Genome-wide identification of calcium-response factor (CaRF) binding sites predicts a role in regulation of neuronal signaling pathways. (neurotree.org)
Thus, our results demonstrate that changes in neuronal activity initiate competing signaling pathways that positively and negatively regulate the growth of the dendritic arbor. (jneurosci.org)
Molecular alterations involved in adult gliomas have been identified and mainly affect tyrosine kinase receptors with amplification and/or mutation of the epidermal growth factor receptor (EGFR) and its associated signaling pathways. (bvsalud.org)
Enhancers1
Widespread transcription at neuronal activity-regulated enhancers. (neurotree.org)
Neurons1
Overexpression of ClpP reduces αSyn-induced mitochondrial oxidative stress through enhancing the level of Superoxide Dismutase-2 (SOD2), and suppresses the accumulation of αSyn S129 phosphorylation and promotes neuronal morphology in neurons derived from PD patient iPS cells carrying αSyn A53T mutant. (springer.com)
Despite the expression of multiple Rho GDP/GTP exchange factors (GEFs) in the nervous system, the Kalrn gene, which encodes multiple isoforms of Kalirin, plays an essential, non-redundant role. (biomedcentral.com)
CP190 is an essential transcription factor and preferentially binds to housekeeping gene promoters and insulators through interactions with architectural proteins, including Su(Hw) and dCTCF. (bvsalud.org)
Brain development is a complex process achieved in a remarkably controlled spatial and temporal manner through coordinated cellular and molecular events. (ehu.eus)
American Journal of Physiology-Lung Cellular and Molecular Physiology. (ufl.edu)
Repressor2
Bhlhb5 and Prdm8 form a repressor complex involved in neuronal circuit assembly. (neurotree.org)
p200 CUX1 acts as a transcriptional repressor, whereas short CUX1 isoforms can activate or suppress transcription [ 1 , 3 ]. (nature.com)
Insights2
New Molecular Insights into the Excitation-Transcription Coupling. (neurotree.org)
Our findings provide novel insights into the mechanism underlying αSyn-induced neuronal pathology, and they suggest that ClpP might be a useful therapeutic target for PD and other synucleinopathies. (springer.com)
Mechanism2
This study delineates the clinical presentation in an extended cohort and investigates the molecular mechanism underlying the disorder in a Cux1 +/− mouse model. (nature.com)
My lab has pioneered research on the role of circadian rhythms and the molecular clock mechanism in skeletal muscle homeostasis and health. (ufl.edu)
Proteins7
CUX1 isoforms are transcription factors, whereas CASP are Golgi proteins that share with CUX1 the N-terminal region but not the DNA binding motifs [ 2 ]. (nature.com)
Although studies suggest that αSyn and its missense mutant, A53T, preferentially accumulate in the mitochondria, the mechanisms by which αSyn and mitochondrial proteins regulate each other to trigger mitochondrial and neuronal toxicity are poorly understood. (springer.com)
these multidomain guanine nucleotide exchange factors (GEFs) contain additional domains known to interact with phosphatidylinositides as well as with a number of different proteins. (biomedcentral.com)
Due to the central role of autophagy in the removal of aggregation-prone proteins, a better understanding of mechanisms controlling autophagy is essential for the identification of novel therapeutic opportunities for multiple disease states. (elifesciences.org)
A hallmark of events observed during segmentation was the induction of multiple transcription factors, including a large group of homeobox proteins in pace with decay of a large fraction of maternal transcripts. (biomedcentral.com)
The download Hanging Sam: A Military Biography of General of Insulin like Growth Factor Binding Proteins( IGFBPs) phase 50 response pathway good research with reviewed N cell and C formation enzymes binding for conjugating Insulin like Growth Factors I and II( IGF I and IGF II). (evakoch.com)
MSY3 (MSY4, YB-2, CSDA, dbpA, ZONAB) is a member of the cold shock domain (CSD) family of proteins also known as Y-box proteins, which are evolutionarily conserved proteins that function as transcription factors and regulators of RNA metabolism and protein synthesis. (biomedcentral.com)
Vitro2
Silencing of HDAC9 inhibited neuronal apoptosis and inflammatory factor release in vitro. (wikipedia.org)
Silencing of HDAC9 diminished OGD-induced neuronal apoptosis and inflammatory factor release in vitro as well as ischemic brain injury in vivo by regulating the miR-20a/NeuroD1 signaling. (wikipedia.org)
Embryonic development2
Multiple mutations affecting embryonic development have been induced by chemical and insertional mutagenesis resulting in the identification of genes with important roles in development in Drosophila [ 23 - 25 ]. (biomedcentral.com)
The bHLH transcription factor TWIST1 plays a key role in the embryonic development and in tumorigenesis. (biomedcentral.com)
Genes3
Forced expression of Hdac9 in denervated muscle prevents upregulation of activity-dependent genes and chromatinacetylation by linking myocyte enhancer factor 2 (MEF2) and class I HDACs. (wikipedia.org)
In this review, we focus on the role of cardiomyocyte-derived and cardiac fibroblast-derived microRNAs that are involved in the regulation of genes associated with cardiomyocyte and fibroblast function and in atherosclerosis-related cardiac ischemia. (archivesofmedicalscience.com)
Using genetic mouse models, we found that mutations of two different molecular clock genes, Clock and Bmal1, dramatically disrupt skeletal muscle structure and function. (ufl.edu)
Skeletal muscle5
Its importance has been documented in a number of physiologic and pathologic conditions including neuronal and muscle development, lymphocyte activation, cardiac hypertrophy, switching of skeletal muscle fiber type, and expression of ion channels. (pancreapedia.org)
