Role of histone chaperones. Medical search. Frequent questions

This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. (wikipedia.org)
Studies in yeast and animals indicate that ASF1 proteins play important roles in various chromatin-based processes, including gene transcription, DNA replication and repair. (nih.gov)
Here we report that both AtASF1A and AtASF1B proteins bind histone H3, and are localized in the cytoplasm and the nucleus. (nih.gov)
The main proteins found in chromatin are called histones. (hstalks.com)
They are small, basic proteins called H3, H4, H2A, and H2B for the core histones and H1 for the linker histone. (hstalks.com)
Generally chromatin-remodeling proteins histone chaperones and histone acetylation enzymes are believed to do something synergistically to stimulate transcription on chromatin web templates (26). (exposed-skin-care.net)
Histones (biology) are highly alkaline proteins that are found in cells nuclei that package and order the Deoxyribonucleic acid into nucleosomes. (histoready.com)
The heterochromatin-enriched HP1 proteins play a critical role in regulation of transcription. (cipsm.de)
The co-chaperone Hep1 is required to prevent the aggregation of mitochondrial Hsp70 proteins. (cipsm.de)
Plastid-specific ribosomal proteins (PSRPs) have been proposed to play roles in the light-dependent regulation of chloroplast translation. (cipsm.de)
Histones are evolutionarily conserved DNA-binding proteins. (aging-us.com)
Along with PTMs, the partial or complete disassembly of nucleosomes allows the exchange and degradation of pre-existing histone proteins, with the incorporation of newly synthesised histones onto chromatin that can eventually result in the resetting of previous epigenetic marks. (aging-us.com)
Throughout evolution, eukaryotes adopted a network of highly conserved proteins that buffer the positive charges of histones, maintaining their solubility and, therefore, avoiding aberrant interactions with other cellular components. (aging-us.com)
These dedicated proteins are generally known as histone chaperones and effectively control histone supply and chromatin dynamics [ 8 ]. (aging-us.com)
Thus, GrassCoRegDB includes proteins with functions such as covalent histone modification (acetylation, methylation, phosphorylation, ubiquitination and sumoylation), as members of the ATP dependent chromatin remodeling complexes, and as histone chaperones, among others. (grassius.org)
The specific role of many of these proteins in transcription is still unknown. (grassius.org)
As identification of proteins with roles in transcriptional regulation is a growing research field, GrassCoRegDB will be frequently updated to keep pace with the literature. (grassius.org)
In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. (nih.gov)
Nucleosome assembly proteins (NAPs) are histone chaperones that are crucial for the shuttling and incorporation of histones into nucleosomes. (biomedcentral.com)
Histone chaperones are proteins that regulate the interaction of histones with other proteins and DNA and also prevent the highly basic histones from forming inappropriate aggregates [ 2 , 3 ]. (biomedcentral.com)
and nonhistone proteins (CHROMOSOMAL PROTEINS, NON-HISTONE) found within the nucleus of a cell. (lookformedical.com)
To identify proteins interacting with alpha A-crystallin (CRYAA) and to investigate the potential role that these protein interactions play in the function of CRYAA using a human proteome (HuProt) microarray. (molvis.org)
Acetylation of histones controls access of regulatory proteins to the DNA. (moodcoaching.nl)
Histones undergo posttranslational modifications that alter their interaction with DNA and nuclear proteins. (moodcoaching.nl)
Nucleosomes are an example of chromatin structure, where you've got DNA wrapped around a core of histone proteins. (moodcoaching.nl)
Post-translational modification of histone proteins regulates all processes requiring access to DNA. (grantome.com)
Histone H1, H2B, H2A and H3 were detected among the 9 most abundant nitrated DNA binding proteins using this proteomic approach. (omicsdi.org)
This work provides the first global profile of nitrated DNA binding proteins in T. cruzi and additional evidence for modification in the nitration profile of histones upon parasite incubation with ECM. (omicsdi.org)

