• Taking into account the important regulatory roles that miRNAs have in cancer development, by acting either as oncogenes or as tumor-suppressor genes, they represent potential biomarkers in ovarian cancer [ 5 ]. (biomedcentral.com)
  • The latest version of miRBase consists of 1881 human miRNAs, and most of them regulate more than 60% of human protein-coding genes. (biomedcentral.com)
  • miRNAs regulate target genes through biological processes, such as cell growth, proliferation, differentiation and apoptosis. (biomedcentral.com)
  • Thus, the function of miRNA may ultimately depend on the specific microenvironment of a particular cell type, which can provide different repertoire of target genes. (bvsalud.org)
  • Besides its role in the regulation of genes, DNA methylation silences repetitive elements and appears to be important for the stability of the mammalian genome. (caister.com)
  • MicroRNAs (miRNAs or miRs) are involved in the post-transcriptional regulation of gene expression via complete or partial base pairing with the 3′untranslated region of target genes ( 3 ). (spandidos-publications.com)
  • miRNAs can be transcribed from specific genes or introns of protein-coding genes. (cmbr-journal.com)
  • A single miRNA species can control the expression of hundreds of genes, and also one gene can be the target of different miRNAs. (cmbr-journal.com)
  • SNPs in 6 miRNA processing genes and in 78 miRNAs which target genes known to be important in breast cancer among 906 African American (AA) and 653 European American (EA) cases and Author Manuscript controls enrolled in the Women's Circle of Health Study (WCHS). (cdc.gov)
  • We found a number of SNPs in miRNAs and processing genes in association with breast cancer overall or stratified by estrogen receptor (ER) status. (cdc.gov)
  • About 30% of the human protein-coding genes are negatively regulated by miRNAs which suggests that they have a major role in regulating gene expression. (usda.gov)
  • The U-M researchers want to study whether miRNAs are regulating the cell's nucleus, which would have an effect on the number of genes expressed through epigenetics. (umich.edu)
  • Identification of miRNA-regulated targeting genes is important for understanding their specific biological functions [ 11 ]. (degruyter.com)
  • The central dogma of molecular biology stated that genes encode for proteins and that DNA, which makes up our genomes, mainly produces RNAs which are translated into proteins. (atlasofscience.org)
  • MicroRNAs (miRNAs) are an endogenous group of small non-coding RNAs that post-transcriptionally repress the expression of protein-coding genes. (biomedcentral.com)
  • Considering that various protein coding genes are targeted by one miRNA, researchers should determine the mechanisms of miR-140-5p mediated phenotypic changes in GC cells. (biomedcentral.com)
  • Stimulating the expression of angiogenic microRNAs or genes in EPCs of low activity (such as those from patients with cardiovascular diseases) might allow the development of novel therapeutic strategies. (biomedcentral.com)
  • It is one of the largest gene families accounting for approximately 1% of the genome and regulate approximately 1/3rd of all human genes 4 , 5 , 6 . (openaccesspub.org)
  • Bioinformatic technologies were used to identify the deferentially expressed miRNAs (DE-miRNAs) and hub target genes of arecoline-induced cancers. (biomedcentral.com)
  • These DE-miRNAs, hub genes and pathway were proved in arecoline-treated HepG2 cells. (biomedcentral.com)
  • A total of 86 DE-miRNAs and 460 target genes were identified. (biomedcentral.com)
  • In the present study, we used bioinformatics approaches to analyze the miRNA expression data of arecoline-induced cancer from the Gene Expression Omnibus (GEO) database, and identified the target genes of the differentially expressed miRNAs (DE-miRNAs) compared to healthy volunteers. (biomedcentral.com)
  • We performed Kyoto Encyclopedia of Genes and Genomes (KEGG) and hub target genes analysis to illuminate potential biomarkers and related pathways in arecoline-induced cancer. (biomedcentral.com)
  • To date, 1527 human miRNAs have been identified (Sanger miRBase 18 http://www.miRbase.org/index.shtml), forming less than 1% of all human genes, potentially regulating more than 10% of all protein coding genes [ 1 ]. (intechopen.com)
  • MicroRNAs (miRNAs or miRs) are small non-coding RNAs that participate in diverse cellular processes and negatively regulate gene expression at the post-transcriptional level by binding with 3′-untranslated regions (3′-UTRs) ( 2 - 4 ). (spandidos-publications.com)
  • MicroRNAs (miRNAs) are small noncoding RNAs that posttranscriptionally regulate gene expression by imperfect matching of mRNA [ 6 ]. (hindawi.com)
  • MicroRNAs (miRNAs) are small noncoding endogenous RNAs containing 19 to 25 nucleotides that promote posttranscriptional control in regulating the expression of target gene by binding to the 3′-UTR sequences of its mRNA [ 5 ]. (hindawi.com)
  • RNA modifications have emerged as key gene regulators. (nature.com)
  • Here the authors identify chromatin-bound RNAs and their binding sites in human embryonic stem cells suggesting that most chromatin-associated RNAs act proximal to their encoding loci and single RNAs are unlikely to alter gene expression. (nature.com)
  • MicroRNAs (miRNAs) are short, noncoding RNAs that negatively regulate gene expression at a post-transcriptional level. (elsevierpure.com)
  • The other approach is to screen CRISPR-Cas9-based guide RNA (gRNA) libraries that target either the whole genome using cancer cell and immune cell co-culture systems 9 , 10 , or focused gene sets using immunocompetent murine tumors 11 , 12 . (nature.com)
  • MicroRNAs (miRNAs) are small non-coding RNAs that bind complementary messenger RNAs (mRNAs) to repress gene expression and regulate essentially all cellular processes 19 . (nature.com)
