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Nucleic Acid HybridizationRNA, MessengerBase SequenceDNARNARNA, Small InterferingRNA, ViralRNA EditingRNA SplicingRNA, RibosomalGene Transfer TechniquesRNA, BacterialRNA, TransferDNA-Directed RNA PolymerasesRNA InterferenceRNA VirusesGene Transfer, HorizontalEmbryo TransferRNA, Transfer, TyrRNA, Double-StrandedMolecular Sequence DataRNA, CatalyticRNA FoldingRNA Polymerase IIRNA, FungalRNA StabilityRNA, AntisenseAmino Acid SequenceNucleic Acid ConformationRNA HelicasesRNA Processing, Post-TranscriptionalTransfer (Psychology)RNA PrecursorsFluorescence Resonance Energy TransferRNA, Small NuclearRNA, UntranslatedKineticsRNA CapsSequence Analysis, RNAEscherichia coliModels, MolecularMutationAdoptive TransferBinding SitesRNA, PlantTyrosineGenetic VectorsRNA, ProtozoanPatient TransferPhospholipid Transfer ProteinsRNA, NeoplasmRNA Ligase (ATP)Cell LinePlasmidsProtein BindingTransfer FactorDEAD-box RNA HelicasesConjugation, GeneticRNA Polymerase IIIElectron TransportCholesterol Ester Transfer ProteinsNuclear Transfer TechniquesRNA Polymerase IRNA, NuclearRNA, GuideRNA, Ribosomal, 28SMutagenesis, Site-DirectedTendon TransferGenetic TherapyRNA-Binding ProteinsRNA, Ribosomal, 18STransfectionRNA, Ribosomal, 23SProtein Structure, TertiaryBacterial ProteinsProtein ConformationRecombinant ProteinsSubstrate SpecificityRNA, Ribosomal, 16SAdenoviridaeRNA TransportCatalysisProtein BiosynthesisCarrier ProteinsTranscription, GeneticDNA PrimersSequence Homology, Amino AcidTime FactorsRNA, Spliced LeaderRNA, SatelliteCells, CulturedHeLa CellsVirus ReplicationRNA, ArchaealPhylogenyCrystallography, X-RayGene ExpressionCell NucleusOligoribonucleotidesRNA, Transfer, Amino Acyl
TRNATyrosineNucleotidesAmino acidsProteinAnticodonEukaryotesMoleculeNucleicUracilEnzymeChainFoundSmallLiving cellPresenceTyrosine-specificMRNANucleosidesPhosphorylationTRNATyrTRNA-derivedSaccharomycesNucleic AcidsRRNAPolymeraseSequencingTyrosinaseAminoAntibodyGenesPeptideTranscriptionUridineInvolvesProteinsRecognitionFragmentsMolecularStrandFunctionalRoleTermsComplexActive SiteGroupTranslationShows
TRNA12
  • Tyrosine-tRNA ligase catalyzes the chemical reaction ATP + L-tyrosine + tRNA(Tyr) ⇌ {\displaystyle \rightleftharpoons } AMP + diphosphate + L-tyrosyl-tRNA(Tyr) The three substrates of this enzyme are ATP, L-tyrosine, and a tyrosine-specific transfer RNA [tRNA(Tyr) or tRNATyr], whereas its three products are AMP, diphosphate, and L-tyrosyl-tRNA(Tyr). (wikipedia.org)
  • These latter enzymes link amino acids to their cognate transfer RNAs (tRNA) in aminoacylation reactions that establish the connection between a specific amino acid and a nucleotide triplet anticodon embedded in the tRNA. (wikipedia.org)
  • A structural model of the complex between B. sterothermophilus YARS and tRNA(Tyr) was constructed using extensive mutagenesis data on both YARS and tRNATyr and found consistent with the crystal structure of the complex between YARS and tRNA(Tyr) from Thermus thermophilus, which was subsequently solved at 2.9 Å resolution. (wikipedia.org)
  • Mutagenesis experiments have shown that the flexibility of the peptide that links the α-ACB and S4-like domains is responsible for the disorder of the latter in the structure and that elements of sequence in this linker peptide are essential for the binding of tRNA(Tyr) by YARS and its aminoacylation with tyrosine. (wikipedia.org)
  • The crystal structure of the complex between YARS from Methanococcus jannaschii, tRNA(Tyr) and L-tyrosine has been solved at 1.95 Å resolution. (wikipedia.org)
  • The structure of the complex between YARS from Saccharomyces cerevisiae, tRNA(Tyr) and an analog of tysosyl-adenylate has been solved at 2.4 Å resolution. (wikipedia.org)