specific histone deposition pathways for each variant? (hstalks.com)
Here, we focused on the histone deposition factors, CAF-I and HIRA. (nii.ac.jp)
We established a protocol for the large-scale purification of CAF-1 (a replication-dependent histone deposition factor), which enabled us to obtain images from EM analyses. (nii.ac.jp)
Regarding HIRA, which is a replication-independent histone deposition factor, we have obtained crystals of the HIRA-C domain. (nii.ac.jp)
Furthermore, we found that both ASF1A and ASF1B participate in the DNA synthesis-independent deposition of H3.3 in HeLa cells, thus highlighting an unexpected role for ASF1B in this pathway. (omicsdi.org)
CONCLUSIONS: We conclude that ASF1 is critically required to load H3.3-H4 dimers on the HIRA complex prior to histone deposition on paternal DNA. (ens-lyon.fr)
Based on our results, we propose an allosteric communication model in which the ATP hydrolysis of Abo1 changes the configuration of histones to facilitate their deposition onto DNA. (molcells.org)
Franklin R , Murn J and Cheloufi S (2021) Cell Fate Decisions in the Wake of Histone H3 Deposition. (cheloufilab.org)
A histone chaperone protein that plays a role in the deposition of NUCLEOSOMES on newly synthesized DNA. (lookformedical.com)
Moreover, this inheritance pathway must be coordinated with the deposition of newly synthesized histones to ensure chromosome duplication. (mpg.de)
These unique experimental approaches will clarify the distinct roles of key factors in coordinating inheritance and deposition. (mpg.de)
DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition (PubMed:16678110, PubMed:17041588, PubMed:24209620). (icr.ac.uk)

Anti-silencing function1 (ASF1) is an evolutionarily conserved histone chaperone. (nih.gov)
What is the effect of H3 acetylation in transferring histones from Asf1 to either Rtt105 or CAF-1 and eventually nucleosome incorporation? (umich.edu)
The TLKs play a key role in chromatin assembly through the regulation of the ASF1 histone chaperones and mutations in TLK2 have been implicated in a distinct neurodevelopmental disorder characterized by microcephaly and intellectual disability. (cancer.gov)
In vivo study of the nucleosome assembly functions of ASF1 histone chaperones in human cells. (omicsdi.org)
ASF1 is a highly conserved histone H3/H4 chaperone that synergizes in vitro with two other histone chaperones, chromatin assembly factor 1 (CAF-1) and histone repression A factor (HIRA), in DNA synthesis-coupled and DNA synthesis-independent nucleosome assembly. (omicsdi.org)
Tousled-like kinases phosphorylate Asf1 to promote histone supply during DNA replication. (omicsdi.org)
Asf1, a key histone H3-H4 chaperone required for this process, is phosphorylated by Tousled-like kinases (TLKs). (omicsdi.org)
We thus propose that TLK signalling promotes histone supply in S phase by targeting histone-free Asf1 and stimulating its ability to shuttle histones to sites of chromatin assembly. (omicsdi.org)
BACKGROUND:Asf1 is a well-conserved histone chaperone that regulates multiple cellular processes in different species. (omicsdi.org)
ASF1 is required to load histones on the HIRA complex in preparation of paternal chromatin assembly at fertilization. (ens-lyon.fr)
BACKGROUND: Anti-Silencing Factor 1 (ASF1) is a conserved H3-H4 histone chaperone involved in both Replication-Coupled and Replication-Independent (RI) nucleosomeassembly pathways. (ens-lyon.fr)
At DNA replication forks, ASF1 plays an important role in regulating the supply of H3.1/2 and H4 to the CAF-1 chromatin assembly complex. (ens-lyon.fr)
ASF1 also provides H3.3-H4 dimers to HIRA and DAXX chaperones for RI nucleosome assembly. (ens-lyon.fr)

How HCs distinguish histone variants, e.g. histone H3.1 by CAF-1 and histone H3.3 by HIRA? (umich.edu)
Here, we identify mutants of histones H3.1 and H3.3 that are unable to interact with human ASF1A and ASF1B isoforms but that are still competent to bind CAF-1 and HIRA, respectively. (omicsdi.org)
Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly. (omicsdi.org)
Human HIRA, ASF1a, ASF1b and CAF-1 are evolutionally conserved histone chaperones that form multiple functionally distinct chromatin-assembly complexes, with roles linked to diverse nuclear process, such as DNA replication and formation of heterochromatin in senescent cells. (omicsdi.org)
Consistent with this, biochemical analysis of wild-type and phospho-mimetic Asf1a shows that phosphorylation enhances binding to histones and the downstream chaperones CAF-1 and HIRA. (omicsdi.org)