  • Combined with miRNAs-based transcriptome sequencing assay, it was found that Tanshinone IIA downregulated miR-125b level and upregulated its target gene STARD13 (StAR-related lipid transfer protein 13) level, thus inactivating the miR-125b/STARD13 axis, which had been previously confirmed to promote breast cancer progression. (biomedcentral.com)
  • MicroRNAs (miRNAs) are small endogenous non-coding RNAs with length of about 22 nt and can regulate gene expression mainly through post-transcription [ 1 ]. (biomedcentral.com)
  • MicroRNAs (miRNA) are small noncoding RNAs, preserved throughout the evolution, able to regulate gene expression through repression of translation or degradation of target molecules of messenger RNA. (bvsalud.org)
  • Pseudogene, a subclass of long non-coding RNAs (lncRNAs), are considered as genomic loci that resemble real gene, but lost some functionality because they are lack of protein-coding ability because of disabling mutation, lack of transcription, or their inability to encode RNA [ 3 ]. (biomedcentral.com)
  • MicroRNAs (miRNAs) are small non-coding RNAs that function in transcriptional and post-transcriptional regulation of gene expression. (illinois.edu)
  • MicroRNAs (miRNAs, miRs) are endogenously expressed small non-coding RNAs that generally regulate gene expression by binding to the 3ʹ untranslated region (3ʹ-UTR) of their targets, resulting in silencing [ 13 ]. (biomedcentral.com)
  • MicroRNAs, a key class of gene expression regulators, have emerged as crucial players in various biological processes such as cellular proliferation and differentia-tion, development and apoptosis. (123dok.net)
  • Colorectal cancer Core tip: MicroRNAs (miRNAs), a key class of gene ex-pression regulators, have emerged as crucial players in various biological processes such as cellular prolifera-tion and differentiaprolifera-tion, development and apoptosis. (123dok.net)
  • MicroRNAs (miRNAs) are an integral part of the post-transcriptional machinery of gene expression and have been implicated in the carcinogenic cascade. (cdc.gov)
  • Background: MicroRNAs (miRNA) are small, highly conserved, non-coding RNAs that regulate gene expression of target mRNAs through cleavage or translational inhibition. (usda.gov)
  • Micro-RNA (miRNAs or miRs) are small noncoding RNAs that negatively regulate protein coding gene transcripts and exert an important role in the control of gene expression. (atlasofscience.org)
  • Another level of regulation may lie on microRNAs (miRNAs), which are endogenously expressed small non-coding RNAs of 18-24 nucleotides in length that regulate gene expression on the posttranscriptional level [ 14 ]. (biomedcentral.com)
  • Micro-RNAs (miRNAs) are small non-coding RNAs of approximately 21-25 nucleotides that negatively regulate gene expression 1 , 2 , 3 . (openaccesspub.org)
  • MicroRNAs (miRNAs) are non-coding small RNAs that regulate gene expression and that are frequently dysregulated in tumorigenesis. (biomedcentral.com)
  • MiRNAs, short (18-24 nucleotides) non-coding RNAs, are derived from long transcripts pri-miRNAs and pre-miRNAs [ 26 - 30 ].By targeting 3' untranslated regions (3'UTRs) of cognate mRNAs, miRNAs post-transcriptionally regulate gene expression and induce translational repression [ 29 , 30 ]. (intechopen.com)
  • It has been shown that lncRNAs play an important role in various cellular processes including angiogenesis by interacting with RNA, DNA or proteins through diverse mechanisms to regulate gene expression. (upm.edu.my)
  • Although more and animals and plants and regulate gene/protein expression more progressions have been made about the through direct complementarity between their 5' region pathogenesis of asthma in recent years, the increasing and the 3' untranslated region of target mRNAs. (cdc.gov)
  • MiRNAs are generated by stepwise cleavage via double-stranded ribonuclease III enzymes DROSHA and DICER1 and loaded onto Argonaute (AGO) proteins to pair with target sequences on mRNAs 20 . (nature.com)
  • A molecular regulatory network consisting of three circRNAs, seven miRNAs and seven mRNAs was constructed, resulting in identification of two signaling axes, hsa_circ_0035431/hsa‑miR‑940/fucosyltransferase 6 (FUT6) and hsa_circ_0035431/hsa‑miR‑940/cingulin‑like 1 (CGNL1). (spandidos-publications.com)
  • The DNA instructions are transcribed into RNA molecules called messenger RNAs (mRNAs), which serve to produce these proteins (translation). (debra.org.uk)
  • MicroRNAs (miRNAs) are non-coding RNAs that block protein production by interacting with specific mRNAs. (debra.org.uk)
  • This extracellular vesicles play a major role in cell-to-cell communication and contain materials, such as proteins, mRNAs, microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). (upm.edu.my)
  • Furthermore, the miRNAs correlated negatively with the immunohistochemical expression of NRF1 and NRF2 but positively with their respective mRNA. (hindawi.com)
  • Luciferase reporter assay was performed to verify that miR-455 directly binds to the 3′-noncoding region (UTR) of RAB18 mRNA in Huh7 cells. (hindawi.com)
  • The miRNA-mRNA pairing triggers casein kinase 1α (CK1α)-induced phosphorylation and dissociation of AGO2 from the active complex, whereas the ANKRD52-PPP6C phosphatase complex dephosphorylates AGO2 to restore its miRNA loading activity 21 , 22 . (nature.com)
  • The present study aimed to screen and explore the key circRNA/microRNA (miRNA or miR)/mRNA interactions in head and neck squamous cell carcinoma (HNSCC) using bioinformatics. (spandidos-publications.com)
  • Circular RNAs (circRNAs) are closed, long, non-coding RNAs that are formed via direct reverse splicing of precursor mRNA that function by regulating RNA transcription and protein production, as well as sponging miRNAs ( 4 ). (spandidos-publications.com)
  • Notably, previous studies revealed that circRNAs participate in cancer pathogenesis by sponging miRNAs that target mRNA and circRNAs exhibit potential as predictive biomarkers and therapeutic targets for cancer treatment ( 5 , 6 ). (spandidos-publications.com)
