LAD1 is caused by low expression of CD11 and CD18. (wikipedia.org)
CD18 is found on chromosome 21 and CD11 is found on chromosome 16. (wikipedia.org)
The CD11/CD18 complex is part of the beta-2 integrin family and is important in adhesion and phagocytosis (see Table 1). (medscape.com)
CD11c/CD18 binds to CD54, iC3b and fibrinogen and plays a role in leukocyte adhesive interactions. (thermofisher.com)
CD11, along with CD18, form a heterodimer adhesion molecule. (thermofisher.com)
CD11a/CD18 (LFA-1) expressed on lymphocytes is known to play an important role in lymphocyte trafficking (adhesion to vascular endothelium), as well as interactions to antigen presenting cells (APC). (medscape.com)
This increase in neutrophil adhesion caused by CD66 antibodies was blocked by a CD18 antibody and associated with up-regalation of CD11/CD18 on the neutrophil surface. (umn.edu)
The data suggest that CD66, CD66b, CD66c, and CD66d antibody binding to the neutrophil surface triggers a transient activation signal that requires extracellular calcium and regulates the adhesive activity of CD11/CD18. (umn.edu)
Three CD11 alpha chains and a common CD18 beta chain form heterodimer transmembrane complexes (CD11a/CD18, CD11b/CD18, CD11c/CD18). (medscape.com)
CD11a/CD18 is also known as leukocyte factor antigen-1 (LFA-1), CD11b/CD18 is known as CR3, and CD11c/CD18 is known as CR4. (medscape.com)
CD11/CD18 belongs to the integrin family of proteins. (biolegend.com)
PMA-stimulated human peripheral blood granulocytes were stained with CD11/CD18 (clone m24) Alexa Fluor® 647 (filled histogram) or mouse IgG1, κ Alexa Fluor® 647 isotype control (open histogram). (biolegend.com)
Children with leukocyte adhesion deficiency type I are at risk for overwhelming infection because their neutrophils lack surface beta 2 integrins (CD18/CD11) that normally interact with endothelial cell adhesion molecules and mediate migration to sites of bacterial invasion. (ox.ac.uk)
In vitro studies of phagocytic cells from an infant with leukocyte adhesion deficiency type I demonstrated that complement receptor 3 (CD18/CD11b) mediates nonopsonic phagocytosis of some Pseudomonas aeruginosa strains and might play a control role in the control of Pseudomonas infections at sites where there are low levels of opsonins. (ox.ac.uk)
We examined the mechanism of adherence within the avian heterophil system using an in vitro bovine serum albumin (BSA) matrix in which neutrophil adherence is primarily CD11/CD18 integrin mediated in mammalian systems. (tamu.edu)
Thus, the CD11b/CD18 heterodimer is apparently up regulated in response to the injected SE-ILK and plays a major role in the adherence of activated heterophils. (tamu.edu)
CD18/CD11 heterodimeric molecules are involved with cell/cell and cell/extracellular adhesion in immune and inflammatory responses. (m-entrepreneurship.com)
Valmu L , Autero M, Siljander P, Patarroyo M and Gahmberg C G (1991) Phosphorylation of the ß-subunit of CD11/CD18 in-tegrins by protein kinase C correlates with leukocyte adhesion. (leenavalmu.fi)
Valmu L and Gahmberg C G (1995) Treatment with okadaic acid reveals strong threonine phosphorylation of CD18 after activation of CD11/CD18 leukocyte integrins with phorbol esters or CD3 antibodies. (leenavalmu.fi)
Valmu L , Fagerholm S, Suila H and Gahmberg C G (1999) The cytoskeletal association of CD11/CD18 leukocyte integrins in phorbol ester activated cells correlates with CD18 phosphorylation. (leenavalmu.fi)
Leukocyte4
2 ] in 1994 and is defined by the expression of a variety of cell surface antigens, including the stem cell marker CD34, the pan-leukocyte marker CD45, and monocyte markers CD14 and CD11. (ersjournals.com)
Patients with leukocyte adhesion deficiency II manifest the Bombay phenotype (ie, negative for O and H blood group antigens with potential production of anti-H antibody). (medscape.com)
1997. The Leukocyte Antigen FactsBook Academic Press. (elabscience.com)
Molecules1
T cells displaying CD4 molecules (and not CD8 ) on their surface, therefore, are specific for antigens presented by MHC II and not by MHC class I (they are MHC class II-restricted ). (wikidoc.org)
Differentiation2
