• SOX1, SOX2 and SOX3, members of the SOX gene family (specifically the SOXB1 group), contain transcription factors related to SRY, the testis-determining factor. (wikipedia.org)
  • SOX1 exerts its importance in its role in development of the central nervous system (neurogenesis) and in particular the development of the eye, where it is functionally redundant with SOX3 and to a lesser degree SOX2, and maintenance of neural progenitor cell identity. (wikipedia.org)
  • SOX1 is a member of the SOX gene family, in particular the SOXB1 group, which includes SOX1, SOX2, and SOX3. (wikipedia.org)
  • In a recent study, we showed that human fibroblasts can be reprogrammed into induced trophoblast stem (iTS) cells by transcription factor-mediated nuclear reprogramming using the Yamanaka factors OCT4, KLF4, SOX2 and c-MYC (OKSM) and a selection of TS cell culture conditions. (edu.au)
  • This supports the claim that SOXB1 group proteins have redundant roles. (wikipedia.org)
  • Second, goosecoid was identified as a central player in a regulatory sub-circuit controlling mouth formation, while tbx2/3 emerged as a critical factor for differentiation of the dorsal ectoderm . (echinobase.org)
  • A subclass of SOX transcription factors that are expressed in neuronal tissue where they may play a role in the regulation of CELL DIFFERENTIATION . (nih.gov)
  • Induction of antisense Pax-3 expression leads to the rapid morphological differentiation of neuronal cells and an altered response to the mitogenic growth factor bFGF. (jefferson.edu)
  • By using a combination of in situ hybridization screening, overexpression of mRNA, recombinant ligand treatments, and morpholino-based loss-of-function studies, we identified a cohort of transcription factors and signaling molecules expressed in the ventral ectoderm , dorsal ectoderm , and interposed neurogenic ("ciliary band") region in response to the known key signaling molecules Nodal and BMP2/4 and defined the epistatic relationships between the most important genes. (echinobase.org)
  • Acquisition of pluripotency by transcriptional regulatory factors is an initial developmental event that is required for regulation of cell fate and lineage specification during early embryonic development. (biomedcentral.com)
  • The acquisition of pluripotency plays a pivotal role in determining developmental fate during early vertebrate embryogenesis. (biomedcentral.com)
  • In ectodermal cells committed to a certain cell fate, SOX1 has shown to be one of the earliest transcription factors expressed. (wikipedia.org)
  • It is suggested the three members of the SOXB1 group have redundant roles in the development of neural stem cells. (wikipedia.org)
  • During early mammalian embryonic development, trophoblast cells play an essential role in establishing cell-cell interactions at the maternal-fetal interface to ensure a successful pregnancy. (edu.au)
  • N-acetyl-L-cysteine (NAC) is a precursor of reduced glutathione (GSH), which can enter cells to play an antioxidant role, so it is better than glutathione. (bvsalud.org)
  • SOX1 is a gene that encodes a transcription factor with a HMG-box (high mobility group) DNA-binding domain and functions primarily in neurogenesis. (wikipedia.org)
  • The SOX gene family encodes transcription factors. (wikipedia.org)
  • Gene expression profiles of transcription factors and signaling molecules analyzed in this study. (echinobase.org)
  • Interestingly, Trpm8-/- animals displayed increased expression of the clock gene Per2 and vasopressin (AVP) in the SCN, suggesting a regulatory role of TRPM8 on the central oscillator. (bvsalud.org)
  • The evolutionarily conserved core transcriptional factors regulating the pluripotency network in fishes, amphibians, and mammals have been elucidated. (biomedcentral.com)
  • There are also species-specific maternally inherited transcriptional factors and their intricate transcriptional networks important in the acquisition of pluripotency. (biomedcentral.com)
  • HN - 2009 BX - alpha-Globin MH - AMP-Activated Protein Kinases UI - D055372 MN - D8.811.913.696.620.682.700.85 MN - D12.644.360.62 MN - D12.776.476.62 MS - Intracellular signaling protein kinases that play a signaling role in the regulation of cellular energy metabolism. (nih.gov)
  • It plays an important role in sphingolipid degradation by catalyzing the lysosomal hydrolysis of ceramide to sphingosine and free fatty acid. (nih.gov)
  • In non-mammalian vertebrates, loss of one SOXB1 protein results in minor phenotypic differences. (wikipedia.org)
  • This graph shows the total number of publications written about "PAX6 Transcription Factor" by people in this website by year, and whether "PAX6 Transcription Factor" was a major or minor topic of these publications. (jefferson.edu)
  • These results suggest that chickens have a unique pluripotent circuitry since maternally inherited c NANOG and cSOX3 may play an important role in the initial acquisition of pluripotency. (biomedcentral.com)
  • A paired box transcription factor that has important functions in the development of the eye, nose, central nervous system and pancreas. (jefferson.edu)
  • Since the ion channel TRPM8 is a critical cold sensor, we investigated its role in circadian function. (bvsalud.org)