Role in cardiac. Medical search. Frequent questions

Cardiac events such as myocardial infarction (MI), in which tissue is damaged, leading to fibrosis and possibly heart failure, offer a particularly compelling area for implementing regenerative medicine. (jax.org)
In mammals, fibrosis following cardiac injury results in stiffer, less compliant cardiac muscle, contributing to failure. (jax.org)
CRT effects are related to alterations in genes and microRNAs (miRs) expression, which regulate cardiac processes involved in cardiac apoptosis, cardiac fibrosis, cardiac hypertrophy and angiogenesis, and membrane channel ionic currents. (hindawi.com)
Heart failure (HF) disease progression is related to numerous adaptive processes including cardiac fibrosis, hypertrophy and apoptosis by activation of the 'fetal' gene program and downregulation of mRNA signatures, suggesting the importance of molecular mechanisms that suppress mRNA steady-state levels. (elsevierpure.com)
In this updated critical appraisal we report on the main miRs that play a key role in response to cardiac resynchronization therapy (i.e., responder vs nonresponder HF patients), focusing on the miR-mediated modulation of cardiac angiogenesis, apoptosis, fibrosis and membrane ionic currents. (elsevierpure.com)

While echocardiography and cardiac magnetic resonance imaging remain at the forefront of diagnosing and monitoring patients with heart failure, cardiac computed tomography (CT) has largely been considered to have a limited role. (kcl.ac.uk)
These cardiac techniques are otherwise referred to as echocardiography , Cardiac MRI , Cardiac CT , Cardiac PET and Cardiac SPECT including myocardial perfusion imaging . (wikipedia.org)
Echocardiography and cardiac magnetic resonance imaging are fundamental techniques for the diagnosis, characterization, and evaluation of tumor extension. (scielo.edu.uy)
This educational activity will review the importance of understanding the different types of cardiac masses seen by echocardiography. (philips.com)
Because of the possibility that the disorder is familial, it is recommended that family members have clinical evaluation for possible cardiac events (eg, syncope, palpitations) and limited testing, including ECG, exercise stress testing, and echocardiography. (msdmanuals.com)

In selected patients affected by HF and severe dysfunction of left ventricle ejection fraction (LVEF), with left bundle brunch block, the cardiac resynchronization therapy with a defibrillator (CRT) is the treatment of choice to improve symptoms, NYHA class, and quality of life. (hindawi.com)
In patients under optimal medical therapy with moderate to severe HF and cardiac dyssynchrony, cardiac resynchronization therapy (CRT) with a defibrillator improves contractile function and reverse ventricular remodeling, ameliorating symptoms, quality of life (QoL), and clinical outcomes [ 7 , 8 ]. (hindawi.com)
2 In the past decade, cardiac resynchronization therapy (CRT), achieved by simultaneous LV and right ventricular (RV) pacing, has emerged as a potent therapeutic option that improves the quality of life and functional status of patients with congestive heart failure, as well as prolongs survival. (amrita.edu)
Cardiac resynchronization therapy improves cardiac performance and myocardial mechanical efficiency. (elsevierpure.com)

Modifications of cardiac inward rectifier potassium currents including IK1 are known to play an important role in the pathogenesis of various types of arrhythmias including those observed under alcohol intoxication. (muni.cz)
The incidence and clinical significance of cardiac arrhythmias during long-term exposure to microgravity experienced on the International Space Station (ISS) or during a prolonged (that is, up to 3 years) sojourn to Mars or on the Moon are a concern for the National Aeronautics and Space Administration (NASA). (wikipedia.org)
At present, there are only anecdotal reports of cardiac arrhythmias in space, including one documented episode of non-sustained ventricular tachycardia. (wikipedia.org)
Concurrent with efforts by Flight Medicine to improve screening techniques, as NASA enters the era of exploration class missions, it will be critical to determine with the highest degree of certainty whether space flight by itself alters cardiac structure and function sufficiently to increase the risk for arrhythmias. (wikipedia.org)
From a clinical perspective, according to the "biological model" of sudden cardiac death, both the substrate and the trigger for arrhythmias should be considered to determine whether long-term space flight could lead to an increased risk of sudden death. (wikipedia.org)
While there are no definitive data showing that long-duration space flight is associated with cardiac arrhythmias, there are observational data that have been documented over many years that are suggestive of cardiac electrical changes during long flights. (wikipedia.org)
This raises the possibility that exposure to environmental PAHs in many animals -- including humans -- could lead to cardiac arrhythmias and bradycardia, or slowing of the heart. (ibtimes.com)
In conclusion, decreased or increased protein expression of several TRPM4 variants linked to cardiac conduction disorders or ventricular arrhythmias were found to be caused by altered TRPM4 half-life compared to the WT form. (frontiersin.org)
In response, international regulatory agreements were developed that mandate testing of all new drugs, both cardiac and non-cardiac, for cardiac liability, including drug-induced long QT interval (LQT) and risk for development of life-threatening arrhythmias, such as Torsade de Pointes (TdP) 5 . (nature.com)

