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  • biological
  • On the other hand, microarray analysis showed that genes related to mRNA processing and response to stress were overrepresented among the up-regulated genes in cold-stress, but are not directly corresponding to any of the GO molecular functions and biological processes predicted from the differential miRNAs. (biomedcentral.com)
  • interference
  • Parallel RNA interference screens identify EGFR activation as an escape mechanism in FGFR3-mutant cancer. (aacrjournals.org)
  • RNA interference has revolutionized human functional genomics and therapeutics, but its impact on neuroscience research has been limited by the lack of simple and efficient methods to deliver oligonucleotides to primary neurons and the brain. (selectbiosciences.com)
  • Finally, we will develop therapeutic antisense and small interference RNAs (siRNAs) specifically targeting CD44 in order to effectively block CD44 expression, inhibit HA-mediated downstream oncogenic signaling events and block breast tumor progression. (labome.org)
  • synaptic
  • Mice lacking the RNA had deregulated microRNAs in the brain, disrupted synaptic communication, and behavioral abnormalities associated with neuropsychiatric disorders. (the-scientist.com)
  • endothelial
  • The tumor microenvironment, which includes cells such as macrophages, T cells, endothelial cells, and fibroblasts, as well as extracellular matrix components, plays an important role during tumor evolution and metastasis ( 1, 2 ). (aacrjournals.org)
  • Proinflammatory factors present in sera from patients with acute dengue infection induce activation and apoptosis of human microvascular endothelial cells: possible role of TNF-alpha in endothelial cell damage in dengue," Cytokine , vol. 30, no. 6, pp. 359-365, 2005. (hindawi.com)
  • target
  • The Role of MicroRNAs in Regulating the Translatability and Stability of Target Messenger RNAs During the Atrophy and Programmed Cell Death of the Intersegmental Muscles of the Tobacco Hawkmoth Manduca sexta. (umass.edu)
  • Chan, Elizabeth, "The Role of MicroRNAs in Regulating the Translatability and Stability of Target Messenger RNAs During the Atrophy and Programmed Cell Death of the Intersegmental Muscles of the Tobacco Hawkmoth Manduca sexta. (umass.edu)
  • They identified CCL5, a protumorigenic chemokine that is highly expressed in tumors, as a key target of miR-214 , thus showing that microRNA perturbation in the stromal microenvironment can affect tumor growth. (aacrjournals.org)
  • This study exhaustively identifies miRNAs and their target genes, which will ultimately pave the way for understanding their role in skin of A. davidianus and other amphibians. (springer.com)
  • lung cancer
  • Specifically, human let-7 and miR-34 are poorly expressed or deleted in lung cancer, and over-expression of let-7 or miR-34 in lung cancer cells inhibits their growth, demonstrating a role for these miRNAs as tumor suppressors in lung tissue. (selectbiosciences.com)
  • important
  • Although the signals that govern the transition are not fully understood, recent evidence suggests that TGF-β and IL-1β play important roles ( 6, 7 ). (aacrjournals.org)
  • The bridging moieties play an important role in determining the optical and electrochemical properties. (jove.com)
  • In an email to The Scientist, Julia Salzman , an RNA researcher at Stanford University, calls the paper "a fascinating and important study, and a great advance for the field. (the-scientist.com)
  • recognition
  • Binding sites were mapped to the non-canonical RNA recognition motif (RRM) of eIF3b and a central 11 amino acid-long region of P311, here referred to as eIF3b binding motif (EBM). (jove.com)
  • sponge
  • Our current study demonstrated that SNHG5 is involved in the mechanism of OA through functioning as a ceRNA to competitively sponge miR-26a, therefore, regulating the expression of SOX2. (deepdyve.com)
  • When the Max Delbrück Center's Nikolaus Rajewsky and colleagues described it in 2013, they noted the molecule's potential to act as a microRNA "sponge"-it has more than 60 binding sites for the microRNA miR-7-although the role of this sponging remained unclear. (the-scientist.com)
  • tissues
  • miR-92 plays a survival role in several mammalian tissues and is repressed in two types of cardiomyopathy. (umass.edu)