Role transcription genetic. Medical search. Frequent questions

Hence, the genes that rely upon σ 54 for their transcription have a wide range of different functions suggesting that the repertoire of functions performed by genes, directly or indirectly affected by σ 54 , is not yet exhaustive. (nih.gov)
Transcription factors bind to specific areas of DNA and help control whether particular genes are turned on or off. (medlineplus.gov)
Some of these genes likely play a role in cell growth and division. (medlineplus.gov)
It directly impacts chromatin structure and can modulate gene transcription, or even completely silence or activate genes, without mutation to the gene itself. (wikipedia.org)
Either increased or decreased transcription of genes around the modification can occur. (wikipedia.org)
A protein duo increases transcription of growth-related genes to enhance axon regeneration and boost plasticity, a study finds-but fails to improve mobility. (the-scientist.com)
Previously, we described a role for the master regulator of erythropoiesis, GATA-1, in inducing genes encoding components of the autophagy machinery. (nih.gov)
This synthetic genetic interaction is seen at the level of single genes and acts downstream of promoter nucleosome reorganization. (sdbonline.org)
Proteins/genes with a putative catabolic role and bacterium adaptation mechanisms during OPP degradation were identified via genomic and proteomic analysis. (nature.com)
Transcription analysis of all putative catabolic genes established their role in the metabolism of OPP. (nature.com)
The downstream transformation of BA involved a meta -cleavage pathway, although its genetic organization and function was not revealed and the overall network of genes driving the full metabolic pathway of OPP is still not known. (nature.com)
Regulation of these two genes is complex, involving 2 activators and 3 repressors of transcription. (rochester.edu)
The common plant regulatory factors (CPRFs) from parsley are transcription factors with a basic-leucine-zipper motif that bind to cis-regulatory elements frequently found in promoters of light-regulated genes. (embl-heidelberg.de)
Proposed to function in concert with members of other transcription factor families, CPRFs regulate the transcriptional activity of many target genes. (embl-heidelberg.de)
This genetic resource will aid in isolating the celastrol biosynthetic genes as well as engineering the celastrol biosynthesis pathway. (techscience.com)
Stem cell treatments, such as those affecting the states of the network of pluripotency genes, are expected to play a central role in future personalized medicine. (aps.org)
Downregulation of AP-2 transcription factor genes is not required for lactogenic differentiation of HC11 cells but may functionally be involved in aspects of lactogenic differentiation in vivo that are not reflected by the HC11 system. (biomedcentral.com)
Advances in molecular genetic tools and an increased understanding of the functional roles of specific genes allow us to test hypotheses concerning the role of variable environments in shaping transcription at known-function candidate loci. (datadryad.org)
In an attempt to address these issues with a genetic intervention, scientists reprogrammed neurons in mouse eyes to regrow after inducing glaucoma or crushing the optic nerve, and restored visual acuity in healthy, middle-aged mice to that of younger mice by expressing a set of genes known to revert cells to a pluripotent state, according to a study published in Nature Wednesday (December 2). (the-scientist.com)
They looked to genes that encode transcription factors that de-differentiate cells. (the-scientist.com)
MODY can result from mutations in any one of the six different genes, one of which encodes the glycolytic enzyme Glucokinase, associated with MO-DY2 and the other five encode transcription factors HNF4-alpha associated with MODY 1, HNF1-alpha associated with MODY 3, IPF with MODY 4, HNF1-Beta with MODY 5 and NeuroD1 with MO-DY6. (scirp.org)
Studies related to mutations in the MODY genes have led to a better understanding of the genetic causes of the Beta cell dysfunction as genetic factors plays a great role in this disorder. (scirp.org)
Objective: To investigate the mutation pattern in the different transcription factor genes with special reference to HNF1-alpha which are highly penetrant with 63% mutation carriers manifesting clinical diabetes by the age of 25 years. (scirp.org)
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. (thebiogrid.org)
Reprime la TRANSCRIPCIÓN GENÉTICA de los GENES diana y desempeña una función fundamental en la ODONTOGÉNESIS. (bvsalud.org)
It represses GENETIC TRANSCRIPTION of target GENES and plays a critical role in ODONTOGENESIS. (bvsalud.org)
The genetic structure includes 4 zinc-finger regions, which suggest that WT1 may be important in controlling the expression of other genes. (medscape.com)
Computational analysis unveiled a hitherto unknown role for ACVRL1 in relation to genes modulating the functionality of the immune cell compartment. (lu.se)
The T-box gene family is a group of related genes that play a critical role in human embryonic development. (medscape.com)
For the last 20 years, the NIEHS Personalized Environment and Genes Study (PEGS) has gathered health, exposure, medical, and genetic data from nearly 20,000 participants in North Carolina from diverse backgrounds. (medlineplus.gov)
In particular, exposure to CAS resulted in the upregulation of hypha-specific genes known to play a role in biofilm formation, such as ALS3 and HWP1. (who.int)

