Role of apoptosis apoptosis. Medical search. Frequent questions

These data show that di-GA exhibits three distinct anticancer activities: induction of apoptosis, cell-cycle arrest and disruption of cancer cell-induced lymphendothelial disintegration. (nature.com)
Therefore, based on clinical experience as well as cytotoxic activity against multiple human cancer cells, we hypothesized that induction of apoptosis is the underlying mechanism for the treatment of psoriasis. (hindawi.com)
Strong induction of apoptosis in one compartment of the Drosophila wing disc causes apoptosis of cells in the other compartment, indicating that dying cells can release long-range death factors. (elifesciences.org)
Present results show that the higher sensitivity to PS-3-PDT in glioma cells arise on account of a higher level of apoptosis and suggest that induction of apoptosis is an important determinant of photodynamic sensitivity in certain cell types. (elsevierpure.com)
Induction of apoptosis by ethanol extracts of Ganoderma lucidum in human gastric carcinoma cells. (springer.com)
Solanum nigrum (SN) is a herb with anticancer effects such as destruction of tumor cell membrane, induction of apoptosis by NF-kappaB, caspase activation, nitric oxide production and inhibition of angiogenesis [ 3 ]. (ijpsonline.com)
Induction of apoptosis leads to characteristic cellular changes leading to death. (ijpsonline.com)

Infection of epithelial cells and lymphocytes has been shown to induce apoptosis in vitro ( 4 - 8 ). (cdc.gov)
Truncated BID (tBID), a proapoptotic BCL2 family protein, induces BAK/BAX-dependent release of cytochrome c and other mitochondrial intermembrane proteins to the cytosol to induce apoptosis. (nih.gov)
Inhibition of miR-149-5p can induce apoptosis in THP-1 cells. (medscimonit.com)
We suggest that 4-hydroxynonenal may induce apoptosis through activation of protein kinase C-delta and of Jun N-terminal kinase, and consequent up-regulation of activator protein-1 DNA binding. (unito.it)

7 Severe hypoxia in the presence of energy stimulates cells to undergo apoptosis, whereas oxygen levels above 0.5% prevent cell death. (bmj.com)
For example, the separation of fingers and toes in a developing human embryo occurs because cells between the digits undergo apoptosis. (wikipedia.org)
There are a few types of cancers that persist as a result of a cell's inability to undergo apoptosis. (heidelbergmedical.com)
Many of the current efforts regarding anti-cancer drug development are focused on directing tumor cells to undergo apoptosis. (mdpi.com)

ATZ also induces morphological changes similar to apoptosis and initiates mitochondria-dependent cell death in several experimental models. (frontiersin.org)
Khz ( fusion of Ganoderma lucidum and Polyporus umbellatus mycelia ) induces apoptosis by increasing intracellular calcium levels and activating JNK and NADPH oxidase-dependent generation of reactive oxygen species. (springer.com)
A series of caspases proteins have been shown to be activated by the death induced signal complex [a form of death ligand that binds to the corresponding death receptor on the cell surface ( 13 )], which in turn induces apoptosis. (spandidos-publications.com)
it also induces very early activation of Jun N-terminal kinase, in parallel increasing activator protein-1 DNA-binding activity in a time-dependent manner and triggering apoptosis after only 120 min treatment. (unito.it)
Another theory is that interactions between Fas (a cell-surface receptor that induces apoptosis) and its ligand, particularly a soluble form of Fas ligand released from mononuclear cells, lead to cell death and blister formation. (msdmanuals.com)