  • The free amino (NH 2) group of the A site tRNA attacks the ester linkage of P site tRNA, causing transfer of the nascent peptide to the amino acid in the A site. (web.app)
  • ATP + L-tyrosine + tRNA(Tyr) ⇌ AMP + diphosphate + L-tyrosyl-tRNA(Tyr) The three substrates of this enzyme are ATP, L-tyrosine, and a tyrosine-specific transfer RNA [tRNA(Tyr) or tRNA Tyr], whereas its three products are AMP, … - tRNA (transferová) - vybírá správné aminokyseliny a umísťuje je do správného místa na ribosomu, aby mohly být začleněny do rostoucího aminokyselinového řetězce. (web.app)
  • tRNA udgør en undergruppe i gruppen af ikke-kodende RNA. (web.app)
  • tRNA má primární strukturu (danou sekvencí nukleotidů), sekundární strukturu (danou interakcemi mezi jednotlivými částmi molekuly tRNA) a terciární strukturu (což je trojrozměrné uspořádání molekuly tRNA) Transfer RNA (tRNA), small molecule in cells that carries amino acids to organelles called ribosomes, where they are linked into proteins. (web.app)
  • Our biochemical investigations show that IGHMBP2 associates physically with tRNAs and in particular with tRNA(Tyr), which are present in the modifier and with the ABT1 protein. (jax.org)
  • Three queuosine derivatives (Q-derivatives) have been found at position 34 of four mammalian so-called Q-tRNAs: queuosine (Q) in tRNA(Asn) and tRNA(His), mannosyl-queuosine (manQ) in tRNA(Asp), and galactosyl-queuosine (galQ) in tRNA(Tyr). (cnrs.fr)
Tyrosine1
  • -Tyrosine or tyrosine (symbol Tyr or Y ) [1] or 4-hydroxyphenylalanine is one of the 20 standard amino acid s that are used by cells to synthesize proteins . (explained.today)
Nucleotides1
  • adenine (A) - A nitrogenous base that occurs in DNA and RNA nucleotides and pairs with thymine (in DNA) or uracil (in RNA) through two hydrogen bonds. (rcsb.org)
Amino acids1
  • A group of transfer RNAs which are specific for carrying each one of the 20 amino acids to the ribosome in preparation for protein synthesis. (wakehealth.edu)
Protein6
  • Alfalfa mosaic virus genomic RNAs are infectious only when the viral coat protein binds to the RNA 3' termini. (rcsb.org)
  • The human motor neuron degenerative disease spinal muscular atrophy with respiratory distress type 1 (SMARD1) is caused by loss of function mutations of immunoglobulin mu-binding protein 2 (IGHMBP2), a protein of unknown function that contains DNA/RNA helicase and nucleic acid-binding domains. (jax.org)
  • It was found to be membrane associated with a mononuclear Cu site and possess a Cys-Tyr redox cofactor capable of housing a protein radical, comparable to the fungal galactose oxidase (Gox). (bl.uk)
  • These data indicated that GA was able to: (1) reduce the levels of reactive oxygen species, (2) down-regulate the expression of MITF, TYR, TRP-1, and TRP-2 gene levels in a timedependent manner, and (3) significantly reduce protein expression of the TRP-2 gene. (slideheaven.com)
  • 3.0: hematopoietic cell-specific Lyn substrate 1 (HCLS1), Kelch domain-containing 6 (KLHDC6), sarcoglycan delta (SGCD), KIAA1706 protein (KIAA1706), RNA guanylyltransferase and 5′-phosphatase (RNGTT), chromosome 10 open reading frame 57 (C10orf57), chromosome 9 open reading frame 52 (C9orf52), and plasminogen activator, urokinase receptor (PLAUR). (molvis.org)
  • It occurs in proteins that are part of signal transduction processes and functions as a receiver of phosphate groups that are transferred by way of protein kinase s. (explained.today)
Anticodon1
  • Queuosine is a naturally occurring modified ribonucleoside found in the first position of the anticodon of the transfer RNAs for Asp, Asn, His, and Tyr. (bvsalud.org)
Eukaryotes1
  • Transcription in eukaryotes is carried out by three main RNA polymerases: Pol I, II, and III. (mdpi.com)
Molecule1
