Using the chorioallantoic membrane angiogenesis model, it was found that systemic inhibition of endogenous H 2 S production was able to decrease vascularization of VHL-deficient ccRCC xenografts. (uwo.ca)
The AKT-pathway also plays an important role in cytostatic therapy resistance and response to hypoxia and angiogenesis. (fu-berlin.de)
Angiogenesis plays a key role in various physiologic and pathologic conditions, including tumor growth. (unibs.it)
Knockout models have shown that the coagulation system has a role in vascular development and angiogenesis. (elsevierpure.com)
Aidoudi S, Bikfalvi A. (2010) Interaction of PF4 (CXCL4) with the vasculature: a role in atherosclerosis and angiogenesis. (u-bordeaux.fr)
and Ms K L Surekha, ARI, demonstrated positive enhancement of angiogenesis in the chorioallantoic membrane of chick embryos by insulin and FGF2. (ifcbiol.com)
The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. (lu.se)
Embryo8
The Chorioallantoic membrane performs the following functions: The CAM functions as the site of gaseous exchange for oxygen and carbon dioxide between the growing embryo and the environment. (wikipedia.org)
There are also problems associated with the handling of the embryo, as the yolk membrane is prone to rupture both during and after the culture. (wikipedia.org)
In this method, fertilized eggs are rotated inside an incubator for three days in order to prevent the embryo from sticking to the membranes of the shell. (wikipedia.org)
The biological consequences of these observations are underscored by the finding that CS-1 cells expressing wild-type alpha v beta 3 acquire the capacity to form spontaneous pulmonary metastases in the chick embryo when grown on the chorioallantoic membrane. (silverchair.com)
The chick chorio-allantoic membrane (CAM) assay is a commonly used method for studying angiogenic or anti-angiogenic activities in vivo . (biomedcentral.com)
An in vivo assay to serve these purposes is the chick chorio-allantoic membrane (CAM) assay. (biomedcentral.com)
Our data suggest that the LIM-homeobox genes, Lhx1 and Lhx9 , regulated by ventral and/or dorsal signals, may play important roles in controlling regionalization of the diencephalon during chick development. (ehu.eus)
We also assessed the potency of AKT- and HSP90 inhibition to slow tumor growth in vivo, by using the chick chorioallantoic membrane assay. (fu-berlin.de)
2010) A combined metabonomic and transcriptomic approach to investigate metabolism during development in the chick chorioallantoic membrane. (u-bordeaux.fr)
Assay2
In this study the ACC hydrogels were prepared through freeze drying procedure and their angiogenic potential was studied by chorioallantoic membrane assay (CAM assay). (lancs.ac.uk)
The human umbilical vein endothelial cell (HUVEC) tubule formation and Transwell migration assays and chicken chorioallantoic membrane (CAM) assay were used to examine the angiogenic capacity of conditioned media from URG4/URGCP-overexpressing and knockdown cells. (biomedcentral.com)
Chicken chorioallantoic membrane2
This protocol illustrates two novel animal models for the disease: the orthotopically implanted mouse model and the chicken chorioallantoic membrane model, both of which demonstrate lung metastasis resembling clinical cases. (jove.com)
Transgene and knock down/out approaches, biochemical studies, and microscopic analyses are central for assessing the role of genes and the processes determining cell fate, cell growth and proliferation, cell specification, cell to cell interactions, cell to extracellular matrix interactions, the influence of nutritional and environmental factors, and the interaction with microbes. (au.dk)
It is now well established that a key requirement for invasion and metastasis of cancer cells is the degradation of both the extracellular matrix (ECM) that surrounds the tumor and the basement membrane which presents the final barrier between the tumor cells and the blood stream [ 1 - 5 ]. (oncotarget.com)
Endothelial cells, which form the inner lining of microvessels, create this semipermeable barrier via a combination of cellular junctions, their glycocalyx, and the basement membrane that consists of vessel-specific extracellular matrix (ECM) [ 2 ]. (biomedcentral.com)
Basement6
Both the epithelial layers are separated from the mesodermal layer by basement membranes. (wikipedia.org)
Degradation of the ECM facilitates invasion of tumor cells into the organ parenchyma, whereas degradation of the basement membrane is required for their entry into the blood stream as well as their metastasis to distant organs. (oncotarget.com)
they degrade their underlying basement membrane, are mobilized, and migrate into surrounding dead tissue and clot. (docksci.com)
We thus hypothesized that MMC will promote the accumulation of vascular ECM (basement membrane) components and lead to a stabilization of MVN with improved functionality. (biomedcentral.com)
