Roles gene of drosophila. Medical search. Frequent questions

The biological process was discovered and is best understood in the species Drosophila melanogaster. (wikipedia.org)
Made using the fly model Drosophila melanogaster, this finding has been published in PloS Genetics this week. (sciencedaily.com)
MicroRNA-34 ( miR-34 ) is crucial for preventing chronic large-scale neurite degeneration in the aged brain of Drosophila melanogaster. (sdbonline.org)
This study examined the roles of hormone-dependent transcription factors (Nuclear Receptors), in accessory gland development, function and male fertility of a genetically tractable insect model, Drosophila melanogaster. (sdbonline.org)
Our previous studies showed that HEG drive was more difficult to achieve in Drosophila melanogaster than Anopheles gambiae and we therefore investigated ways of improving homing performance in Drosophila . (plos.org)
Chan Y-S, Huen DS, Glauert R, Whiteway E, Russell S (2013) Optimising Homing Endonuclease Gene Drive Performance in a Semi-Refractory Species: The Drosophila melanogaster Experience. (plos.org)
Her lab at UAB utilizes a classical genetics model system, the fruit fly Drosophila melanogaster , to study various open questions in the area of epigenetics and chromatin. (uab.edu)
My lab uses the fruit fly Drosophila melanogaster as a model system to investigate epigenetic systems and their influence on development and gene regulation. (uab.edu)
Based on this domain structure, four additional HP1 family proteins have been identified in Drosophila melanogaster. (uab.edu)
We are using the fruit fly Drosophila melanogaster as a model for exercise biology. (uab.edu)
The Long 3′UTR mRNA of CaMKII Is Essential for Translation-Dependent Plasticity of Spontaneous Release in Drosophila melanogaster. (tcd.ie)
In this presentation I will describe transcriptional patterns of some genes (Hsps, Frost and Stravin) with respect to cold stress and I will discuss their roles in cold tolerance of Drosophila melanogaster. (univ-lyon1.fr)
Reduced expression of alpha-1,2-mannosidase I extends lifespan in Drosophila melanogaster and Caenorhabditis elegans. (neurotree.org)
The predicted binding site and dynamics of peptide inhibitors to the Methuselah GPCR from Drosophila melanogaster. (neurotree.org)
Extension of Drosophila melanogaster life span with a GPCR peptide inhibitor. (neurotree.org)
The armadillo (Arm) repeat is an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila melanogaster segment polarity gene armadillo involved in signal transduction through wingless. (embl.de)
Scanning electron micrograph of the Drosophila melanogaster sestrin-null mutant used to study pathways involved in oxidative stress and aging. (skoltech.ru)

These genes and their product proteins play a key role in the circadian clock. (wikipedia.org)
Subsequently, by using independent RNAi/ dominant negative forms, it was shown that Ecdysone Receptor (EcR) is essential for male fertility due to its requirement in the normal development of accessory glands in Drosophila: EcR depleted glands fail to make seminal proteins and have dying cells. (sdbonline.org)
It is suggested that these proteins act synergistically to enhance transcriptional efficiency by acting as co-factors for LIM homeodomain and Otx class transcription factors both of which have essential roles in development. (nih.gov)
Genes for endoplasmic reticulum (ER)-shaping proteins are among the most commonly mutated in hereditary spastic paraplegia (HSP). (frontiersin.org)
The endoplasmic reticulum (ER) is implicated in these mechanisms, with HSP mutations affecting ER proteins with a variety of roles including lipid metabolism, ER membrane-contact-site function, and ER architecture ( Blackstone, 2018 ). (frontiersin.org)
We then use it to show perturbation of Ca 2+ handling in Drosophila in which ER organization is disrupted by loss of HSP-related ER-modeling proteins. (frontiersin.org)
Scientific and social factors have resulted in a focus on well-studied proteins, leading to a concern that poorly understood genes are unjustifiably neglected. (biorxiv.org)
The advent of genome sequencing revealed in humans and other species thousands of genes encoding proteins that had not been identified by previous biochemical or genetic studies. (biorxiv.org)
The mystery and the potential biological significance of these unknown genes is enhanced by many of them being well conserved, and many of them being completely unrelated to known proteins and thus lacking clues to their function. (biorxiv.org)
This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. (nih.gov)
It is now clear that Armadillo and beta-catenin bind directly to members of the T-cell factor/lymphoid enhancer factor subfamily of HMG box DNA-binding proteins, forming bipartite transcription factors that regulate Wingless/Wnt responsive genes in both Drosophila and vertebrates. (embl.de)
All genes in this SD protein endocytosis and recycling pathway, as well as SD proteins themselves, are highly conserved from flies to humans. (sdbonline.org)
Thus, these results suggest that the SD proteins in human kidney undergo the same endocytosis and recycling pathway to maintain the filtration structure, and mutations in any genes in this pathway could lead to abnormal SD and renal diseases. (sdbonline.org)
In addition my research group has developed the use of Drosophila as a model system to identify the normal and pathological roles of proteins associated with neurodegenerative disease. (kcl.ac.uk)
Sestrins are a family of proteins that play key roles in regulating aging and metabolism. (skoltech.ru)
The humoral immune response in insects is characterized by cascades of genes whose expression is controlled by a range of recognition proteins that bind pathogen cell wall components and end with the production of a range of secreted host proteins that target bacteria for destruction [ 3 ]. (biomedcentral.com)
Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)