  • In addition, a previous study demonstrated that circRNA/miRNA/mRNA networks are involved in the development and progression of multiple types of malignancy ( 7 ). (spandidos-publications.com)
  • Thus, further investigations into the specific molecular mechanisms underlying circRNA/miRNA/mRNA regulation are required to aid discovery of effective therapeutic targets. (spandidos-publications.com)
  • Or the miRNAs may just be sequestered away in the nucleus and not doing their jobs in the cytoplasm, which ultimately changes how much mRNA regulation they do," Walter said. (umich.edu)
  • MicroRNAs (miRNAs) are a kind of small noncoding RNAs that regulate the expression of protein through targeting the 3′UTR of messenger RNA (mRNA), resulting in mRNA degradation or suppression of translation [ 5 ]. (degruyter.com)
  • The seed region in miRNAs, approximately six nucleotides long, recognizes and binds to the complementary binding site of the target mRNA 3'untranslated region (3'UTR) to regulate its expression. (molcells.org)
  • Results showed that exosomes derived from SW480-7 increased tube formation and up-regulated expression FGFR3 mRNA in TIME. (upm.edu.my)
  • Expression level of exosomal lncRNA H19 was significantly up-regulated in advanced-stage of CRC (p value= 0.04).In conclusion, exosomal lncRNAs derived from SW480-7 increased tube formation and up-regulated expression of FGFR3 mRNA in TIME. (upm.edu.my)
  • As binding of miRNAs to a target mRNA may result in an airway inflammatory disease closely correlates with either mRNA degradation or inhibition of protein immune regulation, more and more evidences suggest translation.1 More than 2000 miRNAs have been discovered in humans. (cdc.gov)
  • Mechanistically, PTTG3P upregulated the expression of miR-383 targets Cyclin D1 (CCND1) and poly ADP-ribose polymerase 2 (PARP2) by sponging miR-383, acting as a competing endogenous RNA (ceRNA). (biomedcentral.com)
  • A series of studies indicate that lncRNAs serve as competing endogenous RNAs (ceRNA) by sponging miRNAs, and modulate the targets of miRNAs [ 15 , 16 ]. (biomedcentral.com)
  • Micro RNAs (MiRNAs) are endogenous, small RNA molecules that were identified in a wide range of eukaryotes. (usda.gov)
  • Non-coding RNAs (ncRNAs) are ribonucleic acid (RNA) molecules that are not translated into protein products. (nature.com)
  • Live cells showing the trajectories of single miRNA molecules. (umich.edu)
  • To track the miRNA molecules, the researchers attach what's called a fluorophore to the molecule. (umich.edu)
  • In many cancers, RAS proteins are constitutively activated by their oncogenic mutations or activation of their upstream molecules. (atlasofscience.org)
  • McroRNAs are small RNA molecules (miRNA), inhibit the messenger RNAs that produce our proteins. (atlasofscience.org)
  • Skin cells (fibroblasts) from people with RDEB are being grown in the laboratory and the levels and types of molecules called microRNAs they produce are being investigated. (debra.org.uk)
  • The role of these molecules in controlling scarring (fibrosis) may make them targets for EB therapies. (debra.org.uk)
  • Four microRNA molecules have been chosen for further study because they are present at much higher (three of the four) or lower levels in cells from people with RDEB. (debra.org.uk)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Given the limitations of serum creatinine as a biomarker of kidney function, different urinary and serum proteins, molecules, and, most recently, microRNAs have been rigorously investigated over the past decade as possible biomarkers for kidney disease. (medscape.com)
  • Recently, increasing evidences elucidated that miRNAs was involved in the cancer pathogenesis, including cell proliferation, metastasis, and apoptosis [ 6 ]. (hindawi.com)
  • Also, in gastric cancer, miR-455 inhibited human cell proliferation and invasion and promoted cell apoptosis [ 12 ]. (hindawi.com)
  • In addition, miR-455 inhibited cell viability, while it induced cell apoptosis in colorectal cancer [ 13 ]. (hindawi.com)
  • Transforming growth factor-β (TGF-β) signaling pathway is a multifunctional cytokine and plays important roles in regulating cell proliferation, cell cycle, differentiation, migration, and apoptosis in a broad spectrum of tissues [ 12 ]. (degruyter.com)
  • To this end, we overexpressed and inhibited gga-miR-155 in an MDV-transformed cell line using mimics and inhibitors respectively, and analyzed their growth, proliferation, apoptosis and invasiveness to explore the possible role of gga-miR-155 in MDV-mediated tumorigenesis. (biomedcentral.com)
  • Furthermore, we predicted and demonstrated that Retinoid Acid Receptor-Related Orphan Receptor Alpha (RORA) is one of the targets of gga-miR-155, and the gga-miR-155 regulated the proliferation, cell cycle, apoptosis and invasiveness of MSB1 cells by targeting RORA. (biomedcentral.com)
  • APS regulated osteocyte autophagy and apoptosis via SP1/miR-200b-3p axis and activated Wnt/β-catenin signaling, thereby alleviating SONFH, shedding new insights for therapy of SONFH. (biomedcentral.com)
  • Recently, APS was reported to improve SONFH via regulating cell autophagy and apoptosis [ 9 ]. (biomedcentral.com)
  • Micro-RNAs have been demonstrated to have multiple roles in regulating embryonic development, proliferation, apoptosis, etc. (openaccesspub.org)
  • Here we provide evidence of a novel mechanism for PRIMA-1 Met , a small molecule with anti-tumor activity in phase I/II clinical trial, showing that PRIMA-1 Met induces apoptosis in MM cells by suppressing c-Myc and upregulating miRNA-29a. (oncotarget.com)
  • In addition, ectopic expression of miRNA-29a or exposure to PRIMA-1 Met reduced cell proliferation and induced apoptosis in MM cells. (oncotarget.com)
