• FOXO4 is a member of the forkhead family transcription factors O subclass, which is characterized by a winged helix domain used for DNA binding. (wikipedia.org)
  • In this study, we demonstrate that Akt also regulates the activity of FKHRL1, a member of the Forkhead family of transcription factors. (scienceopen.com)
  • We have found that depressed FOXP2 [a member of the forkhead family of transcriptional regulators] and elevated levels of its upstream inhibitor microRNA 199a are prominent features of clinically advanced breast cancers that associate with poor patient survival. (newswise.com)
  • This protein is a transcription factor, which means it helps regulate the activity of other genes. (medlineplus.gov)
  • Specifically, the forkhead box G1 protein acts as a transcriptional repressor, turning off (repressing) the activity of certain genes when they are not needed. (medlineplus.gov)
  • The aim of the present work is to review cumulative evidence regarding the participation of PI3K pathways in neuronal function, focusing on their role in neuronal metabolism and transcriptional regulation of genes involved in neuronal maintenance and plasticity or on the expression of pathological hallmarks associated with neurodegeneration. (mdpi.com)
  • Forkhead box protein M1 (FOXM1) is a key transcription factor (TF) that regulates a common set of genes related to the cell cycle in various cell types. (mdpi.com)
  • gatae and otx genes provide input into the pregastrular regulatory system of foxa , and Foxa represses its own transcription,resulting in an oscillatory temporal expression profile. (biologists.com)
  • Further, the team used peripheral mononuclear blood cells (PBMCs) from healthy human donors to isolate RNA and test the expression of respective genes relative to β-Actin by reverse transcription-polymerase chain reaction (RT-PCR). (oullins-patriote.com)
  • Forkhead box protein O1 (FoXO1) is a transcription factor involved in the regulation of a wide variety of physiological process including glucose metabolism, lipogenesis, bone mass, apoptosis, and autophagy. (scienceopen.com)
  • Various modifications cooperate to regulate FoXO1 activity and FoXO1 target gene transcription. (scienceopen.com)
  • Considerable data support the idea that forkhead box O1 (Foxo1) drives the liver transcriptional program during fasting and is then inhibited by thymoma viral proto-oncogene 1 (Akt) after feeding. (nature.com)
  • Rather, they show that a major role of hepatic Akt is to restrain the activity of Foxo1 and that in the absence of Foxo1, Akt is largely dispensable for insulin- and nutrient-mediated hepatic metabolic regulation in vivo . (nature.com)
  • Here we show that adenoviral delivery of constitutively nuclear forkhead box O1 (FoxO1) to mouse liver results in steatosis arising from increased triglyceride accumulation and decreased fatty acid oxidation. (jci.org)
  • This unexpected dual role of FoxO1 in promoting insulin sensitivity and lipid synthesis in addition to glucose production has the potential to explain the peculiar admixture of insulin resistance and sensitivity that is commonly observed in the metabolic syndrome. (jci.org)
  • We have previously shown that the forkhead transcription factor FoxO1 is a prominent transcriptional effector of GLP-1 signaling in the β-cell. (diabetesjournals.org)
  • Forkhead Box Protein O1 ( Foxo1) is another essential transcription factor for IL-9 induction in Th cells. (oullins-patriote.com)
  • While they used Foxo1 fl/fl mice to study the role of IL-9, bronchoalveolar lavage fluid (BALF) from test animals' lungs helped them quantify IL-4/9/10 and interferon-gamma (IFN-γ) by enzyme-linked immunosorbent assay (ELISA). (oullins-patriote.com)
  • Both PI3K and AKT modify FOXO4 and prevent it from translocating to the nucleus, effectively preventing the transcription of the downstream FOXO targets. (wikipedia.org)
  • FOXO transcription factors have been shown to be the down downstream effector molecules of insulin-like growth factor (IGF) signaling pathway. (wikipedia.org)
  • FoxO transcription factors are considered effectors of the pathway regulating hepatic glucose production. (jci.org)
  • Second, we deduced the forkhead transcription factor (FOXO) familty to be a downstream mechanis through which SIRT1 regulates cocaine action. (upenn.edu)
  • FOXO proteins are a subgroup of the Forkhead family of transcription factors. (paleovegeo.com)
  • Here we show that the mammalian SIR2 ortholog SIRT1 deacetylates and represses the activity of the forkhead transcription factor Foxo3a and other mammalian forkhead factors. (scienceopen.com)
  • FOXO3a (forkhead box transcription factor 3a) is involved in regulating multiple biological processes in cancer cells. (chinaphar.com)
  • In this study we investigated the role of FOXO3a in regulating the sensitivity of glioma cells to temozolomide (TMZ) and its relationship with BNIP3-mediated mitophagy. (chinaphar.com)