Here, we show that the non-receptor Src family tyrosine kinases, SRC64B and SRC42A, are involved in WNT5-mediated signaling through Derailed in the Drosophila embryonic central nervous system. (biologists.com)
obs) which are adding to the study of the molecular mechanisms that regulate the development of connectivity in the embryonic central nervous system (CNS) of Drosophila. (kcl.ac.uk)

They discovered the gene called period (per), mutations of which alter the circadian rhythm. (wikipedia.org)
In recent years, our understanding of genetic predisposition to PD has advanced vastly, including causative mutations in the genes encoding α-synuclein, LRRK2, parkin, PINK1, and DJ-1 just to name a few 5 . (nature.com)
Furthermore, we found that disruption of the sole Clic Drosophila orthologue significantly blunted sensitivity to alcohol in flies, that mutations in two C. elegans Clic orthologues, exc-4 and exl-1, altered behavioral responses to acute ethanol in worms and that viral-mediated overexpression of Clic4 in mouse brain decreased the sedating properties of ethanol. (nih.gov)
Whithout mutations we would know very little about inheritance and the existence of genes. (intechopen.com)
Rothmund-Thomson syndrome, or poikiloderma congenitale, is a rare autosomal recessive disorder attributed to mutations of the RECQL4 helicase gene on 8q24. (medscape.com)
Rothmund-Thomson syndrome (poikiloderma congenitale) has been attributed to mutations of the RECQL4 gene on 8q24, which encodes a RecQ DNA helicase. (medscape.com)
Association between osteosarcoma and deleterious mutations in the RECQL4 gene in Rothmund-Thomson syndrome. (medscape.com)
Rothmund-Thomson Syndrome: novel pathogenic mutations and frequencies of variants in the RECQL4 and USB1 (C16orf57) gene. (medscape.com)
At least five mutations in the DCTN1 gene have been found to cause Perry syndrome. (medlineplus.gov)
We also found the novel mutations in these genes in azole-resistant isolates with different genetic backgrounds. (cdc.gov)
Furthermore, a large portion of the non- cyp51A azole-resistant A. fumigatus strains have yet to be investigated to determine which genes and mutations could be responsible for azole resistance. (cdc.gov)

