Aquaglyceroporin 7 (AQP7) facilitates glycerol flux across the plasma membrane with a critical physiological role linked to metabolism, obesity, and associated diseases. (lu.se)
To understand the role of aquaglyceroporins in skin, we examined the relevance to human skin of the conclusion, from studies on mice, that skin AQP3 is only important for glycerol transport. (edu.sa)
Herein, we studied the hypothesis that glycerol, a by-product of triacylglycerols (Figure 1), may play a role in this association. (mitoeagle.org)
In fact, SC metabolism is essential for spermatogenesis and, hence, for male fertility [3] and it is known that these cells express aquaglyceroporins, being capable of importing glycerol [4]. (mitoeagle.org)
In this work, we proposed to study the potential role of glycerol in Sertoli cell metabolism. (mitoeagle.org)
Glycerol is imported in Sertoli cells by aquaglyceroporins (AQGPs) or it is obtained as a result from lipolysis. (mitoeagle.org)
Roles of aquaporins in human cancer have been reviewed as have their folding pathways. (wikipedia.org)
Aquaporins and aquaglyceroporins belong to the ancient superfamily of Major Intrinsic Proteins (MIPs) and facilitate passive transport of water and small solutes across membranes of various organisms [ 1 , 2 ]. (biomedcentral.com)
AQP32
But in keratinocytes, the major cell type of the epidermis, only the aquaglyceroporins AQP3, 10 were found. (edu.sa)
However, the relationships of AQP3 with GIM classification and with other proteins, and their roles in the transition from GIM to gastric carcinoma (GC) remain unknown. (oncotarget.com)
AQPs2
Transport of NO and ROS by AQPs would be required for cell homeostasis to play a critical role in maintaining endothelial function. (hindawi.com)
In the present work, we examined the overall expression of AQPs in cells from human skin and we reviewed data on the functional role of AQPs in skin, particularly in the epidermis. (edu.sa)
AQP91
Thus, this study suggests that AQP9 may play a role in the sex-specific effects of in utero arsenic exposure. (biomedcentral.com)
Proteins1
Transport pathways play an essential role in the functioning of a large number of proteins. (plos.org)
Unique1
Here, I present results from different biological projects where SANS has played a crucial role by providing unique restraints for structural refinement and interpretation, complementary to other techniques (NMR, EM, crystallography). (lu.se)
Play a role1
A 2009 case report provided clear histopathologic evidence that sweat glands do not play a role in dyshidrosis. (medscape.com)
Human1
Sex-specific factors play a major role in human health and disease, including responses to environmental stresses such as toxicant exposure. (biomedcentral.com)
Important role2
This issue is of particular relevance since changes in NO release could play an important role in endothelial function maintenance, in addition to regulating proliferation of smooth muscle cells, leukocyte adhesion, platelet aggregation, angiogenesis, thrombosis, vascular tone, and hemodynamics. (hindawi.com)
NO is a gas which plays an important role in blood pressure modulation due to its signaling action on renal, cardiovascular, and central nervous system functions [ 9 ]. (hindawi.com)
Essential role1
It plays essential role in crop production by stimulating the growth and development. (researchsquare.com)
Study1
The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. (plos.org)
Although aquaporins have a proven crucial role in water homeostasis, the physiological and pathological importance of aquaporins as glycerol channels is not fully understood. (medscape.com)
Aquaporins in lung health and disease: Emerging roles, regulation, and clinical implications. (nih.gov)
This review provides an update on the involvement of Aquaporins (AQPs), a family of membrane channel proteins with important role in many body functions, in the beneficial effects imparted by food polyphenols and herbal phytocompounds, both in health and disease. (frontiersin.org)
The role of aquaporins as dual water and gated ion channels is likely to have physiological and potentially translational relevance, and can be evaluated with newly developed molecular and pharmacological tools. (elsevierpure.com)
Recently, various proteins/enzymes were shown to be possible targets for therapeutic or diagnostic metal complexes, including metallo-enzymes and membrane water-glycerol channels (aquaporins) with essential roles in both physiological and pathophysiological states. (cardiff.ac.uk)
Initial gene knock-out studies established a physiological role for lung AQPs, particularly AQP5, in maintaining homeostasis, by mediating fluid secretion from submucosal glands onto the airway surface liquid (ASL) lining. (nih.gov)
Plant-derived bioactive compounds have protective role for plants but may also modulate several physiological processes of plant consumers. (frontiersin.org)
AQP71
Besides AQP9 individual hepatocytes are reported expressing three various other aquaglyceroporins: AQP3 AQP7 and AQP10 although to low BAIAP2 extents [42]. (biodiversityhotspot.org)
Proteins2
Herein, we present an overview of the most representative studies in the field with particular focus on the emerging protein targets - namely zinc-finger proteins, aquaglyceroporins, nitric oxide synthase, thymidine kinases and carbonic anhydrases - which have been also characterized for their interactions with metal-based compounds at a molecular level via different biophysical, analytical and computational methods. (cardiff.ac.uk)
HN - 2006(1998) MH - Actin-Related Protein 2-3 Complex UI - D051376 MN - D5.750.78.730.246 MN - D12.776.220.525.246 MS - A complex of seven proteins including ARP2 PROTEIN and ARP3 PROTEIN that plays an essential role in maintenance and assembly of the CYTOSKELETON. (nih.gov)
Protein2
The encoded protein may also play a role in specialized leukocyte functions such as immunological response and bactericidal activity. (nih.gov)
Aquaglyceroporins have already been connected with caveolins as essential membrane protein implicated in preserving metabolic and energy homeostasis [46]. (biodiversityhotspot.org)
Water homeostasis1
It plays an important role in maintaining water HOMEOSTASIS in the LUNGS and may also regulate release of SALIVA and TEARS in the SALIVARY GLANDS and the LACRIMAL GLAND . (nih.gov)
Transport1
In this article, we review recent advances in the understanding of arsenic toxicity and its transport routes in prokaryotes and eukaryotes, including a dual role of aquaglyceroporins in the uptake and efflux, active transport out of the cell via secondary ion pumps and sequestration of metalloid-thiol conjugates into vacuoles by primary ABC transporters. (am-online.org)
Homeostasis1
Desempeña un papel importante en el mantenimiento de la HOMEOSTASIS del agua en los PULMONES y puede regular también la liberación de SALIVA y LÁGRIMAS en las GLÁNDULAS SALIVALES y en la GLÁNDULA LACRIMAL. (bvsalud.org)
Regulation1
The molecular characteristics of renal progenitors have been extensively studied, revealing that numerous classical and evolutionarily conserved pathways, such as Notch or Wnt/β-catenin, play a major role in cell regulation. (preprints.org)
Play1
A 2009 case report provided clear histopathologic evidence that sweat glands do not play a role in dyshidrosis. (medscape.com)
Channels1
In AqpM, isoleucine replaces a key histidine residue found in the lumen of water channels, which becomes a glycine residue in aquaglyceroporins. (lbl.gov)