Histone chaperone ASF1B is a protein that in humans is encoded by the ASF1B gene. (wikipedia.org)
The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly. (wikipedia.org)
Histone modifications and chromatin-associated protein complexes are crucially involved in the control of gene expression, supervising cell fate decisions and differentiation. (researchgate.net)
Histones are the main protein components of chromatin. (histoready.com)
A comparison of their known functions has identified, besides a common role within protein folding, multiple roles for the cyclophilins within pre-mRNA splicing and cellular signalling, and within transcription and cell cycle regulation for the parvulins. (biomedcentral.com)
Multifunctional redox sensitive protein with various roles in different cellular compartments. (nih.gov)
A retinoblastoma-binding protein that is involved in CHROMATIN REMODELING, histone deacetylation, and repression of GENETIC TRANSCRIPTION. (lookformedical.com)
Although initially discovered as a retinoblastoma binding protein it has an affinity for core HISTONES and is a subunit of chromatin assembly factor-1 and polycomb repressive complex 2. (lookformedical.com)
A retinoblastoma-binding protein that has an affinity for core HISTONES. (lookformedical.com)
It is found as a subunit of protein complexes that are in involved in the enzymatic modification of histones including the Mi2 and Sin3 histone deacetylase complexes and the polycomb repressive complex 2. (lookformedical.com)
Chất nhiễm sắc là một phức hợp của DNA và protein histone. (moodcoaching.nl)
Nó bao gồm một chuỗi các thể nhân được bọc bằng các protein histone. (moodcoaching.nl)
Attachment of the small protein, ubiquitin, to histone H2B is a universal feature of actively transcribed genes and has been proposed to play a role in dynamic changes in chromatin structure. (grantome.com)
In living organisms, catassemblers such as molecular chaperones, histone chaperones and allosteric factors are critical to protein folding, chromatin remodeling, and regulation of enzyme activities, respectively. (complexsystem.cn)
The current concepts of sperm biochemical markers and the central role of the HspA2 chaperone protein, a measure of sperm cellular maturity and fertilizing potential, are reviewed. (cdc.gov)

In this talk, I'd like to discuss with you the issue concerning histone dynamics, their heritability, and their existence in the form of variants. (hstalks.com)
In such a crowded molecular picture, recent exciting insights have uncovered the role of histone variants as key regulators of the chromatin structure. (aging-us.com)
Compared to the canonical ones, histone variants contain limited amino acid differences or unique domains with distinct biochemical properties. (aging-us.com)
Incorporation of histone variants confers variability to the chromatin and expands the repertoire of epigenetic marks in a functional alphabet that controls genome plasticity and dynamics [ 4 ]. (aging-us.com)
H2A is the core histone with the largest number of variants. (moodcoaching.nl)
The histone H2A variants include H2AZ and H2AX, which … The histone octamer is composed of a central heterotetramer of histones H3 and H4, flanked by two heterodimers of histones H2A and H2B. (moodcoaching.nl)

FACT (facilitates chromatin transcription) is an evolutionarily conserved histone chaperone that was initially identified as an activity capable of promoting RNA polymerase II (Pol II) transcription through nucleosomes in vitro. (open.ac.uk)

In this respect HBO1 (a MYST family members histone acetyltransferase that binds to ORC) originally determined through its physical connections with individual ORC1 (27) was lately discovered to associate with replication roots through relationship with Cdt1 also to enhance licensing and DNA replication through its acetylation activity GSK 525762A (28-30). (exposed-skin-care.net)

Together, these studies begin to define the molecular determinants of assembly of functionally diverse macromolecular histone chaperone complexes. (omicsdi.org)
Here, we focus essentially on the histone variant H3.3 and the associated complexes that selectively regulate its homeostasis and dynamics. (aging-us.com)
Chromatin dynamics is regulated by many factors, including histone tail modifiers, remodeling complexes, and histone chaperones ( Peterson and Almouzni, 2013 ). (molcells.org)