  • MicroRNAs (miRNAs) are a class of small non-coding RNA, 20-22 nucleotides in length. (molcells.org)
  • Long non-coding RNAs (lncRNAs) are non-protein-coding RNAs consisting of more than 200 nucleotides in length. (upm.edu.my)
  • This review will summarize the role of miRNAs in the pathogenesis of gastrointestinal malignancies. (elsevierpure.com)
  • Therefore, identification of disease-related miRNAs would benefit research on pathogenesis and diagnosis. (biomedcentral.com)
  • The aberrant expression of miRNAs is associated with the pathogenesis of sepsis. (degruyter.com)
  • Increasing evidence has suggested that the dysregulation of miRNAs is associated with the pathogenesis of sepsis. (degruyter.com)
  • MicroRNAs (miRNAs) are associated with cytogenetics and molecular subtypes of acute myelogeneous leukemia (AML), but their impact on AML pathogenesis is poorly understood. (ashpublications.org)
  • The proto-oncogene c-Myc plays substantial role in multiple myeloma (MM) pathogenesis and is considered a potential drug target. (oncotarget.com)
  • MicroRNAs participate in the regulation of asthma, the goal of this study is to summarize recent researches on the roles of microRNAs in the pathogenesis of asthma. (cdc.gov)
  • Understanding the roles of Asthma is a worldwide problem, the prevalence of miRNAs in asthma pathogenesis may also aid to asthma ranged from 1% to 18% of the population in explore new therapeutic targets. (cdc.gov)
  • Abstract: Colon cancer is a complex disease with significant implications for healthcare systems, patients, and their families. (pexacy.com)
  • Aberrant miRNA expression has been observed in various types of human cancers including ovarian cancer [ 5 ]. (biomedcentral.com)
  • It is now evident that miRNAs are essential for normal physiological functioning, and aberrant miRNA expression is a hallmark of human cancers, including gastrointestinal cancers. (elsevierpure.com)
  • Aberrant expression of miRNAs is involved in a large number of biological disorders, which illustrates their great potential to be applied in the diagnosis and treatment of various diseases. (cmbr-journal.com)
  • The aberrant expression of microRNA-140-5p (miR-140-5p) has been described in gastric cancer (GC). (biomedcentral.com)
  • However, to the best of our knowledge, the miRs that regulate RUNX2 expression in tumors are unknown. (spandidos-publications.com)
  • Brain tumors account for 20-25% of pediatric cancers. (frontiersin.org)
  • The aim of this study was to isolate three members of miR-200 family from tumor tissue, plasma and urine of high-grade serous ovarian cancer patients in comparison with samples from patients with benign ovarian tumors. (biomedcentral.com)
  • Hundreds of dysregulated miRNAs have been found in studies comparing the expression profiles of miRNAs in malignant ovarian tumors and normal ovaries. (biomedcentral.com)
  • miR-494 and miR-125a-5p were found to be differentially regulated in tumors with an anaplastic component and even the well-differentiated component (FTC) of these tumors were found to be aligned with the anaplastic profile. (openaccesspub.org)
  • It has also emerged as an important modulator of oncogenesis and have been demonstrated to be deregulated in various hematological neoplasms, prostate cancer, thyroid neoplasms, lung cancer, pancreatic and colo-rectal tumors etc 5 . (openaccesspub.org)
  • Recently, Nikiforva et al showed that miR-187 was the most up-regulated miRNA in tumors harboring RET/PTC rearrangements and RAS mutations, however it's expression is much lower in tumors with BRAF mutation 10 . (openaccesspub.org)
  • Importantly, intratumor delivery of miRNA-29a mimics induced regression of tumors in mouse xenograft model of MM and this effect synergized with PRIMA-1 Met . (oncotarget.com)
  • Further, it will serve to highlight the potential role of miRNAs in cancer prevention: namely their use as biomarkers and as targets for chemoprevention. (elsevierpure.com)
  • A better understanding of the function of miRNAs is pro-viding new insights into the molecular basis of human pathologies, and new biomarkers for disease diagnosis and therapy. (123dok.net)
  • In this study, in general, the biogenesis and the role of miRNAs, the origin of miRNAs, viral miRNAs, miRNA detection procedures, in silico miRNA analysis tools, miRNA-based therapies and their obstacles, and miRNAs as potential non-invasive biomarkers are discussed. (cmbr-journal.com)
  • However, the effect of exosomes derived from an invasive colorectal cancer cell line on angiogenesis is unclear and the potential of lncRNAs in circulating exosomes as biomarkers have not been completely studied. (upm.edu.my)
  • Hence, the aims of this study is to investigate the effect of exosomes derived from an invasive colorectal cancer cell line on angiogenesis of endothelial cells and to identify the potential of lncRNAs in circulating exosomes as biomarkers for detection of colorectal cancer. (upm.edu.my)
  • Among the six exosomal lncRNAs detected in the sera, LINC00152 and H19 may be useful as biomarkers in liquid biopsies for diagnosis and treatment monitoring in colorectal cancer. (upm.edu.my)
  • The first seven chapters describe the different biological mechanisms of the epigenetic machinery including: DNA methylation, histone tails, chromatin structure, nucleosome occupancy, Polycomb group proteins, siRNAs and miRNAs. (caister.com)
  • The use of mouse models, as well as human diseases resulting from deficiencies in the methylation machinery, have been integral parts of understanding the role of these proteins in development and cellular homeostasis. (caister.com)
  • In a person's cells, RNA receives instructions from DNA about how to build proteins, then directs the cell to build those proteins. (umich.edu)
  • However, scientists estimate that while upward of 95 percent of DNA transcribes into RNA, most of that RNA does not actually translate into proteins. (umich.edu)
