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  • Genes
  • A credible proposition is that tRNA was formed from the duplication of an RNA hairpin half the length of the contemporary tRNA molecule, with the point at which the hairpins were joined marked by the canonical intron insertion position found today within tRNA genes. (beds.ac.uk)
  • codons
  • However, modification of the initial uridine to a pseudouridine (Ψ) allows efficient recognition and read-through of these stop codons by a transfer RNA (tRNA), although it requires the formation of two normally forbidden purine-purine base pairs. (rcsb.org)
  • Gene
  • TRS-TGA4-1 (Transfer RNA-Ser (TGA) 4-1) is an RNA Gene, and is affiliated with the tRNA class. (genecards.org)
  • Para tal, induzimos a expressão do gene do tRNACGA Ser de C. albicans, nas versões mutantes e original, em S. cerevisiae e determinámos o impacto das mesmas no crescimento celular, bem como na estabilidade, eficiência na tradução e aminoacilação do tRNA. (ua.pt)
  • This gene provides instructions for making a particular type of RNA, a molecule that is a chemical cousin of DNA. (nih.gov)
  • The MT-TS1 gene provides instructions for a specific form of tRNA that is designated as tRNA Ser(UCN) . (nih.gov)
  • The MT-TS1 gene mutation that causes palmoplantar keratoderma with deafness leads to reduced levels of tRNA Ser(UCN) to assemble proteins within mitochondria. (nih.gov)
  • We have used this annotated assembly to investigate the genetic basis of a range of traits critical to the evolution of the Hexapoda, the phylogenetic position of H. duospinosa and potential horizontal gene transfer events. (biomedcentral.com)
  • Our detection of candidate horizontal gene transfer candidates confirms that this phenomenon is occurring across Collembola. (biomedcentral.com)
  • Abstract
  • Abstract: Selenium, a trace element essential for human health, is incorporated into more than 25 human selenocysteine-containing (Sec) proteins, via unique Sec-insertion machinery that includes a specific, nuclear genome-encoded, transfer RNA (tRNA[Ser]Sec). We report the first human tRNA[Ser]Sec mutation, with markedly reduced expression of stress-related but not housekeeping selenoproteins. (duhnnae.com)
  • nuclear
  • Theoretically, among various possibilities, an established somatic cell nuclear transfer system with genetically engineered donor cells seems to be an efficient and reliable approach to achieve this goal. (publish.csiro.au)
  • The authors conclude that although in this early phase of research no direct evidence can be provided about the practical use of transgenic pigs produced by somatic cell nuclear transfer as organ donors or disease models, the future chances even in medium term are good, and at least proportional with the efforts and sums that are invested into this research area worldwide. (publish.csiro.au)
  • mutant
  • This deficit, likely mediated by reduced expression and diminished 2'-O-methylribosylation at uridine 34 in mutant tRNA[Ser]Sec, is restored by cellular complementation with normal tRNA[Ser]Sec, demonstrating the importance of such tRNA modification for normal selenoprotein synthesis. (duhnnae.com)
  • modification
  • According to the RNA modification database http://library.med.utah.edu/RNAmods/ , 107 different modified nucleosides were found in RNA as at 2008. (biomedcentral.com)
  • expression
  • Our data demonstrate that these mutants are expressed and misincorporate Ser at CUGs, but their expression is repressed through an unknown molecular mechanism. (ua.pt)
  • The overall data show that repression of expression of the mistranslating tRNACAG Ser played a critical role on the evolution of CUG reassignment from Leu to Ser. (ua.pt)
  • N-&-N1 also down-regulates the expression of RNA polymerase. (aacrjournals.org)
  • energy
  • However, the mechanism underlying transfer of the absorbed energy from these pigments to the site of chemical catalysis is unclear. (sciencemag.org)