Analysis of DNA-binding proteins extracted from the nuclei of untreated BU-11 cells indicated DNA-binding complexes comprising NF-κB subunits p50, c-Rel, and/or Rel A. NF-κB down-regulation with previously described inhibitors induced BU-11 cell apoptosis, demonstrating that the default apoptosis pathway blocked by NF-κB is functional at this early stage in B cell development. (aspetjournals.org)
Communication between the cell survival pathway of autophagy and the cell death pathway of apoptosis is crucial for determining the best outcome for the cell, and ultimately its fate. (edu.au)
Weak external signals may also activate the intrinsic pathway of apoptosis. (wikipedia.org)
There was also no translocation of apoptosis-inducing factor (AIF) from mitochondria to the nucleus in apoptotic keratinocytes, indicating Tan IIA-induced apoptosis occurs mainly through the caspase pathway. (hindawi.com)
found that the JNK pathway activated apoptosis in anterior cells. (elifesciences.org)
Transforming growth factor-β (TGF-β) signaling pathway is a multifunctional cytokine and plays important roles in regulating cell proliferation, cell cycle, differentiation, migration, and apoptosis in a broad spectrum of tissues [ 12 ]. (degruyter.com)
Eldadah and Faden, 2000 ), we hypothesized that suppression of apoptotic capability during maturation of mammalian brain results from repression of genes involved in the caspase-3 activation pathway, and that injury-induced neuronal apoptosis in the mature brain results from reactivation of these genes. (jneurosci.org)
In the present study, we evaluated the role of the intrinsic pathway in neuronal apoptosis at different stages of rat brain development and during maturation of primary cortical neurons in vivo as well as in response to brain injury. (jneurosci.org)
The present study explored the effect of NAC on LPS‑induced apoptosis of HUVECs and determined the participation of the p38 mitogen‑activated protein kinase (MAPK) pathway in the process of apoptosis. (spandidos-publications.com)
The death receptor pathway plays an important role in cell apoptosis ( 12 ). (spandidos-publications.com)
The mitochondrial pathway is also referred to as the endogenous apoptosis pathway ( 15 ). (spandidos-publications.com)
Here, we report that overexpression of the RUNX2 gene in lung cancer may be related to the inhibition of the intrinsic apoptosis pathway, specifically, through direct transcriptional regulation of the antiapoptotic gene BCL2 and indirect regulation of BCL-XL and MCL1. (unab.cl)
These findings highlight the roles of both transcription-dependent and -independent apoptosis by p53 and identify an essential role for caspase-8 in the transcription-independent pathway. (elsevierpure.com)
This pathway plays a prominent role in inter- and intracellular communication and subversion can lead to cancer, fibrosis vascular disorders, and immune diseases. (lu.se)

Whether 5,7,3′,4′-tetramethoxyflavone (TMF) plays the chondroprotective role in inhibition of PGE 2 -induced chondrocytes apoptosis associating with ERS has not been reported. (hindawi.com)
The results demonstrated that NAC pretreatment alleviated LPS‑induced apoptosis and inhibition of NO production in HUVECs. (spandidos-publications.com)
Thus, inhibition of oxidative stress and myocardial apoptosis is beneficial in the treatment of myocardial I/R injury. (spandidos-publications.com)

Apoptosis regulatory proteins are delicately balanced. (bmj.com)
The key regulator of this process, hypoxia inducible factor 1 (HIF-1), can initiate apoptosis by inducing high concentrations of proapoptotic proteins, such as BNIP3, and can cause stabilisation of p53. (bmj.com)
There is some evidence that Bcl-2 pro-survival proteins (which normally keep cells alive by inhibiting the cell death program of apoptosis) are expressed at unusually high levels in melanoma compared to normal melanocytes. (edu.au)
The first is to use an in vivo approach to analyse transgenic mice in which the autophagy regulator known as Beclin has been engineered to either disrupt or enhance its regulation by key components (i.e. proteins) of the apoptosis pathways. (edu.au)
Our resources and products to study apoptosis include apoptosis kits and antibodies to key proteins such as caspases and the Bcl-2 family. (abcam.com)
Some factors like Fas receptors and caspases promote apoptosis, while some members of the Bcl-2 family of proteins inhibit apoptosis. (wikipedia.org)
In fruit flies, apoptosis is activated by proteins known as Grim, Hid and Reaper. (elifesciences.org)
created 'undead' cells in which one of these proteins was turned on, but other downstream proteins (that are responsible for the cellular execution phase of apoptosis) had been turned off: these cells were undergoing apoptosis, but could not complete the process and die. (elifesciences.org)
Further, small interfering RNA (siRNA) against the target gene was co-transfected with miR-149-5p inhibitor, and then the cell apoptosis and the expression of apoptosis-related proteins were assessed. (medscimonit.com)
C1QBP significantly increased ROS level, apoptosis, and the expression of apoptotic proteins such as cleaved caspase-3 and bax/bcl2 via regulating XDH. (medsci.org)

