.com)
  • Instead, the researchers view these results as a starting point with great potential for altering the microbiome to improve vaccine performance and ultimately better protect children in low-income settings from rotavirus, which continues to be a life-threatening disease. (sciencedaily.com)
  • The implications of the above findings for further research into rotavirus and diarrhoeal disease in general are also considered. (gla.ac.uk)
  • This discovery, which helps explain why rotavirus causes severe, life-threatening disease in some people and only mild disease in others, could lead to possible treatments and preventive measures for rotavirus infection. (drugtargetreview.com)
  • Even within particular societies, rotavirus causes mild disease in some individuals and severe life-threatening disease in others. (drugtargetreview.com)
  • The Georgia State researchers found SFB reduces rotavirus infectivity and protects against the disease by causing epithelial cells to be shed and replaced with new, uninfected cells. (drugtargetreview.com)
  • We show here the production of a model human antibody for passive protection against the enteric pathogen rotavirus in transgenically labelled tomato fruits. (upv.es)
  • Calves were randomly assigned to receive 3.0 mL of a modified-live virus vaccine against bovine enteric coronavirus and rotavirus or 3.0 mL of saline (0.9% NaCl) solution. (avma.org)
  • Between June 1984 and June 1986 a variety of studies on rotavirus diarrhoea and its prevention were conducted in Bakau, a peri-urban Gambian community. (gla.ac.uk)
  • The developed NCDV-EIA was as sensitive and specific for rotavirus as the HRV-EIA, and it allowed the detection of both established rotavirus types 1 and 2 from stools with equal sensitivity. (bmj.com)
  • The patient was discharged after a 14- the qualitative detection of rotavirus in and rotavirus co-infection during day course of meropenem treatment a stool specimen. (who.int)
  • EN] Edible fruits are inexpensive biofactories for human health-promoting molecules that can be ingested as crude extracts or partially purified formulations. (upv.es)
  • Variation in neutralization epitopes of human rotaviruses in relation to genomic RNA polymorphism. (microbiologyresearch.org)
  • Derivation of neutralizing monoclonal antibodies to human rotaviruses and evidence that an immunodominant neutralization site is shared between serotypes 1 and 3. (microbiologyresearch.org)
  • Sequence homology between human and animal rotavirus serotype-specific glycoproteins. (microbiologyresearch.org)
  • Animal rotaviruses are considered potential reservoirs for genetic exchange with human rotaviruses. (news-medical.net)
  • A comparison of the developed NCDV-EIA with an identical EIA, using antisera against human rotavirus (HRV-EIA) instead of NCDV antisera, was made with 216 stool specimens positive or negative for rotavirus. (bmj.com)
  • Rotavirus is a common cause of severe diarrhoea among young children and the elderly. (labtestsonline.org.uk)
  • B- cells isolated from adults encode neutralizing antibodies , some with affinity for VP5*, that afford broad protection in mice . (bvsalud.org)
  • Antigenic characterization using a panel of serotype G1-specific neutralizing monoclonal antibodies classified lineage II isolates (1990-1993) as monotype G1a while lineage I isolates were classified as monotype G1b (1993-1995). (microbiologyresearch.org)
  • Cross-subtype neutralizing single domain antibodies against influenza present new opportunities for immunoprophylaxis and pandemic preparedness. (frontiersin.org)
  • Mice that received the experimental vaccine produced neutralizing antibodies against both rotavirus and norovirus. (medicalxpress.com)
  • This study shows that one big determinant of proneness to rotavirus infection is microbiota composition," explained Dr Andrew Gewirtz , senior author of the study and a professor at the Institute for Biomedical Sciences at Georgia State. (drugtargetreview.com)
  • Further investigation revealed that a predominant determinant of resistance to rotavirus was the presence of a single bacterial species called Segmented Filamentous Bacteria, or SFB. (drugtargetreview.com)
  • La présente étude détermine la prévalence de l'infection par le virus de l'hépatite C en en determinant les génotypes ainsi que les facteurs y associés dans ce groupe de patients. (bvsalud.org)
  • Rotavirus infects the proximal small intestine, where it elaborates an enterotoxin and destroys the epithelial surface, resulting in blunted villi, extensive damage, and shedding of massive quantities of virus in stool ( 13 ). (cdc.gov)
  • Furthermore, probiotics may reduce the risk of spreading rotavirus infection by shortening diarrhea duration and volume of watery stool output and by reducing the fecal shedding of rotavirus, and they have been found useful in preventing the dissemination of hospital-acquired diarrheas. (medscape.com)
  • Rotavirus is highly contagious and can cause severe diarrhoea, vomiting, fever, abdominal pain and death. (drugtargetreview.com)
  • Abdominal ultrasonog- age via rotavirus infection. (who.int)
  • Our results indicated that temporal genetic variation of the VP7 of serotype G1 rotaviruses was associated with changes in the antigenicity of these isolates. (microbiologyresearch.org)
  • Given the variety and diverse rotavirus types in the region, use of a vaccine with broad and consistent serotype coverage would be important to help decrease the burden of RVGE in the Middle East and North Africa. (biomedcentral.com)
  • Rotavirus kills over 200,000 children each year and is the most important cause of diarrheal death in children. (sciencedaily.com)
  • Rotavirus, which is a genus within the family Reoviridae , is among the most important etiological agents of severe diarrheal illness in humans and animals around the world. (news-medical.net)
  • Three of the seven sero-groups of rotavirus identified affect humans, known as groups A-C. The most dominant, group A, causes diarrheal diseases worldwide [ 2 ]. (biomedcentral.com)