Role ring finger domains. Medical search. Frequent questions

In molecular biology, a RING (short for Really Interesting New Gene) finger domain is a protein structural domain of zinc finger type which contains a C3HC4 amino acid motif which binds two zinc cations (seven cysteines and one histidine arranged non-consecutively). (wikipedia.org)
The C6HC zinc finger motif is the fourth family member of the zinc-binding RING, LIM, and LAP/PHD fingers. (embl.de)
The novel C6HC motif has been called DRIL (double RING finger linked). (embl.de)
11 Both proteins possess an N-terminal RING finger motif and two BRCA1 C-terminal (BRCT) domains present in numerous proteins involved in DNA repair and cell cycle regulation. (bmj.com)
The N-terminal domain makes extensive DNA contacts, using a novel beta turn motif that binds in the minor groove and a helix-turn-helix unit with a docking arrangement surprisingly similar to that of the lambda repressor. (embl.de)
It was initially observed in mitochondria while later it was also found to be localized in other cellular compartments [1 2 HAX1 exhibits weak sequence homology with the anti-apoptotic protein B cell/lymphoma/leukemia-2 (Bcl-2) containing an N-terminal acidic domain putative Bcl-2 homology domains (BH1 and BH2) a PEST motif and a predicted C-terminal transmembrane domain [1]. (healthweeks.com)
The plant homeodomain (PHD) finger is a C4HC3 zinc-finger-like motif found in nuclear proteins thought to be involved in epigenetics and chromatin-mediated transcriptional regulation. (embl-heidelberg.de)
The PHD finger binds two zinc ions using the so-called 'cross-brace' motif and is thus structurally related to the RING finger and the FYVE finger . (embl-heidelberg.de)
The PHD finger motif is reminiscent of, but distinct from the C3HC4 type RING finger. (embl-heidelberg.de)
Whether ST2L includes a distinct ubiquitin dependent endocytosis like motif that engages an F box protein or interacts with endocytic adaptors via ubiquitin binding domains to market proteasomal sorting needs further evaluation. (gp120inhibitor.com)
A five-residue motif for the design of domain swapping in proteins. (ncbs.res.in)
This gene encodes a protein with a coiled-coil motif and a RING-H2 motif (C3H2C2) at its carboxy-terminus. (antibodypedia.com)
The RING motif is a zinc-binding domain found in a large set of proteins playing roles in diverse cellular processes including oncogenesis, development, signal transduction, and apoptosis. (antibodypedia.com)

Zinc finger (Znf) domains are relatively small protein motifs that bind one or more zinc atoms, and which usually contain multiple finger-like protrusions that make tandem contacts with their target molecule. (wikipedia.org)
11 The functionally important BARD1/BRCA1 heterodimer formation is mediated by the RING finger motifs and has also been shown to markedly increase the stability of both proteins. (bmj.com)
Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. (embl-heidelberg.de)
This protein has several conserved regions, including baculoviral IAP repeat (BIR) motifs and a RING finger E3 ligase domain. (utsouthwestern.edu)
Crystal structure in the extracellular proteaseassociated (PA) domain (residues 4498) of RNF43 within a complicated with all the CRD Rspo1 along with the LGR5 ectodomain (ECD) was solved (PDB ID: 4KNG).56 PA domains that function as ligand recognition motifs and play regulatory roles are frequently located in proteases and receptors.124 Fig. ten sho. (calcium-channel.com)
a Domain organization of the four subunits of human Pol δ and amino acid sequence of PCNA-interacting (PIP-box) motifs. (nature.com)