The aim of the present investigation was to elucidate the cellular mechanisms whereby Tanshinone IIA (Tan IIA) leads to cell cycle arrest and apoptosis in vitro in keratinocytes, the target cells in psoriasis. (hindawi.com)
Granulosa cells were isolated and treated with SiAmh interference and hPMSC supernatant to observe the effects of AMH expression on granulosa cell apoptosis in vitro. (biomedcentral.com)
C1QBP knockdown and overexpression cells were established via lentiviral infection and subjected to apoptosis and ROS assay in vitro . (medsci.org)
The secreted isoforms 2 to 6 block apoptosis (in vitro). (lu.se)

In contrast to necrosis, which is a form of traumatic cell death that results from acute cellular injury, apoptosis is a highly regulated and controlled process that confers advantages during an organism's life cycle. (wikipedia.org)
Unlike necrosis, apoptosis produces cell fragments called apoptotic bodies that phagocytes are able to engulf and remove before the contents of the cell can spill out onto surrounding cells and cause damage to them. (wikipedia.org)
Kerr had initially used the term programmed cell necrosis, but in the article, the process of natural cell death was called apoptosis. (wikipedia.org)
We identified Eiger, the Drosophila tumor necrosis factor (TNF) homolog, as the signal responsible for apoptosis-induced apoptosis (AiA). (elifesciences.org)
Cell death caused by PDT (through the generation of reactive oxygen species) can occur either by apoptosis (interphase death or as a secondary event following mitosis) and/or necrosis depending on the cell type, concentration and intracellular localization of the sensitizer, and the light dose. (elsevierpure.com)
However, a decrease was observed at a concentration of 10 μg/ml, possibly due to a shift in the mode of cell death from apoptosis to necrosis. (elsevierpure.com)
These cells had an increase in late apoptosis and necrosis after AngII Toac, hCG + Ang-(1 - 7) and hCG + Ang-(1 - 7)-Fmoc treatments. (scirp.org)
The underlying mechanisms behind myocardial I/R injury are associated with a number of factors, including substantial free radical production, intracellular calcium overload, increased inflammation, myocardial necrosis and apoptosis ( 6 ). (spandidos-publications.com)
[ 6 ] NF-KB protects cells from apoptosis in response to tumor necrosis factor-alpha (TNF-alpha). (medscape.com)

The apoptosome signals apoptosis by binding to and activating specific INITIATOR CASPASES such as CASPASE 9. (bvsalud.org)
The resulting death-inducing signaling complex performs Caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. (lu.se)

To understand the genetic basis of this differential susceptibility, we examined the expression of apoptosis-related genes in these cell lines. (aacrjournals.org)

Ganoderic acid Mf and S induce mitochondria mediated apoptosis in human cervical carcinoma HeLa cells. (springer.com)
Reactive oxygen species (ROS) and mitochondria play an important role in apoptosis induction under both physiologic and pathologic conditions. (huji.ac.il)

However, oxidative stress could play salient role in the observed cellular and genetic toxicity and apoptosis-like effects which could be abrogated by antioxidant vitamins and flavonoids, including vitamin E, quercetin, kolaviron, myricetin and bioactive extractives with antioxidant effects. (frontiersin.org)
The mechanisms of the cytotoxicity, apoptosis, and oxidative stress induced by the 5-15 nm SiNPs still remain unclear. (mdpi.com)
Oxidative stress as a mediator of apoptosis. (springer.com)
However, the role of C1QBP in metabolism, oxidative stress, and apoptosis of renal cell carcinoma (RCC) cells have not yet been explored. (medsci.org)

Nitric oxide (NO) plays an important role in apoptosis. (spandidos-publications.com)

Miyajima, A, Nakashima J, Yoshioka K. Role of reactive oxygen species in cis-dichlorodiammineplatium-induced cytotoxicity on bladder cancer cells. (springer.com)
In this investigation, the role of autophagy and apoptosis in Solanum nigrum fruit extract-induced cytotoxicity in MDA-MB-468, a triple negative breast cancer cell line was studied. (ijpsonline.com)