What's the role of defibrillation during a sudden cardiac arrest (SCA) and how does an automated external defibrillator (AED) work? (stryker.com)
Unlike a heart attack, there is rarely any warning before a sudden cardiac arrest. (stryker.com)
While CPR is critical immediately following a sudden cardiac arrest, using an AED in tandem with CPR within a few minutes of the event is crucial to prevent death. (stryker.com)
In fact, a cardiac arrest victim's chance of survival decreases by 7 to 10 percent for every minute without defibrillation. (stryker.com)
Medical intervention succeeds best when administered to or performed on the right patient at the right time, and the use of epinephrine in treating a victim of cardiac arrest is no different. (ems1.com)
A randomized trial of epinephrine in out-of-hospital cardiac arrest. (ems1.com)
Cardiac arrest frequently happens at home, and victims don't always have someone around to call for help. (engadget.com)
University of Washington researchers have crafted a proof-of-concept AI that can detect the audio cues of cardiac arrest and respond accordingly. (engadget.com)
The system is trained on 911 call samples to listen for the telltale sounds of agonal breathing (that is, distinctive gasps for air) that come with cardiac arrest. (engadget.com)
MAs may be manifested either in hemodynamic collapse or in cardiac arrest: The sudden loss of effective blood flow due to atrial fibrillation (AF) with rapid VT leads to hemodynamic collapse, and VT and VF result in cardiac arrest necessitating CPR or electric defibrillation. (medscape.com)
What is sudden cardiac arrest (SCA)? (medlineplus.gov)
Sudden cardiac arrest (SCA) is a condition in which the heart suddenly stops beating. (medlineplus.gov)
How is sudden cardiac arrest (SCA) different from a heart attack? (medlineplus.gov)
Who is at risk for sudden cardiac arrest (SCA)? (medlineplus.gov)
What are the symptoms of sudden cardiac arrest (SCA)? (medlineplus.gov)
How is sudden cardiac arrest (SCA) diagnosed? (medlineplus.gov)
Cardiac Arrest Cardiac arrest is the cessation of cardiac mechanical activity resulting in the absence of circulating blood flow. (msdmanuals.com)
Cardiac arrest stops blood from flowing to vital organs, depriving them of. (msdmanuals.com)
Ventricular fibrillation is much less common among infants and children, in whom asystole is the more common presentation of cardiac arrest. (msdmanuals.com)

The novel mechanism of action on cellular compartments has been found continually, which opens a new way for their potential application in cardiac failure and other cardiac events like post-myocardial infarction. (benthamscience.com)
Cardiac hypertrophy primarily happens when the myocardium's total volume is increased and its contractility is strengthened due to prolonged myocardial pressure overload. (alliedacademies.org)
Myocardial ischemia results when the blood supply from the coronary arteries is unable to keep up with the increased oxygen demand of the myocardium due to cardiac hypertrophy. (alliedacademies.org)
We enrolled women who had myocardial infarction (MI) and were being referred for cardiac catheterization to evaluate their MI. (medscape.com)

Combined, these physiologic adaptations suggest that changes in cardiac structure and neurohumoral environment during space flight could alter electrical conduction, although the evidence supporting this contention consists mostly of minor changes in QT interval in a small number of astronauts after long-duration space flight. (wikipedia.org)
Despite recent findings regarding the functional implications of TRPM4 in cardiac diseases, the molecular and cellular mechanisms leading to altered conduction are poorly understood. (frontiersin.org)
His son presented with cardiac conduction disturbance with no congenital heart or skeletal defect. (medscape.com)

