Rna tertiary. Medical search. Frequent questions

We updated a model for the conformational ensemble of the RNA helix using crystallographic structures of Watson-Crick base pair steps. (biorxiv.org)
She has focused her research to understand how large RNAs assemble into specific, stable tertiary structures, and also how ATP-dependent enzymes in the cell recognize and remodel RNA. (wikipedia.org)
Using two breast cancer patient cohorts, we show that CD169 + macrophages were spatially associated with the presence of B and T cell tertiary lymphoid-like structures (TLLSs) in both PTs and lymph node metastases (LNMs). (lu.se)
macrophages were spatially associated with the presence of B and T cell tertiary lymphoid-like structures (TLLSs) in both PTs and lymph node metastases (LNMs). (lu.se)
They also fold into semi-rigid structures before turning into more complicated tertiary models. (dictionary.com)
The various three-dimensional, tertiary structures proteins reliably form are largely responsible for adaptive functions, like giving off color when exposed to certain wavelengths of light. (dictionary.com)
The genome of the SARS virus is a single strand of RNA that folds into regular repeating patterns to form secondary structures such as helices. (sciencedaily.com)
These then fold and bend in three dimensions to form complex tertiary structures. (sciencedaily.com)
Jan. 11, 2022 Tertiary lymphoid structures are formations that occur outside of the lymphatic system. (sciencedaily.com)
many molecules have several possible three-dimensional structures, so predicting these structures remains out of reach unless obvious sequence and functional similarity to a known class of nucleic acid molecules, such as transfer RNA (tRNA) or microRNA (miRNA), is observed. (wikipedia.org)
In vivo , DNA structures are more likely to be duplexes with full complementarity between two strands, while RNA structures are more likely to fold into complex secondary and tertiary structures such as in the ribosome , spliceosome , or transfer RNA . (wikipedia.org)
RNA molecules are structural flexible and can adopt different structures. (biosyn.com)
RNA molecules are generally folded into compact and defined tertiary structures. (biosyn.com)
mRNAs can also adopt complex tertiary structures, especially in the untranslated terminal regions (UTRs). (biosyn.com)
RNA molecules in solution may adopt secondary structures that are only partially determined by thermodynamics since RNA molecules can undergo conformational changes during interaction with other RNAs, RNA binding proteins or RNA binding peptides. (biosyn.com)
The mapping of RNA-protein or RNA-RNA interactions by protein pull-down or affinity pull-down methods allow studying RNA structures, as well as RNA-protein, and RNA-RNA interactions. (biosyn.com)
Assembly of Protein Tertiary Structures from Fragments with Similar Local Sequences using Simulated Annealing and Bayesian Scoring Functions. (rosettacommons.org)
In this respect, a deeper knowledge of complex three-dimensional RNA structures is essential to understand their new biological functions. (biomedcentral.com)
A number of bioinformatic tools have been proposed to explore two major structural databases (PDB, NDB) in order to analyze various aspects of RNA tertiary structures. (biomedcentral.com)
One of these tools is RNA FRABASE 1.0, the first web-accessible database with an engine for automatic search of 3D fragments within PDB-derived RNA structures. (biomedcentral.com)
RNA FRABASE 2.0 has stored information on 1565 PDB-deposited RNA structures, including all NMR models. (biomedcentral.com)
The RNA FRABASE 2.0 search engine algorithms operate on the database of the RNA sequences and the new library of RNA secondary structures, coded in the dot-bracket format extended to hold multi-stranded structures and to cover residues whose coordinates are missing in the PDB files. (biomedcentral.com)
The library of RNA secondary structures (and their graphics) is made available. (biomedcentral.com)
RNA FRABASE 2.0 also stores data and conformational parameters in order to provide "on the spot" structural filters to explore the three-dimensional RNA structures. (biomedcentral.com)
An instant visualization of the 3D RNA structures is provided. (biomedcentral.com)
A deep knowledge of complex three-dimensional folds of RNA structures is essential to understand the range of their biological functions. (biomedcentral.com)
This reservoir has dramatically increased in the past few years and it now contains over 1700 tertiary RNA structures, both, in the form of isolated molecules as well as RNA-protein and ligand complexes. (biomedcentral.com)
The first program calculates a complete set of rigid-body parameters that describe the detailed geometry of double helices extracted from the tertiary RNA structures. (biomedcentral.com)
RNA molecules can fold into intricate, highly dynamic, secondary and tertiary structures that are essential for their biological function. (findaphd.com)
Protein analyses examine the primary structure (amino acids) as well as the secondary folded structure, more complex tertiary structures, and protein interactions. (jax.org)
However, RNA catalysis is dependent upon RNA folding, and this yields structures that can block replication of such RNAs. (elifesciences.org)
The triplets cooperatively invaded and unraveled even highly stable RNA secondary structures, and support non-canonical primer-free and bidirectional modes of RNA synthesis and replication. (elifesciences.org)
Yet, some RNA strands can also fold to form ribozymes, 3D structures that could have guided life's chemical processes the way proteins do now. (elifesciences.org)
For example, these triplets work together to bind tightly to RNA strands and unravel structures that block RNA copying. (elifesciences.org)
Specific subsets of these fibroblasts drive the formation of tertiary lymphoid structures, which are associated with severe disease and which constitute a risk factor for the development of lymphoma in Sjögren's syndrome. (intechopen.com)
The structures page is separated into secondary and tertiary structures with a listing of files in .pdf, .jpg, and .pdb format. (asu.edu)
In recent years, an increasing number of researchers have developed novel RNA algorithms for predicting RNA secondary and tertiary structures. (nyu.edu)
To evaluate the performance of the most recent RNA 3D folding algorithms, we provide a comparative study in order to test the performance of available 3D structure prediction algorithms for an RNA data set of 43 structures of various lengths and motifs. (nyu.edu)