Menin interacts with many other proteins, including several transcription factors. (medlineplus.gov)
This makes TCF7L2 variants the strongest known genetic risk factors for T2DM. (medscape.com)
This gene encodes a member of the zinc finger superfamily of transcription factors whose expression, thus far, has been found only in neuronal tissues. (nih.gov)
Forced expression of this gene in combination with the basic helix-loop-helix transcription factor NeuroD1 and the transcription factors POU class 3 homeobox 2 and achaete-scute family basic helix-loop-helix transcription factor 1 can convert fetal and postnatal human fibroblasts into induced neuronal cells, which are able to generate action potentials. (nih.gov)
E2F1 is one of the transcription factors that cells enter the S phase and plays a key role in cell cycle. (hindawi.com)
NAC transcription factors regulate the stress response in plants. (frontiersin.org)
The NAC domain transcription factors in Arabidopsis function in plant development, senescence, and stress regulation. (frontiersin.org)
Scholars@Duke publication: Transcribing the connectome: roles for transcription factors and chromatin regulators in activity-dependent synapse development. (duke.edu)
Recent studies have elucidated a number of molecular mechanisms that allow nuclear transcription factors and chromatin regulatory proteins to encode aspects of specificity in experience-dependent synapse development. (duke.edu)
Krüppel-like factors (KLFs) are zinc finger transcription factors that share homology in three C-terminal zinc finger domains. (jci.org)
Role of Transcription Factors. (routledge.com)
CPRF5, CPRF6 and CPRF7 are transcription factors that exhibit sequence-specific DNA-binding as well as transactivation abilities, whereas the function of CIP remains elusive. (embl-heidelberg.de)
Root-specific transcription factors (TFs) that may play regulatory roles in celastrol biosynthesis were also discussed. (techscience.com)
One of the central anti-apoptotic pathways in cells is mediated by NF-kB nuclear factor kappa-B transcription factors. (dtic.mil)
For example, the genome in each eukaryotic cell is tightly packed by sharply bending DNA around nucleosome and, similarly, DNA bending by transcription factors is a common cellular mechanism that participates in the regulation of gene expression. (lanl.gov)
It has been established that transcription factors find their target on DNA by facilitated diffusion, i.e. by alternating 3D diffusion and 1D random walk along the DNA. (aps.org)
The genetic regulatory network consisting of the Oct4, Nanog, and TET transcription factors (TF's) is understood to control cell fate, specifically the transitions between somatic and pluripotent states. (aps.org)
Transcription factors AP-2alpha and AP-2gamma are downregulated during lactation, and their overexpression in transgenic mice impaired the secretory differentiation of the mammary epithelium, resulting in lactation failure. (biomedcentral.com)
These findings suggest a functional role of AP-2 transcription factors in preventing lactogenesis. (biomedcentral.com)
We combine in vivo genetic mouse models with in vitro tissue culture and molecular biology techniques to better understand the role of specific signaling pathways and transcription factors in regulation of bone and joint development as well as in the onset and progression of osteoarthritis. (rochester.edu)
DELLA proteins play a central role in these processes via direct protein-protein interactions with key transcription factors. (duke.edu)
Despite the requirement for a number of transcription factors and secreted signalling molecules in sex determination, intracellular signalling components functioning in this process have not been defined. (plos.org)
As a group leader in Copenhagen and in Italy, his lab focused on understanding the role of the E2F transcription factors in cell cycle control, DNA replication and apoptosis. (icr.ac.uk)
The lab continues studying the role of epigenetic factors in transcription, cell fate decisions and in cancer. (icr.ac.uk)
Researchers repaired what is otherwise irreversible damage in the animals' ocular neurons, by activating transcription factors ordinarily used to generate induced pluripotent stem cells. (the-scientist.com)
In a 2016 Cell paper, a different group of scientists had activated these transcription factors in mice with progeria, a condition that causes premature aging, and found that the treatment alleviated symptoms and extended their lifespan by a matter of weeks. (the-scientist.com)
The next challenge: to see if these transcription factors could successfully revert old and injured neurons back to a more youthful and healthy state. (the-scientist.com)
To test whether adult mice can regain this ability, the researchers crushed the optic nerves of some mice and induced glaucoma in another set of mice by inserting tiny beads into their eyes, then injected the virus encoding the three transcription factors into all the mice's eyes. (the-scientist.com)
Our data reveal the differential expression landscape of 493 transcription factors and 682 lncRNAs and highlight specific expression clusters operating in HSCs. (lu.se)
Consequent abnormal expression of the cardiac and limb-specific T-box transcription factors lead to the malformations described in HOS. (medscape.com)
Abnormal cardiac development appears to occur through a process that is heterogeneous and complex, with both environmental and genetic risk factors. (cdc.gov)
Background: Recent studies have associated the transcription factors, Oct4, Sox2 and Nanog as parts of a self-regulating network which is responsible for maintaining embryonic stem cell properties: self renewal and pluripotency. (lu.se)
Researchers seek to use this information to understand the causes of diseases and the effects of environment, diet, lifestyle, and genetic factors on human health. (medlineplus.gov)
e.g. inflammation, genotoxicity, and This chapter focuses on issues as- ellers, growth factors, growth factor epigenetic alterations) and can have sociated with the understanding and receptors, signal transducers, and both genetic and epigenetic origins. (who.int)