The MDM2 oncoprotein plays multiple regulatory roles in the control of p53-dependent gene expression. (ed.ac.uk)
Homeodomain proteins play key roles in development and gene regulation in eukaryotes. (embl.de)
DNA methylation is an epigenetic modification that regulates gene expression and plays an essential role in hematopoiesis. (bvsalud.org)
A novel gene containing SNF2, PHD-finger, RING-finger, helicase, and linker histone domains termed SHPRH, is a possible candidate for a tumor suppressor gene. (phosphosolutions.com)
Mapping of this gene to 6q24, a region reported to contain a tumor suppressor locus suggests a role in tumor suppression. (phosphosolutions.com)
This gene encodes an E3 ubiquitin-protein ligase required for the maintenance of the antephase checkpoint that regulates cell cycle entry into mitosis and, therefore, may play a key role in cell cycle progression and tumorigenesis. (utsouthwestern.edu)
Here, we identified a gene, named Arabidopsis thaliana abscisic acid (ABA)-insensitive RING protein 4 ( AtAIRP4 ), which is induced by ABA and other stress treatments. (jipb.net)
Using degenerate oligonucleotide primers corresponding to the RING domain, we isolated a novel RING finger gene from the mouse testis cDNA library, which was about 1.8 kb and was termed Trif (testis-specific ring finger). (ntnu.edu.tw)
The androgen receptor (AR) N-terminal domain plays a critical role in androgen-responsive gene regulation. (endocrinology-journals.org)
Here we identify recurrent mutations within Wilms tumours that involve the highly conserved YEATS domain of MLLT1 (ENL), a gene known to be involved in transcriptional elongation during early development. (nature.com)

Some Zn finger domains have diverged such that they still maintain their core structure, but have lost their ability to bind zinc, using other means such as salt bridges or binding to other metals to stabilise the finger-like folds. (wikipedia.org)
For example, some family members form salt bridges to stabilise the finger-like folds. (embl-heidelberg.de)

Many proteins containing a RING finger play a key role in the ubiquitination pathway. (wikipedia.org)
Many RING finger domains simultaneously bind ubiquitination enzymes and their substrates and hence function as ligases. (wikipedia.org)
The domain structure includes: (i) a hydrophobic pocket at the N terminus of MDM2 that is involved in both its transrepressor and E3-ubiqutin ligase functions, (ii) a central acid domain that recognizes a ubiquitination signal in the core DNA binding domain of p53, and (iii) a C-terminal C2H2C4 RING finger domain that is required for E2 enzyme-binding and ATP-dependent molecular chaperone activity. (ed.ac.uk)
The U box is a modified RING finger - a common domain in ubiquitination. (embl.de)
We showed that HAX1 promotes auto-ubiquitination and degradation of cIAPs by facilitating the intermolecular homodimerization of RING finger domain. (healthweeks.com)
E3 ligases recognize ligand proteins and dictate the high specificity of protein degradation, and thus, play a pivotal role in ubiquitination. (jipb.net)
Thus, identification of a novel AR-interacting protein with ubiquitin ligase activity will stimulate further investigation into the role of ubiquitination and the ubiquitin-proteasome system in AR-mediated cellular functions. (endocrinology-journals.org)
One can find very limited information on the role of F box proteins within the ubiquitination and degradation of cytokine receptors, while a number of RING finger E3 selleck chemical ligases, just like TRAF6, c Cbl22 and RNF41, regulate the turnover of cytokine receptors. (gp120inhibitor.com)

IBR domain is a cysteine-rich (C6HC) zinc finger domain that is present in Triad1, and which is conserved in other proteins encoded by various eukaryotes. (embl.de)
The encoded protein has an N-terminal forkhead-associated domain, a central RING-finger domain, and a cysteine-rich C-terminal region. (utsouthwestern.edu)

Thus, mutations within the RING domain that affect zinc coordination, but not one that inhibits ATP binding, produce MDM2 proteins that have a higher affinity for the BOX-I transactivation domain of p53 and a reduced I(0.5) for p53 transrepression. (ed.ac.uk)
11- 13 The finding of breast cancer associated mutations within the RING finger domain of BRCA1 , disrupting BRCA1/BARD1 interaction, 11, 14 and the occurrence of BARD1 missense mutations in breast cancer patients, 15- 17 implies participation of BARD1 in BRCA1 mediated tumour suppression. (bmj.com)
Crystal structure of a paired domain-DNA complex at 2.5 A resolution reveals structural basis for Pax developmental mutations. (embl.de)
Together, our findings highlight the crucial role of pVHL-HIF dysregulation in VHL disease and strengthen the clinical relevance and significance of the missense mutations of Ser65 residue in pVHL in the familial VHL disease. (biomedcentral.com)
Mutations affecting the BHLHA9 DNA-binding domain cause MSSD, mesoaxial synostotic syndactyly with phalangeal reduction, Malik-Percin type. (medscape.com)