She researches the architectural features of large RNA molecules and RNA remodeling enzymes using experimental biochemistry and crystallography. (wikipedia.org)
Secondary structure of small RNA molecules is largely determined by strong, local interactions such as hydrogen bonds and base stacking . (wikipedia.org)
Mechanisms of regulation of gene expression by structured RNA molecules and RNA-protein complexes. (nyu.edu)
Testing regulatory RNAs and small-molecules as novel therapeutic agents. (nyu.edu)
RNA molecules with conserved catalytic cores but variable peripheries fold along unique energetically optimized pathways. (nyu.edu)
Using Analytical Ultra Centrifugation to measure global structural changes during equilibrium folding of RNA molecules. (nyu.edu)
Over the last decades, a variety of RNA methods have been developed for the study of RNA-DNA, RNA-RNA, and RNA-protein interactions including RNA complexes with ligand molecules. (biosyn.com)
RNA molecules are functionally diverse and involved in many cellular processes such as catalysis, ligand binding, and protein recognition. (biosyn.com)
RNAs are single-stranded molecules and the unlinked monomer building blocks are known as nucleotides. (biosyn.com)
Because alternative RNA splicing allows different types of mRNA molecules to be created from a single gene, it generates the diversity of protein function and structure that is essential to complex organisms. (genomicglossaries.com)
RNA molecules which hybridize to complementary sequences in either RNA or DNA altering the function of the latter. (genomicglossaries.com)
More specifically, antisense oligonucleotides that are useful as reagents for target validation , or as drugs, are engineered molecules that differ from natural RNA but that have a base sequence that is recognized as being complementary to a very specific mRNA sequence. (genomicglossaries.com)
Previously, he was a PhD student working on modelling the tertiary structure of RNA molecules at the Theoretical Biochemistry Group at the University of Vienna. (darkdaily.com)
Here, we present a comparison between in silico RNA fingerprinting and published experimental data that sheds light on efficient design of the hammerhead ribozyme molecules with a high intracellular efficiency. (edu.au)
Since the structural features of RNA are of major importance to their biological function, there is much interest in predicting RNA structure, either in free form or in interaction with various ligands, including proteins, metabolites and other molecules. (nyu.edu)

Fast Fenton footprinting: a laboratory-based method for the time-resolved analysis of DNA, RNA and proteins. (nyu.edu)
Bioinformatic algorithms allowing predicting of biomolecular folding for proteins, peptides, and RNAs, even though sometimes successful, have all their limitations. (biosyn.com)
Since RNA-binding proteins (RBPs) are key players in the post-transcriptional regulation of gene expression precise knowledge of their binding sites is critical for determining their molecular function and for understanding their roles in cell development and disease. (biosyn.com)
However, some scientists think that before life adopted DNA and proteins, it relied primarily on RNA. (elifesciences.org)
All life on Earth today uses a triplet RNA code to make proteins from DNA, and these experiments showed how RNA triplets might have helped RNA sustain early life forms. (elifesciences.org)
Most of the proteins interact with multiple RNA elements, often from different domains. (embl.de)
Proteins S4 and S7, which initiate assembly of the 16S rRNA, are located at junctions of five and four RNA helices, respectively. (embl.de)
In this way proteins serve to organise and stabilise the rRNA tertiary structure. (embl.de)
While the crucial activities of decoding and peptide transfer are RNA based, proteins play an active role in functions that may have evolved to streamline the process of protein synthesis. (embl.de)
The Telomerase RNP contains two essential core components, the telomerase reverse transcriptase (TERT) and the telomerase RNA (TR), along with other species-specific telomerase associated proteins. (asu.edu)