Conclusions: We conclude that the observed changes of IK1 under clinically relevant concentrations of acetaldehyde might contribute to the alcohol-induced alterations of the cardiac electrophysiology, namely in people with a genetic defect of aldehyde dehydrogenase and, thus, higher plasma levels of acetaldehyde who are often native to Asia. (muni.cz)
Here we show, computationally and experimentally, the limits of all-optical electrophysiology when applied to drug testing, then implement and validate OptoDyCE, a fully automated system for all-optical cardiac electrophysiology. (nature.com)

The heart can maintain regular blood flow thanks to cardiac hypertrophy. (alliedacademies.org)
Heart failure and palpitations are two of the main signs and symptoms of cardiac hypertrophy, along with dyspnea, chest pain, exhaustion, wooziness and fainting. (alliedacademies.org)

Diabetic cardiac autonomic neuropathy is a common and serious chronic complication of diabetes, which can lead to sympathetic and parasympathetic nerve imbalance and a relative excitation of the sympathetic nerve. (bvsalud.org)
This "heart rate variability (HRV) analysis" provides a substantial amount of additional information about the cardiovascular system and enables quantification of cardiac regulatory influences on the autonomic nervous system. (nursingcenter.com)
2017) Affect during incremental exercise: The role of inhibitory cognition, autonomic cardiac function, and cerebral oxygenation. (bvsalud.org)

Cardiac ischemia-reperfusion injury (IRI) occurs intra-operatively during heart transplantation (HTx), underpinning graft survival. (uwo.ca)
Cardiac ischemia-reperfusion injury (IRI) occurs when transplanting a heart from donor to recipient. (uwo.ca)
The "ischemia" phase of cardiac IRI occurs when the donor heart is being collected and blood/oxygen is not going to the heart. (uwo.ca)

Pediatric patients undergoing cardiac procedures are at risk for bleeding and thrombosis complications. (pcics.org)

[1] Stress cardiac imaging is discouraged in the evaluation of patients without cardiac symptoms or in routine follow-ups. (wikipedia.org)
SCDs in psychiatric patients compared to nonpsychiatric patients were more often unexplained (65% vs 40%, P = .02), and cardiac symptoms were reported prior to death in 46% of psychiatric patients. (psychiatrist.com)
Since almost 50% had possible cardiac symptoms prior to death, cardiovascular risk monitoring and management in the mentally ill are essential. (psychiatrist.com)

Cardiac surgery-associated acute kidney injury (CSA-AKI) occurs in ≥50% of patients with chronic kidney disease (CKD) undergoing cardiac surgery with cardiopulmonary bypass (CPB) 2 . (nature.com)
Patients with pre-existing CKD undergoing cardiac surgery are at higher risk of perioperative AKI compared to those without CKD. (nature.com)
Studies of renal transplant recipients and patients undergoing cardiac surgery suggest that damage and inflammation caused by IRI and CPB is amplified by complement activation 4 . (nature.com)
In fact, in the Multicenter Automatic Defibrillator Implantation Trial with CRT (MADIT-CRT) and the Cardiac Resynchronization-HF (CARE-HF), the mean age of enrolled patients was 65 and 66.4, respectively [ 11 , 12 ]. (hindawi.com)
Lauren Graf, M.S., R.D., is the nutritionist for the Montefiore-Einstein Cardiac Wellness Program, providing both individual counseling and group teaching to patients. (montefiore.org)
We intend to investigate the effect of GTN in patients undergoing cardiac surgery being subjected to RIPC in its role as a Nitric Oxide (NO) donor. (druglib.com)
With the advancements in scanner design, technology, and computer processing power, cardiac CT is now emerging as a valuable adjunct to clinicians managing patients with heart failure. (kcl.ac.uk)
In the current manuscript, we review the current applications of cardiac CT to patients with heart failure and also the emerging areas of research where its clinical utility is likely to extend into the realm of treatment, procedural planning, and advanced heart failure therapy implementation. (kcl.ac.uk)
Medical specialty professional organizations discourage the use of routine cardiac imaging during pre-operative assessment for patients about to undergo low or mid-risk non-cardiac surgery because the procedure carries risks and is unlikely to result in the change of a patient's management. (wikipedia.org)
The incidence of sudden cardiac death (SCD) in psychiatric patients is unknown in a nationwide setting. (psychiatrist.com)
PURPOSE: To determine the diagnostic performance of weight loss to identify fat mass loss in cardiac rehabilitation (CR) patients. (nursingcenter.com)
The unit opened today will serve cardiac surgery patients, while the first 36-bed unit, which opened in November, serves structural heart disease patients who have complex disorders and diseases of the heart. (prnewswire.com)
With this much-needed expansion complete, we will be able to offer exemplary cardiac care to more patients who trust Morristown Medical Center's experts with their hearts," said Linda D. Gillam , MD, MPH, MACC the Dorothy and Lloyd Huck Chair of Cardiovascular Medicine at Morristown Medical Center and medical director of the cardiovascular service line for Atlantic Health System. (prnewswire.com)
In addition to 72 new private patient rooms, the 55,400 square foot addition increases clinical space and adds a dedicated MRI, for the exclusive use of cardiac patients. (prnewswire.com)
Isogai T, Yasunaga H, Matsui H, Tanaka H, Hisagi M, Fushimi K. Factors affecting in-hospital mortality and likelihood of undergoing surgical resection in patients with primary cardiac tumors. (medscape.com)

