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  • genetics
  • Responsible communication of research findings is essential to prevent common misunderstandings about the role of genetics in addiction liability, to prevent its premature or inappropriate use, and to reduce discrimination and stigmatization experienced by addicted individuals. (jhu.edu)
  • In addition, advances in genetics and the development of large databases and biobanks to study associations between genetic or genomic variation and diseases have made the protection of privacy and confidentiality of genetic data far more difficult. (jhu.edu)
  • genomic
  • We are using an integrative genomics approach, incorporating genomic, proteomic, epigenetic, transcriptomic, metabolomic, and microbiome data obtained from ethnically diverse Africans living in distinct environments to identify genetic and environmental factors that play a role in a number of anthropometric, metabolomic, cardiovascular, and immune related traits. (upenn.edu)
  • We illustrate the approach on a publicly-available dataset from a study of Crohn's disease that consists of genotypes at multiple SNP markers in a small genomic region. (frontiersin.org)
  • In addition to the new focus on medical sequencing, the plan continues NHGRI's emphasis on using comparative genomic sequencing analysis to understand the structure and function of the human genome and the biological processes at work in human health and disease. (genome.gov)
  • infection
  • To make matters more challenging, celiac symptoms can also mimic symptoms of other diseases, such as anemia, Crohns disease, gastric ulcers, irritable bowel, parasitic infection, even various skin disorders or nervous conditions. (celiac.com)
  • factors
  • Hatmi ZN, Tahvildari S, Gafarzadeh Motlag A, Sabouri Kashani A (2007) Prevalence of coronary artery disease risk factors in Iran: a population based survey. (springer.com)
  • We are also studying how these networks are impacted by variable environmental factors such as lifestyle, diet, drug response, and infectious disease exposure. (upenn.edu)
  • The World Health Organization (WHO) estimates that alcohol ranks eighth among global risk factors for death and is the third leading global risk factor for disease and disability (World Health [End Page Organization 2011, 34). (jhu.edu)
  • There might be other factors that may influence disease susceptibility. (termedia.pl)
  • The launch of each project will depend on a number of factors, including the strategic selection of specific diseases and the availability of patient samples with appropriate informed consent. (genome.gov)
  • gastric
  • 1. Efficacy of esomeprazole (Eso) for treatment of poorly controlled asthma (A). Asthmatics frequently have gastric esophageal reflux disease (GERD) as determined by symptoms and/or esophageal pH, but often, overt symptoms are lacking. (worldallergy.org)
  • autoimmunity
  • These Th cells are further divided into subtypes, that is, the Th1 subset producing interferon (IFN) gamma that promotes cellular immune responses, the Th2 subset producing mainly interleukin-4 (IL-4), IL-13, and IL-5 to aid humoral immune responses, and the Th17 subset producing IL-17, which plays a crucial role in autoimmunity and allergen-specific immune responses. (hindawi.com)
  • The plasticity of human Treg and Th17 cells and its role in autoimmunity. (yale.edu)
  • infants
  • 2. Multicenter, double-blind, randomized, placebo-controlled trial assessing the efficacy and safety of proton pump inhibitor (PPI) lansoprazole (Lan) in infants with symptoms of gastroesophageal reflux disease (GERD). (worldallergy.org)
  • important
  • These results could provide important insights into the biological mechanism underlying the detected disease risk association. (plos.org)
  • Our results indicated that PON1-Arg-192 allele can be important independent risk factor of CAD in a west population of Iran, with carriers of PON1-Arg-192 having an increased frequency of three-vessel disease and also having a distinct plasma lipids profile. (springer.com)
  • Hypercholesterolemia (HC), especially high levels of low density lipoprotein-cholesterol (LDL), seems to be an important risk factor accounting for severe atherosclerotic diseases, since LDL enters into the vessel walls by a concentration-dependent mechanism. (pubmedcentralcanada.ca)
  • human
  • We combine field work, laboratory work, and computational approaches to address fundamental questions about modern human evolutionary history and the genetic architecture of traits related to adaptation and disease risk in Africa. (upenn.edu)
  • Functional Foods, Nutraceuticals and Degenerative Disease Prevention is a compilation of different segments of functional foods and nutraceuticals focusing on their mechanism of action in the human body leading to disease prevention. (wiley.com)
  • Aimed primarily at an audience comprised of researchers, industry professionals, food scientists, medical professionals and graduate level students, Functional Foods, Nutraceuticals and Degenerative Disease Prevention offers a mechanism-based interpretation for the effect of nutraceuticals within the human body. (wiley.com)
  • By understanding the familial forms of these diseases, scientists can apply what they learn to uncover the genetic components underlying the more common types of these heart disorders in the human population. (genome.gov)
  • prevention
  • This survey was conducted under the framework of the weight disorders survey, which is part of a national surveillance programme entitled Childhood and Adolescence Surveillance and Prevention of Adult Non - communicable Diseases-IV. (cambridge.org)
  • significant
  • So, while many people show classic symptoms, significant numbers of adults with celiac disease present few or no symptoms, including no gastrointestinal symptoms, when diagnosed. (celiac.com)
  • polymorphism
  • The role of the paraoxonase (PON1) codon 192 polymorphism [glutamine (Q)/arginine (R)] in coronary artery disease (CAD) is controversial. (springer.com)
  • Kharrazi H, Vaisi-Raygani A, Sabokroh AR, Pourmotabbed T (2006) Association between apolipoprotein E polymorphism and coronary artery disease in the Kermanshah population in Iran. (springer.com)
  • biological
  • For metastatic soft tissue sarcoma (STS) patients not eligible for surgery, systemic treatments, including standard chemotherapy and newer biological compounds, still play the most relevant role in the managem. (biomedcentral.com)
  • frequency
  • Additionally, several common complex diseases occur at higher frequency in African Americans, and are rapidly on the rise in urban regions of Africa, including hypertension, obesity, and type II diabetes. (upenn.edu)
  • additional
  • In order to make an accurate assessment and gather community input into this program, NHGRI has issued a Request for Information to seek additional examples of such diseases from investigators around the world. (genome.gov)
  • Experimental
  • Riskind PN, Massacesi L, Doolittle TH, Hauser SL (1991) The role of prolactin in autoimmune demyelination: suppression of experimental allergic encephalomyelitis by bromocriptine. (springer.com)
  • parameters
  • In this study the physical parameters of RA patients were collected, and the disease activity was measured by DAS28. (termedia.pl)
  • study
  • The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. (plos.org)