M7G modification, known as one of the common post-transcriptional modifications of RNA, is present in many different types of RNAs. (beds.ac.uk)
Transfer RNA (tRNA) molecules contain various post-transcriptional modifications that are crucial for tRNA stability, translation efficiency, and fidelity. (mdpi.com)
PROTEINS6
The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS . (lookformedical.com)
Serine and arginine-rich (SR) proteins are RNA-binding proteins (RBPs) known as constitutive and alternative splicing regulators. (molcells.org)
This mini-review will summarize the roles of SR proteins as RNA binders, regulators, and connectors from transcription in the nucleus to translation in the cytoplasm. (molcells.org)
In this mini-review, the essential functions of SR proteins in splicing regulation, with a focus on their roles as RNA binders in the ribonucleoprotein complex (RNP) will be summarized. (molcells.org)
F o For as long as living things have been building proteins based on the code of messenger RNA molecules, there have been aminoacyl-tRNA synthetases. (fascea.pics)
TRNAs2
Besides their canonical roles in translation, tRNAs also originate tRNA-derived small RNAs (tsRNAs), a class of small non-coding RNAs with regulatory functions ranging from translation regulation to gene expression control and cellular stress response. (mdpi.com)
These enzymes, abbreviated as AARS, link transfer RNAs (tRNAs) with the corresponding amino acids. (fascea.pics)
RBPs1
Our laboratory is interested in the understanding of pathophysiological function and molecular mechanism of new non-coding RNAs (and RBPs) and new modes of gene regulation in c. (rochester.edu)
Regulation of Gene Ex2
With the accurate identification of m7G modifications within RNAs, their functional roles in the regulation of gene expression and different physiological functions have been revealed. (beds.ac.uk)
The detection of RNA modifications is fundamental to the study of m7G modifications in the regulation of gene expression. (beds.ac.uk)
Metabolism1
Not only is m7G involved in the normal physiological metabolism of RNA, but recent research also shows that m7G and related regulators appear to be considerably dysregulated in tumors [ 12 ]. (beds.ac.uk)
AMINO ACIDS1
A group of transfer RNAs which are specific for carrying each one of the 20 amino acids to the ribosome in preparation for protein synthesis. (wakehealth.edu)
Molecular3
Molecular formula of common RNA modifications. (beds.ac.uk)
He received his Ph.D. degree in the laboratory of Dr. En-Duo Wang in Biochemistry and Molecular Biology from Shanghai Institute of Biochemistry and Cell Biology of Chinese Academy of Science in 2008, where he studied the structural and functional interplay of transfer RNA (tRNA) and tRNA synthetase in bacteria, yeast and human. (rochester.edu)
The long-term objective of our laboratory is to identify novel RNA-based molecular mechanisms that control gene expression and conduct pathophysiological function in cardiac system, as well as to develop novel therapeutic approaches for the prevention or treatment of human cardiovascular diseases. (rochester.edu)
Transcription1
Transcription in eukaryotes is carried out by three main RNA polymerases: Pol I, II, and III. (mdpi.com)
Gene2
Recent global analyses of SR-RNA interaction maps have advanced our understanding of SR-regulated gene expression. (molcells.org)
Epigenetics refers to heritable changes in gene expression without changing the nucleotide sequence of the gene, including DNA methylation, histone modifications, and RNA modifications. (beds.ac.uk)
Interactions1
In general, RRM domains recognize RNA, whereas RS domains participate in diverse protein-protein and protein-RNA interactions. (molcells.org)
Regulate1
Recently, noncoding RNAs (ncRNAs) have been reported to regulate protein expression, and it is definite that PTEN expression is controlled by ncRNAs epigenetically or posttranscriptionally as well. (biomedcentral.com)
We recently discovered a new type of stress-responsive, protein-directed human RNA switch that regulates expression of vascular endothelial growth factor-A in human monocytic cells (Ray, PS, et al. (rochester.edu)
Intriguingly, some of these RNA switches involve the interplay between microRNA and RNA-binding protein (Jafarifar, F, et al. (rochester.edu)
Specific3
RNA, Transfer, Amino Acid-Specific" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
This graph shows the total number of publications written about "RNA, Transfer, Amino Acid-Specific" by people in this website by year, and whether "RNA, Transfer, Amino Acid-Specific" was a major or minor topic of these publications. (wakehealth.edu)
Below are the most recent publications written about "RNA, Transfer, Amino Acid-Specific" by people in Profiles. (wakehealth.edu)
Research1
With the rapid development of sequencing technology, m7G has become a new research hotspot of RNA modification. (beds.ac.uk)
