• Existence and possible roles of independent non-CpG methylation in the mammalian brain. (go.jp)
  • Epigenetic mechanisms , including DNA methylation, chromatin remodeling, and noncoding RNAs have profound regulatory roles in controlling mammalian gene expression. (wisc.edu)
  • Our results imply that rare 6mA in the mammalian genome is introduced by RNA m 6 A machinery via a non-targeted mechanism. (nature.com)
  • Mammalian HP1 isoforms HP1α, HP1β, and HP1γ play different roles in genome stability, but their precise role in heterochromatin structure is unclear. (cipsm.de)
  • SCOPE OF REVIEW: AQP knockout studies in whole animals and cultured cells, along with naturally occurring human mutations suggest that the transport of neutral solutes through AQPs has important physiological roles. (ox.ac.uk)
  • Using this method, we examined the genomic positions of 6mA in bacteria ( E. coli ), green algae ( C. reinhardtii ), and mammalian cells (HEK239T, Huh7, and HeLa cells). (nature.com)
  • it also controls specification of mammalian retina cells. (johnshopkins.edu)
  • This paper summarizes recent advances from studies of Hmgn1 knockout mice and genetically engineered cell lines that are beginning to reveal the diverse roles that HMGN proteins play in DNA repair and transcription within mammalian cells. (silverchair.com)
  • We also describe their expression and possible roles in glial cells. (nih.gov)
  • Emerging research on the roles of stromal cells in modulating adaptive immune responses has included a new focus on lymphatic endothelial cells (LECs). (jci.org)
  • LECs can modulate dendritic cell function, present antigens to T cells on MHC class I and MHC class II molecules, and express immunomodulatory cytokines and receptors, which suggests that their roles in adaptive immunity are far more extensive than previously realized. (jci.org)
  • Lymphatic endothelial cells (LECs) themselves have been shown to play active roles in controlling their transport functions and in directly communicating with immune cells to modulate their immediate and downstream functions. (jci.org)
  • Primary cilia are found on many types of cells in our body and play important roles in development and physiology. (nih.gov)
  • We have performed the first reported proteomic analysis of primary cilia from mammalian cells. (nih.gov)
  • As epimastigotes (depicted in the first image below) move to the hindgut, they differentiate into metacyclic trypomastigotes (depicted in the second image below), which are nondividing forms resistant to mammalian complement that have the capacity to infect mammalian cells. (medscape.com)
  • Mammalian cells are one of the two types of eukaryotic cells, in which contains many internal membrane bounded structures called organelles, they are separated into different groups in order to increase their efficiency at bringing out particular function, and this is called compartmentalization, however there is processes that requires different organelles working together in order to take place, such as respiration (involves the cytoplasm and mitochondria) and Protein Synthesis (Nucleus, Ribosomes). (markedbyteachers.com)
  • Mammalian cells are different to Plant cells (which are also eukaryotic), they do not have a cellulose cell wall, and they are bounded by only plasma membrane, so they are sensitive to Osmotic lysis (the bursting or rupturing of the plasma membrane due to osmotic movement of water into the cell when the cell is in a hypotonic environment. (markedbyteachers.com)
  • Consistent with the different origins of dorsal and ventral dermal cells, our results demonstrate both conserved and divergent roles ofβ-catenin/Wnt signaling in dermal development. (biologists.com)
  • The protein diversity of mammalian cells is determined by arrays of isoforms from genes. (elifesciences.org)
  • Mammalian organisms are composed of numerous cells with multiple different roles. (elifesciences.org)
  • In the adult, stem cells exist in many tissues throughout life and may play critical roles in physiological functions and tissue regeneration. (wisc.edu)
  • Neural stem cells in the postnatal brain have significant roles in both normal brain functions, such as learning and memory and the brain's response to injuries. (wisc.edu)
  • With roughly 30,000 genes in mammalian genomes, fection with a vector encoding MyoD (Tapscott et al. (lu.se)
  • mTORC2 (mammalian focus on of rapamycin organic 2) plays essential roles in indication transduction by regulating a range of downstream effectors, including proteins kinase AKT. (healthanddietblog.info)
  • Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase that integrates stimulation intracellular and extracellular environment to control many fundamental processes through two distinct protein complexes, i.e., mTOR complex 1 (mTORC1) and mTORC2. (shsmu.edu.cn)
  • In the continental US, four terrestrial mammalian species are reservoirs for seven antigenic rabies virus variants. (cdc.gov)
  • The initial data from our investigation indicates the presence of Leptospira sp in rodent vectors, Rattus, Lophuromys and Praomys , which are the potential small mammalian reservoirs of this pathogen in Cote d'Ivoire. (who.int)
  • Although these examples clearly illustrate the major roles played by the posterior Hox genes,little is known regarding the stage or stages at which Hox transcription factors intersect with the limb development program to ensure proper patterning of the principle elements of the limb. (silverchair.com)