Cluster of differentiation 14 (CD14) was described as monocyte/ macrophage differentiation antigen on the surface of myeloid lineage, such as monocytes, macrophages and dendritic cells (DCs). (studybuff.com)
This gene encodes a B-lymphocyte surface molecule that plays a role in the development and differentiation of B-cells into plasma cells . (wikidoc.org)
CD11c4
In particular, CD11 is composed of CD11a, CD11b and CD11c. (thermofisher.com)
CD11c has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b. (biolegend.com)
adipose tissue expression of plasminogen activator inhibitor type-1 (PAI-1) and CD11 antigen-like family member C (CD11c), markers produced by macrophages, were negatively correlated with adjusted glucose disposal rate (= ?0.28, = 0.05 and = ?0.31, = 0.03). (bioinbrief.com)
Overall, CD11c was expressed in all B cell subpopulations, suggesting a role in all B-cell development steps, with an increased frequency in antigen-driven B cells, which accumulate with age of HD, independently of gender. (studybuff.com)
Lymphocyte2
Lymphocyte function-associated antigen 1 (LFA-1) is an integrin found on lymphocytes and other leukocytes. (wikipedia.org)
B-lymphocyte antigen CD20 or CD20 is an activated- glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase ( CD45 R+, CD117 +) and progressively increasing in concentration until maturity. (wikidoc.org)
Antibody2
antibody responses to polysaccharide antigens are decreased and antibody responses to protein antigens are slightly reduced. (medscape.com)
Antibody FMC7 ( F linder M edical C entre) appears to recognise a conformational variant of CD20 [10] [11] also known as the FMC7 antigen. (wikidoc.org)
Monoclonal1
The antigen that bound to the monoclonal antibodies was identified as an important molecule in cellular recognition processes. (wikipedia.org)
Proteins3
These experiments yielded the protein name "integrin" as a description of the proteins' integral role in cellular adhesion processes and the transmembrane association between the extracellular matrix and the cytoskeleton. (wikipedia.org)
In neutrophils these proteins are activation antigens in that their surface expression is increased following stimulation. (umn.edu)
0000002324 00000 n Assays for oxidant products (hydrogen peroxide, superoxide) or proteins (CR3 [CD11] adhesive glycoproteins, NADPH oxidase components), History of staphylococcal abscesses or certain gram-negative or fungal infections (eg, Serratia marcescens, aspergillosis). (ferienwohnung-uelsen.de)
Neutrophils1
A noncanonical role for the engulfment gene ELMO1 in neutrophils that promotes inflammatory arthritis. (antibodies-online.com)
Endothelial1
To examine their potential role in neutrophil signaling, the effects on neutrophil adhesion to human umbilical vein endothelial cells of a panel of well characterized CD66 mAbs was tested, CD66a, CD66b, CD66c, and CD66d antibodies each increased neutrophil adhesion to human umbilical vein endothelial cell monolayers. (umn.edu)
Protein2
The protein has no known natural ligand [4] and its function is to enable optimal B-cell immune response, specifically against T-independent antigens. (wikidoc.org)
PAS-2 ' ) plays a functionally important role in maintaining erythrocyte shape and regulating membrane material properties, possibly through its interaction with protein 4.1. (wikidoc.org)
Infant1
The aim of this study was to determine whether infant dietary antigens could be immunizing agents of IAA. (shengsci.com)
Cells10
[ 3 ] Thus, it enhances and prolongs antigen signaling on B cells. (medscape.com)
Dendritic cells (DCs) are specialized antigen-presenting cells that have a notable role in the initiation and regulation of innate and adaptive immune responses. (mdpi.com)
In addition, they act as antigen presenting cells and promote angiogenesis [ 8 ]. (ersjournals.com)
LFA-1 also plays a role of cytotoxic killing by T cells. (medscape.com)
CD11 is involved in numerous adhesion-related associations between cells such as monocytes, macrophages, natural killer (NK) cells, and granulocytes. (studybuff.com)
As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin. (wikidoc.org)
PSGL-1 is expressed on all white blood cells and plays an important role in the recruitment of white blood cells into inflamed tissue: White blood cells normally do not interact with the endothelium of blood vessels. (wikidoc.org)