During hypoxia, an intricate balance exists between factors that induce or counteract apoptosis, or even stimulate proliferation. (bmj.com)
The development of an increasing number of tumors has been shown to involve the deregulation of not only cell proliferation but also normal cell death by apoptosis. (aacrjournals.org)
Excessive apoptosis causes atrophy, whereas an insufficient amount results in uncontrolled cell proliferation, such as cancer. (wikipedia.org)
For apoptotic inducing activity, human osteogenic sarcoma (HOS) cell proliferation, chromosomal DNA degradation and changes in apoptosis-related protein levels were measured. (nutrimedical.com)
Ellagic acid significantly reduced HOS cell proliferation, and induced apoptosis evidenced by chromosomal DNA degradation and apoptotic body appearance. (nutrimedical.com)
Tan IIA inhibited proliferation of mouse keratinocytes in a dose- and time-dependent manner and induced apoptosis, resulting in S phase arrest accompanied by down-regulation of pCdk2 and cyclin A protein expression. (hindawi.com)
JAM3 knockdown additionally inhibited trophoblast proliferation and increased the number of trophoblasts in the sub-G1 and G2/M phases, indicating cell-cycle disturbance and apoptosis. (bioone.org)
These results point out hCG and Ang-(1 - 7) as effective compounds to inhibit cell proliferation, since they decrease cell viability and increase apoptosis in both normal and in tumoral breast cells, being the effect more pronounced in the tumoral cell line. (scirp.org)
Specify the components and their interactions and set up cluding proliferation, differentiation, apoptosis, embryonic the system of equations. (lu.se)

Discover pathways on apoptosis induction, caspase activation and phagocytosis of apoptotic cells. (abcam.com)

An introductionto the mechanisms of apoptotic cell death and apoptosis assays and markers. (abcam.com)

Apoptosis can be initiated through one of two pathways. (wikipedia.org)
In conclusion, the present study demonstrated that SA inhibits the apoptosis of H9c2 cardiomyocytes following H/R injury via reduced activation of the p38MAPK and JNK signaling pathways. (spandidos-publications.com)
The results demonstrated that SA inhibited apoptosis signaling in H9c2 cardiomyocytes via downregulation of p38 mitogen-activated protein kinase (p38MAPK) and c-Jun N-terminal kinase (JNK) signaling pathways following hypoxia/reoxygenation (H/R) injury. (spandidos-publications.com)

Furthermore, Tan IIA-induced apoptosis and mitochondrial membrane potential changes were also further demonstrated by DNA fragmentation, single-cell gel electrophoresis assay (SCGE), and flow cytometry methods. (hindawi.com)
Cell apoptosis was analyzed by flow cytometry. (degruyter.com)
The rate of apoptosis was determined using flow cytometry. (spandidos-publications.com)
Loss-of-function assays using sh-RNA from lentiviral particles and coupled with Annexin/propidium iodide (PI) assays (flow cytometry), immunofluorescence, and quantitative PCR analysis of genes related to cell apoptosis (BAD, BAX, BCL2, BCL-XL, and MCL1) were performed. (unab.cl)

Overexpression of miR-128-3p or knockdown of TGFBR2 ameliorated LPS-induced inflammation and apoptosis. (degruyter.com)

Understanding the regulation of apoptosis during hypoxia and the mechanisms of resistance to apoptosis might lead to more specific treatments for solid tumours. (bmj.com)
These results extend previous observations by demonstrating that 1) NF-κB is a survival factor at an earlier stage of B cell development than previously appreciated and 2) NF-κB down-regulation is likely to be part of the molecular mechanism resulting in PAH-induced preB cell apoptosis. (aspetjournals.org)
CONCLUSION: Ellagic acid exhibited both antioxidant activity in V79-4 cells and apoptosis-inducing activity in HOS cells through the up-regulation of Bax and activation of caspase-3. (nutrimedical.com)
Mitochondrial regulation of apoptosis further downstream was investigated, showing changes in the mitochondrial membrane potential, cytochrome c release into the cytoplasm, and enhanced activation of cleaved caspase-3 and Poly ADP-ribose polymerase (PARP). (hindawi.com)
This process plays a major role in development and tissue homeostasis, and abnormal regulation of apoptosis is associated with a variety of human diseases ( Fuchs and Steller, 2011 ). (elifesciences.org)
This is especially interesting as we have shown in our previous work that regulation of apoptosis might be disturbed, especially in systemic lupus erythematosus. (biomedcentral.com)
This review focuses on the role of ROS in the regulation of apoptosis, especially in inflammatory cells. (huji.ac.il)
p53's Dual regulation of arrest versus apoptosis may underlie tumor-selective effects of anti-cancer therapy. (elsevierpure.com)
The protein product of the murine double minute gene 2 (mdm-2) plays a central role in the regulation of p53. (lu.se)

