Role of cyclic gmp. Medical search. Frequent questions

Recently, signaling by GCC and its downstream effector, cyclic GMP (cGMP) has emerged as a principal regulator of proliferation in human colon cancer cells. (jefferson.edu)
These results suggest that nicorandil relaxes bovine tracheal smooth muscle through 2 mechanisms: opening of K ATP channels and activation of the nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway. (karger.com)
It has been well known that secondary messengers i.e. cAMP (cyclic AMP) and cGMP (cyclic GMP) regulate brain function and has a potential to rescue neurons under stress. (researchsquare.com)
CIALIS® (tadalafil), an oral treatment for erectile dysfunction, is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). (theodora.com)
This then activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation in the corpus cavernosum, resulting in increased inflow of blood and an erection. (rxmedworld.co)
BACKGROUND AND PURPOSE: 8-Nitroguanosine 3′,5′-cyclic monophosphate (8-nitro-cGMP), formed nitric oxide (NO)-dependently, is a physiological second messenger, yet little is known about its role in the pathophysiology of vascular diseases. (elsevierpure.com)

Garg, U.C. and Hassid, A. (1989) Nitric Oxide-Generating Vasodilators and 8-Bromo-cyclic Guanosine Monophosphate Inhibit Mitogenesis and Proliferation of Cultured Rat Vascular Smooth Muscle Cells. (scirp.org)

Cyclic GMP-AMP synthase (cGAS, cGAMP synthase), belonging to the nucleotidyltransferase family, is a cytosolic DNA sensor that activates a type-I interferon response. (wikipedia.org)
RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. (medchemexpress.com)
G150 is a highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor with an IC 50 of 10.2 nM. (medchemexpress.com)
G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS) , with IC 50 s of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively. (medchemexpress.com)
PF-06928215 is a cGAS (cyclic GMP-AMP Synthase) inhibitor with an IC 50 of 4.9 μΜ. (medchemexpress.com)
IRAK4-IN-4 also inhibits cyclic GMP-AMP synthase ( cGAS ) with an IC 50 of 2.1 nM. (medchemexpress.com)
cGAS-IN-1 (compound C20) is a flavonoid and Cyclic GMP-AMP Synthase (cGAS) inhibitor with IC 50 s of 2.28 μM (human cGAS) and 1.44 μM (mouse cGAS). (medchemexpress.com)
This leads to the activation of the cGAS-STING (cyclic GMP-AMP synthase-stimulator of interferon genes) cytosolic DNA-sensing pathway and downstream noncanonical NF-κB signalling. (escholarship.org)
The cellular enzyme cyclic GMP-AMP synthase (cGAS) is an immune sensor protein that detects pathogen- or tumor-derived DNA. (cancerresearch.org)

instead the vasoprotective nitric oxide (NO ⋅ ), plays a critical role in vascular dysfunction under various pathophysiological conditions and in aging. (frontiersin.org)
During his postdoctoral training Dr. Garg received an American Heart Association Fellowship to study the role of nitric oxide and atrial natriuretic factor in the regulation of smooth muscle cell growth. (aacc.org)
Along with his mentor, he demonstrated that nitric oxide and cyclic GMP inhibit smooth muscle and mesangial cell growth and proliferation induced by serum and various growth factors, such as platelet-derived growth factor, epidermal growth factor, insulin-like growth factor, and fibroblast growth factor. (aacc.org)
They also demonstrated that nitric oxide exerts its effect both through and independent of cyclic GMP. (aacc.org)
As part of nitric oxide-cyclic GMP transduction signaling operative in higher eukaryotes and involved in the long-term potentiation, a soluble guanylyl cyclase has also been detected in this lower eukaryote. (ias.ac.in)
We are working on the role of intestinal host defenses such as nitric oxide and on the immune modulatory effects of adenosine. (buffalo.edu)
Much additional work by our group and others' is now elucidating the nitric oxide and c-di-GMP-mediated signalling pathway, and its exploitation for biofilm control in medical and industrial contexts. (southampton.ac.uk)
Nitric oxide (NO) is thought to be involved in E-LTP, but until now there has been no information about the role of the NO-signaling pathway in L-LTP. (jneurosci.org)

Hence, ANP, via its guanylyl cyclase-A (GC-A) receptor and intracellular cyclic GMP as second messenger, stimulates endothelial albumin permeability. (uni-wuerzburg.de)

Chen, Z.S., Lee, K. and Kruh, G.D. (2001) Transport of Cyclic Nucleotides and Estradiol 17-Beta-d-glucuronide by Multidrug Resistance Protein 4. (scirp.org)
Apart from these remarkable actions of vinpocetine it also acts though PDE1 inhibition Phosphodiesterases (PDEs) are the enzymes which reduce the level of cyclic nucleotides by their metabolism (Oliva Jr et al. (researchsquare.com)

cGAS can induce signaling that is known to promote the up-regulation of inflammatory genes and play a critical role in age-related macular degeneration and cellular senescence. (medchemexpress.com)
Upon binding DNA, cGAS activates an innate immune pathway by rapidly synthesizing a small signaling molecule called cGAMP (cyclic GMP-AMP), which binds to the receptor STING to drive expression of immune-related genes. (cancerresearch.org)