The Drosophila protein Chip is required for segmentation and activity of a remote wing margin enhancer. (nih.gov)
When a HEG is integrated into its recognition sequence in the genome, its protein product acts to cleave its cognate site on the homologous chromosome and gene conversion or homologous recombination can result in a new copy of the HEG being inserted. (plos.org)
A C-terminal ataxin-2 disordered region promotes Huntingtin protein aggregation and neurodegeneration in Drosophila models of Huntington's disease. (tcd.ie)
A genome-wide resource for the analysis of protein localisation in Drosophila. (tcd.ie)
The furry ( fry ) gene encodes an evolutionarily conserved protein with a wide variety of cellular functions, including cell polarization and morphogenesis in invertebrates. (nature.com)
The Furry (Fry) gene encodes a large protein (~ 330 kDa) that is evolutionarily conserved from yeast to humans. (nature.com)
Drosophila ciD encodes a hybrid Pangolin/Cubitus interruptus protein that diverts the Wingless into the Hedgehog signaling pathway. (uzh.ch)
The ci gene in ciD is controlled by the ubiquitous pan promoter and encodes a hybrid Ci protein that carries the N-terminal region of Pan. (uzh.ch)
Ja WW , Carvalho GB, Madrigal M, Roberts RW , Benzer S . The Drosophila G protein-coupled receptor, Methuselah, exhibits a promiscuous response to peptides. (neurotree.org)
Description of the protein which includes the UniProt Function and the NCBI Gene Summary. (nih.gov)
G-protein coupled Phospholipase-C-β (PLCβ) signaling and its various components are vital to the regulation of development and behaviour of Drosophila. (isgpb.org)
Using the Drosophila nephrocyte as a genetic screen platform, most genes involved in endocytosis and cell trafficking were screened, and the key components were identified of the cell trafficking pathway required for SD protein endocytosis and recycling. (sdbonline.org)
We have begun to combat this by investigating the role of the transmembrane protein Cln3, which is affected in the most common form of NCL, using Drosophila. (kcl.ac.uk)
Systemic profiling of ATM regulated genes, including protein-coding genes, miRNAs, and long non-coding RNAs, will greatly improve our understanding of ATM functions and its regulation. (biomedcentral.com)
1) differentially expressed protein-coding genes, miRNAs, and long non-coding RNAs in atm mutated flies were identified at physiological condition and after X-ray irradiation. (biomedcentral.com)
2) functions of differentially expressed genes in atm mutated flies, regardless of protein-coding genes or non-coding RNAs, are closely related with metabolic process, immune response, DNA damage response or oxidative stress. (biomedcentral.com)
We provide a valuable resource of protein-coding genes, miRNAs, and long non-coding RNAs, for understanding ATM functions and regulations. (biomedcentral.com)
The V(D)J-recombination generates programmed breaks, these breaks are held together in a synapse by the Recombination Activating Genes (RAG) protein. (biomedcentral.com)
Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)
Here, we review ADAR gene expression, splice forms, posttranslational modifications, subcellular localizations and functions of ADAR protein isoforms. (muni.cz)
The DCTN1 gene provides instructions for making a protein called dynactin-1. (medlineplus.gov)
To carry out these roles, the complex's p150-glued subunit attaches (binds) to a protein called dynein, which acts as a motor, and also binds to a track-like system of small tubes called microtubules. (medlineplus.gov)
The DCTN1 gene mutation associated with this disorder replaces the amino acid arginine with the amino acid lysine at protein position 1101 (written as Arg1101Lys or R1101K). (medlineplus.gov)
Most azole-resistant strains harbor a mutation in the cyp51A gene, encoding a target protein for azole drugs ( 4 ). (cdc.gov)
[ 1 ] His prediction was subsequently supported by the cloning of the retinoblastoma tumor suppressor gene ( RB1 ) and by functional studies of the retinoblastoma protein, Rb. (medscape.com)
For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)

At the same time, Michael W. Young's team at the Rockefeller University reported similar effects of per, and that the gene covers 7.1-kilobase (kb) interval on the X chromosome and encodes a 4.5-kb poly(A)+ RNA. (wikipedia.org)

The genetics was first understood in 1971, when Seymour Benzer and Ronald J. Konopka reported that mutation in specific genes changes or stops the circadian behaviour. (wikipedia.org)
We are using molecular genetics and genomics approaches to understand the relationship between HP1a, HP1B, and HP1C, and their effect on gene regulation. (uab.edu)
Taking advantage of the genetics resources available in Drosophila, our experiments are designed to determine the relative importance of genetics and epigenetics in generating the variability in exercise response. (uab.edu)

Gene regulation by steroid hormones plays important roles in health and disease. (sdbonline.org)
My research focuses on understanding the mechanisms establishing and regulating epigenetic information, and how epigenetic systems ultimately contribute to gene regulation, disease, and other phenotypes. (uab.edu)
These epigenetic systems play vital roles in gene regulation, and defects in epigenetic regulation have been implicated in a variety of human diseases including cancer. (uab.edu)
Glomerulus-Selective Regulation of a Critical Period for Interneuron Plasticity in the Drosophila Antennal Lobe. (tcd.ie)
Here, we show that in Xenopus, Fry plays a role in morphogenetic processes during gastrulation, in addition to its previously described function in the regulation of dorsal mesoderm gene expression. (nature.com)
To better understand the interface between nutrient availability and growth regulation, we are focusing on how nutrition controls systemic growth through Drosophila insulin-like peptides (Dilps). (riken.jp)
Members of the insulin family peptides have conserved roles in the regulation of growth and metabolism in a wide variety of metazoans. (riken.jp)
Other ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and possibly in chromatin structure modification. (nih.gov)
Consistent with a broad role in transcriptional regulation, the expression of a large number of genes is altered in Iswi mutant larvae. (ca.gov)
Regulation of gene expression at the beginning of mammalian development and the TEAD family of transcription factors. (embl-heidelberg.de)
Specifically, our analyses show that the POU homeodomain gene nubbin (nub) plays a critical role in the establishment of the limbless abdomen via the up-regulation of the hox gene abdominal-A (abd-A) in the milkweed bug (Oncopeltus fasciatus) that is not present in Drosophila. (wayne.edu)
Sestrins are a family of stress-responsive genes involved in the regulation of cell viability and metabolism. (skoltech.ru)
Coenzyme A (CoA) is a key cellular metabolite which participates in diverse metabolic pathways, regulation of gene expression and the antioxidant defense mechanism. (bvsalud.org)
TP53 activates the expression of genes involved in apoptosis, cell cycle regulation (p21), and MDM2. (medscape.com)

