Embryo LossGenes, LethalEmbryo, MammalianEmbryonic DevelopmentGene TargetingFetal DeathGene Expression Regulation, DevelopmentalMice, KnockoutEmbryonic and Fetal DevelopmentBlastocystHomozygoteHeterozygoteMammalsMice, Mutant StrainsPhenotypeMutationMice, Inbred C57BLMice, TransgenicGene DeletionEmbryonic Stem CellsPregnancyCrosses, GeneticMolecular Sequence DataAllelesTranscription FactorsBase SequenceNuclear ProteinsDNA-Binding ProteinsSignal TransductionIn Situ HybridizationCell DifferentiationStem CellsIntegrasesApoptosisMesodermCell LineRNA, MessengerGrowth and DevelopmentAmino Acid SequenceGenotypeCells, CulturedExonsFibroblastsCarrier ProteinsCell ProliferationTumor Suppressor ProteinsCell Cycle ProteinsReverse Transcriptase Polymerase Chain ReactionYolk SacEmbryologyChimeraSequence Homology, Amino AcidGenomic ImprintingTime FactorsCell LineageZygoteAnimal Nutrition SciencesCell SurvivalCell DivisionDNA PrimersMorphogenesisTumor Suppressor Protein p53Fibroblast Growth Factor 5Cloning, MolecularTrophoblastsMembrane ProteinsGerm CellsGene Expression RegulationModels, BiologicalProteinsPlacentaHomeodomain ProteinsEndodermDNA, ComplementaryTranscription, GeneticProtein BindingEmbryo, NonmammalianDNA MethylationCardiovascular AbnormalitiesDNA (Cytosine-5-)-MethyltransferaseRepressor ProteinsCaenorhabditis elegans ProteinsCaenorhabditis elegansGene ExpressionOrgan SpecificityHistonesDNAEpigenesis, GeneticDrosophilaSequence AlignmentGenomeNeural Tube DefectsTransfectionBlotting, WesternBody PatterningTissue DistributionNerve Tissue ProteinsAnimals, Genetically ModifiedGene Expression ProfilingImmunohistochemistry