Malignant cardiac tumors are rare neoplasms that can present in various forms, making their diagnosis difficult. (scielo.edu.uy)
The role of orthotopic heart transplantation for malignant cardiac tumors continues to be debated. (medscape.com)
Primary cardiac tumors: 32 years of experience from a Spanish tertiary surgical center. (medscape.com)

Although the "gold standard" for this purpose is the pathological study (obtained by biopsy or surgical resection), in cases where this is not possible, cardiac resonance is the non-invasive technique that provides a better diagnostic approach. (scielo.edu.uy)

It is distinct from structural cardiac disorders such as coronary artery disease, valvular disorders, and congenital heart disorders. (msdmanuals.com)

Cardiac imaging refers to minimally invasive imaging of the heart using ultrasound , magnetic resonance imaging (MRI), computed tomography (CT), or nuclear medicine (NM) imaging with PET or SPECT . (wikipedia.org)

a cardiologist, is the founder and co-director of the Montefiore-Einstein Cardiac Wellness Program, an associate professor of Clinical Medicine at the Albert Einstein College of Medicine, and the associate director of the Cardiology Fellowship at Montefiore-Einstein. (montefiore.org)
The clinical cardiac MRI scan is performed using magnets of high field strength (1.5 or 3 Tesla), multichannel phased-array coils, parallel imaging techniques and echocardiogram gating. (ecrjournal.com)
Siontis BL, Leja M, Chugh R. Current clinical management of primary cardiac sarcoma. (medscape.com)
In the last 40 years, over 20% of drugs discontinued at all phases of development, including discovery, preclinical and clinical evaluation, and post-market surveillance has been due to cardiac toxicity, where unintended interactions with cardiac ion channels result in pro-arrhythmic effects 4 . (nature.com)

Complete surgical excision remains the mainstay of therapy for primary cardiac sarcoma, followed by radiotherapy with or without sequential chemotherapy. (medscape.com)
In one case report, preoperative chemotherapy reduced the size of an unresectable undifferentiated cardiac sarcoma, allowing complete resection of residual tumor. (medscape.com)
Cardiac sarcoma is rarely cured, but prolonged survival or significant palliation is possible with surgical resection. (medscape.com)
Complete or partial excision of primary or metastatic cardiac sarcoma can provide hemodynamic improvement and relief from congestive heart failure. (medscape.com)

Heart failure is the inability of the cardiac systolic and/or diastolic functions to completely empty the veins of the heart's blood, which ultimately results in venous system blood stasis and inadequate arterial blood perfusion. (alliedacademies.org)
Heart failure also causes a condition known as cardiac circulation disorder, which shows up as pulmonary and venous congestion. (alliedacademies.org)
The research team led by Professor Jakovljevic developed an easy-to-use, non-invasive, patient friendly Cardiac Output Response to Stress (CORS) test to enhance risk stratification and early diagnosis of heart failure (HF) in primary care. (jobs.ac.uk)
Its expert team presents research across the world and is comprised of cardiac surgeons and interventional cardiologists, electrophysiologists, heart failure experts, and advanced imagers. (prnewswire.com)