  • In U87 and U251 cells, TMZ (200 μM) induced DNA double strand breaks (DSBs) and nuclear translocation of apoptosis inducing factor (AIF), which was accompanied by BNIP3-mediated mitophagy and FOXO3a accumulation in nucleus. (chinaphar.com)
  • Finally, we directly establish a role for FOXO3a in promoting cocaine-elicited behavioral responses by use of viral-mediated gene transfer: we show that overexpressing FOXO3a in NAc enhances cocaine place conditioning. (upenn.edu)
  • It has been reported that Forkhead box transcription factor class O3a (Foxo3a) is expressed in rheumatoid arthritis, a chronic inflammatory condition accompanied by bone resorption, and plays a role in its pathology. (go.jp)
  • Our results suggest that Foxo3a transcription factors may be involved in the pathogenesis of periapical granulomas. (go.jp)
  • But reporting in the Sept. 3 issue of Molecular and Cellular Biology, found that FOXO3a, a transcription factor that regulates gene expression, becomes active when growing cancer cells begin to starve. (paleovegeo.com)
  • Forkhead Box Protein O1: Functional Diversity and Post-Translational Modification, a New Therapeutic Target? (scienceopen.com)
  • 4 In addition, vascular endothelial growth factor (VEGF) is an angiogenic factor that regulates endothelial survival, proliferation, differentiation, and vascular permeability, and has been shown to be an important candidate for cancer therapy as it is upregulated in many tumors. (beckman.com)
  • A worldwide database analysis revealed that younger age, smaller tumor size, early stage, and granulosa cell tumor histologic type appear to be independent prognostic factors for improved survival in patients with malignant sex cord-stromal tumors who undergo lymph node dissection. (medscape.com)
  • Furthermore, senescent cells, with the secretory features known as the senescence-associated secretory phenotype (SASP), could produce proinflammatory cytokines, such as tumor necrosis factor- α (TNF- α ), interleukin-6 (IL-6), and monocyte chemoattractant protein1 (MCP-1), to greatly affect the neighboring cells [ 17 , 18 ]. (hindawi.com)
  • The inhibition of forkhead activity by SIRT1 parallels the effect of this deacetylase on the tumor suppressor p53. (scienceopen.com)
  • Glioblastoma (GBM), a very aggressive and incurable tumor, often results from constitutive activation of EGFR (epidermal growth factor receptor) and of phosphoinositide 3-kinase (PI3K). (sdbonline.org)
  • In conclusion, our meta-analysis suggests that the prognostic role of FoxP3(+) Tregs was highly influenced by tumor site, and was also correlated with the molecular subtype and tumor stage. (nih.gov)
  • The forkhead box D3 ( FOXD3 ) gene encodes a forkhead transcription factor that plays an important role in neural crest specification in vertebrates and therefore may be involved in human eye disease. (molvis.org)
  • From NCBI Gene: This intronless gene encodes a protein that belongs to the forkhead family of transcription factors. (nih.gov)
  • The FOXL2 (forkhead box L2) gene is located on chromosome 3 and encodes for forkhead box (FOX) family of transcription factors which play a critical role in various biological processes. (bmj.com)
  • Forkhead box C1 (Foxc1) is a member of the forkhead transcription factor family that has been found to regulate in cell migration. (spandidos-publications.com)
  • However, the role of Foxc1 in neuroinflammation during SAE remains unknown. (spandidos-publications.com)
  • In the present study, the mechanistic role of Foxc1 on microglial migration, neuroinflammation and neuronal apoptosis during the occurrence of cognitive dysfunction in SAE was investigated. (spandidos-publications.com)
  • Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/ threonine kinase Akt, which then phosphorylates and inactivates components of the apoptotic machinery, including BAD and Caspase 9. (scienceopen.com)
  • By restraining mammalian forkhead proteins, SIRT1 also reduces forkhead-dependent apoptosis. (scienceopen.com)
  • BCL2L11 expression can be stimulated by nerve growth factor (NGF), in addition to the forkhead transcription factor (FKHR-L1) which proposes a role of the BCL2L11 gene in neuronal and lymphocyte apoptosis. (neuromics.com)
  • The winged-helix transcription factor Xfoxi1a is one of the earliest markers for the preplacodal region at the mid-neurula stage. (biologists.com)
  • The NAD-dependent deacetylase SIR2 and the forkhead transcription factor DAF-16 regulate lifespan in model organisms, such as yeast and C. elegans. (scienceopen.com)
  • Now a research team led by investigators at Beth Israel Deaconess Medical Center (BIDMC) has identified an unexpected link between a transcription factor known to regulate speech and language development and metastatic colonization of breast cancer. (newswise.com)