While canonical histones H3.1 and H3.2 are synthetized and loaded during DNA replication, the histone variant H3.3 is expressed and deposited into the chromatin throughout the cell cycle. (aging-us.com)

The elementary unit of chromatin is a nucleosome in which approximately 147 bp DNA is wrapped 1.67 turns around a histone octamer ( Fierz and Poirier, 2019 ). (molcells.org)
Fluorescence spectroscopy data suggest that PfNapS interacts with core histones (tetramer, octamer, H3, H4, H2A and H2B) at a different site from its interaction with linker histone H1. (biomedcentral.com)
A histone chaperone that facilitates nucleosome assembly by mediating the formation of the histone octamer and its transfer to DNA. (lookformedical.com)
The distinct length of these arms allows quantifying the length of DNA in a nucleosome and assessing the number of DNA turns around a histone octamer ( Fig. (PubMed PMID: 29138400) (PMC5686127) 5. (moodcoaching.nl)

This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. (antibodies-online.com)
Bano D , Piazzesi A , Salomoni P , Nicotera P , . The histone variant H3.3 claims its place in the crowded scene of epigenetics. (aging-us.com)
In addition, we review the importance of histone H3.3 turnover in human health as well as its emerging role in disorders. (aging-us.com)

Many promoters in embryonic stem (ES) cells harbor a distinctive histone modification signature that combines the activating histone H3 Lys 4 trimethylation (H3K4me3) mark an. (researchgate.net)
We present evidence that loss of FACT has a dramatic impact on Pol II elongation-coupled processes including histone H3 lysine 4 (H3K4) and H3K36 methylation, consistent with a role for FACT in coordinating histone modification and chromatin architecture during Pol II transcription. (open.ac.uk)
Histone chaperones have been implicated in nucleosome assembly and disassembly as well as histone modification. (omicsdi.org)
They consist of a dimer of dimers with two copies each of the histones H3, H4, H2A and H2B, that tightly bind and wrap DNA, while leaving long exposed tails available for post-translational modification that can carry epigenetic information. (mpg.de)
Many tumors are characterized by low levels of histone H2B ubiquitination, while high levels of the enzyme that removes this modification, USP22, is part of a 'death by cancer' gene signature found in tumors that are resistant to currently available chemotherapeutic agents. (grantome.com)

Among these regulatory processes, core and linker histones are subjected to a large pattern of posttranslational modifications (PTMs) that influence chromatin state and DNA accessibility [ 4 - 7 ]. (aging-us.com)

Importantly, we identify a role for FACT in the maintenance of promoter-proximal Pol II pausing, a key step in transcription activation in higher eukaryotes. (open.ac.uk)
These findings bring to light a broader role for FACT in the regulation of Pol II transcription. (open.ac.uk)
Required for the periodic repression of histone gene transcription during the cell cycle. (nih.gov)
We show that SUPT6H is required for estrogen-regulated transcription and the maintenance of chromatin structure in breast cancer cells, possibly in part through interaction with RNF40 and regulation of histone H2B monoubiquitination (H2Bub1). (diagenode.com)
Role of heat shock transcription factor 2 in the NMDA-dependent neuroplasticity induced by chronic ethanol intake in mouse hippocampus. (u-paris.fr)

Given the considerable stability of the nucleosome, eukaryotic cells employ a staggering array of interconnected molecular mechanisms that locally modify the electrostatic interaction between the highly basic histones and the negatively charged DNA molecules. (aging-us.com)
However, the molecular mechanism by which Abo1 loads histones remains unknown. (molcells.org)
However, the molecular details underlying histone assembly by Abo1 remain elusive. (molcells.org)
Although they take part in the assembly process, molecular chaperones are not components of the final structures. (lookformedical.com)
The advent of microarray analysis enables a better understanding of the functions of CRYAA as a molecular chaperone. (molvis.org)
Molecular chaperone. (affbiotech.cn)
Molecular assembly plays a critical role in constructing the physical world beyond molecules. (complexsystem.cn)

TETs' role in the crosstalk with specific histone modifications, however, is largely elusive. (researchgate.net)