This finding suggests a role for this σ 54 in gene regulation that extends beyond its known function as an RNAP gene specificity factor. (nih.gov)
Histone methyltransferases are critical for genetic regulation at the epigenetic level. (wikipedia.org)
This valuable data study presents convincing data that expression of the C. elegans transcription factor NHR-67 is sufficient to drive an invasive fate, and that the alternative proliferative fate is associated with NHR-67 transcriptional down-regulation. (elifesciences.org)
As a largest plant-specific transcription factor family, NAC domain proteins play an important role in plant development and regulation of abiotic stress tolerance. (frontiersin.org)
The conserved histone variant H2AZ has an important role in the regulation of gene expression and the establishment of a buffer to the spread of silent heterochromatin. (sdbonline.org)
One point where these regulatory pathways converge is via the sensory experience-dependent regulation of new gene transcription. (duke.edu)
Working on the metabolism of plants under different abiotic stresses, Dr. Khan has found a significant role of phytohormones in the regulation of plant growth and development and have suggested that phytohormones play an important in controlling stress responses and interacts in coordination with each other for defense signal networking to fine tune tolerance mechanisms. (routledge.com)
In this work, we investigate the role of epigenetic regulation in further stabilizing the two states. (aps.org)
Molecular genetic analysis of the switch-like regulation of daf-7 expression in the ASJ neuron pair reveals a hierarchy of regulation among multiple inputs-sex, age, nutritional status, and microbial environment-which function in the modulation of behavior. (elifesciences.org)
Professor Kristian Helin's team studies the role of chromatin-associated proteins (epigenetics) in the regulation of transcription, cell fate decisions and in cancer. (icr.ac.uk)
We also found an unexpectedly dynamic pattern of transcript isoform regulation, suggesting a critical regulatory role during HSC differentiation, and a cell cycle/DNA repair signature associated with multipotency in MPP2 cells. (lu.se)

Accumulating evidence has shown the importance of the epigenetic control of transcription in nocicept. (researchgate.net)
Role of Epigenetic Chromatin Regulators. (routledge.com)
The NIEHS Toxicant Exposures and Responses by Genomic and Epigenomic Regulators of Transcription (TaRGET) Program seeks to understand how environmental exposures lead to epigenetic changes-that is, modifications to DNA that affect gene expression without altering the underlying genetic code. (medlineplus.gov)

Here we performed a genomic synthetic genetic array analysis using a temperature-sensitive allele of TAF9 as a query. (thebiogrid.org)