Previous studies focused on the molecular mechanisms through which PAH induce stromal cells to deliver an apoptosis signal to adjacent preB cells. (aspetjournals.org)
We use a combination of biochemical, cell biology, structural biology and medicinal chemistry approaches to understand the precise molecular mechanisms that control apoptosis. (edu.au)
Moreover, these anergic lymphocytes were extremely sensitive for protein kinase C-mediated apoptosis, indicating that immunosuppressive mechanisms are inter-related. (biomedcentral.com)
The molecular mechanisms underlying the role of JAM3 in placental dysfunction remain unclear. (bioone.org)
To avoid elimination by this mechanism, human papillomaviruses (HPV) have developed several mechanisms that enable the cells they infect to elude both extrinsic and intrinsic apoptosis. (mdpi.com)
In this manuscript, we review the current literature regarding how HPV-infected cells avoid apoptosis and the molecular mechanisms involved in these events. (mdpi.com)
However, the effects of NAC on LPS‑induced apoptosis of human umbilical vein endothelial cells (HUVECs) and the associated mechanisms are not well characterized. (spandidos-publications.com)
These findings indicated that Solanum nigrum extract induced cell death in MDA-MB-468 cells by two distinct mechanisms, apoptosis and autophagy, and these findings further suggest a possibility that this extract could be used to treat triple negative breast cancer. (ijpsonline.com)
Further study on the mechanisms of p38MAPK in human TM cell apoptosis may help to illuminate the pathogenesis of POAG. (molvis.org)

A potential mechanism for the role of calcium in prostate cancer development and progression is that intracellular calcium controls the growth of prostate cancer cells and the process of apoptosis (9). (cdc.gov)

Moreover, TGFBR2 was a direct target of miR-128-3p, and its overexpression reversed the inhibitory effects of miR-128-3p overexpression on inflammation and apoptosis in LPS-induced HK2 cells. (degruyter.com)
LPS (also referred to as endotoxin) is one of the important virulence factors that is known to mediate inflammation and apoptosis ( 2 ). (spandidos-publications.com)

Recent work also has revealed the existence of several bcl-2-related genes that also can inhibit ( e.g., bcl-X L and Mcl-1 ) or activate ( e.g., bax, bcl-X S , bag , and bad ) apoptosis in several systems. (aacrjournals.org)
Northern blot experiments showed no significant difference in the expression of myc and bax apoptosis-promoting genes in susceptible (SP2/0 and D5) and resistant (P3X63) cell lines. (aacrjournals.org)
The 2002 Nobel Prize in Medicine was awarded to Sydney Brenner, H. Robert Horvitz and John Sulston for their work identifying genes that control apoptosis. (wikipedia.org)
The genes were identified by studies in the nematode C. elegans and homologues of these genes function in humans to regulate apoptosis. (wikipedia.org)
Several modes of apoptosis induction and responsible viral genes have been proposed ( 8 - 13 ). (cdc.gov)
Apoptosis refers to the self-regulated and orderly death of cells controlled by genes in order to maintain the stability of internal environment ( 8 ). (spandidos-publications.com)
The expression levels of apoptosis-related genes Bcl2 and Bax were determined by real-time PCR. (ijpsonline.com)
Furthermore, to confirm whether the regulatory role of RUNX2 in the expression of these genes is related to its binding to the promoter region, we performed chromatin immunoprecipitation (ChIP) assays. (unab.cl)
Role of indole curcumin in the epigenetic activation of apoptosis and cell cycle regulating genes. (cdc.gov)

Neuronal apoptosis plays an essential role in early brain development and contributes to secondary neuronal loss after acute brain injury. (jneurosci.org)
Importantly however, when neurons were cocultured with microglia and B. burgdorferi, significant neuronal apoptosis consistently occurred. (tulane.edu)

Strikingly, undead cells in the posterior (back) region of the wing imaginal disc-the tissue in the larva that gives rise to the wing in the adult fruit fly-could trigger apoptosis in cells in the anterior (front) half. (elifesciences.org)
The ability of the host to trigger apoptosis in infected cells is perhaps the most powerful tool by which viruses can be cleared from the host organism. (mdpi.com)

miR-128-3p could inhibit apoptosis and inflammation by targeting TGFBR2 in LPS-induced HK2 cells, which might provide therapeutic strategy for the treatment of sepsis. (degruyter.com)

