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  • strands
  • Dynamical experimental quantification of Turnip mosaic virus RNA strands, together with a nonlinear mathematical model, indicated the SMR model for this pathogen. (springer.com)
  • The same mathematical model for natural infections is here further analyzed, and we prove that the interior equilibrium involving coexistence of both positive and negative viral strands is globally asymptotically stable. (springer.com)
  • Single strands of these RNAs did not activate PKR. (innovations-report.com)
  • mutations
  • Different RMs are expected to produce different evolutionary and dynamical outcomes in viral quasi-species due to differences in the mutations accumulation rate. (springer.com)
  • Mutations within the 5′-UTR affecting RNA structural elements enabled restriction by or antagonism of Ifit1 in vitro and in vivo. (sciencemag.org)
  • However, while within the low viral load group both synonymous and non-synonymous mutations contribute to the variation observed, in the heterogeneity observed in the high viral load group there was an increase in the contribution of the non-synonymous mutations. (deepdyve.com)
  • particles
  • Immunization of mice, chicken, pigs and primates with virus-like particles, naked RNA or layered DNA/RNA plasmids has provided protection against challenges with lethal doses of infectious agents and administered tumor cells. (mdpi.com)
  • Moreover, recombinant particles and replicon RNAs have been encapsulated by liposomes to improve delivery and targeting. (mdpi.com)
  • The RNA carries genetic information to code for the production of new infectious particles. (wikipedia.org)
  • Assembly of viral particles takes place spontaneously. (wikipedia.org)
  • microbial
  • Bacterial, viral, and other microbial RNA-Seq experiments enable annotation and quantification of comprehensive microbial transcripts. (illumina.com)
  • A wide dynamic range enables confident identification of both high and low expressors in a single bacterial, viral, or other microbial RNA-Seq experiment. (illumina.com)
  • transcripts
  • Unlike hybridization-based methods such as microarrays, RNA-Seq enables unbiased strand-specific identification of common and novel transcripts. (illumina.com)
  • adenosine
  • One of these modifications is the addition of methyl groups to adenosine, one of the building blocks that make up RNA. (eurekalert.org)
  • Serum
  • Both spin-column and 96-well plate kits are designed for fast and easy isolation of viral RNA or DNA from cell-free samples such as serum, plasma, cerebrospinal fluid, and cell culture supernatant. (thermofisher.com)
  • Quasispecies
  • The analysis of the possible association between viral set point and quasispecies heterogeneity has important consequences in the understanding of HIV-1 in vivo evolution. (deepdyve.com)
  • biological
  • Viral analysis of biological and environmental samples requires the use of advanced technologies to assure assay effectiveness. (thermofisher.com)
  • genus
  • Barley stripe mosaic virus (BSMV),of genus Hordevirus, is an RNA viral plant pathogen whose main hosts are barley and wheat. (wikipedia.org)
  • base pairs
  • The length needed for one PKR to bind to RNA is fifteen base pairs," said Philip Bevilacqua, professor of chemistry, Penn State, one of the lead scientists on the project along with James Cole, associate professor, University of Connecticut. (innovations-report.com)
  • Both DNA and RNA are nucleic acids, which use base pairs of nucleotides as a complementary language. (wikipedia.org)
  • cells
  • To evaluate, in HIV-infected patients whose baseline CD4 count is 300 to 750 cells/mm3, whether an antiretroviral treatment regimen based upon clinical evaluation and CD4 counts plus HIV RNA viral load is more effective than a treatment regimen based upon clinical evaluation and CD4 counts without the use of HIV RNA viral load information. (clinicaltrials.gov)
  • It is hypothesized that among HIV-infected patients whose baseline CD4 count is in the range of 300 to 750 cells/mm3, those patients who incorporate initial and periodic viral RNA measurements in their therapeutic decisions will have higher CD4 counts after 48 weeks than patients whose therapeutic decisions do not incorporate initial and periodic viral RNA measurements. (clinicaltrials.gov)
  • The team adapted a technique that attaches fluorescent chemical probes to RNA in cells. (technewslit.com)
  • simultaneously
  • In the 1950s a discovery by two labs simultaneously proved that the purified RNA of the TMV was infectious which reinforced the argument. (wikipedia.org)
  • specific
  • By latching on to specific sites on viral RNA, PKR can interrupt this process. (innovations-report.com)
  • López-Galíndez, C. 2004-09-01 00:00:00 The human immunodeficiency virus type 1 (HIV-1) viral set point has been associated with the rate of disease progression and with the level of HIV-specific immune response. (deepdyve.com)