• Burkholderia cenocepacia is a Gram-negative, rod-shaped bacterium that is commonly found in soil and water environments and may also be associated with plants and animals, particularly as a human pathogen. (wikipedia.org)
  • CDC of a cluster of eight invasive infections with Burkholderia bacterial bioburden (7.0 x 106-5.8 x 107 colony-forming stabilis , a bacterium in the Burkholderia cepacia complex units/mL) in bottles from two of these lots. (cdc.gov)
  • The facultative, intracellular bacterium Burkholderia pseudomallei is the causative agent of melioidosis, a serious infectious disease of humans and animals. (biomedcentral.com)
  • Moraes recognised the ability of the bacterium Burkholderia cenocepacia to secrete toxin DddA, a cytidine deaminase that catalyses the conversion of nucleotide base cytosine into uracil in neighbouring bacteria to kill them in scarce conditions. (wats-on.co.uk)
  • We report the characterization of BC2L-C, a soluble lectin from the opportunistic pathogen Burkholderia cenocepacia, which has two distinct domains with unique specificities and biological activities. (qub.ac.uk)
  • Within the Burkholderia genus, the Burkholderia cepacia complex contains over 20 related species that cause opportunistic infections and possess antibiotic resistance. (wikipedia.org)
  • The TNF-alpha-like domain triggers IL-8 production in cultured airway epithelial cells in a carbohydrate-independent manner, and is therefore proposed to play a role in the dysregulated proinflammatory response observed in B. cenocepacia lung infections. (qub.ac.uk)
  • Members of the Burkholderia cepacia complex (Bcc), found in many environments, are associated with clinical infections. (cdc.gov)
  • Although closely related, the species within the Bcc have differing severity of pathogenicity, and B. cenocepacia is one of the most intensively studied due to its higher pathogenicity and antibiotic resistance compared to other species in the complex. (wikipedia.org)
  • Burkholderia pseudomallei (Bp) strains 1026b and K96243 and B. thailandensis strain E264 are able to utilize DNA as a sole carbon source for growth, while only strains 1026b and E264 are naturally transformable. (nau.edu)
  • abstract = "Burkholderia spp. (nau.edu)
  • No IIIC isolates have been found in studies on the natural environment, whereas all IIID isolates studied have been in clinical isolates of B. cenocepacia. (wikipedia.org)
  • The most recent of these studies reported evidence that a B. cenocepacia strain, isolated from soil, was indistinguishable by several typing methods (pulsed-field gel electrophoresis [PFGE] genomic fingerprinting and repetitive extragenic palindromic [rep]-PCR) from isolates of the problematic CF lineage PHDC ( 10 ). (cdc.gov)
  • These critical roles of immunology in health and disease are areas of intense scientific study. (wikidoc.org)
  • are frequently isolated from a wide range of ecological niches and have various biological roles, as plant epi- or endophytes, biocontrol agents, plant-growth promoters or as pathogens of both plant and animal hosts. (uni-bielefeld.de)
  • Therefore, although Bcc species may have an important environmental role in agriculture and biotechnology industries, their use also represents a potential clinical risk to susceptible members of the community ( 7 , 8 ). (cdc.gov)
  • We assume that the K1 capsule and OmpA porin play a key role in the virulence of E. marmotae. (bvsalud.org)
  • B. cenocepacia has been demonstrated to colonize an array of ecological niches with diverse lifestyles. (wikipedia.org)
  • B. cenocepacia encodes a type VI secretion system (T6SS) under control by the global negative regulator, AtsR. (uwo.ca)
  • This study demonstrates that while the T6SS is not involved in the characteristic phagosome maturation delay associated with B. cenocepacia, it may play a role in the induction of host cell death. (uwo.ca)
  • however, its role in Bcc pathogenesis is unknown. (cnr.it)
  • This study aimed to determine the role of point mutations as well as the expression level of the oprD gene in the emergence of imipenem-resistant P. aeruginosa strains isolated from patients referred to Ardabil hospitals. (bvsalud.org)