Therefore, different TF families have evolved their unique DNA-binding domains, which confer binding specificity. (ashs.org)

Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). (abcam.com)

Intriguingly, ARNIP, and in particular its RING-H2 domain, functioned as a ubiquitin-protein ligase in vitro in the presence of a specific ubiquitin-conjugating enzyme, Ubc4-1. (endocrinology-journals.org)

The domain binds DNA through a helix-turn-helix (HTH) structure. (embl.de)
The N-terminal baculovirus IAP repeat (BIR) domains of IAP family members have been demonstrated to bind to Smac/DIABLO (second mitochondrion-derived activator of caspase) protein which induces rapid proteasomal degradation of cIAPs [27 28 In addition cIAP1/2 also contain an ubiquitin-associated (UBA) domain that binds to polyubiquitin chains [29] and a less well characterized caspase-recruitment domain (CARD) which was found to be an intrinsic inhibitory domain. (healthweeks.com)
pVHL is best known as the substrate-binding subunit of an E3 ubiquitin ligase, which binds the transcription elongation factors C and B (elongin C/B) forms the VCB complex, then interacts with Cullin-2 (CUL2) and the RING finger protein RBX1 forming the VCB-CR complex(3). (biomedcentral.com)

This protein may also have a role in intranuclear degradation of polyglutamine aggregates. (nih.gov)
This degradation is mediated by at least two domains indicating the presence of at least two different pathways impinging on ICK1/KRP1 protein stability. (uni-bielefeld.de)

The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. (nih.gov)
In this study, we found that RING finger protein 4 (RNF4), a RING finger E3 ubiquitin ligase, is required for the RIPK1 autophosphorylation and subsequent cell death. (mdpi.com)
These studies are expected to provide new information on the physiological function of this domain and how it is potentially used to modulate the ligase activity of Mulan. (ucf.edu)
In animals, 5mC is maintained during DNA replication by DNMT1 together with UHRF1, which directly recognizes hemimethylated cytosine via the SRA domain and stimulates activity of DNMT1 in a manner dependent on its ubiquitin-ligase activity ( Nishiyama and Nakanishi, 2021 ). (elifesciences.org)
AtAIRP4 encodes a cellular protein with a C3HC4-RING finger domain in its C-terminal side, which has in vitro E3 ligase activity. (jipb.net)
Yang L, Liu Q, Liu Z, Yang H, Wang J, Li X, Yang Y (2016) Arabidopsis C3HC4-RING 﫿nger E3 ubiquitin ligase AtAIRP4 positively regulates stress-responsive abscisic acid signaling. (jipb.net)
Other reports suggesting that the PHD finger is a ubiquitin ligase have been refuted as these domains were RING fingers misidentified as PHD fingers. (embl-heidelberg.de)
Mutation of a single cysteine residue in the ARNIP RING-H2 domain (Cys145Ala) abolished this E3 ubiquitin ligase activity. (endocrinology-journals.org)
NEDD8 Deamidation Inhibits Cullin RING Ligase Dynamics. (ncbs.res.in)

Ed metabolic liver zonation and controls hepatic development and size during development, homeostasis, and regeneration.120 Human ZnRF3 (UniProt ID: Q9ULT6) is often a singlepass transmembrane protein containing N-terminal signal peptide ( IFN-alpha 2a Proteins Recombinant Proteins residues 15), extracellular domain (residues 5619), transmembrane helix (residues 22040), in addition to a cytoplasmic domain (residues 241936), where the zinc finger domain (RING-type, residues 29334) is embedded. (calcium-channel.com)
Figure 9C show that, regardless of becoming a transmembrane protein, ZnRF3 is predicted to include important degree of intrinsic disorder (50 ), in particular at its cytoplasmic domain, which appears to become mostly disordered. (calcium-channel.com)
Comparable to ZnRF3, human RNF43 is a single-pass transmembrane protein that contains signal peptide (residues 13), extracellular domain (residues 2497), transmembrane helix (residues 19818), as well as a cytoplasmic domain (residues 21983), together with the zinc finger domain (RING-type, residues 27213). (calcium-channel.com)

