Role in the pathogenesis. Medical search. Frequent questions

To date how such force is sensed in host cells and contribute to bacterial pathogenesis has been poorly explored. (anr.fr)

Furthermore, they can exit the cell to enter the blood where they can display powerful immunological activities, seemingly unrelated to their nuclear function, and can drive the pathogenesis of autoimmunity. (frontiersin.org)
These results suggest that elevated nitric oxide production could be important in the pathogenesis of autoimmunity, and that treatments to block the production of nitric oxide or block its effects might be valuable therapeutically. (duke.edu)
We therefore hypothesise that defects in immunosuppression might contribute to the pathogenesis of autoimmunity in man. (biomedcentral.com)

Among the candidate agents, the possible role of mycobacterial infection in the pathogenesis of sarcoidosis has attracted by far the most attention. (nih.gov)
The purpose of this review is to summarize current evidence concerning the role of mycobacterial infection in sarcoidosis. (nih.gov)
First, the similarities in clinical and histological features of tuberculosis and sarcoidosis that have raised suspicion that mycobacterial infection could be involved in the pathogenesis of sarcoidosis are discussed. (nih.gov)
In addition, experimental evidence for and against a role of mycobacterial infection is summarized, including recent attempts to detect mycobacterial DNA in clinical samples from patients with sarcoidosis by polymerase chain reaction. (nih.gov)
The possible contribution of mucin degrading enzymes to the pathogenesis of infection is, therefore, not to be underestimated. (bmj.com)
The overall objective of this proposal is to decipher the role of Tfp retraction in meningococcal pathogenesis and to determine how this influences the outcome of infection. (anr.fr)
Histoplasma capsulatum cell wall {beta}-glucan induces lipid body formation through CD18, TLR2, and dectin-1 receptors: correlation with leukotriene B4 generation and role in HIV-1 infection. (microbiologyresearch.org)
DESCRIPTION (provided by applicant): Role of cellular prion protein in the pathogenesis of NeuroAIDS HIV infection of the central nervous system (CNS) results in the development of a spectrum of neurological complications known as HIV associated neurologic disorders (HAND) in a significant number of individuals. (elsevierpure.com)
Welcome to the Macrophage Infection of HIV Implications for Pathogenesis and Cure meeting, jointly organized by the National Institute of Mental Health and the Ragon Institute of MGH, MIT, and Harvard. (nih.gov)

This review article focuses on the role of T reg cells and outlines the pathogenesis and therapeutic strategies of IBD based on previous reports. (wjgnet.com)
We show that the epigenetic silencing of miR-34b/c by methylation is a crucial alteration and plays an important role in the tumorigenesis of MPM, suggesting potential therapeutic options for MPM. (nih.gov)
The discovery of new genes/pathways improves our knowledge of cancer pathogenesis and presents novel potential therapeutic options. (ac.ir)
This review aims to discuss SF3B1 and NOTCH1 roles in the pathogenesis of various types of leukemia and the therapeutic potential of targeting these genes or their mutations to provide a foundation for leukemia treatment. (ac.ir)

Role of neutrophil extracellular la NETosis en las enfermedades infecciosas pulmonares. (bvsalud.org)
Despite not having a standardized measurement parameter, the excess of neutrophil extracellular traps corresponds conception, manuscript to the severity of tissue damage observed in patients with respiratory tract infections, revealing the important prognostic role design, literature search, data of the neutrophil response and NETosis process in pulmonary infectious diseases. (bvsalud.org)

Although several studies have shown some aspects of this pathogenesis in animal models, direct evidence of pathogenic mechanisms in humans has been limited to only a few autopsy studies ( 1 - 3 ). (cdc.gov)
In conclusion, these data clearly provide evidence that a disturbance of physiological immunosuppressive mechanisms might contribute to the pathogenesis of autoimmune diseases. (biomedcentral.com)
Emerging data also support a key role for epigenetic mechanisms in the pathogenesis of T2D and obesity. (lu.se)

The coronavirus disease 2019 (COVID-19) pandemic has elicited a swift response by the scientific community to elucidate the pathogenesis of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)-induced lung injury and develop effective therapeutics. (ersjournals.com)
This study aimed to screen specific biomarkers of PT and CPP and elucidate their underlying pathogenesis . (bvsalud.org)