Study1
Circular dichroism study of nine species of transfer ribonucleic acid. (colorado.edu)
Ribosomal1
PANDORA-seq identified abundant modified sncRNAs-mostly transfer RNA-derived small RNAs (tsRNAs) and ribosomal RNA-derived small RNAs (rsRNAs)-that were previously undetected, exhibiting tissue-specific expression across mouse brain, liver, spleen and sperm, as well as cell-specific expression across embryonic stem cells (ESCs) and HeLa cells. (nih.gov)
Proteins4
Transfer RNAs help assemble protein building blocks (amino acids) into functioning proteins. (medlineplus.gov)
Within mitochondria, tRNA Leu(UUR) is involved in the assembly of proteins that carry out a series of chemical steps called oxidative phosphorylation. (medlineplus.gov)
The A3243G mutation reduces the ability of tRNA Leu(UUR) to add leucine to proteins that are being assembled, which slows protein production. (medlineplus.gov)
The m 6 A modification is recognized by the reader proteins, such as YTH-domain family proteins and specific RNA binding proteins (RBPs), which mediate the downstream effects of m 6 A methylation [ 4 ]. (biomedcentral.com)
Repertoire2
PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications. (nih.gov)
18. A Comprehensive Repertoire of Transfer RNA-Derived Fragments and Their Regulatory Networks in Colorectal Cancer. (nih.gov)
Mutation1
The mutation, A3302G located at the acceptor arm of tRNA-Leu, caused the dysfunction via reducing the mitochondrial copy number [ 10 ]. (biomedcentral.com)
Regulatory1
Subsequent to the integration of regulatory information, RNA Polymerase II (Pol II) and general transcription factors (GTFs) must recognize core promoters to together initiate transcription at specific sequences, transcription start sites (TSSs). (biomedcentral.com)
Regulation2
In addition, we focused on elaborating the feasible clinical application of bone exosomes and the characteristics of exosomal noncoding RNAs in the regulation of bone reconstruction. (hindawi.com)
Transcription regulation has been of intense interest for decades as it determines how much RNA is synthesized for a given gene or locus. (biomedcentral.com)
Modification1
Here, we present PANDORA-seq (panoramic RNA display by overcoming RNA modification aborted sequencing), employing a combinatorial enzymatic treatment to remove key RNA modifications that block adapter ligation and reverse transcription. (nih.gov)
Recipient cells1
Exosome production, secretion, and cargo transfer from donor cells to recipient cells. (hindawi.com)
Assembly1
During protein assembly, this molecule attaches to the amino acid leucine (Leu) and inserts it into the appropriate locations in the growing protein. (medlineplus.gov)
Small8
Although high-throughput RNA sequencing (RNA-seq) has greatly advanced small non-coding RNA (sncRNA) discovery, the currently widely used complementary DNA library construction protocol generates biased sequencing results. (nih.gov)
2. Serum transfer RNA-derived fragment tRF-31-79MP9P9NH57SD acts as a novel diagnostic biomarker for non-small cell lung cancer. (nih.gov)
4. tRF-Leu-CAG promotes cell proliferation and cell cycle in non-small cell lung cancer. (nih.gov)
9. AS-tDR-007872: A Novel tRNA-Derived Small RNA Acts an Important Role in Non-Small-Cell Lung Cancer. (nih.gov)
15. LINC01123, a c-Myc-activated long non-coding RNA, promotes proliferation and aerobic glycolysis of non-small cell lung cancer through miR-199a-5p/c-Myc axis. (nih.gov)
16. Circular RNA circPVT1 Promotes Proliferation and Invasion Through Sponging miR-125b and Activating E2F2 Signaling in Non-Small Cell Lung Cancer. (nih.gov)
17. Circular RNA hsa_circ_0008305 (circPTK2) inhibits TGF-β-induced epithelial-mesenchymal transition and metastasis by controlling TIF1γ in non-small cell lung cancer. (nih.gov)
19. A novel class of small RNAs: tRNA-derived RNA fragments (tRFs). (nih.gov)
Role2
These organelles play a crucial role in intercellular messengers, transferring bioactive molecules to nearby or distant cells under physiological and pathological conditions [ 14 , 15 ]. (hindawi.com)
In order to better understand the mechanism of exosomes as noncoding RNA vectors regulating bone remodeling, we reviewed the newest findings on the feature and role of exosomes in bone formation. (hindawi.com)
Expression1
Noncoding RNAs in exosomes supply a method that cells can straightly regulate the expression of protein in target cells. (hindawi.com)
Cells1
Our findings highlight the fact that tissue sEV-mediated miR-142-3p transfer can serve as a communication mode between T lymphocytes and thyrocyte cells in HT, favoring the progression of HT. (biomedcentral.com)
Present1
The tRNA Leu(UUR) molecule is present in cellular structures called mitochondria. (medlineplus.gov)
Affect1
Inhibition of ALS enzyme will affect synthesis of the branched-chain amino acids (Val, Leu and Ile) and eventually result in the death of plants. (biomedcentral.com)