  • Some of these RNA strands break into smaller chunks called microRNAs, or miRNAs, which stop messenger RNA from producing proteins. (umich.edu)
  • However, some RNAs, called non-coding RNAs, are not translated into proteins but regulate the amount of proteins produced. (debra.org.uk)
  • We also identified miRNAs that bind to receptor proteins, such as ACE2, ADAM17, and TMPRSS2, which are important for understanding the infection mechanism of SARS-CoV-2. (molcells.org)
  • Previous studies have demonstrated that microRNAs (miRs) serve important roles in the progression of human cancer types, including pancreatic cancer (PC), a highly lethal malignancy. (spandidos-publications.com)
  • A number of studies have demonstrated that altered expression of miRs serves critical roles in human cancers by directly regulating cell behaviors ( 5 - 7 ). (spandidos-publications.com)
  • miRNA inhibitors (anti-miRs) and artificial miRNAs (miRNA mimics) are two general approaches to balance the dysregulated miRNA levels that make it possible to treat various biological disorders. (cmbr-journal.com)
  • MiRNAs are reported to involved in multiple cellular processes [ 14 ]. (biomedcentral.com)
  • Tanshinone II A is an effective component extracted from Salvia miltiorrhiza and the roles of Tanshinone IIA in regulating the stemness of tumor cells remain unclear. (biomedcentral.com)
  • The gga-miR-155 is downregulated in the MDV-infected chicken tissues or lymphocyte lines, although its exact role in tumorigenesis remains unclear. (biomedcentral.com)
  • However, the role of miR-140-5p in GC remains unclear. (biomedcentral.com)
  • However, the molecular mechanisms for APS in regulating SONFH remain unclear. (biomedcentral.com)
  • Accumulating evidences have elucidated connection between the expression of GTPases members and several diseases, including colorectal cancer, lung cancer, and prostate cancer [ 16 - 18 ]. (hindawi.com)
  • Colon cancer is also known as colorectal cancer, is a formidable adversary in the realm of oncology, posing a significant threat to global public health. (pexacy.com)
  • The previous work has shown that Tanshinone IIA could ameliorate inflammation microenvironment in colorectal cancer via repressing miRNA-155 expression ( 8 ) and exert an anti-angiogenic effect in vascular endothelial cells via inhibiting the VEGF/VEGFR2 pathway [ 9 ]. (biomedcentral.com)
  • In the present study, the exosomes from the cell culture supernatants of an invasive colorectal cancer cell line SW480-7 were characterized and lncRNAs in these exosomes were profiled. (upm.edu.my)
  • We aimed to evaluate the selected miRNAs expression based on bioinformatic analysis and their changes before and after an ultramar. (researchgate.net)
  • Altered expression of circular RNAs (circRNAs) has previously been investigated in breast cancer. (researchgate.net)
  • miR-205 expression in humans was validated by Landgraf et al ( 8 ), however, its role in tumor progression is contradictory ( 9 - 12 ). (spandidos-publications.com)
  • Zhang et al ( 9 ) revealed that expression of miR-205 was significantly decreased in radioresistant subpopulations of breast cancer cells and loss of miR-205 expression was associated with poor distant relapse-free survival in patients with breast cancer. (spandidos-publications.com)
  • By contrast, miR-205 expression has been identified to be significantly increased in several human cancer types, including ovarian cancer, endometrial cancer and laryngeal squamous cell carcinoma, in which it was identified to function as an oncoprotein ( 10 , 11 , 13 ). (spandidos-publications.com)
  • RAB18 was upregulated in HCC tissues and cell lines, and the expression of RAB18 was regulated by miR-455. (hindawi.com)
  • A correlation between the miRNA-200 expression in urine and plasma was observed in malignant samples only. (biomedcentral.com)
  • found differences in miRNA expression profiles of different human body fluids within an individual. (biomedcentral.com)
  • However, no direct correlation between miRNA expression levels in blood and urine has been yet clearly demonstrated. (biomedcentral.com)
  • In this methodological study, we wanted to examine whether urinary miRNA expression correlates with plasma miRNA expression. (biomedcentral.com)
  • Expression of each miRNA machinery component strongly correlates with intratumoral T cell infiltration in nearly all human cancer types. (nature.com)
  • Tanshinone IIA attenuated the stemness of breast cancer cells, evident by downregulating the expression of stemness markers, hindering the capacity of spheroid formation, decreasing the CD24 − /CD44 + sub-population in a concentration-dependent manner and reducing the tumor-initiating ability of breast cancer cells. (biomedcentral.com)
  • The expression of miRNA is deregulated in several pathological processes, including cancer. (bvsalud.org)
  • However, changes in expression of miRNA may be secondary to the tumor phenotype. (bvsalud.org)
  • Thus, is not completely clear whether the altered expression of miRNAs is cause or consequence of malignant transformation. (bvsalud.org)
  • Using microarray expression profiling, we identified miRNA338-3p as among the top deregulated miRNAs associated with ERG status in PCa. (illinois.edu)
  • We investigated miR338-3p function using in vitro and in vivo experimental models and its expression was assessed and validated in clinical samples and a public cohort of localized and metastatic prostate cancer. (illinois.edu)
  • Finally, TGF-β expression plasmids were transfected into NPC cells to verify the role of TGF-β in the miR-296-5p-mediated inhibition of nasopharyngeal carcinoma cell metastasis. (biomedcentral.com)
  • In this study, we established that miR-296-5p has a significantly lower expression in NPC tissues and cells and was involved in regulating the EMT and metastasis of NPC cells in vitro. (biomedcentral.com)