MMC promoted the enrichment of cellular junctions and basement membrane components, while reducing cellular contractility. (biomedcentral.com)
Embedded within the basement membrane and in direct contact with endothelial cells are pericytes, which are crucial for microvessel maturation, maintenance, as well as proper function. (biomedcentral.com)
The microvascular system and especially endothelial cells play a major role in inflammation, act as an endocrine organ and tightly regulate blood coagulation [ 1 ]. (biomedcentral.com)
The resulting membrane consists of two mesodermal layers: the somatic mesoderm of the chorion and the splanchnic mesoderm of the allantois. (biomedcentral.com)
Inhibition1
2014]. This lateral inhibition is broken when VEGFR2 is activated by VEGF-A. Delta-like 4 (Dll4), a membrane-bound ligand for Notch1 and Notch4, is selectively expressed in response to VEGF-A induction. (aopwiki.org)
Actin2
The present review summarizes recent progress made regarding the roles of actin filaments in the asymmetric oocyte division. (bioone.org)
Through a proffered presentation Ms Ruchi Jain, a student member, illustrated transient association of calcium-binding protein 1 of Entamoeba histolytica with actin, mediating critical roles in cellular activities such as phagocytosis. (ifcbiol.com)
Development3
CAM provides several features such as ease of access, and the rapid development of the membrane structure, presence of an immunodeficient environment, ease of visualization for imaging techniques ranging from microscopic to PET scans. (wikipedia.org)
The physiological role of the CAM is to serve as a respiratory organ until hatching, to store waste products and to absorb calcium from the shell for bone development[ 7 ]. (biomedcentral.com)
In the study, the researchers focused on the role of astrocytes in development of the disease. (technologynetworks.com)
Plasma2
Despite conflicting reports, several investigators agreed that calcium concentration in the fetal blood is mainly regulated by fetal parathyroid hormone and plasma concentration of vitamin D3, a metabolite that plays a key role in calcium transport through the syncytial cells. (scirp.org)
Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. (lookformedical.com)
Protein2
Role of mitogen-activated protein kinases. (wakehealth.edu)
Background: Recent reports indicate the potential role of the stimulated by retinoic acid 6 (STRA6) protein in developing insulin resistance. (mdpi.com)
Demonstrate1
Our results provide further evidence for the non-hemostatic functions of FX and FXa and demonstrate for the first time a biological role for the zymogen FX. (elsevierpure.com)
Diseases1
Choroidal neovascular membranes (CNVs) are associated with many diseases. (medscape.com)
Tissue1
Chitosan/collagen-based hydrogels were studied for their promising role in skin tissue engineering applications due to their unique biocompatibility and biodegradation properties. (lancs.ac.uk)
Cell1
These results strongly suggest that increases in cell surface levels of S100A10, by oncogenic RAS, plays a critical role in RAS-stimulated plasmin generation, and subsequently, in the invasiveness of oncogenic RAS expressing cancer cells. (oncotarget.com)
Blood capillaries and sinuses are found in the intermediate mesodermal layer allows close contact (within 0.2 μm) with air found in pores of the shell membrane of the egg. (wikipedia.org)
Found1
The Chorioallantoic Membrane (CAM), also known as the chorioallantois, is a highly vascularized membrane found in the eggs of certain amniotes like birds and reptiles. (wikipedia.org)
Play a role2
Blocking HMGB1, ROS, or the JNK pathway may attenuate VEGF-A production, suggesting HMGB1 and related signaling molecules play a role in diabetic retinopathy. (molvis.org)
The basal level increases with each myoelectric motor C G P. Ligand binding triggers intracellular signaling through avb3 to survival mechanisms [176] and has also been shown to play a role in the activation of VEGFR-2 [177]. (myforextradingsecret.com)
Human1
Role of Bach-1 in regulation of heme oxygenase-1 in human liver cells: insights from studies with small interfering RNAS. (wakehealth.edu)
Present1
The first is the chorionic epithelium that is the external layer present immediately below the shell membrane. (wikipedia.org)
Central1
Our findings highlight the role of astrocytes as a central element in the disease and suggest they could therefore be a target for novel therapies," Daniel Martins-de-Souza , penultimate author of the article and a professor at UNICAMP's Institute of Biology, told Agência FAPESP . (technologynetworks.com)
Cancer1
In this review, we will discuss the mechanisms according to which T2D induces cellular senescence and the role of type 2 diabetes-induced cellular senescence in the pathogenesis and progression of colorectal cancer. (frontiersin.org)