Specific tertiary structure types are observed for transfer RNA (tRNA), ribosomal RNA (rRNA), small nuclear RNA (snRNA), certain introns, and ribozymes. (biosyn.com)
These results provide information about the overall tertiary structure of rRNA in ribosomes. (caltech.edu)
PacBio today announced it has begun taking orders for its groundbreaking Kinnex RNA kits, which increase throughput for full-length RNA, single-cell RNA, and 16S rRNA sequencing on PacBio's long-read sequencing systems to enable large-scale studies at a resolution difficult to attain with short-read RNA sequencing. (news-medical.net)

RNA sequencing is beginning to show promise for understanding how a DNA variant may disrupt the normal transcription to RNA, post-transcriptional modifications, or the subsequent protein structure. (jax.org)

However, in the case of RNA much of the final structure is determined by the secondary structure or intra-molecular base pairing interactions of the molecule. (wikipedia.org)
Most popular methods for predicting RNA and DNA's secondary structure involve dynamic programming . (wikipedia.org)
[7] [8] One of the early attempts at predicting RNA secondary structure was made by Ruth Nussinov and co-workers who developed a dynamic programming-based algorithm that maximized the length and number of a series of "blocks" (polynucleotide chains). (wikipedia.org)
This search is based upon the user-defined RNA secondary structure pattern. (biomedcentral.com)
Despite the wealth of data on RNA secondary structure, conformational dynamics and tertiary structure in vitro and in vivo, predicting RNA biological activity in cellular environments remains difficult. (edu.au)
The ML predictors utilize features representing evolutionary conservation, sequence context, secondary structure and tertiary interactions. (lu.se)

Finding a similar 90° kink in a region of ribosomal RNA that binds factors necessary for the initiation of protein synthesis, the researchers speculate that the SARS virus may use the s2m element to hijack its host cell's protein synthesis machinery. (sciencedaily.com)

From sensitive and specific assay for SARS-CoV RNA. (cdc.gov)
In spite of this similar organization, the SARS-CoV RNA cells showed the virions within cell vesicles and around the sequence is only distantly related to that of previously cell membrane. (cdc.gov)

1500 tertiary assemblies with differing helical sequences and compared calculations to independent measurements from a high-throughput experimental platform. (biorxiv.org)

They include coding mRNAs and non-coding (nc) RNAs among them antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), micro-RNAs (miRNAs), small activating RNAs (saRNAs), RNA aptamers and RNA guides. (frontiersin.org)
There are currently several products containing RNA on the market, and many are under development, among them mRNA, antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), small activating RNAs (saRNAs), micro-RNAs (mi-RNAs), RNA aptamers and RNA guides. (frontiersin.org)
Endogenous antisense RNAs function as regulators of gene expression by a variety of mechanisms. (genomicglossaries.com)
Synthetic antisense RNAs are used to effect the functioning of specific genes for investigative or therapeutic purposes. (genomicglossaries.com)

We present diffBUM-HMM, a noise-aware model that enables accurate detection of RNA flexibility and conformational changes from high-throughput RNA structure-probing data. (biomedcentral.com)

Among them, sulfur modifications of tRNA are important for tRNA functions, such as codon recognition and stabilization of the tertiary structure [Fig. 1]. (go.jp)

Protein synthesis, folding, and tertiary and quaternary structure ultimately determine much of the body's structure and function. (msdmanuals.com)

Post-transcriptional modification is one of the characteristic features of RNA. (go.jp)

A common problem for researchers working with RNA is to determine the three-dimensional structure of the molecule given only a nucleic acid sequence. (wikipedia.org)
For early life to be built on RNA, though, this molecule must have had the ability to make copies of itself. (elifesciences.org)
RNA-like oligonucleotides that are complementary to a portion of a target mRNA molecule. (genomicglossaries.com)
A complementary RNA sequence that binds to a naturally occurring (sense) mRNA molecule, thus blocking its translation. (genomicglossaries.com)
A gene, the basic unit of heredity, is a segment of DNA containing all the information necessary to synthesize a polypeptide (protein) or a functional RNA molecule. (msdmanuals.com)
We have isolated a SARS-associ- the complete genome of SARS-CoV has shown an RNA ated CoV (SARS-CoV) strain by injecting Vero cells with a molecule of about 29,750 bases in length, with a genome sputum specimen from an Italian patient affected by a organization similar to that of other coronaviruses (9-11). (cdc.gov)

