• In molecular biology, one of the founding dogmas states that genetic information, stored in the form of DNA molecules in the majority of living organisms, is translated into proteins via transient intermediaries, the RNAs. (frontiersin.org)
  • Exosomes transport bioactive cargo carrying selective proteins, lipids, DNA, messenger RNAs (mRNAs), and small and large noncoding RNAs such as microRNAs (miRNAs). (springer.com)
  • However, the role of single bacterial RNA species in immune activation has not been characterized in detail. (rupress.org)
  • Bacterial and viral RNA are potent stimulators of the innate immune system, leading to immune cell activation and type I IFN production ( Takeuchi and Akira, 2010 ). (rupress.org)
  • The tmRNA is remarkably versatile: it recycles the stalled ribosome, adds a proteolysis-inducing tag to the unfinished polypeptide, and facilitates the degradation of the aberrant messenger RNA. (wikipedia.org)
  • The delivery of short hairpin RNA to HeLa cells resulted in a selective and permanent silencing of MHC class I by up to 90%, even under inflammatory conditions ( 20 ). (diabetesjournals.org)
  • Kosaka N et al (2013) Exosomal tumor-suppressive microRNAs as novel cancer therapy "exocure" is another choice for cancer treatment. (springer.com)
  • Ye SB et al (2014) Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma. (springer.com)
  • Since it has been shown that non-coding RNAs such as microRNAs and long non-coding RNAs are aberrantly expressed in cancer, and furthermore are linked to distinct cancer phenotypes, understanding the effects of dietary compounds and supplements on the epigenetic modulator non-coding RNA is of great interest. (frontiersin.org)
  • One way of exerting its impact is through modulation of non-coding RNA levels, microRNAs (miRs) in particular, in the individual ( 3 , 4 ). (frontiersin.org)
  • Boulianne et al "Production of Functional Chimaeric Mouse/Human Antibody" Nature, 312:643-646 (1984). (patentgenius.com)
  • Thus, an important emerging topic comprises epigenetic changes due to the modulation of non-coding RNA levels. (frontiersin.org)
  • The cloverleaf structure becomes the 3D L-shaped structure through coaxial stacking of the helices, which is a common RNA tertiary structure motif. (wikipedia.org)
  • Single-Step Method of RNA Isolation by Acid Guandinium Thiocyanate-Phenol-Chloroform Extraction, " Anal. (patentgenius.com)
  • Beidler et al "Cloning and High Level Expression of a Chimeric Antibody with Specificity for Human Carcinoembryonic Antigen" The Journal of Immunology, 141(11): 4053-4060 (1988). (patentgenius.com)
  • Breder et al If journal 141 4053, 1988. (patentgenius.com)
  • Sun et al "Chimeric Antibody with Human Constant Regions and Mouse Variable Regions Directed Against Carcinoma-Associated Antigen"Proc. (patentgenius.com)
  • An Ultraviolet-Sensitive RNA Strucural Element in Viroid-Like Domain of the Hepatitis Delta Virus," Science, 243:649-652 (1989). (patentgenius.com)
  • Foreign RNA serves as pathogen-associated molecular pattern (PAMP) and is a potent immune stimulator for innate immune receptors. (rupress.org)
  • Here, we used a dual-purpose therapy/imaging small interfering (si)RNA magnetic nanoparticle (MN) probe that targets β 2 microglobulin (B2M), a key component of the major histocompatibility class I complex (MHC I). In addition to serving as a siRNA carrier, this MN-siB2M probe enables monitoring of graft persistence noninvasively using magnetic resonance imaging (MRI). (diabetesjournals.org)
  • This article reviews the current findings on nutrition-induced changes in breast and gynecological cancers at the non-coding RNA level. (frontiersin.org)
  • A competition between translation and the structural function of RNA has therefore to be envisioned, although the way this competition is controlled remains rather obscure to date. (frontiersin.org)
  • Because these modifications are found at higher frequency in eukaryotic versus prokaryotic/viral RNA, this difference could facilitate the discrimination of foreign RNA from self-RNA. (rupress.org)
  • Sahagan et al "A Genetically Engineered Murine/Human Chimeric Antibody Retains Specificity for Human Tumor-Associated Antigen," The Journal of Immunology, 137 (3): 1066-1074 (1986). (patentgenius.com)
  • Cech, in "Structure and Mechanism of the Large Catalytic RNAs: Group I and Group II Introns and Ribonuclease P," The RNA World Chapter 11, pp. 239-269 (Gesteland and Atkins, eds. (patentgenius.com)
  • Gm18 confers additional conformational rigidity on the local RNA structure. (rupress.org)
  • The balance between non-coding and coding RNAs levels is modulated depending on the stage of development or differentiation, environmental cues, disturbances caused by a pathogen, etc. (frontiersin.org)
  • Hardman et al "Generation of a Recombinant Mouse --Human Chimaeric Monoclonal Antibody Directed Against Human Carcinoembryonic Antigen", Int. J. Cancer, 44: 424-433 (1989). (patentgenius.com)
  • Hardman et al Int. J Cancer 44: 424, 1989. (patentgenius.com)
  • Zhang J et al (2015) Exosome and exosomal microRNA: trafficking, sorting, and function. (springer.com)
  • The first hints emerged when it became evident that the repertoire of genome-encoded RNAs is far more extensive and complex than previously thought. (frontiersin.org)