We employed conditional translating ribosome affinity purification (TRAP) followed by RNA sequencing (TRAP-seq) for transcriptome profiling of DA neurons in transgenic Drosophila lines expressing human PARIS wild type (WT) or mutant (C571A). (nature.com)
Together, our work revealed how PARIS drives adverse effects on modulation of PPAR-γ associated gene clusters in DA neurons. (nature.com)
This study investigated the role of miR-34 in two other types of large-scale axon degeneration in Drosophila: axotomy-induced axon degeneration in olfactory sensory neurons (OSNs) and developmentally related axon pruning in mushroom body (MB) neurons. (sdbonline.org)
We generated GAL4-driven Ca 2+ sensors targeted to the ER lumen, to record ER Ca 2+ fluxes in identified Drosophila neurons. (frontiersin.org)
Here we have expressed this probe and two others with higher Ca 2+ affinities under GAL4 control in Drosophila motor neurons. (frontiersin.org)
Al-Anzi B , Sapin V, Waters C, Zinn K , Wyman RJ , Benzer S . Obesity-blocking neurons in Drosophila. (neurotree.org)

Although carcinogenic roles for the INK4B, INK4C, INK4D, CIP1, KIP1, and KIP2 genes appear to be limited, INK4A is among the most commonly mutated genes in human tumors. (medscape.com)

We initially identified vertebrate Clic4 as a candidate ethanol-responsive gene via bioinformatic analysis of data from published microarray studies of mouse and human ethanol-related genes. (nih.gov)
We have identified that the Drosophila Cln3 shares many properties with the vertebrate form, it is localised to the endosomal-lysosomal compartment in many cell type and found at the synapse. (kcl.ac.uk)
In the present project, we showed that zebrafish rab11 genes are conserved in vertebrate evolution by in silicon analysis. (researchsquare.com)
Drosophila ADAR, an orthologue of vertebrate ADAR2, also regulates let-7 miRNA levels and Adar mutant flies have a circadian mutant phenotype. (muni.cz)

The activities of the two pathways depend on each other during Drosophila embryogenesis. (uzh.ch)
It was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis. (nih.gov)
However, while the post-embryonic functions of these genes have been well characterized in holometabolous lineages such as Drosophila, virtually no data exist about their roles during post-embryogenesis in more ancestral, hemimetabolous species. (wayne.edu)
Therefore, the question remains that if the majority of adult phenotypes are already established during embryogenesis, what are the functions of the hox genes during post-embryogenesis in hemimetabolous lineages? (wayne.edu)
4.Transcription factors play essential roles in every aspect of embryogenesis. (brilliantessay.com)

Choudhury SD, Mushtaq Z, Reddy-Alla S, Balakrishnan SS, Thakur RS, Krishnan KS, Raghu P, Ramaswami M, Kumar V. σ2-Adaptin Facilitates Basal Synaptic Transmission and Is Required for Regenerating Endo-Exo Cycling Pool Under High-Frequency Nerve Stimulation in Drosophila. (tcd.ie)
Gene Dosage in the Dysbindin Schizophrenia Susceptibility Network Differentially Affect Synaptic Function and Plasticity. (tcd.ie)
The present study establishes the role of stmA in olfaction, pupal development and synaptic vesicle recycling in Drosophila. (isgpb.org)
Interaction between stmA and genes for the inositol triphosphate receptor (itpr) and for endocytosis and exocytosis in synaptic vesicles is also shown. (isgpb.org)

Eighty-five percent of these genes are required for nephrocyte function, suggesting that a majority of human genes known to be associated with NS play conserved roles in renal function from flies to humans," says Han. (childrensnational.org)
The research team concluded that the Drosophila nephrocyte can be used to illuminate the clinically relevant molecular mechanisms underlying the pathogenesis of most monogenic forms of NS. (childrensnational.org)