Triplet substrates thus resolve a central incongruity of RNA replication, and here allow the ribozyme to synthesise its own catalytic subunit '+' and '-' strands in segments and assemble them into a new active ribozyme. (elifesciences.org)
RNA which contains an intron sequence that has an enzyme- like catalytic activity. (genomicglossaries.com)
Our method, which we call RNA dactyloscopy, is a reliable tool for assessing the catalytic properties, modeling and design of RNA. (edu.au)
During a processive reaction, the DNA strand (blue) anneals to the alignment region in the TR (pink), the catalytic TERT protein (grey) reverse transcribes the RNA template (red), adding 6 deoxyribonucleotides (blue) to the DNA strand. (asu.edu)

The characterization of RNA and RNA interactions is closely related to transcription, for example, gene expression levels are investigated within a biological context. (biosyn.com)

abstract = "Many exciting discoveries have recently revealed the versatility of RNA and its importance in a variety of functions within the cell. (nyu.edu)

Genomics of Black American colon cancer disparities: An RNA sequencing (RNA-Seq) study from an academic, tertiary referral center. (cdc.gov)

Over 50% of residues within functional structured RNAs are base-paired in Watson-Crick helices, but it is not fully understood how these helices' geometric preferences and flexibility might influence RNA tertiary structure. (biorxiv.org)
Here, we show experimentally and computationally that the ensemble fluctuations of RNA helices substantially impact RNA tertiary structure stability. (biorxiv.org)

Nucleic acid structure prediction is a computational method to determine secondary and tertiary nucleic acid structure from its sequence. (wikipedia.org)
The combination of different biochemical methods with computational modelling allows scientists to gain insight into molecular processes in which RNA is involved. (biosyn.com)
In this review, we describe current experimental and computational advances and discuss recent ideas that are transforming the traditional view of RNA folding. (nyu.edu)
Advancing RNA structural probing techniques with next-generation sequencing has generated demands for complementary computational tools to robustly extract RNA structural information amidst sampling noise and variability. (biomedcentral.com)

Small RNAs such as microRNAs (miRNAs) and small interfering (si)RNAs are short 20-24-nucleotide non-coding RNAs. (ncbs.res.in)
Several 22-nucleotide long miRNAs trigger biogenesis of cascades of trans-acting secondary small interfering RNAs, involved in various developmental and stress responses. (ncbs.res.in)

We report RNA-catalysed RNA synthesis on structured templates when using trinucleotide triphosphates (triplets) as substrates, catalysed by a general and accurate triplet polymerase ribozyme that emerged from in vitro evolution as a mutualistic RNA heterodimer. (elifesciences.org)

RNA testing looks for changes in gene expression, and protein analysis assesses structural changes in the protein product of the gene. (jax.org)
To address these problems, Mark Cembrowski (with help from many others at Janelia) is performing a hippocampus-wide screen of gene expression in genetically and anatomically defined cell types using next-generation RNA sequencing. (janelia.org)

RNA Biology: Tertiary Structure and RNA-Protein. (hhmi.org)
Mitra, S. ( 2014 ) Methods in Molecular Biology, Vol. 1086 (RNA Folding - Methods and Protocols), Chapter 16: 265-288. (nyu.edu)
Doing a PhD in Cancer Biology, you'll develop excellent laboratory skills, particularly in cell culture, working with RNA and studying the proteome. (findaphd.com)
RNA-catalyzed RNA replication is widely believed to have supported a primordial biology. (elifesciences.org)
Understanding the structure of RNA is key to unravel its in vivo function, and it is also highly relevant to biomedicine, drug discovery, and synthetic biology [ 1 - 4 ]. (biomedcentral.com)

After second- strand cDNA synthesis, T7 RNA polymerase was used to generate aRNA. (genomicglossaries.com)

In this apparent paradox, a ribozyme needs to fold to copy RNA, but when folded, is itself copied poorly. (elifesciences.org)