A growing body of literature implicates the peroxisome proliferators-activated receptors (PPARs) in the pathogenesis and treatment of NAFLD. (wjgnet.com)
Based on findings in neurological diseases ( 20-23 ) and pharmacological interactions ( 24-27 ), it appears that a malfunction of 5-hydroxytryptamine (HT)2 receptors may have a major role in the pathogenesis of bruxism. (spandidos-publications.com)
The EGF-CFC family has been identified in all chordate species and consists of Cripto-1 (CR-1) and Cryptic that perform an obligatory role as co-receptors for the TGF beta subfamily of proteins, Nodal/GDF1/GDF3 and that regulate gastrulation, germ layer formation and left-right axis determination. (grantome.com)

Previous studies have suggested the protective role of the Toll-like receptor 3 (TLR3) pathway against WNV entry into the brain, while the WNV non-structural protein 1 (NS1) interferes with the TLR3 signaling pathway, besides being a component of viral genome replication machinery. (uzh.ch)
However, evidence derived mostly from animal models, indicates that Kupffer cells may be implicated in the pathogenesis of various liver diseases including viral hepatitis, steatohepatitis, alcoholic liver disease, intrahepatic cholostasis, activation or rejection of the liver during liver transplantation and liver fibrosis. (wanfangdata.com.cn)
The findings in this case are more likely to reflect viral pathogenesis in the acute phase of the disease. (cdc.gov)

These treatment advances are based on evidence that genetic changes associated with the complement genes and the complement cascade play a role in age-related macular degeneration (AMD). (aao.org)

1999. Infantile methemoglobinemia: reexamining the role of drinking water nitrates. (cdc.gov)

The articles in this Research Topic, "The Role of Nuclear Molecules in the Pathogenesis of Autoimmune Disease," provide an exciting perspective on molecules for which the nucleus is just one site of action. (frontiersin.org)
Scholars@Duke publication: The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine. (duke.edu)
This study examines the role of nitric oxide, a molecule with proinflammatory actions, in the pathogenesis of MRL-lpr/lpr autoimmune disease. (duke.edu)

So we at the NIMH Division of AIDS Research are very happy to be co-sponsoring this conference with the Ragon Institute, recognizing the importance of macrophages in HIV pathogenesis and cure efforts. (nih.gov)

The pathogenesis of avian influenza A (H5N1) virus in humans has not been clearly elucidated. (cdc.gov)
Our data suggest that apoptosis may play a major role in the pathogenesis of influenza (H5N1) virus in humans by destroying alveolar epithelial cells. (cdc.gov)
This pathogenesis causes pneumonia and destroys leukocytes, leading to leukopenia, which is a prominent clinical feature of influenza (H5N1) virus in humans. (cdc.gov)
The pathogenesis of avian influenza A (H5N1) virus in humans is not well understood. (cdc.gov)
Apoptosis has been implicated in the pathogenesis of influenza. (cdc.gov)
In this review we connect the current understanding of the SARS-CoV-2 replication cycle and host response to the clinical presentation of COVID-19, borrowing concepts from influenza A virus-induced ARDS pathogenesis and discussing how these ideas inform our evolving understanding of COVID-19-induced ARDS. (ersjournals.com)
We also consider important differences between COVID-19 and influenza, mainly the protean clinical presentation and associated lymphopenia of COVID-19, the contrasting role of interferon-γ in mediating the host immune response to these viruses, and the tropism for vascular endothelial cells of SARS-CoV-2, commenting on the potential limitations of influenza as a model for COVID-19. (ersjournals.com)
Our review explores influenza A virus-induced acute respiratory distress syndrome (ARDS) as a paradigm for understanding coronavirus disease 2019 (COVID-19)-induced ARDS pathogenesis and ageing as a risk factor for severe disease. (ersjournals.com)

Alveolar macrophage dysfunctions play important roles in asthma pathogenesis. (cdc.gov)

abstract = "Purpose of review: The immunologic causes of allergic rhinitis underscore the important roles of both adaptive and innate immune systems. (johnshopkins.edu)

RESEARCH TRIANGLE PARK, N.C. - The Burroughs Wellcome Fund's Board of Directors is pleased to announce the 2021 Investigators in the Pathogenesis of Infectious Disease (PATH). (bwfund.org)

Saka HA , Valdivia R . Emerging roles for lipid droplets in immunity and host-pathogen interactions. (microbiologyresearch.org)
In recent years, appreciation of the role of nasal innate immunity has grown and evidence suggests that the pathogenesis of allergic rhinitis is partially mediated by the innate immune system. (johnshopkins.edu)
Melvin, TAN & Ramanathan, M 2012, ' Role of innate immunity in the pathogenesis of allergic rhinitis ', Current Opinion in Otolaryngology and Head and Neck Surgery , vol. 20, no. 3, pp. 194-198. (johnshopkins.edu)