Synthetic lethal interactions suggest a role for the Saccharomyces cerevisiae Rtf1 protein in transcription elongation. (embl-heidelberg.de)
Here we present genetic results that indicate a role for the Saccharomyces cerevisiae Rtf1 protein in transcription elongation. (embl-heidelberg.de)
TFIID and Spt-Ada-Gcn5-acetyltransferase functions probed by genome-wide synthetic genetic array analysis using a Saccharomyces cerevisiae taf9-ts allele. (thebiogrid.org)

The MIT physicist has demonstrated the importance of clusters of RNA polymerase and other transcription mediators in regulating RNA production. (the-scientist.com)
Strong evidence indicates that transcription elongation by RNA polymerase II (pol II) is a highly regulated process. (embl-heidelberg.de)
A recent systematic review and meta-analysis found that sensitivity of SARS-CoV-2 antigen rapid diagnostic tests relative to reverse transcription polymerase chain reaction (RT-PCR) increases as the RT-PCR cycle threshold (Ct) value decreases (indicating increasing viral genetic material). (cdc.gov)

Autosomal dominant is a pattern of inheritance characteristic of some genetic disorders. (genome.gov)
Huntington's disease is an example of an autosomal dominant genetic disorder. (genome.gov)
Autosomal Dominant Genetic disorders determined by a single gene (Mendelian disorders) are easiest to analyze and the most well understood. (msdmanuals.com)

The exact cause of autism is not entirely known, although genetics clearly plays an important role. (genome.gov)

[ 29 ] These data suggest that genetic susceptibility to T2DM as determined by TCF7L2 variants might prove an actionable indicator for early intervention and disease prevention. (medscape.com)
The concept that islet autoimmunity results from genetic susceptibility combined with an environmental trigger, first theorised by Eisenbarth [ 10 ], is now generally accepted [ 11 ]. (springer.com)

Researchers can use ENCODE data-which has been combined with other data, such as environmental information-to better understand diseases and drugs, how an individual's genetic makeup interacts with the environment, and how those affect their health. (medlineplus.gov)

Though the mechanisms of this genetic control are complex, hypo- and hypermethylation of DNA is implicated in many diseases. (wikipedia.org)
[ 16 ] Potential mechanisms through which TCF7L2 variants influence T2DM include its role in adipogenesis, myogenesis, and pancreatic islet development, as well as in beta-cell survival and insulin secretory granule function. (medscape.com)
The molecular genetic mechanisms facilitating local adaptation in salmonids continue to be poorly characterized. (datadryad.org)
In addition to providing novel insights into mechanisms regulating transcription, stem cell identity and differentiation, the work in Professor Helin's lab has led to the establishment of biotech company EpiTherapeutics , which in 2015 was sold to Gilead Inc. (icr.ac.uk)

We discussed the structure, function, and string representation of DNA, proteins and RNA and started discussing the basic processes of gene expression (transcription and translation). (ubc.ca)
The study showed that EGFR methylation was mediated by PRMT1, a protein involved in a variety of genetic processes including gene transcription, DNA repair and signaling. (sciencedaily.com)
Enzymes and proteins play a crucial role in gene expression by facilitating the transcription and translation processes. (proprofs.com)
Basic genetic and molecular biology methodologies are combined with complementary bioinformatic and genome-wide approaches, allowing investigation global molecular changes in cells in various differentiation processes. (ki.se)

This homeobox transcription factor is expressed during early cardiac morphogenesis and serves as a master regulatory protein. (cdc.gov)

Written by a team of expert scientists, this book benefits researchers in the field of plant stress biology and is essential reading for graduate students and researchers generating stress tolerant crops through genetic engineering and plant breeding. (routledge.com)

Complex genetic networks control hematopoietic stem cell differentiation into progenitors that give rise to billions of erythrocytes daily. (nih.gov)
Other pharmacological and genetic inhibitors of NF-kappaB also stimulate muscle differentiation in vitro. (ironmagazine.com)
KLF family members are expressed in most if not all tissues and have diverse roles in organismal development and cell differentiation, function, and death. (jci.org)
In this report we analyzed AP-2 transcription factor expression in HC11 cells subjected to lactogenic differentiation conditions. (biomedcentral.com)

Somatic mutations were identified in NXK2-5 and its molecular partners, TBX5 and GATA4 , as well as the transcription factor HEY2 in formalin fixed tissue taken from a collection of hearts with atrial septal defects (ASD), 8 ventricular septal defects (VSD), and atrioventricular canal defects (AVCD). (cdc.gov)