A failure to see improvements in constitutive expression of the cellular genes suggests either that increases might come at too great a cost or that patterns of expression in adults are decoupled from the larval phase where increases would be most effective. (biomedcentral.com)

Beta-catenin participates in signal transduction and developmental patterning in Xenopus and Drosophila embryos as a component of the Wnt signaling pathway. (embl.de)
3.In the syncitial blastoderm stage of Drosophila embryos, nuclei move to the periphery and are held in their positions just beneath the plasma membrane by the cytoskeleton. (brilliantessay.com)

Another circadian behavior in Drosophila is courtship between the male and female during mating. (wikipedia.org)
Using an integrated approach that combined the power of the Drosophila, Caenorhabditis elegans and mouse model systems with bioinformatics analyses, we established a novel, conserved role for chloride intracellular channels (CLICs) in alcohol-related behavior. (nih.gov)
Social communication of predator-induced changes in Drosophila behavior and germline physiology. (tcd.ie)

In this regard, this gene causes overgrowth of the wing, modifies tissue structure, and activates a series of genetic changes in order to facilitate initial tumour growth. (sciencedaily.com)
The homing endonuclease (HEG) gene drive system is one proposed genetic strategy [2] . (plos.org)
Molecular genetic diagnosis can be performed using sequencing and deletion/duplication analysis of the genes NIPBL , SMC3 , RAD21 , SMC1A , and HDAC8 . (medscape.com)
In conclusion, the understanding of the computational techniques in modelling biological switch is important for elucidating genetic switch that has potential for gene therapy and can provide explanation for experimental findings of bistable systems. (lincoln.ac.nz)
It is believed that the occurrence of leukemia is the result of genetic and epigenetic changes in protooncogene and tumor suppressor genes [ 8 ]. (hindawi.com)
research shows that about 90% of the blood system of malignant tumors with at least the height of single gene methylation is closely related since this is a reversible process of genetic modification can be through to handle to restore the normal expression of gene methylation, to achieve the purpose of prevention and treatment of tumor [ 10 ]. (hindawi.com)
The genetic basis of the evolved response was examined using microarrays and was characterised by increased expression for many immunity related genes. (biomedcentral.com)

Some miRNAs are hosted in pri-miRNAs annotated as long non-coding RNAs (lncRNAs) and defined as MIRHGs (for miRNA Host Genes). (mdpi.com)

DI-fusion The mammalian RPS6 gene, homolog of the Drosophila air8 tumor. (ac.be)
The mammalian RPS6 gene, homolog of the Drosophila air8 tumor suppressor gene: is it an oncosuppressor gene? (ac.be)
This study implicates the Drosophila GAK homolog, auxilin (aux) , in a broad spectrum of parkinsonian-like symptoms. (sdbonline.org)

Our lines are useful additions to a Drosophila Ca 2+ imaging toolkit, to explore the physiological roles of ER, and its pathophysiological roles in HSP and in axon degeneration more broadly. (frontiersin.org)

First, an RNAi screen was carried out involving 19 hormone receptors, individually and specifically, in a male reproductive tissue (accessory gland) for their requirement in Drosophila male fertility. (sdbonline.org)
We applied RNAi in Drosophila to 260 unknown genes that are conserved between flies and humans. (biorxiv.org)

Drosophila circadian rhythm have paved the way for understanding circadian behaviour and diseases related to sleep-wake conditions in other animals, including humans. (wikipedia.org)
It was the first gene known to control behaviour. (wikipedia.org)
Once again, studies on Drosophila have contributed to our basic understanding of the behaviour of genes involved in cancer and metastasis, knowledge that will allow cancer researchers to pursue this line further," says the scientist. (sciencedaily.com)
2) hysteresis behaviour where the saddle-node bifurcation points as two critical points in which to turn 'ON' one gene happens at a larger parameter value than to turn 'OFF' this gene (at a lower parameter value). (lincoln.ac.nz)

CRISPR/Cas9 gene disruption validated a component of Notch signalling and two genes contributing to male fertility. (biorxiv.org)

RNA interference is a conserved pathway common to plants and mammals, where double-stranded RNAs (dsRNAs) suppress expression of genes with complementary sequences [ 1-2 ]. (idtdna.com)

Dietary condition-specific phenotype in Drosophila provides new insights into the significance of gene-environment interactions. (riken.jp)
The Brachyury gene is named for its phenotype, which was identified 70 years ago as a mutant mouse strain with a short blunted tail. (embl-heidelberg.de)
Interestingly, while Scr mutants Tribiolium yield an identical phenotype, no such ectopic segment develops when Scr is abolished in either Oncopeltus or Drosophila. (wayne.edu)
2.While studying formation of the dorso-ventral axis in the fly embryo, you learnt that several maternal effect genes, when mutated, cause a dorsalized phenotype. (brilliantessay.com)
Only a single maternal effect gene, when mutated, gives rise to a ventralized phenotype. (brilliantessay.com)