Epigenetic silencing of microRNA-34b/c plays an important role in the pathogenesis of malignant pleural mesothelioma. (nih.gov)

Metabolic characteristics and pathogenesis of precocious puberty in girls: the role of perfluorinated compounds. (bvsalud.org)

Because epigenetic silencing was the major event in miR-34b/c, we investigated the functional role of miR-34b/c in MPM. (nih.gov)

We identified new functional interactions between SF-1 and neuron-restrictive silencer factor/RE1-silencing transcription factor (NRSF/REST) suggesting that SF-1 has a broader role than initially thought in regulating tissue-specific gene expression programs. (endocrine-abstracts.org)

Our recent studies aim to better understand the role of FATE1 in tumor cellular metabolism, mitochondrial morphology and signaling and in drug resistance, potentially important for the aggressive phenotype of adrenocortical carcinoma. (endocrine-abstracts.org)
Currently, there are no studies of the role of PrPc, the cellular non pathogenic isoform of the prion protein, in the context of HIV and neurocognitive impairment. (elsevierpure.com)
Mitochondria play a pivotal role in cellular bioenergetics and cell-survival. (benthamscience.com)

The current review focuses on the role of the eCB system in normal kidney function and various diseases, such as diabetes and obesity, that directly contributes to the development of renal pathologies. (degruyter.com)
The role of hydrolytic enzymes in the pathogenesis of sexually transmitted diseases and their effect on cervical mucus are discussed in this review. (bmj.com)
Role of Type IV pilus retraction in the pathophysiology of meningococcal invasive diseases. (anr.fr)

We also studied the role of, the local immune system of gastric mucosa in the pathogenesis of gastritis. (medscimonit.com)
Large amount of CD lymphocytes (CD 3+ CD 4+ CD 8+) and increased marker expression of CD 11a, CD 45 RO, HLA-DR and, to a lesser degree, CD 15 suggest immune system involvement in the pathogenesis of gastritis in children with collagenosis. (medscimonit.com)

The first single-cell and spatial transcriptomic atlases of PDAC were reported, a mechanism for how Schwann cells promote perineural invasion was explored, and, finally, the role of exercise in abrogating immunosuppression was shown. (nature.com)

Although carpal tunnel syndrome (CTS) is the most common form of peripheral entrapment neuropathy, its pathogenesis remains largely unknown. (bmj.com)
The pathogenesis and mechanism of the pterygium remain largely unknown. (molvis.org)

After identification of the candidate transcription factor(s) that can be regulated by MDI-exposure, we investigate the roles of the candidate transcription factor in regulation of these candidate M2 macrophage associate markers and chemokines in relation to the exposure to MDI. (cdc.gov)

Yamada A, Arakaki R, Saito M, Tsunematsu T, Kudo Y, Ishimaru N. Role of regulatory T cell in the pathogenesis of inflammatory bowel disease. (wjgnet.com)
For example, T reg cells contribute to the complex pathogenesis of inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis during onset or development of that disease. (wjgnet.com)
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man. (medscimonit.com)

The Investigators in the Pathogenesis of Infectious Disease award provides a rare opportunity to explore questions about how humans and our potential pathogens move forward in one another's context, whether in sickness or in health," said Senior Program Officer Dr. Victoria McGovern. (bwfund.org)

Many pathogenesis-related protein families also coincide with groups of human allergens, even though the allergy may have nothing to do with the defense function of the proteins. (wikipedia.org)
Here we investigated the role of IPO13 in the pathogenesis of pterygium and the underlying mechanism including interaction with other cell proliferation-related factors: keratin 17 (K17), a lesional protein and a member of the type I keratins, and c-Jun, a protein of the activator protein-1 complex. (molvis.org)
Although the cause of ALS is still not well understood, some research has suggested that abnormalities in RNA metabolism caused by the displacement of the nuclear protein TDP-43, which is involved in the regulation of RNA expression, into the cytoplasm, may be a factor in disease pathogenesis. (cgtlive.com)

Apoptosis may also play an important role. (cdc.gov)

Des efforts sont requis pour améliorer la qualité de vie des patients asthmatiques parallèlement à la mise en place de plans précis pour leur prise en charge. (who.int)

In order to investigate this further, Sebastian Michels, MD, a postdoctoral fellow and member of the La Spada Lab at University of California, Irvine, and his colleagues evaluated alternative polyadenylation (APA), a mechanism that plays a role in RNA processing and is regulated by TDP-43, and how changes in APA affect RNA expression. (cgtlive.com)