  • The FOXG1 gene provides instructions for making a protein known as forkhead box G1. (medlineplus.gov)
  • Neural excitation appears to act along a chain of molecular events famously known to influence longevity: the insulin and insulin-like growth factor (IGF) signaling pathway. (medicalxpress.com)
  • Less is known regarding its critical role in neuronal physiology, neuronal metabolism, tissue homeostasis, and the control of gene expression in the central nervous system in healthy and diseased states. (mdpi.com)
  • This unique age-related gene expression profile in the red sea urchin nervous system may play a role in mitigating the detrimental effects of aging in this long-lived animal. (nature.com)
  • The validity of co-IP approaches can quickly deteriorate when forced expression of tagged proteins are used to investigate possible interactions, yet this approach, particularly when endogenous factors are assessed, can provide useful information about potential protein associations. (aacrjournals.org)
  • A dysregulated immune system (including changes in the number and/or function of immune cells, cytokine levels, and the expression of inhibitory receptors or their ligands) plays a key role in the development of HCC. (wjgnet.com)
  • It also stimulates insulin gene expression and insulin biosynthesis ( 6 ), in part via increased expression and activity of the β-cell-specific transcription factor Pdx1 ( 7 , 8 ). (diabetesjournals.org)
  • Experiments in which blastomere transplantation is combined with foxa MASO treatment demonstrate that, in the normal endoderm, a crucial role of Foxa is to repress gcm expression in response to a Notch signal, and hence to repress mesodermal fate. (biologists.com)
  • The factors responsible for the postnatal and starvation-associated induction of HMGCS2 gene expression have been identified and shown to involve changes in circulating hormone and fatty acid levels. (aacrjournals.org)
  • FoxL2 is a novel player in pituitary gene expression that has been shown to interact with Smad3 and play a role in ovary development and therefore reproduction. (escholarship.org)
  • Mechanistically, Foxi2 stimulated AgRP expression by directly binding to it and activating its transcription. (figshare.com)
  • Collectively, our data suggest that Foxi2 plays an important role in controlling energy metabolism by regulating AgRP expression. (figshare.com)
  • Violin plots show distribution of expression levels for Forkhead box protein (SMED30035239) in cells (dots) of each of the 12 neoblast clusters. (stowers.org)
  • Expression of Forkhead box protein (SMED30035239) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells. (stowers.org)
  • Violin plots show distribution of expression levels for Forkhead box protein (SMED30035239) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells. (stowers.org)
  • Exploring Confluence-Related Signalling to Modulate the Expression of Oct4 - A Role in Facilitating Mouse Somatic Cell Reprogramming? (eurekaselect.com)
  • Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
  • The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treat- ment. (lu.se)
  • The activity for the FoxL2 transcription factor is located at -350 from the transcriptional start site. (escholarship.org)
  • Although mutations affecting Nodal and Hedgehog signaling disrupt hypothalamic development, the time and site of action and the exact roles of these pathways remain very poorly understood. (silverchair.com)
  • This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. (cancerindex.org)
  • Besides their distinct roles in the regionalization of the diencephalon, we reveal cooperation between Nodal and Hedgehog pathways in the maintenance of the anterior-dorsal hypothalamus. (silverchair.com)
  • Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. (cancerindex.org)
  • Immunosuppression caused by measles virus: role of viral proteins. (nih.gov)
  • In the presence of survival factors, Akt phosphorylates FKHRL1, leading to FKHRL1's association with 14-3-3 proteins and FKHRL1's retention in the cytoplasm. (scienceopen.com)
  • These proteins participate in very diverse functions: for example, FOXE3 is necessary for proper eye development, while FOXP2 plays a role in language acquisition. (paleovegeo.com)
  • This review summarizes some immunological factors involved in the development and control of this oral disease, such as: the participation of inflammatory cells in local inflammation, the synthesis of chemotaxis proteins with activation of the complement system and a range of antimicrobial peptides, such as defensins, cathelicidin and saposins. (bvsalud.org)
  • Members of this family contain a conserved 100-amino acid DNA-binding 'forkhead' domain. (nih.gov)
  • In this region, we have identified a protein of the Forkhead (Fox) family of transcription factors that binds to a site. (escholarship.org)