[ 2 ] The product of the WT1 gene has zinc finger arrays that bind to specific DNA sequences, whereas the amino terminus appears to regulate transcription. (medscape.com)

We assayed gene transcription at candidate loci that play a role in the molecular genetic response to these stresses, and correlated transcription with temperature data from the streams and the abundance and diversity of bacteria as characterized by massively parallel pyrosequencing. (datadryad.org)

Researchers are working to identify the proteins that interact with menin and determine its specific role as a tumor suppressor. (medlineplus.gov)
The extent to which transcription is higher in tumor cells than in surrounding nontumor cells is associated with bad prognoses in several cancer types. (the-scientist.com)
Studies have found that E2F1 is highly expressed in a variety of tumor tissues and cells and plays a role of oncogenic gene [ 10 - 13 ]. (hindawi.com)
The constitutional loss of one allele of the Wilms tumor gene ( WT1 ) results in GU anomalies and forms the first of 2 genetic events in the development of a Wilms tumor. (medscape.com)
Patients with early bilateral Wilms Tumor suggests the possibility that they have a constitutional genetic defect that predisposes them to the development of a Wilms tumor, like that seen in WAGR syndrome. (medscape.com)
Only 2% of patients with Wilms tumor have an associated genetic disorder. (medscape.com)

A variant-based heritability analysis can partition disease risk into environmental and genetic components, and the genetic components can be further decomposed by variant frequency (a proxy of variant age) and pancreatic islets regulatory annotation (a proxy of functional relevance to T2D risk). (diabetesjournals.org)
An association between PAX6 abnormalities and diabetes may indicate that it plays a role in pancreatic development as well. (medscape.com)

Lecture 2, 04/09/09, thu In this lecture we reviewed some general background in molecular biology, particularly the central genetic process (from DNA to Proteins). (ubc.ca)

Transcription factor 7-like 2 ( TCF7L2 ) variants have been associated with type 2 diabetes mellitus (T2DM) in multiple ethnic groups. (medscape.com)
[ 11 ] Subsequent studies have shown that several noncoding genetic variants of TCF7L2 are associated with T2DM risk in populations of diverse ancestries in the United Kingdom, the Netherlands, Finland, Sweden, France, India, and Japan. (medscape.com)
Recent studies have revealed that variants of histone H2A and histone H3 play important roles not only in gene expression but also in the repair of DNA breaks and the assembly of chromosome centromeres. (sdbonline.org)
These findings show a role for rare, non-coding variants in the genetic architecture of type 2 diabetes. (diabetesjournals.org)
Genetic, structural, and functional characterization of a multi-donor class of 'public' antibodies revealed an NTD epitope that is recurrently mutated among emerging SARS-CoV-2 variants of concern. (cdc.gov)

Without the activity of enzymes and proteins, the genetic information in the genome would not be able to be expressed and translated into functional proteins. (proprofs.com)
The team is also using functional genetic screens to identify potential novel targets for the development of anti-cancer therapy. (icr.ac.uk)

Hattersley, A.T. (1998) Maturity-onset diabetes of the young: Clinical heterogeneity explained by genetic heterogeneity. (scirp.org)
A cardiomelic developmental field has also been postulated to relate the genetic heterogeneity of HOS (and other similar syndromes) to a cascade of molecules, including the brachyury, sonic hedgehog, bone morphogenetic protein, retinoic acid receptor, and transforming growth factor beta families. (medscape.com)

To investigate how this dichotomy in cellular behavior is controlled in vivo , we used C. elegans , leveraging its highly stereotypical development ( Sulston and Horvitz, 1977 ), as well as its genetic and optical tractability. (elifesciences.org)
Our study investigated the role of extracellular methylation in EGFR signaling, and unexpectedly discovered new information about how EGFR renders cancer cells resistant to cetuximab antibody therapy," said Mien Chie Hung, Ph.D., chair of Molecular and Cellular Oncology. (sciencedaily.com)
Transcription is the first step in cellular reproduction: when genetic information in DNA is made into an RNA copy. (mit.edu)
In high-complexity organisms (such as humans), little is understood of how transcription is carried out at the cellular level. (mit.edu)

He is also exploring the regulatory role of signalling molecules and their impact on nutrient homeostasis and source-sink relationship under abiotic stresses. (routledge.com)