One of the interesting features of cIAP1 and cIAP2 is that they can act as an E3 ubiquitin ligases with their own RING finger domain [19]. (healthweeks.com)
Deamidation disrupts native and transient contacts to weaken the interaction between UBC13 and RING-finger E3 ligases. (ncbs.res.in)
The MG132 proteasome inhibitor, and knockdown of checkpoint with forkhead and ring finger domains (CHFR) and ring finger protein 146 (RNF146), E3 ubiquitin ligases targeting PARP1, suppressed nutlin-3a-induced PARP1 reduction. (oncotarget.com)

When the turned on progenitor small percentage of DDC-treated tissues was likened with the dormant progenitor small percentage of neglected livers (Supplemental Desk S i90004), it was noticed that the turned on progenitor small percentage features higher phrase of cell cycle-associated genetics and lower phrase of zinc ring finger domain-containing genetics. (baxkyardgardener.com)

Mulan plays a major role in various cell processes including cell growth, mitophagy, apoptosis, and mitochondrial dynamics. (ucf.edu)
RING point mutants of XIAP were as competent as their full-length counterparts in inhibiting apoptosis, although impaired in their ability to oligomerize with full-length XIAP. (rupress.org)
While first identified for its role in blocking apoptosis, this protein modulates many other signaling processes including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) pathways and inflammatory responses. (utsouthwestern.edu)
More importantly, the cellular factors affected by the HBV also modulate various biological processes, including innate immune response, cell cycle, proliferation, apoptosis, and invasion, and play vital roles in the development of liver diseases [ 12 ]. (biomedcentral.com)

The COOH-terminal A168-170 region of the giant sarcomeric protein titin interacts with muscle-specific RING finger-1 (MURF-1). (rupress.org)

Each of these domains contains a helical region resembling the homeodomain and the Hin recombinase. (embl.de)
Members of the zinc-finger homeodomain (ZF-HD) family play a key role in the control of plant growth and development, which are involved in plant responses to stress. (ashs.org)
Based on previous phylogenetic analyses in arabidopsis ( Arabidopsis thaliana ), our results showed that some tomato SL-ZH ( S. lycopersicum zinc-finger homeodomain) genes cluster into the same neighbor-joining (NJ) branch as arabidopsis, indicating that these genes may share similar structures and functions in these plants. (ashs.org)

In the I-band part skeletal muscle titin is composed of a series of proximal Ig-domains, the N2A-domain (including the N2-A unique sequence), the PEVK domain [high abundance of proline (P), glutamic acid (E), valine (V), and lysine (K)] and the distal Ig-domains. (frontiersin.org)
Note ring finger proximal interphalangeal (PIP) joint flexion deformity due to complete syndactyly between border digits. (medscape.com)

Mammalian HP1 isoforms HP1α, HP1β, and HP1γ play different roles in genome stability, but their precise role in heterochromatin structure is unclear. (cipsm.de)

Ser65 residue, located within the β-domain and nearby the interaction sites with hypoxia-inducing factor α (HIFα), is highly conserved among different species. (biomedcentral.com)

The PHD finger and the bromodomain are small protein domains that occur in many proteins associated with phenomena related to chromatin. (embl-heidelberg.de)

Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) is a protein essential for the maintenance of DNA methylation in somatic cells. (life-science-alliance.org)
However, UHRF1 is predominantly localized in the cytoplasm of mouse oocytes and preimplantation embryos, where it may play a role unrelated to the nuclear function. (life-science-alliance.org)
These findings suggest that UHRF1 and DNMT1 play a pivotal role in regulating differentiation and proliferation of THP-1 cells and targeting these proteins may improve the efficiency of differentiation therapy in AML patients. (bvsalud.org)
Ubiquitin-like protein containing PHD and RING finger domains 1 (UHRF1) is a major regulator of epigenetic mechanisms and is overexpressed in various human malignancies. (biomedcentral.com)
Ubiquitin-like protein containing PHD and RING finger domains 1 (UHRF1), also known as ICBP90 in human and Np95 in mouse, plays an important role in reading and maintaining the epigenetic marks [ 4 ]. (biomedcentral.com)

Click on the protein counts, or double click on taxonomic names to display all proteins containing IBR domain in the selected taxonomic class. (embl.de)

Mechanistic studies indicate that the regulatory role of TRIM28 on MAGEC2 protein expression in tumor cells depends on proteasome-mediated pathway. (biomedcentral.com)
Here, we provide an overview of the ISR and the role the various ISR pathway components play in hematologic malignancies. (biomedcentral.com)

