Loading...
  • diseases
  • These syndromes may also be associated with immunological diseases and may exhibit distinct phenotypic characteristics. (medscape.com)
  • In developed societies, where the incidence of a clutch of chronic and so-called lifestyle diseases has risen as the threat of infectious disease has retreated, disturbances in the relationship between our external and microbial worlds have emerged as prime suspects in explaining rates of inflammatory bowel disease, colorectal cancer, allergies, asthma, rheumatoid arthritis, type 1 diabetes, multiple sclerosis, metabolic syndrome and obesity. (themonthly.com.au)
  • The epidemic increase in obesity has been paralleled by the rise in cardiovascular disease, type 2 diabetes, fatty liver, cirrhosis, asthma, neurodegenerative diseases, and certain types of cancer [ 1 , 2 ] and subsequently linked to reduced life expectancy and premature death [ 3 ]. (hindawi.com)
  • Obesity is the main cause of metabolic syndrome, which can lead to various complications, including hardening of the arteries and an increased risk of cardiovascular diseases. (hindawi.com)
  • Accordingly, understanding the mechanisms by which particular herbal medicines affect adipocyte differentiation could help prevent obesity and its associated diseases [ 2 ]. (hindawi.com)
  • The present paper focuses on the current status of our knowledge regarding chronic inflammation, a link between obesity and CVDs, including heart diseases, vascular disease and atherosclerosis. (pubmedcentralcanada.ca)
  • Moreover, the development of metabolic diseases induced by environmental factors during development is controlled by epigenetic regulation rather than the genetic regulation such as DNA sequence-dependent transcriptional regulation. (springer.com)
  • In this section, we introduce these epigenetic regulations and their relationship with nutrient intake and discuss the link between epigenetic regulation and the development of metabolic diseases. (springer.com)
  • While the term "pandemic" generally conjures images of a deadly virus or bacterium rapidly infecting a population, one of the most significant pandemics currently facing humanity is the global rise of diabetes and related metabolic diseases. (frontiersin.org)
  • NORD gratefully acknowledges Abhimanyu Garg, MD, Professor of Internal Medicine, Chief, Division of Nutrition and Metabolic Diseases, Distinguished Chair in Human Nutrition Research, UT Southwestern Medical Center at Dallas, for assistance in the preparation of this report. (rarediseases.org)
  • Effective management of cardiovascular related syndromes, especially cardiometabolic diseases, to improve the quality of life and reduce the overwhelming health care costs has become a burning issue for NIH and the American Heart and American Diabetes Associations. (uwyo.edu)
  • Increased fructose consumption has been suggested to contribute to non-alcoholic fatty liver disease (NAFLD), dyslipidemia, and insulin resistance, but a causal role of fructose in these metabolic diseases remains debated. (mdpi.com)
  • Finally, fructose-containing sugars are a major source of excess calories, suggesting that a reduction of their intake has potential for the prevention of NAFLD and other obesity-related diseases. (mdpi.com)
  • Systemic iron overload and the elevated level of ferritin, a ubiquitous intracellular protein that stores and releases iron to maintain the iron homeostasis in cells, has long been epidemiologically associated with obesity and obesity-related diseases. (genetics.org)
  • This study reveals a completely novel pathway in which sgk-1 plays a central role to synergistically regulate iron and lipid homeostasis, offering not only experimental evidence supporting a previously unverified link between iron and obesity, but also novel insights into the pathogenesis of iron and obesity-related human metabolic diseases. (genetics.org)
  • The role of sperm miRNA, not only as innovative markers of fertility issues but also as vectors involved in the inheritance of paternal diseases, appears to be crucial. (medworm.com)
  • Conclusions In conclusion, articles in this Research Topic made a very significant contribution to our understanding of the role played by environmental factors, dysbiotic conditions, and infections in triggering diseases. (medworm.com)
  • Future research needs to focus on confirming that the rodent findings are translatable to human physiology and to diseases such as irritable bowel syndrome, autism, anxiety, depression, and Parkinson's disease. (jci.org)
  • Adipose
  • After the acknowledgment of the adipose tissue (AT) as a true endocrine organ secreting hormones, cytokines, chemokines, and growth factors with influence on metabolism, vascular function, appetite and satiety, and fertility, among many others, came its recognition as a fundamental player in innate and acquired immune processes [ 4 ]. (hindawi.com)
  • Adipose tissue is recognized as an important player in obesity-mediated CVD. (pubmedcentralcanada.ca)
  • 2003). In addition to macrophages, mast cells are present in adipose tissue, playing a central role in the inflammatory process (Zhang & Shi 2012, Theoharides et al. (oulu.fi)
  • Components of the innate immune system in the muscle, bone, liver and adipose tissue, as well as macrophages, have been revealed to play a role in systemic insulin action. (springer.com)
  • lipid profile
  • Individuals with MetS, particularly those with abdominal obesity, exhibit a highly atherogenic lipid profile, which may account for their high risk of CVD. (hindawi.com)
  • type
  • The specific symptoms present, severity, and prognosis can vary greatly depending upon the specific type of acquired lipodystrophy and the presence and extent of associated symptoms. (rarediseases.org)
  • There was a graded increase in the proinflammatory cytokine IL-6 and acute-phase reactants such as C-reactive protein, with the highest levels observed in type 2 diabetic individuals with the metabolic syndrome, intermediate levels in type 2 diabetic individuals without the syndrome, and the lowest levels in controls. (springer.com)
