• Focus of this year's meeting were basic and translational aspects of antigen-specific immunotherapy and the monitoring of immune responses with three dedicated sessions organized by the recently founded committee of the CIMT Immunoguiding Program (CIP). (springer.com)
  • Furthermore, injection of colon cancer EVs in the tail vein of NOD-SCID mice determined neoplastic transformation and metastases in the lungs of the mice confirming for the first time the hypothesis that transfer of malignant epithelial cancer traits to distant target cells is a concept applicable to in vivo models. (springer.com)
  • We propose transgenic Tpr-Met mice as a new model of cardiac cachexia, which will constitute a powerful tool to understand such complex pathology and test new drugs/approaches at the preclinical level. (hindawi.com)
  • Transfer experiments involving fractionated HBsAg primed spleen cells obtained from DNA immunised mice into Tg mice showed that both CD4+ and CD8+ T cells were able to control transgene expression even in the absence of antibody production. (bmj.com)
  • Results from HBsAg-Tg mice that are knockout for the γ interferon receptor gene indicate that the regulation of the HBV envelope messenger RNA was mediated by type 1 cytokines produced by the activated T lymphocytes. (bmj.com)
  • We reported that horizontal transfer of malignant traits to target cells is a potential pathway to explain cancer dissemination. (springer.com)
  • H arvard biologist George Church burst into the headlines (yet again) last week when he helped organize a closed-door meeting of scores of top scientists to discuss accelerating efforts to create synthetic DNA - including a complete human genome. (statnews.com)
  • Whole genome sequencing, transcriptome analysis and RNA sequencing of cancer EVs and fibroblasts prior and after exposure to cancer EVs were performed. (springer.com)
  • Depletion of eIF2·GTP·Met-tRNAi translation initiation complex up-regulates BRCA1 expression in vitro and in vivo. (nih.gov)
  • a ) RNA pool for in vitro selection of catalytic precursor tRNAs. (nih.gov)
  • d ) Doped RNA pool for in vitro selection of the second generation of prototype flexizyme. (nih.gov)
  • f ) Doped RNA pool for in vitro selection of dFx, eFx and aFx that recognize aromatic leaving groups. (nih.gov)
  • The 5′-leader ribozyme recognizes a specific amino acid and self-charges to the 3′-end of RNA. (nih.gov)
  • They reported that the three RNA 2'- O -methyltransferases have three conserved motifs, termed motifs 1, 2 and 3 ( Figure 3 ) [ 2 ]. (pubmedcentralcanada.ca)
  • It reveals that eIF2 interacts with the 40S subunit via its α subunit and supports Met-tRNAiMet in an unexpected P/I orientation (eP/I). The structural core of eIF3 resides on the back of the 40S subunit, establishing two principal points of contact, whereas DHX29 binds around helix 16. (jijitang.com)
  • The common feature of SPOUT RNA methyltransferases is the formation of a deep trefoil knot in the catalytic domain. (pubmedcentralcanada.ca)
  • These discoveries shed new light into the molecular mechanisms behind the horizontal transfer of malignant traits and confirm the notion that metastatic disease might be reproduced through transfer of circulating genetic material. (springer.com)
  • We observed that EV-mediated transfer of cancer microRNAs was responsible for the transition from a mesenchymal to an epithelial phenotype (MET) in the treated fibroblasts as well as activation of cell cycle progression and cell survival pathways. (springer.com)
  • Of all the chicken tRNA's, only tRNATrp and a tRNA4{}Met bind to the enzyme with high enough affinity to be selected from a mixture of the chicken cell tRNAs. (caltech.edu)
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  • The current meeting report summarizes selected presentations providing a broad overview on the scientific content covered at the meeting. (springer.com)
  • We generated a new model of cardiac cachexia: a transgenic mouse expressing Tpr-Met receptor, the activated form of c-Met receptor of hepatocyte growth factor, specifically in the heart. (hindawi.com)
  • Subsequently, the cells would undergo the reverse transition, which would allow the reacquisition of their epithelial state (MET) and would enable the malignant cells to escape the circulation and home to the target organs. (springer.com)
  • This function enables you to search for a Keystone Symposia meeting by any word in the meeting title, location, organizer names, meeting summary or sessions (including session names, speaker names and talk titles). (keystonesymposia.org)
  • For a complete list of the meetings for the upcoming/current season, see our meeting list , or search for a meeting. (keystonesymposia.org)