HIF1α and HIF2α play crucial roles in VHL disease, particularly with respect to ccRCC and hemangioblastoma. (biomedcentral.com)

Structure of the C3HC4 domain by 1H-nuclear magnetic resonance spectroscopy. (wikipedia.org)

29 Moreover, a recent study in mice showed that loss of Bard1 results in early embryonic lethality and chromosomal instability, indicating a role of Bard1 in maintenance of genomic integrity. (bmj.com)

Fluorescent protein tagging studies revealed that AR-ARNIP interaction was hormone-independent in COS-1 cells, and suggest that colocalization of both AR and ARNIP to the nucleus upon androgen addition may allow ARNIP to play a role in nuclear processes. (endocrinology-journals.org)
In addition, we show that ICK1/KRP1 localizes to different subnuclear domains, i.e. in the nucleoplasm and to the chromocenters, hinting at specific actions within the nuclear compartment. (uni-bielefeld.de)

Selective silencing of 2Cys and type-IIB Peroxiredoxins discloses their roles in cell redox state and stress signaling [J]. J Integr Plant Biol. (jipb.net)

Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. (wikipedia.org)

Colocalisation of BARD1 with BRCA1 and RAD51 in response to DNA damage indicates a role in DNA repair, 19, 20 which is supported by the recent observation of BARD1 participation along with BRCA1 in homology directed repair of chromosome breaks. (bmj.com)

The ubiquitin-proteasome system (UPS) is in charge of the majority of protein turnover in eukaryotic cells and plays an integral role in maintaining cellular protein homeostasis. (researchassistantresume.com)

Pol δ is anchored to one of the three PCNA monomers through the C-terminal domain of the catalytic subunit. (nature.com)
The catalytic subunit (p125) harbours the polymerase and exonuclease activities, and a metal-binding C-terminal domain (CTD). (nature.com)

Our study suggests that a unique specialized role of CDCA7 in HELLS-dependent DNA methylation maintenance is broadly inherited from the last eukaryotic common ancestor. (elifesciences.org)
The results suggest that the roles for the two factors in DNA methylation maintenance pathways can be traced back to the last eukaryotic common ancestor and that the CDC7A-HELLS-DNMT axis shaped the evolutionary retention of DNA methylation in eukaryotes. (elifesciences.org)

A conserved and buried edge-to-face aromatic interaction in Small Ubiquitin-like Modifier (SUMO) has a role in SUMO stability and function. (ncbs.res.in)

A picture of MDM2 is emerging where structurally discrete but interdependent functional domains are linked through changes in conformation. (ed.ac.uk)
Here we show that the binding affinity of MDM2s hydrophobic pocket can be regulated through the RING finger domain and that increases in pocket affinity are reflected by a gain in MDM2 transrepressor activity. (ed.ac.uk)
An allosteric model for regulation of the hydrophobic pocket is supported by differences in protein conformation and pocket accessibility between wild-type and the RING domain mutant MDM2 proteins. (ed.ac.uk)
Additionally the data demonstrate that the complex relationship between different domains of MDM2 can impact on the efficacy of anticancer drugs directed toward its hydrophobic pocket. (ed.ac.uk)

Members of the RING finger family are implicated in a variety of functions such as signal transduction, transcriptional regulation and other developmental processes. (ntnu.edu.tw)
Transcription factors (TFs), which bind to specific nucleotide sequences, have been shown to play important roles in the regulatory networks of numerous developmental processes in plants. (ashs.org)

In similarity to the RING finger and the LIM domain, the PHD finger is thought to bind two zinc ions. (embl-heidelberg.de)

The easy Band finger E3s support the E2-binding Band domain and substrate-binding domain inside the same polypeptide. (researchassistantresume.com)

Proteins that contain two Ring fingers and an IBR domain (these proteins are also termed RBR family proteins) are thought to exist in all eukaryotic organisms. (embl.de)

Cancer/testis antigen MAGEC2 (also known as HCA587) is highly expressed in a wide variety of tumors and plays an active role in promoting growth and metastasis of tumor cells. (biomedcentral.com)
To our knowledge, this is the first time to report the role of TRIM28 in regulating the expression of cancer/testis antigen MAGEC2. (biomedcentral.com)