  • In addidifferentia-tion, microR-NAs are coming to light as crucial regulators of innate and adaptive immune responses, and their abnormal expression and/or function in the immune system have been linked to multiple human diseases including inflammatory disorders, such as inflammatory bowel disease, and cancers. (123dok.net)
  • A recent study of the disparity in breast cancer mortality between AA and EA women concluded that differences in mortality are driven by higher hazard rates of breast cancer death in AA women, irrespective of ER expression [9]. (cdc.gov)
  • We now have identified and characterized 54 miRNAs from rainbow trout somatic tissues and profiled their expression patterns. (usda.gov)
  • Real-time PCR was used to measure miRNA expression patterns in adult somatic tissues and unfertilized eggs. (usda.gov)
  • The majority of the miRNAs showed characteristic tissue-specific expression patterns suggesting potential roles in maintaining tissue identity. (usda.gov)
  • For the first time, our analyses will investigate the expression levels of a large number of miRNAs and their functional role in RDEB fibrosis. (debra.org.uk)
  • The aim of our study was to evaluate if there is differential microRNA (miRNA) expression in various tumor subtypes during this progression. (openaccesspub.org)
  • We compared the genome-wide miRNA expression profiles of whole blood-derived RNA samples between patients with arecoline-induced cancer and healthy volunteers using the raw data in the NCBI GEO databases ( http://www.ncbi.nlm.nih.gov/geo ). (biomedcentral.com)
  • The expression patterns of those miRNAs were examined in hamster lung samples infected by SARS-CoV-2. (molcells.org)
  • Five miRNAs (hsa-miR-15b-5p, hsa-miR-195-5p, hsa-miR-221-3p, hsa-miR-140-3p, and hsa-miR-422a) showed differential expression patterns in lung tissues before and after infection. (molcells.org)
  • In addition, RT2 lncRNA PCR array was used for exosomal lncRNA profiling to determine the relative expression level of lncRNAs in the exosomes of sera from 18 CRC (colorectal carcinoma) and 21 non-cancer patients. (upm.edu.my)
  • Among these six lncRNAs, expression level of LINC00152 was found to be significantly lower in CRC patients as compared to non-cancer patients (p=0.04). (upm.edu.my)
  • miRNA analysis will be the starting point to identify and disentangle novel druggable targets/pathway for future, innovative anti-fibrotic therapeutic strategies. (debra.org.uk)
  • In order to resist cancer dissemination, more effective therapeutic strategies are clearly required. (intechopen.com)
  • Our study indicates that miRNA-29a is a tumor suppressor that plays an important role during PRIMA-1 Met -induced apoptotic signaling by targeting c-Myc and provides the basis for novel therapeutic strategies using miRNA-29a mimics combined with PRIMA-1 Met in MM. (oncotarget.com)
  • The transition from ductal carcinoma in situ to invasive ductal carcinoma is a key event in breast cancer progression that is still not well understood. (researchgate.net)
  • Emerging evidence indicates that Long non-coding RNAs (LncRNAs) and microRNAs (miRNAs) play crucial roles in tumor progression, including hepatocellular carcinoma (HCC). (biomedcentral.com)
  • Several miRNAs have been implicated in regulating prostate cancer (PCa) progression. (illinois.edu)
  • miR338-3p was significantly down-regulated with disease progression from benign prostate tissue to primary and metastatic lesions. (illinois.edu)
  • In this study, the prognostic relevance of miR-140-5p in GC was investigated and YES1 was identified as a novel target of miR-140-5p in regulating tumor progression. (biomedcentral.com)
  • We have identified a single microRNA that controls glioma cell proliferation, migration, and responsiveness to glucose deprivation. (researchgate.net)
  • Furthermore, it has been shown that miRNAs have a substantial role in melanocyte and melanoma biology [ 8 ] and that they affect, for instance, melanoma cell proliferation, invasion, and migration [ 9 ]. (hindawi.com)
  • In this review we deal in the molecular mechanisms, the epigenetic effects and modulation of the oxidative stress pathway of ketogenic diets, that underlie its possible role, in the treatment of infantile gliomas, as a complementary approach to conventional cancer therapy. (frontiersin.org)
  • Combined, these approaches have led to the discovery of a myriad of mechanisms underlying cancer susceptibility to or evasion from T cell attack. (nature.com)
  • It is therefore imperative to uncover novel immune evasion mechanisms in the dynamic tumor-immune microenvironment by untangling the genetic heterogeneity of cancer cells. (nature.com)
  • This work aims to explore the roles and underlying mechanisms of Tanshinone IIA in breast cancer stemness. (biomedcentral.com)
  • MiRNAs-based transcriptome sequencing and data analysis, online dataset analysis, luciferase reporter assay combined with rescuing experiments were constructed to explore the underlying mechanisms. (biomedcentral.com)
  • This study performs a literature review of miRNA, focusing on aspects related to biogenesis, mechanisms of action and potential role of these small RNAs in oral carcinogenesis. (bvsalud.org)
  • In this book the molecular mechanisms and biological processes in which epigenetic modifications play a primordial role are described in detail. (caister.com)
  • MDV-miR-M4 is known to complement miR-155 in initiating MD lymphomas, although the underlying mechanisms, especially the role of host miRNAs, have not completely elucidated. (biomedcentral.com)
  • We show that human and chimpanzee cells differentiate in a similar man¬ner and that the difference in interspecies protein abundance is higher than transcript-level differences, suggesting that post-transcriptional mechanisms play a role in the difference between human and chim¬panzee brain development. (lu.se)
  • Taken together, our results suggest that post-transcriptional mechanisms play an important role in the brain both during development and in the adult brain. (lu.se)