Apoptosis was measured by Hoechst 33258/propidium iodide double staining of nuclear chromatin and the formation of gaps into the lymphendothelial barrier in a three-dimensional co-culture model consisting of MCF-7 tumour cell spheroids and human lymphendothelial monolayers. (nature.com)

This study was aimed to reveal the role of miR-149-5p in acute myeloid leukemia (AML) cells apoptosis and the possible mechanism involved. (medscimonit.com)

Thus, VDAC2 acts as a crucial component in mitochondrial apoptosis by allowing the mitochondrial recruitment of BAK, thereby controlling tBID-induced OMM permeabilization and cell death. (nih.gov)

The best studied is apoptosis, a form of programmed cell death used by all multicellular organisms to eliminate cells that are damaged, no longer needed or which might become a threat to the organism. (edu.au)
Apoptosis is a distinct form of programmed cell death in which cells activate an intrinsic suicide program to self-destruct. (elifesciences.org)

Apoptosis was partially blocked by the caspase-3 inhibitor Ac-DEVD-CHO. (hindawi.com)
AML cell line THP-1 was transfected with miR-149-5p mimic or inhibitor, and then cell apoptosis was determined using the APO Percentage assay kit. (medscimonit.com)
The results of CCK‑8 and flow cytometric analyses showed that pretreatment of HUVECs with NAC or p38MAPK inhibitor (SB203580) attenuated LPS‑induced decrease in cell viability and increase in cell apoptosis. (spandidos-publications.com)

Simon, HU, Haj-Yehia, A & Levi-Schaffer, F 2000, ' Role of reactive oxygen species (ROS) in apoptosis induction ', Apoptosis : an international journal on programmed cell death , vol. 5, no. 5, pp. 415-418. (huji.ac.il)

Autophagy and apoptosis are two forms of programmed cell death, which are essential for cellular homeostasis. (ijpsonline.com)

Since, apoptosis induced by PDT treatment plays an important role in determining the photodynamic efficacy, in the present work we have investigated the role of apoptotic cell death in relation to the observed differences in sensitivity to HpD-PDT between a human glioma cell line (BMG-1) carrying wild-type tumour suppressor gene p53 and a human squamous carcinoma cell line (4451) with mutated p53. (elsevierpure.com)

Complementary projects in the lab focus on autophagy, a cell survival process that has significant cross-talk with apoptosis. (edu.au)
A previous study reported that the extract of the whole plant of SN activated cell death in hepatoma cells through autophagy and apoptosis [ 7 ]. (ijpsonline.com)
Autophagy also plays an important role in controlled cell death (apoptosis). (medlineplus.gov)
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. (medlineplus.gov)

Our data suggest that apoptosis may play a major role in the pathogenesis of influenza (H5N1) virus in humans by destroying alveolar epithelial cells. (cdc.gov)
Apoptosis has been implicated in the pathogenesis of influenza. (cdc.gov)
many other tumours, so their role is still important role in cancer pathogenesis controversial. (who.int)

Apoptosis is a mechanism of programmed cell death that occurs in multicellular organisms. (abcam.com)
For many years, neither "apoptosis" nor "programmed cell death" was a highly cited term. (wikipedia.org)
Many cells in our body endure PCD (programmed cell death), or apoptosis, during fetal development. (heidelbergmedical.com)
Defective apoptosis (programmed cell death) does the reverse of what healthy apoptosis could do in treating cancer. (heidelbergmedical.com)
Apoptosis : an international journal on programmed cell death , Vol. 5, No. 5, 2000, p. 415-418. (huji.ac.il)

This study is to investigate the role of p38 mitogen-activated protein kinase (p38MAPK) in tert -butyl hydroperoxide ( t BHP)-induced apoptosis of human trabecular meshwork (iHTM) cells. (molvis.org)
Activation of p38MAPK plays an important role in t BHP-induced apoptosis of iHTM cells. (molvis.org)

By treatment with PGE 2 , the chondrocytes apoptosis was significantly increased, the proapoptotic CHOP and JNK were upregulated, the prosurvival GRP78 and XBP1 were downregulated, and GSK-3 β was also upregulated. (hindawi.com)
PS-3-PDT induced a significantly higher level of apoptosis in BMG-1 cells as compared to 4451 cells. (elsevierpure.com)
hPMSC transplantation can significantly improve the serum levels of high gonadotropin and low estrogen of POF mice, promote follicular development, inhibit excessive follicular atresia and granulosa cell apoptosis, and improve the ovarian reserve capacity. (biomedcentral.com)
Depletion or inactivation of caspase-8 either in cells or cell-free extracts completely prevents this transcription-independent apoptosis and significantly attenuates overall death induced by wild-type p53. (elsevierpure.com)