These outcomes help the emerging proposal of a role for GSK3B in controlling the lifespan of surface receptors with divergent roles, for instance DR5 as well as the receptor for prolactin43. (gp120inhibitor.com)

The 2.5 A resolution structure of a cocrystal containing the paired domain from the Drosophila paired (prd) protein and a 15 bp site shows structurally independent N-terminal and C-terminal subdomains. (embl.de)

CTD C-terminal domain, OB oligonucleotide binding domain, PDE phosphodiesterase domain. (nature.com)

GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq #=GF TP Family #=GF CL CL0229 #=GF RN [1] #=GF RM 21547297 #=GF RT Functional diversification of the RING finger and other #=GF RT binuclear treble clef domains in prokaryotes and the early #=GF RT evolution of the ubiquitin system. (genome.jp)

26 The suggested role in TP53 dependent apoptotic signalling 27 and interaction with the ankyrin repeats of proto-oncoprotein BCL3, thereby possibly modulating the activity of transcription factor NFKB, 28 represent BRCA1 independent functions of BARD1. (bmj.com)
These domains are characteristic of several DNA repair proteins, transcription factors, and helicases. (phosphosolutions.com)

The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. (nih.gov)
PARP14 and PARP9 play a key role in macrophage immune regulation. (bvsalud.org)
These expression data suggest that Trif may play an important role in the regulation of spermatogenesis. (ntnu.edu.tw)

This deduced protein contains an N-terminal RING-finger, a B-box, and a C-terminal B-30.2-like domain, which make the Trif protein a member of the RING finger-B-box-coil-coil family. (ntnu.edu.tw)

Several reports suggest that it can function as a protein-protein interacton domain and it was recently demonstrated that the PHD finger of p300 can cooperate with the adjacent BROMO domain in nucleosome binding in vitro. (embl-heidelberg.de)

Due to the elastic I-band domains and the filament-like integration in the half-sarcomere titin is an important factor for sarcomere assembly and serves as an adaptable molecular spring that determines myofilament distensibility. (frontiersin.org)
It is not yet known if PHD fingers have a common molecular function. (embl-heidelberg.de)

The function of this domain is not yet known but in analogy with the LIM domain it could be involved in protein-protein interaction and be important for the assembly or activity of multicomponent complexes involved in transcriptional activation or repression. (embl-heidelberg.de)
Understanding the role of these transporters is extremely important to elaborate the signaling between various subcellular compartments. (frontiersin.org)
Poly (ADP-ribose) polymerase 1 (PARP1) plays important roles in single strand DNA repair. (oncotarget.com)
Patients and visitors play an important role in preventing the spread of germs that cause serious infections. (cdc.gov)
Each team member in their specific area of expertise played an important role in designing a structured, individualized, varied curriculum. (bvsalud.org)

Protein-interactions e.g., with muscle ankyrin repeat proteins or muscle LIM-protein link titin to hypertrophic signaling and via p62 and Muscle Ring Finger proteins to mechanisms that control protein quality control. (frontiersin.org)
Numbers indicate six superrepeats with seven modular domains and 11 superrepeats with 11 modular domains within the thick filament-associated A band titin. (frontiersin.org)

Anatomy18

Organisms7

Diseases2

Chemicals and Drugs63

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes52

Information Science4

Motif13

Motifs6

Gene10

Stabilise the finger-like folds2

Ubiquitination8

Cysteine-rich2

Mutations5

Specificity1

Zinc finger p1

Ubiquitin-conjug1

Binds3

Degradation2

Ligase9

Cytoplasmic domain3

Ligases3

Genetics1

Apoptosis4

Interacts1

Homeodomain3

Proximal2

Genome1

Highly conserved1

Proteins associated1

UHRF15

Taxonomic class1

Pathway2

Play crucial roles1

C3HC41

GENOMIC1

Nuclear2

Biol1

Linker1

Homology1

Cellular1

Catalytic2

Methylation2

SUMO1

MDM24

Processes2

Bind1

Polypeptide1

Eukaryotic1

Testis2

Receptors1

Structurally1

Oligonucleotide1

Functional1

Transcription2

Regulation3

Protein contains1

Vitro1

Molecular2

Important5

Titin2