Ecdysone-regulated genes are bound by a heterodimer of Ecdysone receptor (EcR) and Ultraspiracle . (sdbonline.org)
Further, the data point to a novel ecdysone receptor that does not include Ultraspiracle but is probably comprised of EcR isoforms in Drosophila male accessory glands. (sdbonline.org)

The mammalian orthologs of Derailed and SRC64B also form complexes, suggesting that Src roles in RYK signaling are conserved. (biologists.com)
With roughly 30,000 genes in mammalian genomes, fection with a vector encoding MyoD (Tapscott et al. (lu.se)

Contrary to expectations, a fragment containing the entire region between the TBPH gene and the bgcn translational start drove strong HEG expression only during late spermatogenesis rather than in the germline stem cells and spermatogonia as expected. (plos.org)
In particular, HEG gene drive could be particularly effective if activity was restricted to the male germline to target genes required for female fertility/viability or engineered to destroy the X-chromosome by cutting at multiple X-specific sites [5] , [6] . (plos.org)
Germline mutation of one TP53 allele is found in patients with Li-Fraumeni syndrome who generally inherit a mutated TP53 gene from an affected parent. (medscape.com)

Implications of the Sap47 null mutation for synapsin phosphorylation, longevity, climbing proficiency and behavioural plasticity in adult Drosophila. (tcd.ie)
Plasticity of recurrent inhibition in the Drosophila antennal lobe. (tcd.ie)

Light activation of an innate olfactory avoidance response in Drosophila. (neurotree.org)
We review related studies on mouse Adarl mutant phenotypes, their rescues by preventing signaling from the antiviral RIG-I-like Sensors (RLRs), as well as Marl mechanisms in innate immune suppression and other roles of Adarl, including editing-independent effects. (muni.cz)
While the transcription of innate immunity genes in response to bacterial infection has been well-characterised in the Drosophila model, we recently demonstrated the capacity for such transcription to evolve in flies selected for improved antibacterial defense. (biomedcentral.com)

Moreover, we identified that PARIS actively modulates expression of PPARγ target genes by physically binding to the promoter regions. (nature.com)
Burt proposed that such methods could be applied to engineer HEGs that recognise and cleave sequences within coding sequences of genes in insect genomes, with the subsequent invasion of these HEGs into a population leading to the inactivation of target genes and the subsequent decline in fitness of the targeted population [2] . (plos.org)

Since Rcd-1 is a regulator of differentiation in other species, it suggests that Rcd-1r may serve a similar role during spermatogonial differentiation in Drosophila . (plos.org)

Walker DW , Hájek P, Muffat J , Knoepfle D, Cornelison S, Attardi G , Benzer S . Hypersensitivity to oxygen and shortened lifespan in a Drosophila mitochondrial complex II mutant. (neurotree.org)

Members of the RYK/Derailed family have recently been shown to regulate axon guidance in both Drosophila and mammals by acting as Wnt receptors. (biologists.com)

To investigate how the physiological roles of the ER might be affected by such disruption, we developed tools to interrogate its Ca 2+ signaling function. (frontiersin.org)

In these roles, it binds to cadherins, Tcf-family transcription factors, and the tumor suppressor gene product Adenomatous Polyposis Coli (APC). (embl.de)
Methylated DNA can prevent transcription factors from binding to it, resulting in low or no gene expression, which is an important alteration in the early initiation and development of malignant neoplastic diseases [ 7 ]. (hindawi.com)

DNA repair pathways function less well, chromatin modifiers become misregulated, and noise in gene expression increases. (uab.edu)
The Hedgehog (Hh) and Wingless (Wg) signaling pathways play important roles in animal development. (uzh.ch)
We are also near completion of a large scale screen to identify genes that modify Cln3 activity and this has provided us with a significant amount of information on the possible molecular pathways that are affected by changes in Cln3 activity. (kcl.ac.uk)
The evolved increases in infection-induced expression of the cellular genes may result from specific cross talk with humoral pathways or from generalised strategies for enhancing immunity gene transcription. (biomedcentral.com)