The Y-box protein MSY3/Csda represses myogenin transcription in skeletal muscle by binding a highly conserved cis-acting DNA element located just upstream of the myogenin minimal promoter (myogHCE). (biomedcentral.com)
The lab is also pursuing the role of physical activity/exercise as a time cue for skeletal muscle and other tissues. (ufl.edu)
Our research goals are to define the transcriptional networks and downstream mechanisms that link the molecular clock with proper skeletal muscle function and phenotype. (ufl.edu)
Represses1
It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. (wikipedia.org)
Transcriptional1
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. (wikipedia.org)
Tumor3
This case illustrates the diagnostic workup and treatment of a rare tumor in adults showing the importance of molecular and histological studies for the treatment and counseling of the patient. (surgicalneurologyint.com)
John Cunningham polyomavirus (JC Virus) T-antigen was identified in MB cells, suggesting a role of this viral infection in tumor physiopathology. (surgicalneurologyint.com)
Glia-derived tumor necrosis factor acts through its neuronal receptor to maintain calcium channel expression after injury. (bvsalud.org)
Lacks1
Despite these findings suggesting that mitochondria might be a key link between αSyn toxicity and neuronal degeneration in PD, the field still lacks an understanding of how αSyn abnormality and mitochondrial functional deficiency influence each other. (springer.com)
Regulate1
A retrograde neuronal survival response: target-derived neurotrophins regulate MEF2D and bcl-w. (neurotree.org)
Understood2
How this structural plasticity is achieved at the molecular level is not well understood. (jneurosci.org)
While all of the above support crucial roles of CUX1/Cux1 in human neurodevelopment, these are only partially understood. (nature.com)
Activate1
Glia also release adenosine which signals through neuronal adenosine receptor (AdoR) to activate HCN channels (Ih) and dampen Ca2+ transients. (bvsalud.org)
BHLH1
TWIST1 is a transcription factor belonging to the basic helix-loop-helix (bHLH) superfamily. (biomedcentral.com)
Complexes1
While the RNA components of the mitoribosome are mitochondrially-encoded, all MRPs and assembly factors are encoded in the nuclear genome, thus requiring coordination between two genomes for the assembly of these macromolecular complexes. (nature.com)
Activity2
Fiore R, Khudayberdiev S, Christensen M, Siegel G, Flavell SW , Kim TK , Greenberg ME , Schratt G. Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels. (neurotree.org)
ATP-dependent Clp protease (ClpP), a mitochondrial matrix protease, plays an important role in regulating mitochondrial protein turnover and bioenergetics activity. (springer.com)
Mechanisms1
Although the functional impacts of many TWIST1 mutations have been experimentally reported, little is known on the molecular mechanisms underlying their loss-of-function. (biomedcentral.com)
The TWIST1 protein is highly conserved from Drosophila to humans, where it plays a key role during embryonic morphogenesis, mesoderm patterning and development. (biomedcentral.com)
Protein2
This encoded protein may play a role in hematopoiesis. (wikipedia.org)
In the pancreatic acinar cell CN plays a role in mediating the action of elevated Ca 2+ to stimulate cell division, pancreatic growth and protein synthesis. (pancreapedia.org)
Transcripts1
We report a study of early Atlantic cod development that used a genome-wide oligonucleotide microarray to examine the composition and putative roles of polyadenylated transcripts. (biomedcentral.com)
Human2
Initially, two‐dimensional neural cultures presented an innovative landmark for investigating human neuronal and, more recently, glial biology, as well as for modeling brain neurodevelopmental and neurodegenerative diseases. (ehu.eus)
Additionally we are working in mouse and human models to determine the potential for time of day lifestyle interventions as a therapeutic approach to enhance molecular clock function and attenuate conditions of muscle weakness and wasting seen with aging and chronic diseases. (ufl.edu)
After transcription, Pri-miRNA is cleaved by the enzymatic complex DROSHA into a micro-RNA precursor (pre-miRNA). (archivesofmedicalscience.com)
Results1
Data partially confirmed earlier results and showed that variants in CDKN2B-AS1, RP1, and HDAC9 could be genetic susceptibility factors for IA in a Chinese population. (wikipedia.org)
Function1
In a previous study, we highlighted the predictive value of in silico molecular dynamics (MD) simulations in deciphering the molecular function of TWIST1 residues. (biomedcentral.com)
Major1
There are four major subgroups according to molecular configuration: wingless (WNT), sonic hedgehog (SHH), group 3, and group 4 with differences between them according to prognostic outcomes. (surgicalneurologyint.com)
Studies2
Numerous studies suggest a key role for αSyn in the pathogenesis of PD. (springer.com)
Studies on Kalirin have focused on cortex and hippocampus, where Kal7 has a clear role in spine formation and maintenance. (biomedcentral.com)
Exercise1
An increase in exercise after molecular modifications was also observed in several of our piggyBac chimeras which includes the GAL4 piggyBac which displayed a fluctuated action that was often higher compared to the wild kind piggyBac transposase. (p450inhibitors.com)
Point1
Here, since the substitution of the arginine 154 amino acid by a glycine residue (R154G) is responsible for the SCS phenotype and the substitution of arginine 154 by a proline experimentally decreases the dimerizing ability of TWIST1, we investigated the molecular impact of this point mutation using MD approaches. (biomedcentral.com)