Salicylic acid plays a role in the resistance to pathogens by inducing the production of pathogenesis-related proteins. (wikipedia.org)
Coagulase-negative staphylococci are pathogens whom also play a distinct role in the presentation of osteomyelitis. (ukessays.com)

The pathogenesis of sarcoidosis has intrigued clinicians since the first descriptions of the disease, and a number of causes have been proposed. (nih.gov)
In the pathogenesis of SLE, immune complexes containing nuclear molecules play a key role in the inflammation characteristic of this disease, especially in the kidney ( Rekvig ). (frontiersin.org)
Exploring the Role of Aggregated Proteomes in the Pathogenesis of Alzheimer's Disease. (amrita.edu)
This project aims to comprehensively characterize the role of the TREM2 T96K mutation using the 5xFAD mouse model of Alzheimer's disease to facilitate the design of potential therapies. (brightfocus.org)
We aim to understand the role of the TREM2 T96K mutation in Alzheimer's disease (AD) pathogenesis. (brightfocus.org)
The proposed study will provide critical insight into the role of the TREM2 T96K mutation in Alzheimer's disease (AD), which may offer personalized AD treatment strategies depending on TREM2 genotype. (brightfocus.org)
In this review we propose a model that demonstrates the role of Kupffer cells in the pathogenesis of liver disease. (wanfangdata.com.cn)

This mini-review discusses the impact of gut dysbiosis in the pathogenesis of RA, the selection of gut microbiota-related biomarkers for diagnosing RA, and provides examples of cross-modulation between the gut microbiota and some drugs commonly used to treat RA. (frontiersin.org)

Epigenetics has an important role in cancer pathogenesis and subtype diagnosis. (cdc.gov)

This review presents a comprehensive but concise overview of pathogenesis , management and prevention of IAH in SCD. (bvsalud.org)

In terms of his team's own research, which falls into the latter category, Michels highlighted that they identified hundreds of changes in genes that function in pathways that have been previously implicated as playing a role in ALS. (cgtlive.com)

Regulatory T (T reg ) cells play key roles in various immune responses. (wjgnet.com)

Recently, IPO13 was reported to play a role in human physiologic and pathologic function. (molvis.org)
Recent evidence suggests that sAPP has growth-promoting properties and may play a role in the formation of neurons in the brain both before and after birth. (medlineplus.gov)
The tempting hypothesis that female sex hormones play a role in pathogenesis remains unproved. (msdmanuals.com)

These findings strongly suggest a role of FBN2 in the pathogenesis of CTS. (bmj.com)
Some of the findings may not reflect the actual pathogenesis at the acute period but may be consequences of secondary events. (cdc.gov)
Michels presented their findings in a talk entitled "Alternative polyadenylation in the pathogenesis of amyotrophic lateral sclerosis" at the 148th Annual Meeting of the American Neurological Association , held September 9-12, 2023, in Philadelphia, Pennsylvania. (cgtlive.com)

I really want to thank the meeting organizing committee who did a lot of work on this meeting, including Dr. Janice Clements from Johns Hopkins University, Mario Stevenson from University of Miami, and Kiera Clayton who played a major role in organizing from the University of Massachusetts Medical School. (nih.gov)

Steroidogenic factor-1 (SF-1, NR5A1) is a transcription factor that plays an essential role in the development of adrenal glands and gonads. (endocrine-abstracts.org)

Our laboratory studies the the EGF-CFC family and their role in the development of the mouse mammary gland and in the initiation and progression of mouse and human breast cancer. (grantome.com)

[ 2 ] Many systematic reviews and a scientific statement from the American Heart Association state the possible role of poor oral health on the elevated risk of CHD. (medscape.com)

Anatomy41

Organisms18

Diseases46

Chemicals and Drugs67

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Psychiatry and Psychology2

Phenomena and Processes55

Disciplines and Occupations1

Information Science3

Named Groups1

Health Care3

Bacterial pathogenesis1

Autoimmunity3

Infection9

Therapeutic4

Extracellular2

Mechanisms3

Elucidate2

Receptors3

Viral3

Macular degeneration1

19991

Autoimmune disease3

Macrophages1

Influenza8

Alveolar1

Abstract1

20211

Immunity3

Malignant1

Metabolic1

Epigenetic1

Gene1

Cellular3

Diseases3

Immune system2

Immunosuppression1

Largely unknown2

Markers1

Inflammatory3

Investigators1

Protein3

Apoptosis1

Patients1

Mechanism1

Pathogens2

Disease7

Modulation1

Diagnosis1

Prevention1

Pathways1

Regulatory1

Play a role3

Findings3

University1

Transcription factor1

Cancer1

Possible role1