Homing endonuclease gene (HEG) drive is a promising insect population control technique that employs meganucleases to impair the fitness of pest populations. (plos.org)
We also observed that the fraction of targets undergoing homing was temperature-sensitive, falling nearly four-fold when the temperature was lowered to 18°C. Taken together, this study demonstrates how a few simple measures can lead to substantial improvements in the HEG-based gene drive strategy and reinforce the idea that the HEG approach may be widely applicable to a variety of insect control programs. (plos.org)

In 1980, Jeffrey C. Hall and his student Charalambos P. Kyriacou, at Brandeis University in Waltham, discovered that courtship activity is also controlled by per gene. (wikipedia.org)

During the process of eclosion by which an adult fly emerges from the pupa, Drosophila exhibits regular locomotor activity (by vibration) that occurs during 8-10 hours intervals starting just before dawn. (wikipedia.org)

Coincidentally, pan and ci are adjacent genes on the fourth chromosome in a head-to-head orientation. (uzh.ch)
To clarify the role of ISWI in vivo, we examined defects in chromosome structure and gene expression resulting from the loss of Iswi function in Drosophila. (ca.gov)

The research was conducted on the fruit fly Drosophila, an established model for studying epithelial tumours. (sciencedaily.com)
Contrary to the prevalent model, recruitment of the dMi-2 corepressor increases upon hormone addition to constrain gene activation through chromatin remodelling. (sdbonline.org)
Mutation of these genes in model organisms can lead to disruption of the ER network. (frontiersin.org)
Zhe Han, Ph.D. , Center for Cancer and Immunology Research , and his team of researchers studied nephrotic syndrome (NS) associated genes in the Drosophila model, which included seven genes that had never been analyzed in a pre-clinical model. (childrensnational.org)
Together with our colleges in IISAGE, we investigate this question using Drosophila as a model. (uab.edu)
Our team's research aims to shed light on the molecular basis for growth control and developmental timing at the cellular and tissue/organ level using Drosophila as a model system. (riken.jp)
Drosophila as a model system to study axonal guidance and neurodegenerative disease. (kcl.ac.uk)
The gene, and its paralogues, have become a well-studied model for the family, and hence much of what is known about the T-box family is derived from the murine Brachyury gene. (embl-heidelberg.de)

In Drosophila, the hormone ecdysone governs transitions between key developmental stages. (sdbonline.org)

In opposition, there were other scientists that stated genes could not control such complex behaviors as circadian activities. (wikipedia.org)

Muffat J , Walker DW , Benzer S . Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila. (neurotree.org)
Given their functional roles, infection induced increases in expression were expected for the humoral genes, while increases in constitutive expression were expected for the cellular genes. (biomedcentral.com)
We hypothesized that selection for improved defense would lead to further increases in the transcription of these genes upon exposure to infection. (biomedcentral.com)

These partners not only play key roles in a variety of cell fate decisions during normal development but, when inappropriately activated, contribute to both colon cancer and melanoma. (embl.de)
Imitation SWI (ISWI) and other ATP-dependent chromatin-remodeling factors play key roles in transcription and other processes by altering the structure and positioning of nucleosomes. (ca.gov)

We have established Drosophila as a whole animal assay to investigate which of these are responsible for the generation of toxic forms of tau in vivo. (kcl.ac.uk)

The functional significance of some of these genes was assessed by gene silencing. (univ-lyon1.fr)
These two avenues for transcriptional change should have different energetic or pleiotropic costs and [ 2 ] may be more or less effective in improving immunity depending on the functional role of the gene. (biomedcentral.com)

Histone variants play important roles in eukaryotic genome organization, the control of gene expression, cell division and DNA repair. (cipsm.de)

Drosophila circadian rhythm is a daily 24-hour cycle of rest and activity in the fruit flies of the genus Drosophila. (wikipedia.org)

Contrary to expectation we show that selection preferentially increased the infection-induced expression of both cellular and humoral immunity genes. (biomedcentral.com)