Among these components, CAFs, as the major mesenchymal cell component surrounding cancer cells, have various interactions within the featured characteristics of cancer related microenvironment and play a vital role in tumor progression. (biomedcentral.com)
They are called helper cells because one of their main roles is to send signals to other types of immune cells, including CD8 killer cells, which then destroy the infectious particle. (wikidoc.org)
A membrane-bound tumor necrosis family member found primarily on activated T-LYMPHOCYTES that binds specifically to CD30 ANTIGEN. (wakehealth.edu)
Immunosuppressive1
However, the tumor microenvironment (TME) imposes different mechanisms that facilitate the impairment of DC functions, such as inefficient antigen presentation or polarization into immunosuppressive DCs. (mdpi.com)
Viral3
Roles of HTLV-1 basic Zip Factor (HBZ) in Viral Chronicity and Leukemic Transformation. (mdpi.com)
In the second part of this review, we provide evidence that frequent exercise enhances-rather than suppresses-immune competency, and highlight key findings from human vaccination studies which show heightened responses to bacterial and viral antigens following bouts of exercise. (frontiersin.org)
they also play roles in viral infection and cell proliferation. (bvsalud.org)
IC3b1
Mac-1 plays an important role in cell-cell interaction by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen. (elabscience.com)
Phenotype2
IL-10 inhibits IL-17 and RORγt expression in macrophages and suppresses macrophages toward the proinflammatory M1 phenotype, which is important for the role of IL-10 in mediating the pathogenesis of CIA. (biomedcentral.com)
Consequently, our in vitro study revealed the possible roles of GCAFs in the malignant phenotype and 5-fluorouracil (5-FU) drug resistance in gastric cancer. (biomedcentral.com)
It may play a role in INFLAMMATION and immune regulation. (wakehealth.edu)
Responses1
Second, autoimmune responses are dynamic and the features of the response to a given antigen can vary within different windows of time and within different tissues. (nartsignaling.com)
Macrophages1
Macrophages appear to play a critical role in RA development because they are numerous in the inflamed synovial membrane and at the cartilage-pannus junction [ 14 ]. (biomedcentral.com)
Antibodies1
Tissue factor over-expression in platelets of patients with anti-phospholipid syndrome: induction role of anti-β2-GPI antibodies. (shengsci.com)
Clinical2
The pre-clinical evidence supporting a pathogenic role for fibrocytes in fibroproliferative disease is compelling. (ersjournals.com)
Innate differences due to MSC sourcing may play a role in the clinical utility of isolated MSCs. (biomedcentral.com)
Innate1
Surfactants and MBL play an important role in innate immunity. (medscape.com)
Deficiency1
vƙv�9c8��ư�b`I�b�1Dd�^�vv�)n�&淄$Lp�Ny��]��p��vC�%��#\ӌX3M�8AUpΩ��� Absence of class I or class II HLA antigens by serologic HLA typing is diagnostic for MHC antigen deficiency. (ferienwohnung-uelsen.de)
Fibroblasts2
Their potential role in the pathobiology of these diseases extends beyond the accumulation of fibroblasts in scar tissue and is now thought to include regulation of fibrogenesis by the secretion of cytokines and growth factors, the production of extracellular matrix and secretion of matrix metalloproteinases [ 7 ]. (ersjournals.com)
Cancer-associated fibroblasts (CAFs) play important roles in tumor progression. (biomedcentral.com)
Human2
An important step in evaluating the role of circulating fibrocytes in human disease will be to provide evidence for their presence in the remodelled vasculature. (ersjournals.com)
Here we investigated the role of NF-κB in mouse and human c-MYC-transformed lymphomas. (ashpublications.org)
Major1
These results demonstrate that AIEC strain LF82, but not C. albicans , may play a major profibrogenic role in the gut. (biomedcentral.com)
Blood1
In 1972 a numerical system for the antigens in this blood group was introduced. (wikidoc.org)
Complex1
CR2 associates with CD19 forming a CR2-CD19 complex when stimulated by C3d-bearing antigen engaging CR2. (medscape.com)
Patients1
The antigen is named after one of the patients - a Mrs Gerbich. (wikidoc.org)