Using small RNA datasets derived from Indian Himalayan accessions, as well as overexpression and knockout lines of miR158, we show that absence of miR158 led to build up of pseudo-PPR derived tertiary small RNAs. (ncbs.res.in)
Our analyses of datasets generated with a variety of RNA probing chemistries demonstrate the value of diffBUM-HMM for quantitatively detecting RNA structural changes and RNA-binding protein binding sites. (biomedcentral.com)
As a consequence, the last few years have seen an increase in the development of a number of bioinformatics tools to detect differentially reactive nucleotides (DRNs) in RNA structure probing datasets. (biomedcentral.com)

When RNA is copied, one strand acts as a template, and a replicase ribozyme would accurately guide which letters are added to the strand under construction. (elifesciences.org)
aRNA is RNA that is transcribed from the coding, rather than the template, strand of DNA. (genomicglossaries.com)

This strong sequence conservation indicates that the tertiary structure of s2m could be important for viral function, and when the researchers solved the three-dimensional crystal structure of the element, they found that it had a unique tertiary structure. (sciencedaily.com)
Our intention is that this advanced version of the RNA FRABASE will be of interest to all researchers working in the RNA field. (biomedcentral.com)
Researchers at Stanford University used such a method to produce amplified heterogeneous populations of RNA from limited quantities of cDNA. (genomicglossaries.com)
More recently, another group of researchers reported that they had developed a process for optimizing low- abundance RNA, by combining aRNA amplification with template- switching. (genomicglossaries.com)
The ability to accurately detect nucleotide regions that differentially react with RNA structure probing reagents under diverse conditions, or due to the effect of mutations, is of great importance to researchers. (biomedcentral.com)
For the study, which was designed according to the REMARK guidelines for diagnostic tumor marker development, the researchers prospectively enrolled 914 patients from three tertiary care centers. (medscape.com)

such as self-splicing introns and other noncoding RNAs. (wikipedia.org)

We functionally validated the tertiary phasiRNA that targets NHX2 a Na -K /H antiporter protein thereby regulating transpiration and stomatal conductance. (ncbs.res.in)

Tertiary structure can be predicted from the sequence, or by comparative modeling (when the structure of a homologous sequence is known). (wikipedia.org)
Using three-letter 'triplet' building blocks, this new ribozyme can copy various folded RNA strands, including the active part of its own sequence. (elifesciences.org)
87(5): 1663-1667] Specifically, the investigators started by priming whole cerebellar RNA with a synthetic oligonucleotide containing a T7 RNA polymerase promoter sequence. (genomicglossaries.com)
Each of these pages lists information related to the component, the RNA or amino acid sequence, the genbank accession number, and a link to the record at the National Center for Biotechnology Information (NCBI) . (asu.edu)
The alignments page contains multiple RNA and amino acid sequence alignments based on both sequence and structural similarities. (asu.edu)

But could the structure of the RNA genome itself also be a target for antiviral drugs? (sciencedaily.com)
SARS-CoV-2 genome load was absent in secondary and tertiary treated effluent. (medrxiv.org)

Metal ions and RNA folding kinetics. (nyu.edu)
Our knowledge of thermodynamic rules and parameters that govern folding patterns of RNAs are far from being complete. (biosyn.com)
We conclude by outlining some suggestions for future RNA folding research. (nyu.edu)

About 2/3 of the mass of the ribosome consists of RNA and 1/3 of protein. (embl.de)

RNA sequencing of breast tumors. (lu.se)
RNA sequencing of breast tumors further confirmed that SIGLEC1 (CD169) expression was associated with mature tertiary lymphoid structure (TLS), and T reg and B reg signatures. (lu.se)
However, for a discrete number of patients whose results are uninformative, it may be possible to get a more definitive answer about the consequences of a variant using additional methods like RNA sequencing, protein analysis and predictive or functional studies. (jax.org)
Lee (2020) and Frésard (2019) demonstrated clinical utility in adding RNA sequencing to genomic testing for cohorts of individuals with undiagnosed Mendelian disease, increasing the diagnostic yield by 18% and 7.5%, respectively. (jax.org)
Because of this, labs are beginning to offer paired simultaneous DNA-RNA testing or request additional samples for RNA sequencing. (jax.org)
Cells of interest are then microdissected and sorted for subsequent RNA library preparation and sequencing (Hempel et al. (janelia.org)
Single cell RNA-sequencing has provided new insights into subsets of fibroblasts in inflamed salivary glands and has provided evidence for the existence of shared inflammation-associated fibroblasts across chronically inflamed tissues. (intechopen.com)
Utility of clinical exome sequencing in the evaluation of neonates with suspected genetic condition - An observational study from tertiary neonatal care unit in South India. (cdc.gov)