In the skin, NF-KB regulates cell growth in the stratified epithelium and apoptosis. (medscape.com)

Additional knowledge of the role of miRNA in host responses might elucidate disease susceptibility and suggest fresh anti-inflammatory therapeutics. (cancer-ecosystem.com)
Recent studies have provided evidence that neuronal susceptibility to apoptosis induced by traumatic or ischemic injury decreases during brain development. (jneurosci.org)

Myelomas are antibody-secreting tumor cells derived from terminally differentiated B lymphocytes, and previous work from our laboratory showed that murine SP2/0 myeloma cells and derived B-cell hybridomas were highly sensitive to apoptosis induction by a block of gene expression (cycloheximide). (aacrjournals.org)

Specifically, PAH induce preB cell apoptosis in primary bone marrow cultures and in cocultures of an early preB cell line (BU-11) and a bone marrow stromal cell line (BMS2). (aspetjournals.org)

Membrane HSP60 correlated with increased apoptosis. (houstonmethodist.org)

In addition, cell apoptosis was measured by double staining, DNA fragmentation and annexin V-fluorescein isothiocyanate binding assays. (ijpsonline.com)

However, the fact cannot be denied that some oncogenic mutations disrupt apoptosis, leading to tumor initiation, progression or metastasis. (heidelbergmedical.com)
Complement component 1 Q subcomponent binding protein (C1QBP) plays a vital role in the progression and metabolism of cancer. (medsci.org)
In vivo , orthotopic tumor xenografts assay was performed to investigate the role of C1QBP in RCC progression. (medsci.org)

Here, the role of NF-κB, a lymphocyte survival factor, in PAH-induced preB cell apoptosis was assessed. (aspetjournals.org)
Infection with virulent influenza (H5N1) virus was also shown to induce lymphopenia and lymphocyte apoptosis in vivo ( 14 ). (cdc.gov)

Cells adapt to this environmental stress, so that after repeated periods of hypoxia, selection for resistance to hypoxia induced apoptosis occurs. (bmj.com)

When apoptosis does not work correctly, cells that should be eliminated may persist and become immortal, for example, in cancer and leukemia . (rxlist.com)
The role of Apoptosis in treating cancer is significant. (heidelbergmedical.com)
When functioning properly, the apoptosis induced can fight cancer by getting rid of the cancer cells. (heidelbergmedical.com)
Thus it is very important to take suitable care to understand how apoptosis can provide new possibilities for diagnosing and treating cancer. (heidelbergmedical.com)
F. Deshayes and C. Nahmias, "Angiotensin Receptors: A New Role in Cancer? (scirp.org)

Multimeric protein complexes formed in the CYTOSOL that play a role in the activation of APOPTOSIS. (bvsalud.org)

Fas-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. (lu.se)

Anatomy31

Organisms9

Diseases12

Chemicals and Drugs134

Analytical, Diagnostic and Therapeutic Techniques and Equipment18

Phenomena and Processes51

Disciplines and Occupations1

Information Science3

Induction of apoptosis7

Induce apoptosis4

Undergo apoptosis4

Induces5

Pathway14

Inhibition3

Proteins10

Vitro4

Necrosis9

Caspases2

Expression of apoptosis-related1

Mitochondria2

Oxidative4

Important role in apoptosis1

Cytotoxicity2

Proliferation9

Caspase activation1

Assays and markers1

Pathways3

Flow cytometry4

Ameliorated LPS-induced1

Regulation9

Mechanisms9

Process of apoptosis1

Inflammation and apoptosis2

Genes9

Neuronal apoptosis2

Trigger apoptosis2

Inhibit apoptosis1

Measured by Hoechst 332581

Cells apoptosis1

Mitochondrial1

Form of programmed cell2

Inhibitor3

Reactive1

Cellular1

Apoptotic cell1

Autophagy4

Pathogenesis3

Programmed cell5

P38MAPK2

Significantly4

Regulates1

Susceptibility2

Tumor cells1

Bone marrow1

Membrane1

Fragmentation1

Progression3

Lymphocyte2

Occurs1

Cancer5

Cytosol1

Antigen1