  • Anaplerotic roles of pyruvate carboxylase in mammalian tissues. (medlineplus.gov)
  • The trace amines are a structurally related group of amines and their isomers synthesized in mammalian brain and peripheral nervous tissues. (erowid.org)
  • Beyond water homeostasis: Diverse functional roles of mammalian aquaporins. (ox.ac.uk)
  • Recent studies have found that mTOR pathways play important roles in skeletal development and homeostasis. (shsmu.edu.cn)
  • Cytosolic lipids participate in the growth, development, and overall health of mammalian oocytes including many roles in cellular homeostasis. (rsc.org)
  • These proteins are retained on the outer nuclear membrane where they appear to perform specific roles in specialized cell types. (usd.edu)
  • GENERAL SIGNIFICANCE: Elucidating the full range of functional roles of AQPs beyond the passive conduction of water will improve our understanding of mammalian physiology in health and disease. (ox.ac.uk)
  • A substantial body of evidence suggests that the trace amines may play very significant roles in the coordination of biogenic amine-based synaptic physiology. (erowid.org)
  • While binding sites or receptors for a few of the trace amines have been advanced, the absence of cloned receptor protein has impeded significant development of their detailed mechanistic roles in the coordination of catecholamine and indolamine synaptic physiology. (erowid.org)
  • Results of this study demonstrate that CARS is able to identify lipids in live mammalian oocytes, and there exists quantifiable and consistent differences in percent lipid composition across ooctyes of different species, developmental stages, and in relation to body composition. (rsc.org)
  • Accurate Long-read transcriptome sequencing at single-cell level is required to decipher the spectrum of protein expressions in mammalian organisms. (elifesciences.org)
  • SIGNIFICANCE STATEMENT We found the roles of hepatocyte growth factor (HGF) signaling in stria vascularis development for the first time and that lack of HGF signaling in the inner ear leads to profound hearing loss in the mouse. (jneurosci.org)
  • Our recent gene knockout studies showed that the odd-skipped family transcription factors play critical roles in development of multiple organs. (cincinnatichildrens.org)
  • Students and postdoctoral candidates interested in mammalian development and birth defect research are encouraged to contact Rulang Jiang, PhD, ( [email protected] ) to discuss opportunities. (cincinnatichildrens.org)
  • The signaling requirements for ventral dermal cell development have not been established in either the chick or the mammalian embryo. (biologists.com)
  • Using both C. elegans and mammalian models, we have significant progress in understanding the signal transduction mechanism as well its biological roles. (umassmed.edu)
  • This mechanism of transmission contrasts with that of the two subspecies of African trypanosomes that cause human disease, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense , which are transmitted via the saliva of their vectors, and with the mechanism by which a nonpathogenic trypanosome found in the Americas, Trypanosoma rangeli , is transmitted to its mammalian hosts. (medscape.com)
  • T cruzi can also be transmitted when mammalian hosts ingest infected insects, and this mechanism of transmission may play a major role in maintaining the sylvatic cycle. (medscape.com)
  • The photoreceptor sensory cilium is recognized for fast membrane renewal, for which rhodopsin and peripherin/rds (P/rds) play critical roles. (jneurosci.org)
  • I will illustrate this with an example of a mammalian-specific set of AS events. (cam.ac.uk)
  • In conclusion, LOOPseq single-cell technology may hold promise to provide a new level of precision analysis on the mammalian transcriptome. (elifesciences.org)
  • Roles of the mammalian subventricular zone in cell replacement after brain injury. (ox.ac.uk)
  • They are closely associated metabolically with the dopamine, noradrenaline and serotonin neurotransmitter systems in mammalian brain. (erowid.org)
  • The trace amines are unique as they are present in trace concentrations, exhibit high rates of metabolism and are distributed heterogeneously in mammalian brain. (erowid.org)
  • The Roux lab investigates the structure and function of the mammalian nuclear envelope in health and disease. (usd.edu)
  • However, their precise roles in vivo have been elusive until recently. (silverchair.com)
  • As with other parasites that infect both mammalian and insect hosts, the life cycle of T cruzi is complex (see image below). (medscape.com)
  • The infective forms of T cruzi are contained in the feces of the insect vectors and gain entry into its mammalian hosts through contamination. (medscape.com)
  • Here, we reviewed their roles and actions in controlling resolution of inflammation, evidence for their impairment in CF, and proofs of principle for their exploitation as innovative, non-immunosuppressive drugs to address inflammation and infections in CF. (frontiersin.org)
  • In this Review, we highlight these connections to reveal new roles of LECs, along with their transport functions, in modulating adaptive immune responses. (jci.org)
  • The trypomastigote is the infective flagellated form of the parasite found in the blood of the mammalian hosts (blood trypomastigote) and in the hindgut of vectors (metacyclic trypomastigote). (medscape.com)