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  • uptake
  • Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. (uniprot.org)
  • ingestion of branched-chain amino acids (BCAA), by competitively inhibiting tryptophan transport into brain, lowers brain tryptophan uptake and serotonin synthesis and release in rats, and reputedly in humans prevents exercise-induced increases in serotonin and fatigue. (springer.com)
  • Transport
  • In cultured human fibroblasts incubated under hypertonic conditions, the specific silencing of SNAT2 expression, obtained with anti-SNAT2 siRNAs, prevents the increase in system A transport activity, hinders the expansion of intracellular amino acid pool, and significantly delays cell volume recovery. (biomedsearch.com)
  • 75 Hartnup disorder: Autosomal recessive abnormality of renal and gastrointestinal neutral amino acid transport noted for its clinical variability. (malacards.org)
  • Among its related pathways are FoxO signaling pathway and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds . (genecards.org)
  • Present review paper highlights role of BBB in endothelial transport of various substances into the brain. (hindawi.com)
  • Present review paper aims to emphasize role of important transport systems with their recent advancements in CNS protection mainly for providing a rapid clinical aid to patients. (hindawi.com)
  • Amino acid transport was Na(+) and Cl(-)-dependent and was attenuated in the presence of 2-aminobicyclo-[2.2.heptane-2-carboxylic acid, a system B(0+) inhibitor. (tcdb.org)
  • These characteristics are consistent with system B(0+) amino acid transport. (tcdb.org)
  • Solute Carriers (SLCs) are involved in the transport of substances across lipid bilayers, including nutrients like amino acids. (readbyqxmd.com)
  • BCAA
  • To investigate the molecular role AIPs might play in BCAA synthesis in Arabidopsis thaliana , we examined the functional contribution of aip1 and aip3 knockout alleles to plant patterning and development and BCAA synthesis under various growth conditions. (biomedcentral.com)
  • tissues
  • Analysis of free amino acid pools in the mutant backgrounds revealed that they differ in the absolute amount of individual BCAAs accumulated and exhibit elevated levels of BCAAs in leaf tissues. (biomedcentral.com)
  • amine
  • In solid state, the amine functionality deprotonates the carboxylic acid group, giving rise to the zwitterionic, dipolar entity. (wikibooks.org)
  • Autosomal
  • Bröer reviews Hartnup disease, an autosomal disease first discovered in 1956, characterized by a neutral aminoaciduria accompanied by a photo-sensitive rash and cerebellar ataxia. (medbullets.com)
  • gene
  • We have also attempted to perform a rigorous analysis of studies regarding the individual roles of ERK1 and ERK2 by the means of morpholinos, siRNA, and shRNA silencing as well as gene disruption or gene replacement in mice. (frontiersin.org)
  • immune
  • By generating peptides from intracellular antigens which are then presented to T cells, the ubiquitin/26S proteasome system plays a central role in the cellular immune response. (springer.com)
  • play
  • Today, the emerging field of human microbiome research has indicated that gut microbiota may play an important role in influencing brain development, behavior, and mood in humans. (neurohacker.com)
  • cellular
  • Amino acids increase the activity of the microenvironmental sensor mechanistic Target of Rapamycin Complex 1 (mTORC1) to promote cellular growth and anabolic processes. (readbyqxmd.com)
  • important
  • This paved the way to assign the nucleus an important role in heredity. (wikibooks.org)
  • However, the RAS also plays an important local role, regulating regional blood flow and controlling trophic responses to a range of stimuli. (hindawi.com)