Researchers have demonstrated that genes activated during metastasis are also able to initiate primary tumor development, and they explain the molecular mechanism involved. (sciencedaily.com)
In cancer research, there has been a tendency to differentiate between the genes responsible for tumour development and those that give rise to metastasis and to study these processes separately since the cell functions required for these two mechanisms differ radically. (sciencedaily.com)
Researchers headed by Jordi Casanova at the Institute for Research in Biomedicine (IRB Barcelona) now demonstrate that genes activated during metastasis are also able to initiate primary tumour development, and they explain the molecular mechanism involved. (sciencedaily.com)
The results strengthen the notion that was already being put forward in cancer research," explains Jordi Casanova, head of the Development and Morphogenesis in Drosophila lab and CSIC professor. (sciencedaily.com)
This overlap made us question whether the so-called epithelial-mesenchymal factors -- which activate genes associated with cell movement and migration, which are common in embryo development and are also present in metastasis -- play a role in tumour initiation," says Casanova. (sciencedaily.com)
Chip is a ubiquitous chromosomal factor required for normal expression of diverse genes at many stages of development. (nih.gov)
To fully understand this process it will be necessary to identify additional genes involved in wiring, define their expression patterns over the course of development and elucidate their cellular functions and molecular interactions. (kcl.ac.uk)
Conclusions: Our results suggest that rab11 genes play important but distinct roles in the development of the nervous system in zebrafish. (researchsquare.com)
We then analyzed the temporal and spatial expression of rab11a gene in embryonic development by RT-PCR and whole mount in situ hybridization. (researchsquare.com)
However in recent years with the development of epigenesis, genomic imprinting and the horizontal transferences of the genes, Lamarck's ideas have resurfaced. (intechopen.com)

Expression of yeast NDI1 rescues a Drosophila complex I assembly defect. (neurotree.org)
RAB11 was first found from cultured MDCK cell cDNA library screening for homologous genes of yeast YPT1/SEC4[3], and later identified as the 11th member of the Rab family[4]. (researchsquare.com)

Hereditary spastic paraplegia (HSP) is a genetically heterogeneous disorder, with over 80 loci and 60 genes identified. (frontiersin.org)

Together, our studies demonstrate key roles for Clic genes in behavioral responses to acute alcohol in Drosophila, C. elegans and mice. (nih.gov)
Mice contain at least four, and perhaps five, genes with the same TEA DNA binding domain (mTEAD genes). (embl-heidelberg.de)

In addition, the molecular basis of thermal adaptation is not well understood, although a number of candidate genes have been proposed. (univ-lyon1.fr)
Our work demonstrates the importance of poorly understood genes, provides a resource for future research acceleration, and highlights a need for our awareness of ignorance to be protected from erosion by automated database annotation. (biorxiv.org)

Identification and structural characterization of interneurons of the Drosophila brain by monoclonal antibodies of the Würzburg hybridoma library. (tcd.ie)
His Ph.D. project on the characterization of the Sestrin2 gene was conducted in the laboratory of Peter Chumakov at the Engelhardt Institute of Molecular Biology and the Cleveland Clinic. (skoltech.ru)

Similarly, GATA-1 has been shown to induce lineage switching expression values even if, for simplicity, we assume only ``on'' of committed cells in hematopoiesis, first in cell lines (Kulessa and ``off'' states for each gene. (lu.se)
explosion further, consider that a fictitious small genome with 2002) More recently and more dramatically, the potential for 260 genes would host the same number of combinations as cell state conversions is exemplified by the reprogramming of the number of atoms in the visible universe! (lu.se)
In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)
Inactivation of tumor suppressor genes, whose products normally provide negative control of cell proliferation, contributes to malignant transformation in various cell types. (medscape.com)
Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)

Carvalho GB, Ja WW , Benzer S . Non-lethal PCR genotyping of single Drosophila. (neurotree.org)

Cyclin-G-associated kinase (GAK) , a PD susceptibility gene identified through genome-wide association studies (GWAS), is a ubiquitous serine/threonine kinase involved in clathrin uncoating (see Drosophila Clathrin heavy chain ), though its PD-related function remains elusive. (sdbonline.org)

Anatomy58

Organisms11

Diseases1

Chemicals and Drugs66

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Psychiatry and Psychology4

Phenomena and Processes100

Disciplines and Occupations1

Information Science4

Health Care3

Melanogaster17

Proteins17

Embryonic central nervou2

Mutations11

Protein26

Encodes1

Genetics3

Regulation14

Neurons6

Among the most commonly mutated1

Vertebrate4

Embryogenesis5

Synaptic4

Nephrocyte2

Larval1

Embryos2

Behavior3

Genetic7

MiRNAs1

Homolog3

Axon degeneration1

RNAi2

Behaviour4

Male fertility1

Expression of ge1

Phenotype5

Receptor2

Mammalian2

Germline3

Plasticity2

Innate3

Target genes2

Species1

Mutant1

Regulate1

Physiological1

Transcription factors2

Pathways4

Insect2

Courtship1

Locomotor1

Chromosome2

Model8

Developmental1

Behaviors1

Increases3

Play key roles2

Assay1

Functional2

Important roles1

Flies1

Contrary1

Development10

Yeast2

Genetically1

Mice2

Understood2

Characterization2

Cell5

Lethal1

Ubiquitous1