  • This family is characterized by a conserved DNA-binding domain (the 'Forkhead box', or FOX) and comprises more than 100 members in humans, classifi ed from FOXA to FOXR on the basis of sequence similarity. (paleovegeo.com)
  • We have previously shown that GLP-1 transactivates the epidermal growth factor receptor ( 12 ) to subsequently activate phosphatidylinositol-3 kinase and Akt signaling ( 7 , 11 ). (diabetesjournals.org)
  • They further link to the activation of protein kinase C- (PKC-) induced generation of reactive oxygen species (ROS) [ 6 , 7 ], which further mediates the activation of downstream transcription factor nuclear factor kappa-light-chain enhancer of activated B cells (NF- κ B). Thus, the main treatments of DN refer to modulate glycemic and blood pressure through insulin and RAS inhibitors. (hindawi.com)
  • All of these genetic changes prevent the production of forkhead box G1 or impair the protein's function. (medlineplus.gov)
  • A deeper understanding of the gut microbiome which comprises of all the genetic material within the gut microbiota and its role in respiratory disorders is likely to help in designing appropriate probiotic cocktails for therapeutic applications. (frontiersin.org)
  • A large twin study demonstrated that 81 % of the variance of the disease was attributed to additive genetic effects, whereas the remaining 19 % was attributed to unique, unshared environmental factors [10]. (springer.com)
  • Remarkably, at age 14 years, facial acne in girls was less influenced by genetic factors than in boys and was significantly influenced by common environmental factors [12]. (springer.com)
  • This regulation appears to be in the opposite direction from the genetic interaction of SIR2 with forkhead in C. elegans. (scienceopen.com)
  • A genetic predisposition combined with environmental risk factors may be involved in the development of pulmonary arterial hypertension (PAH). (ersjournals.com)
  • Characterizing the Shared Genetic Underpinnings of Schizophrenia and Cardiovascular Disease Risk Factors. (cdc.gov)
  • genetic and environmental factors seem to increase the susceptibility of some individuals in developing this severe inflammatory disease (1) ( Fig. 1 ). (bvsalud.org)
  • Forkhead box protein O4 is a protein that in humans is encoded by the FOXO4 gene. (wikipedia.org)
  • Although previous studies had suggested that parts of the nervous system influence aging in animals, the role of neural activity in aging, especially in humans, remained murky. (medicalxpress.com)
  • Currently described online in Cell Stem Cell , the new findings demonstrate that, when silenced, the FOXP2 transcription factor, otherwise known as the speech gene, endows breast cancer cells with a number of malignant traits and properties that enable them to survive - and thrive. (newswise.com)
  • It has histone deacetylase activity and represses transcription when tethered to a promoter. (cancerindex.org)
  • Smad3 is a transcription factor that conveys activin responsiveness, and we have identified a novel region of the FSHb promoter as a major site of Smad3 action. (escholarship.org)
  • In this review, we have discussed the status and roles of various immune effector cells ( e.g ., dendritic cells, natural killer cells, macrophages, and T cells), their cytokine profile, and the chemokine-receptor axis in promoting or impeding HCC. (wjgnet.com)
  • 2015;2015:474032 - 'Resveratrol (RSV) and quercetin (QRC) modify energy metabolism and reduce cardiovascular risk factors included in the metabolic syndrome (MetS). (qualitycounts.com)
  • Researchers believe that this protein plays an important role in brain development, particularly in a region of the embryonic brain known as the telencephalon. (medlineplus.gov)
  • however, it has been shown to play a role in the regulation of embryonic and ocular development. (cancerindex.org)
  • Elizabeth M. Patterson, sophomore in biological sciences, $1,449 for "Discovering the Role of Forkhead Transcription Factor Foxj 1 and its role in Pituitary Development and Maintenance. (siu.edu)
  • Karnoub's lab investigates the roles that mesenchymal stem cells (MSCs) play in the development and metastasis of breast cancer. (newswise.com)
  • We did a meta-analysis to assess the prognostic effect of FoxP3(+) Treg across different types of cancer and to investigate factors associated with variations in this effect. (nih.gov)
  • The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut. (nih.gov)
  • This monolayer of cells is an important endocrine organ, and has been shown to play a major role in regulating blood fluidity, the transfer of solutes and macromolecules, immune responses and inflammation. (beckman.com)
  • To understand the role of autophagy in the pathogenesis of glial tumors in vivo, an established Drosophila melanogaster model of glioma was used based on overexpression in larval glial cells of an active human EGFR and of the PI3K homolog Pi3K92E /Dp110. (sdbonline.org)