First, you have the DNA in the form of a helix, which is wrapped around the core histones to form the nucleosome-the sort of tennis ball that was represented before- which then folds up further to give chromatin fibers, which further fold up and then organize in the nucleus to form different domains. (hstalks.com)
NPM1 continuously shuttles between the nucleus, cytoplasm, nucleolus and chaperoning core histones from the nucleus to the cytoplasm. (thermofisher.com)

As a long-term goal, we like to pursue the structural and biochemical studies of HCs and address questions of: What are structural features of those HCs as it is and as a complex with its substrates, histones? (umich.edu)
Previously we reported the results of studies on the HDAC1 containing CoREST complex and acetylated nucleosome substrates which revealed a notable preference for deacetylation of histone H3 acetyl-Lys9 vs. acetyl-Lys14 (Wu et al, 2018). (moodcoaching.nl)
The role of the histone tails in the action of NURF may, in part, act independently … Previously we reported the results of studies on the HDAC1 containing CoREST complex and acetylated nucleosome substrates which revealed a notable preference for deacetylation of histone H3 acetyl-Lys9 vs. acetyl-Lys14 (Wu et al, 2018). (moodcoaching.nl)
In Aim 3, we will explore the role that histone chaperones play in governing the specificity of both Ubp10 and the DUB module for their histone substrates. (grantome.com)

Background: Bivalent chromatin domains consisting of the activating histone 3 lysine 4 trimethylation (H3K4me3) and repressive histone 3 lysine 27 trimethylation (H3K27me3) histone modifications are enriched at developmental genes that are repressed in embryonic stem cells but active during differentiation. (researchgate.net)
We model central nervous system development using organoids, and select three histone modifications as proxies for dynamic epigenetic change and validate our findings in a primary developing human brain. (researchgate.net)
DNA methylation and histone modifications play a central role in the epigenetic regulation of gene expression and cell differentiation. (cipsm.de)
Recent studies have uncovered an important role for transcriptional elongation and chromatin modifications in controlling ERα activity and estrogen responsiveness. (diagenode.com)

Review/Rese a: Mitochondrial cytochrome c shot towards histone chaperone condensates in the nucleus. (us.es)

Moreover, we find that TLK phosphorylation of Asf1a is induced in cells experiencing deficiency of new histones and that TLK interaction with Asf1a involves its histone-binding pocket. (omicsdi.org)
These results will also provide a foundation for probing how cross-talk with phosphorylation of histone H2A-Y58 regulates DUB module activity in yeast and human cells. (grantome.com)

Protéines histone vs nonhistone: Les protéines histones sont le principal composant protéique de la chromatine. (moodcoaching.nl)

Understanding nucleosome assembly mechanisms by its chaperones is a crucial not only to understand how newly synthesized histones are recruited during DNA replication and repair, but also important to reveal transferring mechanism of epigenetic information to newly incorporated nucleosomes. (umich.edu)
These histones are used for nucleosome assembly and packing of newly synthesized DNA. (moodcoaching.nl)

Conserved bromodomain-containing AAA+ ATPases play important roles in nucleosome organization as histone chaperones. (molcells.org)

Consistently, SUPT6H, similar to H2Bub1, is required for cellular differentiation and suppression of the repressive histone mark H3K27me3 on lineage-specific genes. (diagenode.com)

The chromo-domain binds histone H3 tails methylated on lysine 9. (cipsm.de)
Classification into the various types (designated histone I, histone II, etc.) is based on the relative amounts of arginine and lysine in each. (lookformedical.com)

Taken together, our study establishes crucial roles for the AtASF1A and AtASF1B genes in chromatin replication, maintenance of genome integrity and cell proliferation during plant development. (nih.gov)

Unexpectedly, Abo1 weakly binds DNA regardless of ATP, and neither histone nor DNA stimulates the ATP hydrolysis activity of Abo1. (molcells.org)

DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of p53/TP53 in response to radiation-induced DNA damage and during DNA replication (PubMed:14578910, PubMed:15548678, PubMed:15448697). (icr.ac.uk)

In its cellular structure role, there is evidence suggesting NPM1 is associated with the centrosome, and is the substrate of CDK2/cyclin E during duplication of centrosomes (cellular division). (thermofisher.com)
Emerging Roles of the Histone Chaperone Caf-1 in Cellular Plasticity. (cheloufilab.org)