  • Hynes, Daniel W., "The Type VI Secretion System of Burkholderia cenocepacia: a study of actin cytoskeleton remodeling and involvement in host cell death" (2009). (uwo.ca)
  • During infection, macrophages have diverse roles including phagocytosis of foreign bodies, release of cytotoxic factors, and coordination of the inflammatory response via the secretion of chemokines and cytokines ( 3 , 4 ). (frontiersin.org)
  • This species in the Burkholderia cepacia complex has also created another polysaccharide with one 3-deoxy-d-manno-2-octulosonic acid and three galactose molecules. (wikipedia.org)
  • Furthermore, the chemical and genetic tractability of zebrafish has been central to decipher the complex role of macrophages during infection. (frontiersin.org)
  • Efficient recombinant protein production and crystallization protocols were developed, and high-resolution crystal structures of IspF from P. falciparum ( Pf IspF) and B. cenocepacia ( Bc IspF) in complex with cytidine nucleotides determined. (biomedcentral.com)
  • Burkholderia cepacia was originally defined as a single species, but it is now one of several species in the Bcc. (wikipedia.org)
  • Because of this phenotypic overlap between species, previous nomenclature of Bcc species involved genomovar terms, with Burkholderia cenocepacia categorized as genomovar III of the Bcc. (wikipedia.org)
  • We also observed the differential expression of 19 genes carying putative small RNA molecules, indicating a novel role for these regulatory elements in chlorhexidine tolerance. (cardiff.ac.uk)
  • Mitochondria, the cell's energy producing organelles, have a significant role in biological functions as well a key role in disease, so a method to precisely edit the mtDNA genome has been a long sought-after goal. (wats-on.co.uk)
  • PRIN 2015 - The role of metabolic pathway of hydrogen sulphide in chronic obstructive pulmonary bronchopathy and pulmonary fibrosis: definition of potential therapeutic targets. (unina.it)
  • FIRB 2013 - Role of glia and immune-inflammatory cells in chronic pain: identification of new pharmacological targets in analgesia and peripheral and central neuroinflammation. (unina.it)
  • Burkholderia cenocepacia induces neutrophil necrosis in chronic granulomatous disease. (medscape.com)
  • Agriculture plays a vital role supporting human life on Earth but faces significant challenges to feed the growing population. (cshlpress.org)
  • Experimental studies conducted on the growth of B. cenocepacia in environments akin to the human lungs demonstrated the pathogen's increased success in microaerophilic environments over aerophilic settings. (wikipedia.org)
  • PRIN 2015 - Biological and pharmacological HDAC inhibitors in a genetic model of epilepsy and in experimental pain models: role of the microbiome and SCFAs. (unina.it)
  • In the present study, we analyzed the tolerance of planktonic and sessile Burkholderia cenocepacia J2315 cultures and examined the transcriptional response of sessile cells to treatment with chlorhexidine. (cardiff.ac.uk)
  • The strong environmental protection response of B. cenocepacia is attributed to the biofilm formed by groups of the organism. (wikipedia.org)
  • Given the important role of TLRs in the earliest phase of a host's immune response, the development of TLR agonists is a promising therapeutic strategy. (hospitalhealthcare.com)
  • Burkholderia cenocepacia has been found to thrive in primarily microaerophilic conditions, which consist of little to no oxygen. (wikipedia.org)
  • Burkholderia cenocepacia may also cause disease in plants, such as in onions and bananas. (wikipedia.org)
  • LPP-1 encodes a large array of proteins that have played a major role in the adaptation of the different Pantoea spp. (uni-bielefeld.de)
  • We are now using advanced optical mapping technology to reproduce these maps in the absence of genetic variation, in order to disentangle the role of chromosome structure from the potential for genetic incompatibilities ("speciation genes") skewing our results. (drexel.edu)
  • 0001), confirming that Pal plays a direct role in host cell attachment. (cnr.it)