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  • Regulation
  • The potential roles of the microRNAome in the transcriptomic cold regulation in the zebrafish brain were investigated by various statistical analyses. (biomedcentral.com)
  • Apoptosis
  • These RNA micelles carrying anti-miR21 exhibited strong binding and internalization to cancer cells, inhibited the function of oncogenic miR21, enhanced the expression of the pro-apoptotic factor, and induced cell apoptosis. (osu.edu)
  • regulatory
  • We have identified ncRNAs that selectively kill cancer cells or lead to their terminal differentiation and ncRNAs that selectively enhance cancer cell response to microtubule-targeting agents, revealing new vulnerabilities of cancer cells mediated by complex regulatory relationships between several classes of coding and non-coding RNAs. (selectbiosciences.com)
  • During iron deficiency, IRPs inhibit the translation of FPN by binding to the iron regulatory element (IRE) located in the 5′ untranslated region (UTR) of FPN messenger RNA (mRNA), leading to lower FPN protein levels, decreased export of iron, and cellular iron retention . (prolekare.cz)
  • among them, microRNAs (miRNAs) are versatile and substantial contributors to regulatory networks of development and adaptive plasticity. (biomedcentral.com)
  • We also show that these duplicate gene products have qualitatively different protein-protein interaction capabilities and different regulatory roles. (plantcell.org)
  • Furthermore, we show that species-specific differences in the stamen regulatory network are associated with differences in the expression of the microRNA miR169. (plantcell.org)
  • The role of microRNAs (miRNAs) in the regulatory response of GIFT to S. iniae infection has been underestimated and has not yet been well studied. (biomedcentral.com)
  • Recently, a competitive RNA (ceRNA) hypothesis has been proposed and several studies have suggested the interaction between lncRNA and miRNA in cancer [ 16 - 19 ], adding another piece of puzzle to the miRNA and lncRNA regulatory networks. (biomedcentral.com)
  • polymerase
  • The initial steps take place in the nucleus where promoter recognition, mediated by transcription factors, requires chromatin and nucleosome modifications driven by epigenetic events, and allows the regulation of the RNA polymerase transcriptional activity. (mdpi.com)
  • Furthermore, in each of these species, the mature miRNA sequence is located within −1 to −200 bp of the proximal known gene TSS, suggesting the functional importance of this conserved genomic context in the antisense orientation ( 14 ) ( Fig. 1 A ). miR-320 is encoded directly upstream of the cell cycle gene POLR3D, which is a conserved subunit specific to RNA polymerase III ( 15 ). (pnas.org)
  • epigenetic
  • Small noncoding RNAs regulate epigenetic gene silencing pathways that are well-conserved in eukaryotes ( 1 , 2 ). (pnas.org)
  • RNA binding proteins (RBPs) are emerging epigenetic regulators of various RNA processing events, such as splicing, localization, stabilization and translation, and can regulate various types of stem cells. (mdpi.com)
  • In addition, it is evident that epigenetic regulation, such as histone modification, promoter methylation and microRNA (miRNA) regulation, is important for cancer development and progression. (mdpi.com)
  • transcription
  • Recent reports have identified roles for circRNAs in regulating transcription , protein binding, and sequestration of microRNAs. (fightaging.org)
  • Whereas there is considerable plasticity in individual B-class MADS box transcription factor function, there is overall conservation in the roles of the multimeric MADS box B-class protein complexes, providing robustness in the specification of petal and stamen identities. (plantcell.org)
  • There is increasing evidence that PTB and its paralog PTBP2 play a major role as repressors of alternatively spliced exons, whose transcription is tissue-regulated. (mdpi.com)
  • Transcription factors play essential roles in the developmental processes of plants. (plantphysiol.org)
  • Transcription factors play essential roles in the regulation networks of plant developmental processes. (plantphysiol.org)
  • In the present study, we isolated and characterized the exosomes derived from the laryngeal squamous cell carcinoma (LSCC) cell line AMC‑HN‑8 for the first time, and identified a subset of miRNAs enriched in the exosomes compared with parental cells, such as miR‑1246, miR‑1290, miR‑335‑5p, miR‑127‑3p and miR‑122‑5p through small RNA sequencing combined with reverse transcription‑quantitative PCR (RT‑qPCR) analysis. (readbyqxmd.com)
  • cDNA synthesis was performed for each RNA sample using a Reverse Transcription system (Promega Corporation, Madison, WI, USA), and oligo dT from the system was used to prime cDNA synthesis. (spandidos-publications.com)
  • interference
  • RNA interference has revolutionized human functional genomics and therapeutics, but its impact on neuroscience research has been limited by the lack of simple and efficient methods to deliver oligonucleotides to primary neurons and the brain. (selectbiosciences.com)
  • miR-320 directs the association of RNA interference (RNAi) protein Argonaute-1 (AGO1), Polycomb group (PcG) component EZH2, and tri-methyl histone H3 lysine 27 (H3K27me3) with the POLR3D promoter. (pnas.org)
  • regulation
  • The involvement of microRNA in the iron-responsive regulation of FPN offers additional stability and fine-tuning of iron homeostasis within different cellular contexts. (prolekare.cz)
  • In this review, we summarize current evidences on the roles of miRNA and RBPs in the regulation of colorectal CSCs. (mdpi.com)
  • Total RNA
  • Here, we annotated circRNAs from very deep total RNA-seq data obtained from C. elegans at different aging time points and uncovered 575 novel circRNAs. (fightaging.org)
  • Total RNA from tissues and cells was extracted using the miRNA isolation kit (Ambion, Austin, TX, USA) according to the manufacturer's instructions. (spandidos-publications.com)
  • Small
  • In particular, conserved components of the RNAi machinery direct the formation of heterochromatin, using sequence-specific small interfering RNAs (siRNAs). (pnas.org)
  • Small RNAs regulate a number of developmental processes in plants and animals. (biomedcentral.com)
  • However, the role of small RNAs in legume-rhizobial symbiosis is largely unexplored. (biomedcentral.com)
  • We sequenced ~350000 small RNAs from soybean roots inoculated with B. japonicum and identified conserved miRNAs based on similarity to miRNAs known in other plant species and new miRNAs based on potential hairpin-forming precursors within soybean EST and shotgun genomic sequences. (biomedcentral.com)
  • Construction and analysis of a small RNA library led to the identification of 20 conserved and 35 novel miRNA families in soybean. (biomedcentral.com)
  • crucial roles
  • Despite the crucial roles of the spinal cord and the circadian system in optimizing whole-body function, it remains unclear whether SCI alters diurnal rhythms. (eneuro.org)
  • tissues
  • High-throughput deep sequencing of two libraries (control group [CO] and infected group [IN]) of RNA extracted from GIFT head kidney tissues generated 12,089,630 (CO) and 12,624,975 (IN) clean reads. (biomedcentral.com)
  • mechanism
  • Detailed studies of the structural properties of PTB have contributed to our understanding of the mechanism of RNA binding by RNA Recognition Motif (RRM) domains. (mdpi.com)
  • The aim of this study was to investigate the role and possible mechanism of long noncoding RNA ANRIL in the development of ulcerative colitis (UC). (usda.gov)
  • role
  • 2 ) define a role for a microRNA (miR-206) in reinnervating the neuromuscular junction after injury and improving survival in a mouse model of the neurodegenerative disease amyotrophic lateral sclerosis (ALS). (sciencemag.org)
  • However, knowledge on the role of microRNAs (miRNAs) during nodule development is lacking. (biomedcentral.com)