In this case report, the muscle relaxant action was assessed during administration of the optimized dose of rocuronium under nerve root monitoring in general anesthesia for a patient with long-term dantrolene administration. (ekja.org)
Rocuronium bromide injection is indicated for inpatients and outpatients as an adjunct to general anesthesia to facilitate both rapid sequence and routine tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation. (ncats.io)
Rocuronium bromide is a nondepolarizing neuromuscular blocking agent indicated as an adjunct to general anesthesia to facilitate both rapid sequence and routine tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation. (ncats.io)
Anesthesia in both groups was induced with IV 2 mg/kg propofol, 2 μg/kg fentanyl and muscle relaxation with IV 0.6 mg/kg rocuronium. (bmj.com)
Lack of adequate anesthesia or muscle relaxation during ECT led to fractures and dislocations, and insufficient knowledge about the dose parameters of electrical stimulation led to more severe cognitive adverse effects. (medscape.com)
The authors compared intubation conditions of mivacurium, rocuronium, and a placebo at 90 s and their recovery profiles during anesthesia with nitrous oxide, oxygen, and propofol. (silverchair.com)
Regional anesthesia: Loss of pain sensation, with varying degrees of muscle relaxation, in certain regions of the body. (wikidoc.org)
Propofol1
Since 2016, rocuronium bromide has been the standard drug, along with propofol, administered to patients for euthanasia in Canada. (wikipedia.org)
Bromide7
Rocuronium bromide (brand names Zemuron, Esmeron) is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia to facilitate tracheal intubation by providing skeletal muscle relaxation, most commonly required for surgery or mechanical ventilation. (wikipedia.org)
On July 27, 2012, the U.S. state of Virginia replaced pancuronium bromide, one of the three drugs used in execution by lethal injection, with rocuronium bromide. (wikipedia.org)
On October 3, 2016, the U.S. state of Ohio announced that it would resume executions on January 12, 2017, using a combination of midazolam, rocuronium bromide, and potassium chloride. (wikipedia.org)
On August 24, 2017, the U.S. state of Florida executed Mark James Asay using a combination of etomidate, rocuronium bromide, and potassium acetate. (wikipedia.org)
Rocuronium bromide is a nondepolarizing neuromuscular blocking agent with a rapid to intermediate onset depending on dose and intermediate duration. (ncats.io)
Rocuronium bromide is an aminosteroid, intermediate-acting nondepolarizing muscle relaxant that is similar to vecuronium but with a faster onset. (silverchair.com)
[ 12 ] Succinylcholine, a depolarizing muscle relaxant, was introduced in 1951, and the first controlled study of unilateral ECT was conducted in 1958. (medscape.com)
This study aimed to compare the effect of no muscle relaxants and reduced-dose rocuronium on the anesthetic induction and emergence with fentanyl in children undergoing adenotonsillectomy. (druglib.com)
Reduced-dose rocuronium has been reported to provide optimal anesthetic induction without delayed recovery. (druglib.com)
Reversal1
The acetylcholinesterase inhibitor neostigmine can also be used as a reversal agent of rocuronium but is not as effective as sugammadex. (wikipedia.org)
Tracheal intubation1
Following tracheal intubation, 0.1 mg/kg rocuronium was administered when necessary for muscle relaxation. (bmj.com)
CONCLUSIONS: Sugammadex can improve the success rate of motor-evoked potential monitoring compared with moderate neuromuscular blockade induced by continuous infusion of rocuronium in spinal surgery. (bvsalud.org)
Times to maximum blockade for 0.9 and 1.2 mg/kg rocuronium were the shortest. (silverchair.com)
Sevoflurane1
All patients received a sevoflurane-based general anaesthetic and a continuous infusion of rocuronium, which was reversed with 2 mg kg-1 of sugammadex i.v. BIS, EEG, and EMG measures were captured with the BIS Vista™ monitor. (bvsalud.org)
Neuromuscular junction1