The interaction with the non-selective PDE (cyclic nucleotide phosphodiesterase) inhibitor 3-isobutyl-1-methylxanthine (IBMX) was tested after three days. (scirp.org)

2'3'-cyclic-GMP-AMP (cGAMP), a second messenger that activates the antiviral stimulator of IFN genes (STING), elicits an antitumoral immune response. (tcdb.org)

Cyclic GMP plays a central role in the regulation of many physiologic responses, including the modulation of immune responses. (livonlabs.com)
Thus plays a pivotal role in the modulation of CREB mediated transcription, brain derived neurotrophic factor (BDNF) levels and other neurotrophic signals key initiation factor for Traumatic Brain Injury. (researchsquare.com)

This previously unrecognized role of GCC as a tumor suppressor by restricting proliferation and maintaining genomic integrity suggests that receptor dysregulation reflecting ligand insufficiency is a key event during early colorectal tumorigenesis. (jefferson.edu)
Natriuretic peptides present a potent antimitogenic action, mediating their biological effects via the binding of guanylate cyclase-linked atrial natriuretic peptide (ANP) receptor and the production of cyclic GMP. (aspetjournals.org)
These data suggest that there may be subtypes of the PGE1 receptor in this clone: a high-affinity receptor mediating cyclic AMP formation, and a low-affinity receptor mediating IP accumulation, cyclic GMP formation, and intracellular calcium mobilization. (shengsci.com)

One such method is through the utilization of the second messenger molecule cyclic-di-GMP (c-di-GMP) that has been shown to regulate phenotypes within other bacteria that may control surface colonization in Acinetobacter baumannii . (bepress.com)

HA-1004 is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein, and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. (medchemexpress.com)
A protein kinase C activator, 4 beta-phorbol 12 beta-myristate 13 alpha-acetate, had opposite effects on PGE1-mediated IP release and cyclic GMP formation (inhibitory) and cyclic AMP formation (stimulatory). (shengsci.com)
The present study investigated the role of calcium/calmodulin-dependent serine protein kinase (CASK) in interacti. (shengsci.com)
A specific inhibitor of cyclic GMP dependent protein kinase, Rp-8pCPT-cGMPS, partially inhibited the effect of dinitrosyl-iron-thiosulfate on neurogenic vasoconstriction, but not on [ 3 H]noradrenaline release. (biomedcentral.com)
The effect of phosphorylation by cyclic GMP-dependent protein kinase (G-kinase) on the activity of the plasmalemmal Ca2+-transport ATPase was studied on isolated plasma membranes and on the ATPase purified from pig erythrocytes and from the smooth muscle of pig stomach and pig aorta. (portlandpress.com)
Cyclic AMP-dependent protein kinase (A-kinase) did not exert such an effect. (portlandpress.com)
These include 37 proteases and antiproteases, which are likely to play a role in the formation of the yolk (vitellogenesis), as regulators of protein metabolism. (biomedcentral.com)

Pilz, R.B. and Broderick, K.E. (2005) Role of Cyclic GMP in Gene Regulation. (scirp.org)
The significance of loss of GCC ligands early in intestinal tumorigenesis remains obscure because (patho)physiological roles of GCC signaling in intestine, beyond regulation of intestinal fluid and electrolyte homeostasis, are poorly defined. (jefferson.edu)
The possible role of intracellular Ca 2+ level in the regulation of guanylyl cyclase activity as well as L. donovani infectivity was explored by measuring the intracellular survival of the parasites in mammalian macrophages after treatments, which decrease or elevate the intracellular Ca 2+ . (ias.ac.in)

It is an endogenous inhibitor of RAF KINASES and may play a role in regulating SIGNAL TRANSDUCTION. (bvsalud.org)

Quorum sensing, C-di-GMP, and sometimes s-RNA regulate the biofilm formation. (learnlifescience.com)

Here we show that c-di-GMP also binds the glycogen-debranching-enzyme, GlgX, uncovering a direct link between c-di-GMP and glycogen metabolism in bacteria. (nih.gov)
Overall, we identify a function of c-di-GMP in controlling energy storage metabolism in bacteria, which is widespread in Actinobacteria. (nih.gov)

We isolated and named this phage, showed that it becomes superinfective to its host during biofilm development, and found that it plays a role in phenotypic diversification of biofilm bacteria. (southampton.ac.uk)
Most c-di-GMP-dependent signaling pathways control the ability of bacteria to interact with abiotic surfaces or with other bacterial and eukaryotic cells (Romling et al, 2013). (learnlifescience.com)

Role of a new filamentous prophage Pf4 in Pseudomonas aeruginosa biofilm development. (southampton.ac.uk)