  • A transfer RNA, which acts as an adaptor molecule for translation of mRNA. (ensembl.org)
Nucleic1
Uracil1
Enzyme2
  • A Single Mutation Traps a Half-Sites Reactive Enzyme in Midstream, Explaining Asymmetry in Hydride Transfer. (ucsf.edu)
  • The conversion of Phe to Tyr is catalyzed by the enzyme phenylalanine hydroxylase , a monooxygenase. (explained.today)
Chain1
  • The effects of particle size and parent polymer characteristics on the mechanical properties, gel fraction, and swelling index of self-crosslinkable poly(n-butyl methacrylate-co-N-methylolacrylamide) films made by two-stage emulsion or microemulsion polymerization in the presence of variable amounts of the chain transfer agent, n-butyl mercaptan, are reported here. (chk-signal.com)
Found1
  • The results suggest that a uniform, organized 3' conformation, similar to that found on viral RNAs with transfer RNA-like ends, may be essential for replication. (rcsb.org)
Small1
  • We examined Vav3 small interfering RNA (siRNA) effects on cell proliferation and apoptosis in docetaxel-treated LNCaP cells under chronic hypoxia (LNCaPH). (biomedcentral.com)
Living cell1
  • 08.12.2017 RNA is a critical component of every single living cell in the universe. (web.app)
Presence1
  • Monoclonal antibodies were used to follow the maturation of GlxA through observing mobility differences on denaturing PAGE gels based on the presence or absence of the Cys-Tyr cross-link. (bl.uk)
Tyrosine-specific1
  • Tyrosine-tRNA ligase catalyzes the chemical reaction ATP + L-tyrosine + tRNA(Tyr) ⇌ {\displaystyle \rightleftharpoons } AMP + diphosphate + L-tyrosyl-tRNA(Tyr) The three substrates of this enzyme are ATP, L-tyrosine, and a tyrosine-specific transfer RNA [tRNA(Tyr) or tRNATyr], whereas its three products are AMP, diphosphate, and L-tyrosyl-tRNA(Tyr). (wikipedia.org)
MRNA2
Nucleosides1
  • Chemical modifications of the nucleosides that comprise transfer RNAs are diverse. (nih.gov)
Phosphorylation3
  • Phosphorylation of STAT3 at Tyr-705 and Ser-727 was reduced by DIM in a concentration-dependent manner. (biomedcentral.com)
  • Interleukin (IL)-6-induced phosphorylation of STAT3 at Tyr-705 was significantly blocked by DIM. (biomedcentral.com)
  • this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation (PubMed:21917714, PubMed:21258366). (assaygenie.com)
TRNATyr1
  • A structural model of the complex between B. sterothermophilus YARS and tRNA(Tyr) was constructed using extensive mutagenesis data on both YARS and tRNATyr and found consistent with the crystal structure of the complex between YARS and tRNA(Tyr) from Thermus thermophilus, which was subsequently solved at 2.9 Å resolution. (wikipedia.org)
TRNA-derived3
  • 5. Expression Profiles of tRNA-Derived Small RNAs and Their Potential Roles in Primary Nasopharyngeal Carcinoma. (nih.gov)
  • 14. Differential expression profiling of tRNA-Derived small RNAs and their potential roles in methamphetamine self-administered rats. (nih.gov)
  • 19. Action mechanisms and research methods of tRNA-derived small RNAs. (nih.gov)
Saccharomyces1
Nucleic Acids1
  • Ribonucleic acid (RNA) is made up of a long strand of nucleic acids similar, but not identical to DNA. (notesforshs.com)
RRNA1
  • The most prominent examples of RNA genes are transfer RNA (tRNA) and ribosomal RNA (rRNA), both of which are involved in the process of translation. (wikidoc.org)
Polymerase6
  • This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805). (assaygenie.com)
  • RNA polymerase ( RNAP or RNApol ) is an enzyme that makes an RNA copy of a DNA or RNA template. (wikidoc.org)
  • RNA polymerase enzymes are essential to life and are found in all organisms and many viruses . (wikidoc.org)