The Role of Tertiary Structure in MicroRNA Target Recognition. (nyu.edu)

Recent discoveries concerning novel functions of RNA, such as RNA interference, have contributed towards the growing importance of the field. (biomedcentral.com)

Like DNA, strands of RNA contain genetic data. (elifesciences.org)
RNA strands are made of four different letters attached to each other in a specific order. (elifesciences.org)
Biochemical techniques were used to engineer a ribozyme that copies RNA strands by adding letters not one-by-one, but three-by-three. (elifesciences.org)

While the methods are similar, there are slight differences in the approaches to RNA and DNA structure prediction. (wikipedia.org)

Methods From January to April, 2022, reverse transcription polymerase chain reaction was used to detect the presence of SARS-CoV-2 viral RNA in patient, environmental (floor, equipment, passive air) samples, and HCW's masks (inside surface) during urgent surgery or obstetrical delivery for patients with SARS-CoV-2 infection. (researchgate.net)
5/108 samples (5%) tested positive (SARS-CoV-2 Omicron) viral RNA: 2/5 endotracheal tubes, 1/22 floor samples, 1/4 patient masks and 1 nasal probe. (researchgate.net)

Predicting pseudoknots and long-range and tertiary-structure interactions accurately is also quite difficult. (biosyn.com)

Comparative Epigenomics Reveals that RNA Polymerase II Pausing and Chromatin Domain Organization Control Nematode piRNA Biogenesis. (nyu.edu)
SARS-CoV-2 RNA was detected in 11 out of 39 wastewater samples in Jaipur district and 5 out of 17 wastewater samples in Haridwar District using Reverse-Transcriptase Quantitative Polymerase Chain Reaction (RT-qPCR) for qualitative detection. (medrxiv.org)
Rabies-virus RNA was not detectable by reverse transcriptase polymerase chain reaction assay of either sample. (cdc.gov)
Influenza virus RNA copy number was determined by polymerase chain reaction (PCR), and the mean value of 2 replicates was used in analysis. (cdc.gov)

Pyle is the president of the RNA Society, the vice-chair of the Science and Technology Steering Committee at Brookhaven National Laboratory, and previously she served as chair of the Macromolecular Structure and Function A Study Section at the National Institutes of Health. (wikipedia.org)

However, things are becoming more and more complicated as the current evolution of technology in this field makes it possible to produce similar RNA-based drugs using different approaches. (frontiersin.org)

this has led scientists to try to artificially create RNA replicase ribozymes that could copy themselves. (elifesciences.org)
Yet, although ribozymes can be made to copy straight RNA templates this way, folded RNA templates - including the replicase ribozyme itself - impede copying. (elifesciences.org)

The qualitative analysis of the wastewater for the presence of SARS-CoV-2 RNA was done using different pre-processing methods. (medrxiv.org)
Finally, we speculate how phylogenetic methods with RNA may be further enhanced by integration of the third dimension. (uni-wuerzburg.de)

An intuitionally operated web server platform enables very fast user-tailored search of three-dimensional RNA fragments, their multi-parameter conformational analysis and visualization. (biomedcentral.com)
One of the most difficult issues in mining available structural data is the search of RNA structural motifs and fragments in a conformational space. (biomedcentral.com)

After extension, the DNA dissociates from the RNA and the newly synthesized DNA (blue) anneals to alignment region in the TR (pink), ready for reverse transcription to occur. (asu.edu)

The tertiary stage commonly begins from three to four years after the primary infection. (dictionary.com)

Variability in influenza virus RNA-laden aerosol generation was evident. (cdc.gov)

Anatomy16

Organisms27

Diseases1

Chemicals and Drugs120

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes76

Information Science4

Health Care1

Structures38

Molecules15

Proteins10

RRNA3

Protein Structure1

Secondary structure6

Ribosomal1

SARS-CoV RNA2

Sequences1

Antisense4

Conformational changes1

TRNA1

Quaternary structure1

Post-transcriptional1

Molecule6

Catalytic4

Biological1

ABSTRACT1

Genomics1

Helices2

Computational4

MiRNAs2

Vitro1

Gene expression2

Biology5

Synthesis1

Fold1

Datasets3

Strand2

Researchers6

Introns1

Functionally1

Sequence5

Genome2

Folding3

Ribosome1

Sequencing8

Recognition1

Interference1

Strands3

Structure prediction1

Viral2

Interactions1

Polymerase4

Pyle1

Approaches1

Ribozymes2

Methods2

Fragments2

Transcription1

Primary1

Variability1