  • Germ granules are membraneless organelles that act as organizing centers for small RNA biogenesis during germline development. (nature.com)
  • We find that the core microRNA (miRNA) biogenesis and targeting machinery maintains the sensitivity of cancer cells to PD-1-independent T cell-mediated cytotoxicity. (nature.com)
  • The biogenesis of miRNAs is divided into two canonical and non-canonical pathways. (cmbr-journal.com)
  • The second pathway has a divergent mechanism for the biogenesis of miRNAs. (cmbr-journal.com)
  • Next, they plan to investigate a surprising discovery they made in the current study: the function of miRNAs in the nucleus. (umich.edu)
  • However, little is known about the effects of drugs on their regulation and relationship with the cognate linear transcript (linRNA). (researchgate.net)
  • In particular, miR-23B, miR-93, miR-144, and miR-212 were found to play a role as NRF2 inhibitors, while miR-340 appears to have a role as an NRF1 and MAPK inhibitor with miR-383 and miR-510 having a less clear role in the regulation of NRF1 and NRF2 levels [ 7 ]. (hindawi.com)
  • Circular RNAs (circRNAs) are molecular sponges that are involved in regulation of multiple types of cancer. (spandidos-publications.com)
  • In recent years, emerging studies have highlighted the critical role of these pathways and their regulation by microRNAs (miRNAs) in cancer invasion and metastasis. (intechopen.com)
  • MicroRNAs not only participate in determining DCs phenotype and then naive T lymphocyte differentiation, but also participate in the regulation of airway inflammation and airway remodeling in asthma. (cdc.gov)
  • Zhang et al cytokines, mediators and signals and closely related to demonstrated that microRNA let-7i was upregulated immune regulation. (cdc.gov)
  • DC demonstrated that miRNAs participate in airway maturation, while downregulation of let-7i significantly inflammatory regulation in asthma. (cdc.gov)
  • More so, our results show that the epigenetic regulation of TE transcription is dynamically regulated throughout life (Paper II), upon the beginning of neuroinflammation (Paper III), and in a disease-driving polymorphic TE insertion (Paper IV). (lu.se)
  • Our data indicate that the evolutionarily conserved miRNA pathway can be exploited by cancer cells to escape from T cell-mediated elimination and immunotherapy. (nature.com)
  • miR-455 has been reported to act as a tumor suppressor to inhibit cap-dependent translation and the proliferation in prostate cancer [ 11 ]. (hindawi.com)
  • In this review, we discuss our current understanding of microRNAs with a focus on their role and mode of action in regulating the immune system during inflammation and carcinogenesis. (123dok.net)
  • microR-NAs in the immune system, inflammation and cancer. (123dok.net)
  • microRNAs also play a crucial role in endothelial inflammation, senescence and susceptibility to atherosclerosis: endothelial inflammation is critically regulated by miRNAs such as miR-126 and miR-10a, and endothelial aging is additionally controlled by miR-217 and miR-34a [ 15 ]. (biomedcentral.com)
  • A total of 63 differentially expressed miRNAs have been previously linked to metastatic melanoma, many of which are known to be associated with multiple different cancers [ 10 ]. (hindawi.com)
  • In addition, we also discovered some differentially regulated miRNAs in follicular variant of papillary thyroid carcinoma as compared to follicular thyroid carcinoma (miR-486-5p and miR-31). (openaccesspub.org)
  • Thus, the pivotal roles of miR-455 in cell viability and metastasis in HCC still needed to be explored. (hindawi.com)
  • Thus, it is still an urgent need to explore novel ways treating breast cancer metastasis and drug resistance. (biomedcentral.com)
  • This provides new insight into the role of miR-296-5p in regulating NPC metastasis and invasiveness. (biomedcentral.com)
  • This study revealed a novel mechanism by which miR-296-5p regulates the EMT and metastasis of NPC cells, indicating that it could be a new target for the treatment of NPC. (biomedcentral.com)
  • Most reports found that multiple miRNAs that include miR-548a, miR-1246, miR-632, and miR-5692a played pivotal roles in HCC [ 7 - 10 ]. (hindawi.com)
  • The results of the present study indicate that microRNAs play important roles in regulating asthma immune responses. (cdc.gov)
  • A new study shows that increased levels of reactive oxygen species in cancer induce widespread, sequence-specific modifications of guanines in the seed regions of microRNAs, altering the targets of those miRNAs and influencing tumorigenesis. (nature.com)
  • In this regard, computational methods are used to predict miRNAs that are most likely associated with a disease and provide experimental targets for biological experiments to save cost and time. (biomedcentral.com)
  • Our study further demonstrates that miRNA-29a functions as a tumor suppressor which targets c-Myc. (oncotarget.com)
  • Furthermore, microRNAs are also shown to be targets for asthma therapy in the future. (cdc.gov)
  • For childhood neoplasms, it is safe to assume that cancer is the product of degeneration in a neoplastic sense of tissues undergoing very rapid proliferation and differentiation, in which proliferative and differentiative programs are being disturbed by increasingly early (maternal-fetal) exposure to a growing number of environmental stressors and pollutants. (frontiersin.org)
  • MiRNAs are known to control diverse processes including animal development and growth, cell differentiation, signal transduction, cancer disease, virus-induced immune defense, programmed cell death, insulin secretion and metabolism. (usda.gov)
  • microRNAs have emerged as master regulators of stem cell lineage differentiation and angiogenesis [ 14 ]. (biomedcentral.com)