Nucleosomes impose a block to transcription that can be overcome in vivo by remodeling complexes such as SNF/SWI and histone modification complexes such as SAGA. (sdbonline.org)
The variant histone H2A.Z regulates gene transcription, and deletion of the gene encoding H2A.Z strongly increases the requirement for SNF/SWI and SAGA. (sdbonline.org)

In this context, the Forkhead transcription factor, Foxo3, amplified GATA-1-mediated transcriptional activation. (nih.gov)

A hallmark feature of the σ 54 -RNAP is the obligatory requirement for an activator ATPase to allow transcription initiation. (nih.gov)
Transcription takes place in three steps: initiation, elongation, and termination. (dekooktips.com)

For example, it may play a role in copying and repairing DNA and regulating the controlled self-destruction of cells (apoptosis). (medlineplus.gov)
There are indications that this gene may play a role in cancer as well as in diabetes. (medscape.com)
these peptides play a role in postprandial insulin secretion. (medscape.com)
This implies that the genetic context, i.e. the DNA energy landscape around a specific target finding can play an important role for the transcription factor kinetics. (aps.org)
and CD8 + T cells play a major role as beta cell killers [ 6 , 7 ]. (springer.com)
Ultimately, the goal is to develop new imaging methods that uncover what roles weak and transient interactions play in regulating gene expression in single living cells. (mit.edu)
We agree that occupational safety and health professionals, including occupational physicians, can play an integral role in a workplace's COVID-19 preparedness, response, and control plan. (cdc.gov)

Transactivation assay in yeast cells revealed that CmNAC1 functions as a transcription activator, and its transactivation domain is located in the C-terminus. (frontiersin.org)
TAF9 is a TATA-binding protein associated factor (TAF) conserved from yeast to humans and shared by two transcription coactivator complexes, TFIID and SAGA. (thebiogrid.org)

BAZ1B is an ubiquitously expressed nuclear protein with roles in chromatin remodelling, DNA replication and repair, and transcription. (researchgate.net)

These results describe a novel pathway for regulating transcription using variant histones to modulate chromatin structure (Santisteban, 2000). (sdbonline.org)

Gene transcription is a highly regulated step in the expression of a phenotype and it has been shown to respond to selection and thus may be one mechanism that facilitates the development of local adaptation. (datadryad.org)

The diterpenoid phytohormone gibberellin (GA) plays pivotal roles in regulating growth and development throughout the life cycle of higher plants. (duke.edu)

Using a forward genetic screen, we identified the recessive boygirl ( byg ) mutation. (plos.org)
disorder caused by a mutation in the gene for the transcription factor LMX1B , which plays an important role in vertebrate limb and kidney development. (msdmanuals.com)

These enzymatic reactions are found in many pathways and are implicated in genetic diseases, cancer, and metabolic diseases. (wikipedia.org)
However, the microbial metabolic pathway of the fungicide and the genetic systems driving its degradation by strain P3 remain unknown. (nature.com)
Co-inertia analysis demonstrated significant associations between resting levels of metabolic gene transcription and thermal regime (R2 = 0.19, P = 0.013) as well as in response to challenge (R2 = 0.39, P = 0.001) and resting state and challenged levels of cytokine gene transcription with relative abundances of bacteria (resting: R2 = 0.25, P = 0.009, challenged: R2 = 0.65, P = 0.001). (datadryad.org)

Methylation of proteins has a regulatory role in protein-protein interactions, protein-DNA interactions, and protein activation. (wikipedia.org)

2 - 4 Because of its critical role in cardiogenesis, NKX2-5 has been a prime candidate in studies to identify the genetic basis of structural congenital heart defects. (cdc.gov)

The responsible gene has been mapped to band 12q24.1, which encodes the human transcription factor TBX5. (medscape.com)

A codon is a DNA or RNA sequence of three nucleotides (a trinucleotide) that forms a unit of genetic information encoding a particular amino acid. (genome.gov)

We then found that VGLUT3-persistent neurons express the runt domain transcription factor Runx1. (jneurosci.org)

Sickle cell anemia is an example of an autosomal recessive genetic disorder. (genome.gov)

Here, we review some of the recent advances and studies that highlight the roles of these changes as well as antigen presentation and stress response pathways in beta cells in the onset and propagation of the autoimmune process in type 1 diabetes. (springer.com)