Cyclic GMP is important for normal cell proliferation and differentiation. (livonlabs.com)
Downloaded from plays a mechanistic role in cellular decision-making processes ( a ) 2 during differentiation is currently the object of intense study. (lu.se)

PGE1 had more potent intrinsic activity in cyclic AMP formation, IP accumulation, and cyclic GMP formation than did PGE2, PGF2 alpha, or PGD2. (shengsci.com)

no other antioxidant can perform the many additional physiological and biological roles that Vitamin C fills. (livonlabs.com)
The physiological role and clinical consequence of PDE11 inhibition in humans have not been defined. (theodora.com)

Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. (theodora.com)

This novel role in restricting the proliferating compartment and organizing the crypt-villus axis suggests that dysregulation of GCC, reflecting loss of endogenous ligands, might contribute to tumorigenesis by potentiating hyperproliferation which, in turn, may amplify disruption of genomic integrity. (jefferson.edu)

Recent research provides emerging evidence supporting an essential role of increased activity of arginases including arginase-I and arginase-II in causing eNOS-uncoupling, which results in vascular oxidative stress and inflammatory responses, and ultimately leading to vascular diseases. (frontiersin.org)

PGE1 increased intracellular levels of total inositol phosphates (IP), cyclic GMP, cyclic AMP, and calcium ([Ca2+]i). (shengsci.com)
Vitamin C enhances cyclic GMP levels in lymphocytes. (livonlabs.com)
In contrast, pretreatment with Ca 2+ ionophores, which elevated Ca 2+ levels in L. donovani, significantly enhanced the cyclic GMP level as well as the infectivity of the parasites. (ias.ac.in)

Here we studied the role of caveolae-mediated transendothelial albumin Aims Cardiac atrial natriuretic peptide (ANP) participates in the maintenance of arterial blood pressure and intravascular volume homeostasis. (uni-wuerzburg.de)

PGE1-mediated IP accumulation, cyclic GMP formation, and [Ca2+]i increase depended on both the concentration of PGE1 and extracellular calcium ions. (shengsci.com)

Further, we show c-di-GMP binding is required for GlgX activity. (nih.gov)

Kukovetz WR, Holzmann S, Braida C, Poch G: Dual mechanism of the relaxing effect of nicorandil by stimulation of cyclic GMP formation and by hyperpolarization. (karger.com)
There was more than a 10-fold difference between the ED50 for PGE1 at cyclic AMP formation (70 nM) and its ED50 values at IP accumulation (1 microM), cyclic GMP formation (2 microM), and [Ca2+]i increase (5 microM). (shengsci.com)

This review article will summarize the most recent findings on the functional roles of arginases in vascular diseases and/or dysfunctions and the underlying mechanisms in relation to oxidative stress and inflammations. (frontiersin.org)

Cyclic GMP was able to mimic the antiproliferative effect of SNP on HEK293 cells. (scirp.org)

Our in vivo studies reveal the important biological role of GlgX in Streptomyces glucose availability control. (nih.gov)
Resveratrol plays an important role in the plant's natural defense system against injury, infection, and disease. (lifeextension.com)
Endothelium injury plays an important role in atherosclerosis. (aspetjournals.org)

We studied the possible role of low molecular mass dinitrosyl iron complexes in the control of noradrenaline release in electrically stimulated rat tail artery. (biomedcentral.com)

Parasites loaded with intracellular Ca 2+ chelators displayed significantly decreased infectivity and cyclic GMP level. (ias.ac.in)

Beijing played a crucial role in seeding EV71 to central China as well. (bvsalud.org)

Together with the uniform over-expression of GCC in human tumors, and the standard of care in which hormone deficiencies are treated by replacement therapy, the role of GCC as a tumor suppressor underscores the potential of oral administration of GCC ligands for targeted prevention and therapy of colorectal cancer. (jefferson.edu)
Phytoestrogens: Epidemiology and a possible role in cancer protection. (cdc.gov)

Other recent studies, including one conducted at the Joslin Diabetes Center, have found another member of the sirtuin family of cellular proteins that may play a major role in how fat is produced and stored, offering a new target for treatments to prevent obesity and reduce the risk of type 2 diabetes. (lifeextension.com)

Here, the role of GCC in regulating normal enterocyte dynamics along the crypt-villus axis and the corruption of those mechanisms in tumorigenesis were explored. (jefferson.edu)

Anatomy11

Organisms11

Chemicals and Drugs81

Phenomena and Processes12

CGMP6

Guanosine monophosphate1

Synthase9

Nitric8

Intracellular cyclic1

Nucleotides2

CGAS2

Phosphodiesterase1

CGAMP1

Modulation2

Receptor3

Molecule1

Protein7

Regulation3

Inhibitor1

Regulate1

Metabolism2

Bacteria2

Pseudomonas1

Differentiation2

Potent1

Physiological2

Relaxation1

Endogenous1

Responses1

Levels3

Atrial1

Extracellular1

Activity1

Formation2

Vascular1

Effect1

Important3

Molecular1

Level1

Central1

Cancer2

Type1

Normal1