  • Tumor tissue samples were collected at the operating-room into tubes containing Tissue Tek ® , snap frozen in liquid nitrogen and stored at − 80 °C. 10 × 10 μm sections of the samples were cut using a Leica CM3050S cryostat (Leica Microsystems GmbH, Wetzlar, Germany) and RNA was collected with TRI Reagent ® (Molecular Research Center Inc. Cincinnati, OH, USA) according to the manufacturer's protocol. (biomedcentral.com)
  • It will quite effectively cater to the needs of molecular biologists, molecular geneticists, cell and molecular biologists, animal, plant, and crop geneticists, synthetic biologists, biotechnologists, and researchers involved with the fields of stem cell and molecular aspects of cancer research. (caister.com)
  • Tissue-specific miRNAs may be evaluated to serve as molecular markers predictive of specific functional and diagnostic implications. (usda.gov)
  • Bioinformatics algorithms including miRCODE ( http://www.mircode.org/ ) suggest that miRNAs can interact with lncRNAs. (biomedcentral.com)
  • Moreover, let-7 is a potential therapeutic miRNA for prevention of tumorigenesis. (biomedcentral.com)
  • The exact biological relevance of gga-miRNA-155 in MD tumorigenesis needs to be confirmed. (biomedcentral.com)
  • Our aim was to investigate these redox transcription factors in conjunction with redox-related microRNAs in naevi and melanoma. (hindawi.com)
  • From the same family of transcription factors, NRF1 is generally far less studied and its role in carcinogenesis is insufficiently explored. (hindawi.com)
  • MiRNAs are most often identified through computational prediction from genome sequences. (usda.gov)
  • The rainbow trout genome sequence is not available yet, which does not allow miRNA prediction for this species which is of great economic interest for aquaculture and sport fisheries, and is a model research organism for studies related to carcinogenesis, toxicology, comparative immunology, disease ecology, physiology and nutrition. (usda.gov)
  • Conclusion: The rainbow trout miRNAs identified and characterized in this study provide a new tool for functional genome research in salmonids. (usda.gov)
  • In our research, microRNAs (miRNAs) binding to the genome sequences of severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory-related coronavirus (MERS-CoV), and SARS-CoV-2 were identified by bioinformatic tools. (molcells.org)
  • Results confirm the 100, 98 and 96% of the top 50 predicted miRNAs reported in case studies on colorectal, lung, and pancreatic neoplasms. (biomedcentral.com)
  • For instance, YES1 can promote the nuclear translocation of the epidermal growth factor receptor that induces resistance to cetuximab in the non-small cell lung cancer line NCI-H226 [ 7 ]. (biomedcentral.com)
  • Despite advances in diagnosis and treatment, the morbidity and mortality of lung cancer remains to mount up. (intechopen.com)
  • For the target miRNAs, we chose miR-200a, miR-200b and miR-200c. (biomedcentral.com)
  • Potential miRNA-target interactions were computationally predicted and single nucleotide polymorphisms (SNPs) were identified in the miRNAs and their target sites in the rainbow trout transcripts. (usda.gov)
  • Identification of sequence variations in the miRNA -target interactions may be particularly useful for rainbow trout breeding programs. (usda.gov)
  • By correlating the two numbers, we can figure out what fraction of the microRNAs are now engaged with the regulated messenger RNA target," Walter said. (umich.edu)
  • Now we have a tool with which we can determine how quickly a microRNA engages a messenger RNA target, or how quickly it is lost from the cell and disappears entirely. (umich.edu)
  • Depending on the context and the cell is type they are expressed, one can view miRNA oncogenic or tumor suppressor activity. (bvsalud.org)
  • Oncogenic miRNA and breast cancer Since the early 2000's, the field of RNA has been contributing to major discoveries in cancer research. (atlasofscience.org)
  • Notably, miR-125b overexpression enhanced the stemness of breast cancer cells, and miR-125b overexpression or STARD13 knockdown impaired the inhibitory effects of Tanshinone IIA on the stemness of breast cancer cells. (biomedcentral.com)
  • MiRNAs are approximately 19- to 25-nucleotide estimated about 250,000 and mortality does not appear single-stranded, noncoding RNAs that exist in both to correlate well with prevalence. (cdc.gov)
  • Pancreatic cancer (PC) is one of the most lethal malignancy types, with a 5-year survival rate of ~8% ( 1 ). (spandidos-publications.com)
  • The disparities in breast cancer incidence and survival between AA and EA populations have been attributed to several factors, including disease management, access to proper care, and biological influences. (cdc.gov)
  • MicroRNAs in gastrointestinal malignancy: a tool in cancer prevention? (elsevierpure.com)
  • Dive into the research topics of 'MicroRNAs in gastrointestinal malignancy: a tool in cancer prevention? (elsevierpure.com)
  • How well can serum miRNAs diagnose amyotrophic lateral sclerosis patients? (atlasofscience.org)
  • In vitro mammary spheroid formation, flow cytometry assay on CD24 − /CD44 + sub-population, ALDH activity detection, cell viability assay and western blot analysis, and in vivo tumor-initiating analysis were performed to examine the effects of Tanshinone IIA on the stemness of breast cancer cells. (biomedcentral.com)
  • Luciferase reporter assay and RNA pull-down assay were carried out to detect the interaction between miR-383 and LncRNA PTTG3P. (biomedcentral.com)
  • The binding sites of miR-128-3p and TGFBR2 were predicted by Targetscan online software and confirmed by dual-luciferase reporter assay and RNA immunoprecipitation (RIP) assay. (degruyter.com)
  • Today's dominant paradigm in the field of carcinogenesis can be described as stochastic mutational, a model where cancer is ultimately viewed as the product of a slow accumulation of stochastic DNA mutations. (frontiersin.org)