Thus, it seems that σ 54 's role as a determinant of uniform colony appearance in UPEC bacteria represents a putative non-canonical function of σ 54 in regulating genetic information flow. (nih.gov)

Thus, although antigen tests are less sensitive than RT-PCR tests, they identify infected individuals with the highest amount of viral genetic material. (cdc.gov)
Thus, by preferentially identifying individuals with the highest amount of viral genetic material, antigen tests may preferentially identify those with the greatest potential to transmit infection. (cdc.gov)

Thus, our studies provide new insight into the genetic program controlling C-LTMR development and call for a revisit for the physiological functions of C-LTMRs. (jneurosci.org)
However, the genetic program controlling C-LTMR development is entirely unknown. (jneurosci.org)
PAX6 plays a role in CNS development as well and may be responsible for the mental retardation seen in a reported 75% of children with WAGR syndrome. (medscape.com)
Deletion of the PAX6 gene, which plays a role in myelinization of the cerebral hemispheres during CNS development, may also be responsible for the mental retardation seen in the WAGR association. (medscape.com)

Biophysicist studies transcription with single-molecule resolution in live mammalian cells. (mit.edu)

Binding of complement to a foreign substance, or antigen, amplifies and augments the body's innate immune system by means of its role as an opsonin (a factor that enhances phagocytosis of unwanted particles) and as a chemoattractant (a factor that recruits cells to areas of inflammation). (medscape.com)
These findings appear to argue against the recently proposed role of VGLUT3 in C-LTMRs in mediating mechanical hypersensitivity induced by nerve injury or inflammation. (jneurosci.org)

We are using a combination of genetic, physiologic, and cell biology techniques to better understand the role of the denitrification pathway in gonococcal virulence. (rochester.edu)
Our project was focused on the role of IkB kinases IKKalpha, IKKbeta, and IKKepilson IKKepilson is called in the literature also IKKi due to its inducible nature in constitutive activation of NF-kB in prostate carcinoma PB cell lines and PC tumors. (dtic.mil)
carries copies of the genetic instructions from DNA to other parts of the cell. (dekooktips.com)

This data suggests that this specific methylation plays an important role in regulating EGFR functionality and resistance to cetuximab treatment. (sciencedaily.com)
The model dynamics both suggests the microarray data can quantify functionality of the genetic network. (lu.se)
However, the more common neonatal type is characterized by a progressive inflammatory lesion, which suggests a role for infectious and/or toxic agents causing bile duct obliteration. (medscape.com)

PARP-1 plays a critical role in DSB sensing and we have shown that PARP-1 recruitment and activation occur within 100 ms after introduction of DSBs. (nature.com)
The flexibility of the DNA molecule plays an important role in a multitude of biological functions as well as in the compact storage of the genetic material of cells. (lanl.gov)

We conclude that NF-kappaB exerts a role in regulating myogenesis and that modulation of NF-kappaB activity within muscle tissue is beneficial for muscle repair. (ironmagazine.com)

The grant will support the study of transcription with single-molecule resolution in live mammalian cells. (mit.edu)

Here, we performed genetic fate mapping, showing that VGLUT3 lineage sensory neurons are divided into two groups, based on transient or persistent VGLUT3 expression. (jneurosci.org)

Anatomy15

Organisms9

Chemicals and Drugs124

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes84

Disciplines and Occupations1

Information Science3

Genes31

Factors34

Regulation11

Epigenetic3

Genomic1

Saccharomyces3

Polymerase3

Autosomal dominant3

Genetics1

Susceptibility2

Encode1

Mechanisms4

Processes4

Homeobox1

Crops through genetic1

Differentiation4

Mutations1

Zinc finger1

Loci1

Tumor6

Pancreatic2

Molecular biology1

Variants5

Functional2

Heterogeneity2

Cellular4

Stresses1

Histone2

Transcriptional1

Initiation2

Play7

Yeast2

Replication1

Chromatin structure1

Highly regulated1

Pivotal1

Mutation2

Metabolic3

Regulatory role1

Structural1

TBX51

Amino acid1

Domain transcription1

Disorder1

Pathways1

Putative1

Viral2

Development4

Studies1

Inflammation2

Cell3

Suggests3

Plays2

Myogenesis1

Molecule1

Fate1