Acute kidney injury (AKI) is a major concern following cardiac surgery and has the potential to significantly impact patient outcomes. (nature.com)
Furthermore, as cardiac IRI results in poor outcomes for the patient, we may be able to use research in this field to help future recipients. (uwo.ca)

HRV analysis therefore provides a noninvasive method for investigating the dynamic influence of changing physiological parameters on cardiac regulation. (nursingcenter.com)

This is known as the "reperfusion" phase in cardiac IRI. (uwo.ca)

and Lawrence-Douglas County Fire and Medical's Kevin Joles, NREMT-P, discuss where epi lives within the wheel of survival in the seven steps outlined in this advanced cardiac resuscitation toolkit. (ems1.com)

Women who had MINOCA had multivessel optical coherence tomography (OCT) of the coronary arteries, and then cardiac MRI within a week. (medscape.com)

Several parameters, such as ejection fraction, chamber volumes and cardiac mass, can be quantified. (ecrjournal.com)

A physician may recommend cardiac imaging to support a diagnosis of a heart condition. (wikipedia.org)

The role of intracellular calcium in antimony -induced toxicity in cultured cardiac myocytes. (cdc.gov)

Pathological variants in TRPM4 gene have been linked to several cardiac phenotypes such as complete heart block (CHB), ventricular tachycardia, and Brugada syndrome (BrS). (frontiersin.org)

In this trial [ 23 ] the role of diabetes mellitus has been analyzed as predictor of appropriate/inappropriate internal defibrillator therapy. (hindawi.com)
Role of purinergic receptors in cardiac sympathetic nerve injury in diabetes mellitus. (bvsalud.org)
This paper introduces the abnormal changes of sympathetic nerve in diabetes mellitus and summarizes the recently published studies on the role of several purinergic receptor subtypes in diabetic cardiac sympathetic nerve injury . (bvsalud.org)

A new study has found that a chemical found in crude oil slows the fish's heart rates, reduces cardiac contractility and causes irregular heartbeats. (ibtimes.com)
The research, which was conducted on the tuna population, found that the mixture of chemicals found in the oil slows the fish's heart rates, reduces cardiac contractility and causes irregular heartbeats. (ibtimes.com)
What we found was that oil blocked key processes in the cardiac cells involved with linking excitation to contraction, which means that beat to beat, we slowed the heart cells down and we also decreased their contractility," Block told BBC. (ibtimes.com)

The Cardiac Wellness Program at Montefiore brings a unique, nutrition-centered approach to the management of cardiovascular disease. (montefiore.org)
Hollenberg N. The role of β-blockers as a cornerstone of cardiovascular therapy. (benthamscience.com)
Improved wound healing due to cardiac overexpression RNA m5C modification's emerging role in Cardiovascular Diseases. (alliedacademies.org)
We were thrilled to have a role in shaping cardiovascular care in our community. (prnewswire.com)
In this article, we discuss the current role and applications of cardiovascular MRI. (ecrjournal.com)
1 Department of Regenerative Medicine and Advanced Cardiac Therapeutics, 2 Cardiology Division, Department of Internal Medicine, 3 Department of Cardiovascular Surgery, 4 Division of Diagnostic Pathology, 5 Department of Pathology, Keio University School of Medicine, Tokyo, Japan. (jci.org)

Mycobacterial infections resulting from cardiac implantable electronic devices are rare, but as more devices are implanted, these organisms are increasingly emerging as causes of early-onset infections. (cdc.gov)
We report a patient with an implantable cardioverter-defibrillator pocket and associated bloodstream infection caused by an organism of the Mycobacterium fortuitum group, and we review the literature regarding mycobacterial infections resulting from cardiac device implantations. (cdc.gov)
Infection is an uncommon but potentially devastating complication of cardiac implantable electronic device (CIED) implantation ( 1 ). (cdc.gov)

The CORS test measures haemodynamic function (cardiac output, stroke volume, heart rate, and blood pressure) at rest- (supine), challenge- (standing), and stress-(step-exercise) phases. (jobs.ac.uk)
Both elements play a vital role in how heart cells function. (ibtimes.com)
The protein ion channels we observe in the tuna heart cells are similar to what we would find in any vertebrate heart and provide evidence as to how petroleum products may be negatively impacting cardiac function in a wide variety of animals," Block said. (ibtimes.com)
However, the physiological role for this channel in cardiac function remains unclear. (frontiersin.org)
Cine steady-state free precession (SSFP) sequences are used in the evaluation of cardiac morphology and function and are acquired in several dimensions, such as the short axis and horizontal long axis planes and the two-chamber, three-chamber and four-chamber projections. (ecrjournal.com)