  • Despite expanding knowledge of the role of MSCs to breast malignancy, the underlying molecular responses of breast cancer cells to MSC influences has not been fully delineated. (newswise.com)
  • The integration of pathogen-associated molecular patterns (PAMPs) from microorganisms with their surface receptors in the immune cells, induces the production of several cytokines and chemokines that presents either a pro- and/or anti-inflammatory role by stimulating the secretion of a great variety of antibody subtypes and the activation of mechanisms of controlling the disease, such as the regulatory T cells. (bvsalud.org)
  • The pathogenesis of SAE involves a number of factors, including neuroinflammation, collapse of the blood brain barrier (BBB), ischemic injury, alterations in the neurotransmitter profile and mitochondrial dysfunction. (spandidos-publications.com)
  • In a recent study published in Nature Communications, researchers used a K18-hACE2 transgenic (ACE2.Tg) mouse model to demonstrate that interleukin-9 (IL-9) plays a crucial role in coronavirus disease 2019 (COVID-19) pathogenesis. (oullins-patriote.com)
  • We have identified a previously undescribed function for the transcription factor FOXP2 in breast cancer," explains senior author Antoine Karnoub, PhD, an investigator in the Department of Pathology at BIDMC and Assistant Professor of Pathology at Harvard Medical School. (newswise.com)
  • Previous reports indicate that the mechanisms of DN involve a multifactorial interaction of metabolic and hemodynamic factors such as high blood glucose, advanced glycation end-products (AGEs), and the renin-angiotensin system (RAS). (hindawi.com)
  • The brain's neural activity-long implicated in disorders ranging from dementia to epilepsy-also plays a role in human aging and life span, according to research led by scientists in the Blavatnik Institute at Harvard Medical School. (medicalxpress.com)
  • It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. (cancerindex.org)
  • Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. (cancerindex.org)
  • Cancer Prev Res (Phila), factor 1. (who.int)
  • The fork head domain: a novel DNA binding motif of eukaryotic transcription factors? (wikipedia.org)
  • The p.Asn173His mutation affects a residue in the forkhead domain that is 100% conserved among vertebrate orthologs and is predicted to participate in protein-protein interactions. (molvis.org)
  • Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. (scienceopen.com)
  • Survival factor withdrawal leads to FKHRL1 dephosphorylation, nuclear translocation, and target gene activation. (scienceopen.com)
  • In this new paper, the investigators set out to specifically identify the role that microRNAs were playing in the process. (newswise.com)
  • Progression of this disease occurs due to a combination of factors, including the presence of periodontopathic bacteria, high levels of proinflammatory cytokines, matrix metalloproteinases (MMPs), prostaglandin E2 (PGE2), low levels of anti-inflammatory cytokines including inter- leukin-10 (IL-10), transforming growth factor (TGF- β ) and tissue inhibitors of MMPs (TIMPs) (2,3). (bvsalud.org)
  • These results are consistent with FOXO4 providing a role in inhibiting the epithelia to mesenchymal transition (EMT). (wikipedia.org)
  • The encoded protein functions as a thyroid transcription factor that plays a role in thyroid morphogenesis. (nih.gov)
  • Was this disparity in neural excitation merely occurring alongside more important factors determining life span, or were excitation levels directly affecting longevity? (medicalxpress.com)
  • TTF2 is a widely used alternative name for forkhead box E1 (FOXE1), which can be confused with the official symbol for transcription termination factor 2 (TTF2). (nih.gov)
  • Although various markers have been reported to stain sex cord-stromal tumors (eg, CD99, CD56, A103, müllerian inhibiting factor, vimentin), inhibin and calretinin have proven to be the most helpful to date. (medscape.com)
  • In addition, LPS can indirectly produce neuroinflammation by peripheral inflammatory factors diffusing into the CNS through the blood-brain barrier, thus leading to CNS inflammatory injury ( 1 ). (spandidos-publications.com)
  • Diet plays an important role in determining the composition of the gut microbiota. (frontiersin.org)
  • The forkhead box (FOX) and ETS transcription factor families have been shown to be important in endothelial specification and establishment. (beckman.com)
  • These sites also play a role in activin and Smad3 induction. (escholarship.org)
  • Histological examination of gingivitis or periodontitis lesions reveals that the polymorphonuclear leukocyte (PMN) appears to play a key role in the maintenance of the periodontal health (3). (bvsalud.org)