  • peripheral
  • 1 Leptin has a variety of important central and peripheral actions to regulate energy balance and metabolism, fertility, and bone metabolism that are mediated by specific cell surface leptin receptors. (ahajournals.org)
  • CB1 receptors and their eCB ligands regulate energy balance across all vertebrate species in both the central nervous system and peripheral organs. (frontiersin.org)
  • physiological
  • Two important processes are evident: The first process is the biological embedding of early experiences, the subject of this symposium, that determines operating ranges of physiological systems for the effects of later experiences, and the second process is the cumulative wear and tear of the physical and social environment on the brain and body acting through the neuroendocrine, autonomic, metabolic, and immune systems. (pnas.org)
  • In order to illuminate the potential functional role that adult hypothalamic neurogenesis plays in the regulation of physiological processes, we developed a noninvasive focal irradiation technique to selectively inhibit the birth of adult-born neurons in the hypothalamic median eminence. (jove.com)
  • endocrine
  • Goal: To acquire and demonstrate the fund of knowledge and practical skills necessary to manage common and complex pediatric endocrine conditions in infants, children, and adolescents. (slideshare.net)
  • adipocyte differentiation
  • These results indicate that CDAP has a potent anti-obesity effect due to the inhibition of adipocyte differentiation and adipogenesis. (hindawi.com)
  • Researcher Shiwani Moghe, MS, has gone a step further, investigating whether blueberry polyphenols play a role in adipocyte differentiation. (t-nation.com)
  • Adipocyte differentiation is the process in which an unspecialized cell acquires specialized features of an adipocyte, a cell specialized for the synthesis and storage of body fat. (t-nation.com)
  • Hormones
  • These findings support the role of these 4 hormones as indicators of the patients nutritional status but not as mediators or potential therapeutic targets of the disease. (jove.com)
  • infertility
  • Non-hormonal treatment for male infertility: the potential role of Serenoa repens, selenium and lycopene. (medworm.com)
  • Finally, since prostatitis can affect the sperm quality and considering the anti-estrogenic properties of SrE, we speculate about a possible specific indication in those patients with male infertility and 'metabolic' prostatitis (where obesity and abnormal androgen/estrogen ratio concomitantly occur). (medworm.com)
  • overweight
  • Childhood obesity is on the rise, with 40% of children expected to be overweight by 2010. (diabetesjournals.org)
  • As a consequence, overweight and obesity are associated with increased risks for all-cause and cause-specific mortality [ 4 , 5 ]. (mdpi.com)
  • Overweight and obesity seem to alter sperm miRNA profile, thereby leading to transmission of different miRNA profiles in zygote, with consequences on embryo development. (medworm.com)
  • contributes
  • A habitually high intake of carbohydrates, and particularly fructose, e.g. with sweetened beverages , contributes to insulin resistance and has been linked to weight gain and obesity . (wikipedia.org)
  • Modernization of the world has further increased food availability and decreased energy expenditure, thus shifting the eCB/CB1R system into a state of hyperactive deregulated signaling that contributes to the 21st century metabolic disease pandemic. (frontiersin.org)
  • occurrence
  • Nowadays, the great attention paid to the occurrence of metabolic syndrome and its related aspects has allowed us to put more emphasis on diagnosis and treatment of this disorder. (hindawi.com)
  • preventive
  • PURPOSE: To describe screening measures that will determine which clients are at risk for the metabolic syndrome, common manifestations of the syndrome, preventive diagnostic considerations, and management and treatment options that primary care providers can implement. (mendeley.com)
  • Primary care providers need to be able to diagnose, treat, and provide preventive interventions for the metabolic syndrome. (mendeley.com)
  • Fatty
  • A combination of descriptors was used, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, metabolic syndrome and risk factors. (scielo.br)
  • Metabolic syndrome X. Fatty liver, non-alcoholic. (scielo.br)
  • 5 ) identify a syndrome characterized by the association of fatty liver and lobular hepatitis and chronically elevated alanine aminotransferase plasma levels in patients with negligible alcohol intake. (diabetesjournals.org)
  • inheritance
  • This alteration might be maintained in the zygote and throughout development, thereby leading to the inheritance of newly acquired pathologies. (medworm.com)
  • epigenetic
  • Epigenetic memories are acquired information included in the chromatin or DNA such as methylation and histone modifications. (springer.com)
  • These observations point to an underlying epigenetic process existing in the metabolic memory state. (jove.com)
  • hypothalamic
  • We investigated the role of methyl CpG binding protein (MeCP2) in the effects of prenatal ethanol on POMC gene expression and hypothalamic-pituitary-adrenal (HPA) axis function. (jove.com)
  • diabetic
  • Here we present the methods needed to successfully generate the diabetic and metabolic memory groups of fish and discuss the advantages of this model. (jove.com)
  • insufficiency
  • Modifiable, environmental causes of AD include potential metabolic derangements caused by dietary insufficiency and or excess that may be corrected by nutritional supplementation and or dietary modification. (frontiersin.org)
  • Likewise, models of estrogen insufficiency have unveiled new and unexpected roles for estrogens, in both males and females, many of which apply to the regulation of energy homeostasis [ 11 , 12 ]. (hindawi.com)