  • The 2006 Nobel Prize in Chemistry was awarded to Roger Kornberg for creating detailed molecular images of RNA polymerase during various stages of the transcription process. (wikidoc.org)
  • RNA Polymerase binding involves the α subunit recognizing the upstream element (-40 to -70 base pairs) in DNA, as well as the σ factor recognizing the -10 to -35 region. (wikidoc.org)
  • After binding to the DNA, the RNA polymerase switches from a closed complex to an open complex. (wikidoc.org)
Sequencing5
  • Comparative tRNA sequencing and RNA mass spectrometry for surveying tRNA modifications. (nih.gov)
  • Here, we describe an approach in which rapid prediction of modified sites through reverse transcription-derived signatures in high-throughput transfer RNA-sequencing (tRNA-seq) data is coupled with identification of tRNA modifications through RNA mass spectrometry. (nih.gov)
  • 11. Transfer RNA-derived small RNAs (tsRNAs) sequencing revealed a differential expression landscape of tsRNAs between glioblastoma and low-grade glioma. (nih.gov)
  • High-throughput RNA sequencing showed that structural organization (dendrite growth and migration) and associated pathways were activated in the dorsal skin of LP-12-treated animals. (bvsalud.org)
  • By combining single-cell RNA sequencing and fate mapping approaches, we elucidated the response of retinal microglia and recruited monocyte-derived macrophages (MDMs) to RGC injury. (biomedcentral.com)
Tyrosinase2
  • and Tyr-HSVtk [ 23 ] in which the 3'LTR of pBabe Puro has been replaced by a melanocyte- and melanoma-specific tyrosinase enhancer and in which the HSVtk cDNA [ 45 ] has been cloned downstream of the 5'MLV LTR. (medscape.com)
  • The downregulation of tyrosinase (Tyr), microphthalmia-associated transcription factor (Mitf) expression, and 5-HT7R was consistently restored in stressed skin. (bvsalud.org)
Amino4
  • These latter enzymes link amino acids to their cognate transfer RNAs (tRNA) in aminoacylation reactions that establish the connection between a specific amino acid and a nucleotide triplet anticodon embedded in the tRNA. (wikipedia.org)
  • We can tell from this that Glu must be the C-terminal amino acid, since the sequence must be either A) Ser-Tyr-X-X-X-X- Trp -Glu or b) Ser-X-X-X- Trp -X-Tyr-Glu D) Reaction of the original polypeptide with CNBr produced two tetrapeptides. (brainmass.com)
  • As a natural extension of this approach to RNA-binding proteins, and also because some RNA-binding proteins are shown to bind regions largely characterized by enrichment in one dinucleotide [ 17 ], we explored the possibility of predicting amino acid dinucleotide contacts. (biomedcentral.com)
  • The prediction model takes a matrix of sequence- and evolutionary profile-derived features and simulates the RNA-interacting state of every amino acid residue in a given sequence. (biomedcentral.com)
Antibody1
  • Open in a separate window Number 2 The Rabbit Polyclonal to OR2D3 rates of the assessment of anti-HCV antibody, HCV RNA, and treatment in the prescreening and post-screening periods. (immune-source.com)
Genes5
  • To determine the relative order of the trp ,pyr,cys genes and the distances between them, the Hfr and Fminus strains were mated long enough to allow the transfer of the nic gene, after which Trp + recombinants were selected. (brainmass.com)
  • We name non-coding RNA (ncRNA) genes according to their RNA type, please see our recent review ( https://www.embopress.org/doi/full/10.15252/embj.2019103777 ) for a full description. (bioscience.org)
  • In cells , RNAP is needed for constructing RNA chains from DNA genes , a process called transcription . (wikidoc.org)
  • RNAP will preferentially release its RNA transcript at specific DNA sequences encoded at the end of genes known as terminators . (wikidoc.org)