The human Suppressor of Ty Homologue-6 (SUPT6H) is a histone chaperone that links transcriptional elongation to changes in chromatin structure. (diagenode.com)

CD15 antigen is important for direct carbohydrate-carbohydrate interaction and plays a role in mediating phagocytosis, bactericidal activity and chemotaxis. (exposed-skin-care.net)
Here, we investigated the details concerning Abo1-mediated histone loading onto DNA and the Abo1-DNA interaction using single-molecule imaging techniques and biochemical assays. (molcells.org)

For example, we have applied this innovative system to the study of the HP1β chromodomain (CHD), which is reported to have selectivity for H3K9me1, me2, and me3 histone peptides 7. (moodcoaching.nl)

METHODS:We analyzed the dynamics of histone chaperone Asf1a and Asf1b in oocytes and pre-implantation embryos in mice by immunofluorescence and real-time quantitative PCR, and further investigated the role of Asf1a and Asf1b during fertilization and pre-implantation development by specific Morpholino oligos-mediated knock down approach. (omicsdi.org)

The mechanistic target of rapamycin complex 1 (mTORC1) plays a central role in this regulation and therefore has long been considered as an attractive target for type II diabetes. (umich.edu)
Insights on the regulation of the MLL/SET1 family histone methyltransferases. (umich.edu)
Histones also playing a role in gene regulation and occur in all eukaryotes. (histoready.com)

We provide the first direct determination that ASF1A and ASF1B play a role in the efficiency of nucleosome assembly in vivo in human cells. (omicsdi.org)
Distinct role of histone chaperone Asf1a and Asf1b during fertilization and pre-implantation embryonic development in mice. (omicsdi.org)
Two paralogous genes, Asf1a and Asf1b exist in mammals, but their role during fertilization and early embryogenesis remains to be investigated further. (omicsdi.org)

The repeating unit of chromatin is the nucleosome, formed from two histone H2A-H2B dimers and one histone H3-H4 tetramer around which 147 bp of DNA are wrapped [ 1 ]. (biomedcentral.com)

In addition to playing an important role in histone exchange during nuclear processes, histone chaperones function in nucleocytoplasmic shuttling of histones, in histone storage, in nucleosome assembly and they act as a link between chromatin remodeling factors and histones [ 2 , 3 ]. (biomedcentral.com)

Recently, Np95 (also known as UHRF1 or ICBP90) has been found to interact with Dnmt1 and to bind hemimethylated DNA, indicating together with genetic studies a central role in the maintenance of DNA methylation. (cipsm.de)

This gene plays an important role in the formation of the senescence-associated heterochromatin foci. (antibodies-online.com)

Enzymes that catalyze acyl group transfer from ACETYL-CoA to HISTONES forming CoA and acetyl-histones. (lookformedical.com)

The AAA+ ATPases have two AAA+ domains and a conserved bromodomain that most likely interacts with histones. (molcells.org)

If not, epigenetic information, which is encoded on the N-tail of histones, is eliminated in the course of nuclear reaction coupled nucleosome reassembly. (nii.ac.jp)
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. (lookformedical.com)

Investigation of the most significant over-represented pathway analysis suggests that HDAC1 and CHD4 likely play a central role in the interactome between RTT and RTT-L genes. (bvsalud.org)

Anatomy8

Organisms5

Diseases1

Chemicals and Drugs55

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes35

Information Science2

Proteins28

Deposition12

Asf113

HIRA5

Protein15

Variants6

Evolutionarily conserved1

Acetylation1

Complexes3

H3.11

Octamer4

H3.33

Modification5

Linker1

Transcription5

Molecular7

Specific histone1

Core histones2

Substrates4

Modifications4

Nucleus1

Phosphorylation2

Nonhistone1

Newly2

Play important roles1

Repressive1

Lysine2

Crucial1

Binds1

Ubiquitination1

Cellular2

Transcriptional1

Interaction2

Peptides1

Dynamics1

Regulation3

Asf1a3

Dimers1

Processes1

Methylation1

Gene1

Enzymes1

Interacts1

Nuclear2

Genes1