Sugammadex selectively binds to rocuronium in the plasma and consequently lowers the rocuronium concentration at the neuromuscular junction. (bvsalud.org)
Sugammadex1
The γ-cyclodextrin derivative sugammadex (trade name Bridion) is an agent to reverse the action of rocuronium by binding to it with high affinity. (wikipedia.org)
Injection2
Rocunium 50mg Injection belongs to a group of medicines called muscle relaxants. (365chemists.com)
Rocunium 50mg Injection relaxes the muscles by blocking the impulses from the nerves. (365chemists.com)
Duration of action2
Rocuronium has a rapid onset and intermediate duration of action. (wikipedia.org)
A small dose of oral dantrolene does not prolong the duration of action and recovery of rocuronium. (ekja.org)
Onset1
Rocuronium was faster in onset at the higher doses (0.9 and 1.2 mg/kg) but had more prolonged recovery times to 25% single twitch height. (silverchair.com)
Fentanyl1
5 mg kg-1 , fentanyl 2 mcg kg-1, and rocuronium 0. (druglib.com)
Mivacurium4
Comparisons of the intubation conditions with mivacurium and rocuronium from previous reports are confounded by the use of varied induction regimens. (silverchair.com)
The times to 25% recovery for 0.6 mg/kg rocuronium (mean +/- SD = 27 +/- 8.6 min), 0.9 mg/kg (43.1 +/- 10.8), and 1.2 mg/kg (62.3 +/- 17.4 min) were significantly longer than were those for mivacurium (17.4 +/- 6.2 min). (silverchair.com)
Mivacurium in a 0.25 mg/kg divided dose and rocuronium at 0.9 mg/kg and 1.2 mg/kg provide good or excellent intubation conditions at 90 s in most patients. (silverchair.com)
Surprisingly, the full dose of mivacurium did not provide an adequate muscle relaxation measured by TOF and was accompanied by undesirable spontaneous movement ( fig. 1 , M). Additional doses of 4 mg mivacurium ( fig. 1 , M), 25 mg atracurium ( fig. 1 , A), and 5 mg vecuronium ( fig. 1 , V) still did not suppress the TOF value to zero. (asahq.org)
Concentration1
Hence, the prevention of muscle contraction is presumed to result from the decreased concentration of calcium in the sarcoplasm, followed by the discontinuation of excitation-contraction coupling [ 5 ]. (ekja.org)
Fibers1
The sarcolemma action potential spreads into muscle fibers along the transverse tubule, and the sarcoplasmic reticulum feet subsequently function as a voltage sensor and calcium channel. (ekja.org)
Surgical1
The ideal muscle relaxant requires intense neuromuscular block for optimal surgical work and complete recovery of neuromuscular function immediately after the end of the surgical procedure without postoperative morbidity. (druglib.com)
Patient1
It is assumed that the muscle relaxant action of dantrolene affected this patient, but there are extremely few studies or reported cases with regard to this effect. (ekja.org)
Patients2
The median total dose of dantrolene was 400 mg for patients who experienced a muscle weakness complication. (ekja.org)
Rocuronium at the 0.6 mg/kg dose was excellent in 27% of patients, whereas rocuronium at the 0.45 mg/kg dose had the least number of excellent conditions and the most poor or not possible assessments. (silverchair.com)
Mechanism of act1
Due to its mechanism of action, muscle weakness can occur with the administration of dantrolene [ 6 ]. (ekja.org)
It effectively relieves muscle stiffness or spasm, thereby improving muscle movement. (365chemists.com)
Acetyl cholinesterase ends Ach activity at N. M junction n To ensure purposeful movement , muscle cell electrical response is turned off by acetylcholinestrase(Ach. (slidetodoc.com)
Depression1
Oral dantrolene causes a dose-dependent depression of skeletal muscle contractility. (ekja.org)
Local1
Dexmedetomidine, magnesium sulphateand rocuronium bromidehave been added to local anesthetics to achieve such goal. (longdom.org)
Pain1
It results in a loss of pain sensation and muscle strength, usually up to the level of the chest (nipple line or 4th thoracic dermatome ). (wikidoc.org)
Tone1
Within the airway wall sensory receptors alter bronchial smooth muscle tone through the parasympathetic vagal pathways. (isanagpur.org)