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  • rRNA
  • In 1993, Koonin and Rudd predicted the spoU gene product to be an RNA methyltransferase based on the similarity of its deduced amino acid sequence to that of Streptomyces azureus Tsr [ 1 ], which catalyzes methylation of the ribose of adenosine (A) at position 1067 in 23S rRNA to form 2'- O -methyladenosine (Am1067) [ 4 ]. (pubmedcentralcanada.ca)
  • mRNA
  • Furthermore, we use our internal standard for the quantification of modified nucleosides in mouse tissue messenger RNA (mRNA), where we find different modification profiles in liver and brain tissue. (mdpi.com)
  • In the central dogma of molecular biology, messenger RNA (mRNA) is the molecule linking the genetic code, DNA, with the cellular work force, proteins. (mdpi.com)
  • mRNA (messenger RNA): RNA that copies the coded message from DNA in the nucleus and carries the message into the cytoplasm. (slideserve.com)
  • First, RNA-Seq uses next-generation DNA sequencing to determine every mRNA transcript in a particular sample. (biomedcentral.com)
  • proteins
  • The purpose of this book is to fulfill that need by providing an up-to-date account of all aspects of research on transfer RNA, including its structure, biosynthesis, and interactions with the many proteins involved in protein biosynthesis. (asmscience.org)
  • transcription
  • Sally's DNA sequence and m-RNA transcription are shown below. (studyres.com)
  • Using the transcription-regulatory network, sRNA targets tend to be under multiple regulation (higher indegree, p-val = 0.013) and the targets usually are important to the transfer of regulatory signals (higher betweenness, p-val = 0.012). (biomedcentral.com)
  • As was found for the protein-protein interaction network, the targets that are regulated by the same sRNA also tend to be closely knit within the transcription-regulatory network (larger density, p-val = 0.036), and inward interactions between them are greater than the outward interactions (higher in-degree ratio, p-val = 0.023). (biomedcentral.com)
  • In this article, we have made use of RPOTp and RPOTmp T-DNA insertion mutants to answer the question of whether both plastid-located phage-type RNA polymerases have overlapping or specific functions in plastid transcription. (plantphysiol.org)
  • peptides
  • Streptavidin is devised as a handle to assemble biotinylated cell penetrating peptides (e.g., transactivating transcriptional activator (TAT)), as well as an insulator between the positive charge of TAT and the dense negative charge of RNA. (ucsb.edu)
  • consistent
  • Modifying these residues or nucleotides has a large effect on the communication pathways in the protein:RNA complex consistent with kinetic data. (pnas.org)
  • small
  • ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2FANDS&rft.title=Next Generation Sequencing of Extracellular RNA&rft.publisher=The University of Melbourne&rft.description=Exosomes are small nanovesicles released by cells. (ands.org.au)
  • types
  • Post-transcriptional RNA modifications have been found to be present in a wide variety of organisms and in different types of RNA. (mdpi.com)
  • contains
  • The collection contains data from our studies sequencing exosomal RNA from a variety of sources including cell cultures, serum, plasma, milk, urine, CSF both to look at the normal content of these vesicles and also to identify potential biomarkers for the diseases we are studying. (ands.org.au)
  • cellular
  • Exosomes contain protein and genetic material and have been proposed to play a role in cellular communication whereby their contents can be transferred to other cells. (ands.org.au)
  • mouse
  • Human, rat and mouse cAMP phosphodiesterase isoforms (denoted PDE4D7s), as well as the DNA (RNA) encoding such polypeptides, are disclosed. (freepatentsonline.com)
  • RNA-Seq demonstrates that GRP is not transcribed in mouse, rat, or human sensory ganglia. (biomedcentral.com)
  • RNA-Seq corroborates a primary itch afferent role for NPPB in mouse and potentially NPPB and NPPA in rats and humans, but does not support GRP as a primary itch neurotransmitter in mouse, rat, or humans. (biomedcentral.com)
  • studies
  • The existence of the SpoU-TrmD (SPOUT) RNA methyltransferase superfamily was first predicted by bioinformatics studies [ 1 , 2 , 3 ]. (pubmedcentralcanada.ca)
  • Application
  • In the present report, we address the question of expression of Grp , Nppb , and Nmb and their receptors in DRG and spinal cord through application of RNA-Seq. (biomedcentral.com)
  • central
  • In protein-protein interaction network, sRNA targets tend to occupy more central positions (higher closeness centrality, p-val = 0.022) and more cliquish (larger clustering coefficient, p-val = 0.037). (biomedcentral.com)