Loading...
  • cellular
  • and as a physiological sensor and signal cross-talker in diverse cellular responses. (aspetjournals.org)
  • These results suggest that ASC-1 is a novel coactivator molecule of nuclear receptors which functions in conjunction with CBP-p300 and SRC-1 and may play an important role in establishing distinct coactivator complexes under different cellular conditions. (asm.org)
  • neuronal
  • For sustained axon growth over long distance, gene expression at the neuronal soma is also required to provide signaling molecules that control the intrinsic axon growth ability and raw materials that support axon assembly ( Zhou and Snider, 2006 ). (frontiersin.org)
  • In contrast, we know relatively less about the signaling events occurring at the neuronal soma that controls gene expression during axon growth. (frontiersin.org)
  • tumors
  • Aberrant activation of Wnt signaling, which outcomes from activating mutations of -catenin or inactivating mutations of APC or Axin, continues to be associated with a multitude of human being malignancies, such as for example colorectal, heptocellular, ovarian endometrial, desmoid, and pancreatic tumors . (cancercurehere.com)
  • Among these tumor types, Wnt signaling is usually most regularly deregulated in colorectal tumors. (cancercurehere.com)
  • Therefore, aberrant activation of Wnt signaling is apparently obligatory for the initiation or development of colorectal tumors. (cancercurehere.com)
  • Such an strategy would enhance our knowledge of the oncogenic function of -catenin, and may further serve as a technique for targeted therapy for tumors produced from aberrant Wnt signaling. (cancercurehere.com)
  • transcriptional
  • The nature of the transcriptional switch that interprets and responds to synaptic signals that trigger persistent changes to synapses, remains intensely studied but yet poorly established. (springer.com)
  • Nuclear -catenin enhances transcription of Wnt-responsive genes through getting together with TCF/LEF transcription elements and recruiting different BTZ038 transcriptional co-activators towards the TCF/LEF binding sites. (cancercurehere.com)
  • downstream
  • We further analyzed the downstream of erbB2/EGFR signaling in gallbladder epithelial cells from BK5.erbB2 mice to investigate the mechanism of carcinogenesis. (aacrjournals.org)
  • pore complex
  • The Nuclear Pore Complex (NPC) exhibits eight-fold rotational symmetry and is comprised of approximately 30 nucleoporins (Nups) in different stoichiometries. (tcdb.org)
  • The symmetric core of the nuclear pore complex can be considered as a series of concentric cylinders. (tcdb.org)
  • In concordance with the dimensions and symmetry of the nuclear pore complex core, Hsia et al. (tcdb.org)
  • have determined the crystal structure of the nuclear pore complex coat (~400 kilodaltons) from Saccharomyces cerevisiae at 7.4Å resolution. (tcdb.org)
  • basal
  • These coactivators are postulated to function in transmitting the signal of ligand-induced conformational change to the basal transcription machinery. (asm.org)
  • gene
  • The jumonji (JMJ) gene, obtained by a gene trap strategy, is essential for embryogenesis and is suggested to play important roles in cell growth during development. (novusbio.com)
  • cancer
  • Here, we review the current knowledge of both HMGB1′s oncogenic and tumor-suppressive roles and the potential strategies that target HMGB1 for the prevention and treatment of cancer. (aacrjournals.org)
  • Thus
  • Using in vitro transport assays we showed that the pUL84 nuclear import required importin α, importin β, and Ran, thus following the classical importin-mediated import pathway. (asm.org)
  • activity
  • Overexpression of CAP1 in monocytes enhanced the resistin-induced increased activity of the cAMP-dependent signaling. (jove.com)
  • play
  • 17 These data indicate that the autocrine/paracrine effects of factors secreted from Akt-activated cells could play significant roles in cardiac growth and maintenance. (ahajournals.org)