  • However, since the late 1990s, many new RNA genes have been found, and thus RNA genes may play a much more significant role than previously thought. (wikidoc.org)
Peptide1
  • Mutagenesis experiments have shown that the flexibility of the peptide that links the α-ACB and S4-like domains is responsible for the disorder of the latter in the structure and that elements of sequence in this linker peptide are essential for the binding of tRNA(Tyr) by YARS and its aminoacylation with tyrosine. (wikipedia.org)
Transcription3
  • Transcription in eukaryotes is carried out by three main RNA polymerases: Pol I, II, and III. (mdpi.com)
  • Through RNA mass spectrometric analyses, we showed that two of the V. cholerae-specific reverse transcription signatures reflected the presence of a new modification (acetylated acp3U (acacp3U)), while the other results from C-to-Ψ RNA editing, a process not described before. (nih.gov)
  • Outline the process of RNA transcription. (notesforshs.com)
Uridine1
  • The PTEN download Windows for HSF1( HSE, aspartate symbol uridine) covers transfer of new transcripts acid in well-being SUMOylation, with at least three Laminins representing annealed for the transcriptional phosphate acetyl. (evakoch.com)
Involves1
  • Changing a stop codon seems significantly more challenging than changing any other codon meaning because the mechanism for stop codon recognition is totally different and involves more than RNA-RNA interactions. (uncommondescent.com)
Proteins4
Recognition3
  • [1] Schimmel PR, S?ll D. Aminoacyl-tRNA synthetases: general features and recognition of transfer RNAs. (org.ua)
  • [16] Bedouelle H. Recognition of tRNA(Tyr) by tyrosyl-tRNA synthetase. (org.ua)
  • Knowledge of exact interaction partners and the mechanism of recognition are essential for an understanding and ability to control RNA-level regulatory processes. (biomedcentral.com)
Fragments1
  • 7. Transfer RNA-derived fragments and tRNA halves: biogenesis, biological functions and their roles in diseases. (nih.gov)
Molecular1
Strand2
  • Each RNAP is transcribing an RNA strand which can be seen branching off of the DNA. (wikidoc.org)
  • It then produces an RNA chain which is complementary to the template DNA strand. (wikidoc.org)
Functional1
  • Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis. (ncbs.res.in)
Role1
  • 1. The role of Transfer RNA-Derived Small RNAs (tsRNAs) in Digestive System Tumors. (nih.gov)
Terms1
  • In chemical terms, RNAP is a nucleotidyl transferase that polymerizes ribonucleotides at the 3' end of an RNA transcript. (wikidoc.org)
Complex1
  • The crystal structure of the complex between YARS from Methanococcus jannaschii, tRNA(Tyr) and L-tyrosine has been solved at 1.95 Å resolution. (wikipedia.org)
Active Site1
  • A 2-Tyr-1-carboxylate Mononuclear Iron Center Forms the Active Site of a Paracoccus Dimethylformamidase. (ncbs.res.in)
Group2
  • In this group, the number and percentage of completed anti-HCV assessments, individuals with anti-HCV seropositivity, individuals who underwent HCV RNA screening, and individuals with HCV viremia were 5154 (93.1%), 127 (2.5%), 111 (87.4%) and 52 (46.8%), respectively. (immune-source.com)
  • The percentage of individuals with detectable HCV RNA among anti-HCV seropositive individuals decreased from 69.1% in the baseline 21-Hydroxypregnenolone group to 46.8% in the screening group ( 0.001). (immune-source.com)
Translation1
  • During translation, codons are read by transfer RNAs (tRNA) that bear the matching anticodons. (cancer-pictures.org)
Shows1
  • HCV Screening Results Table 1 shows the age, sex, HCV seropositivity rate and HCV RNA viremia rate among the individuals who already experienced laboratory checks at baseline and among the individuals who completed checks during the screening period. (immune-source.com)