Antimony alters kinetics of calcium transients of neonatal rat cardiac myocytes. (cdc.gov)

Yet, most cardiac malformations remain a mystery as scientists and clinicians continue to examine how inherited mutations and aging affect the normal biological functions of proteins associated with cardiac dysfunction. (wichita.edu)

It can also be used during cardiac surgery to monitor the patient and assess the success of surgical interventions. (wikipedia.org)
Morristown Medical Center, the hub of heart care at Atlantic Health System, is one of the top 30 programs in the country (#26) for Cardiology & Cardiac Surgery ( U.S. News & World Report ) and one of America's 100 Best Hospitals for Cardiac Care (Healthgrades). (prnewswire.com)

Cardiac inward rectifier potassium current IK1 is inhibited by acetaldehyde at clinically relevant concentrations: a role in arrhythmogenesis related to alcohol consumption? (muni.cz)
Sudden cardiac death from acute fluoride intoxication: the role of potassium. (cdc.gov)

Accordingly, these cardiac rhythm disturbances are labeled as MAs. (medscape.com)

We first investigated the utility of TEG for blood product management after cardiac surgical procedures. (pcics.org)
Cardiac Diagnostic And Surgical Facilities In The U.S. (cdc.gov)

Antimony induction of heat shock proteins in neonatal rat cardiac myocytes. (cdc.gov)

these miRs are also regulated in cardiac disease. (elsevierpure.com)

We proposed to investigate the roles of cardiac lymphatic vessels in revascularization and immune modulation, two processes important for heart regeneration. (dtic.mil)
Diabetic cardiac sympathetic nerve injury affects the expression of purinergic receptors , and activated purinergic receptors affect the phosphorylation of different signaling pathways and the regulation of inflammatory processes. (bvsalud.org)

Antimony attenuates mobilization of CA during excitation and contraction in cultured cardiac myocytes. (cdc.gov)

At Alexion, AstraZeneca Rare Disease, we are committed to continuing to investigate the potential role of the complement system in various diseases and accelerating the discovery and development of new therapies. (nature.com)

1980. Biochemical mechanisms in chemical-induced lung injury: roles of metabolic activation. (cdc.gov)

The specific aims: 1a) to investigate whether the protective effects of beta2AR activation are mediated by cardiac or non-cardiac beta2ARs using conventional beta2KO and conditional cardiac-specific beta2KO mice. (nebraska.edu)

Antimony -induced alterations in thiol homeostasis and adenine nucleotide status in cultured cardiac myocytes. (cdc.gov)

Learn about the methods used to measure cardiac troponin, a protein released into the bloodstream during a heart attack, and the benefits of sensitive new technologies for earlier detection in the emergency department. (siemens-healthineers.com)

Anatomy29

Organisms10

Diseases51

Chemicals and Drugs43

Analytical, Diagnostic and Therapeutic Techniques and Equipment75

Phenomena and Processes44

Disciplines and Occupations5

Information Science2

Health Care24

Fibrosis5

Echocardiography5

Resynchronization therapy4

Arrhythmias9

Arrest19

Myocardial4

Conduction3

Electrophysiology2

Hypertrophy2

Autonomic3

Ischemia3

Undergoing cardiac procedures1

Symptoms3

Patients15

Tumors3

Possible cardiac1

Structural cardiac1

Magnetic resonance1

Clinical4

Sarcoma4

Heart failure4

Outcomes2

Changing physiological1

Reperfusion1

Resuscitation1

Coronary arteries1

Ejection fraction1

Diagnosis1

Toxicity1

Ventricular1

Diabetes mellitus3

Contractility3

Cardiovascular6

Implantable3

Function5

Alters1

Dysfunction1

Surgery2

Potassium2

Rhythm1

Surgical2

Proteins1

MiRs1

Processes2

Excitation1

Continuing to investigate1

Injury1

Investigate1

Alterations1

Protein1