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  • Proteins
  • The emerging role of RNA-binding proteins in the life cycle of Trypanosoma brucei. (yale.edu)
  • Kolev, N.G., Ullu, E. and Tschudi C. The emerging role of RNA-binding proteins in the life cycle of Trypanosoma brucei. (yale.edu)
  • Distinct and overlapping roles for two Dicer-like proteins in the RNA interference pathways of the ancient eukaryote Trypanosoma brucei. (yale.edu)
  • The SRP RNA, together with one or more SRP proteins contributes to the binding and release of the signal peptide. (wikipedia.org)
  • Archaeal SRP consists of a 7S RNA and homologues of the eukaryotic SRP19 and SRP54 proteins. (wikipedia.org)
  • For many years scientists assumed that proteins alone had the structural complexity needed to serve as specific catalysts in cells, but around 1980 the research groups of Tom Cech and Sidney Altman independently discovered that some biological catalysts are made of RNA. (encyclopedia.com)
  • Although most ribozyme targets are RNA, there is now very strong evidence that the linkage of amino acids into proteins, which occurs at the ribosome during translation , is also catalyzed by RNA. (encyclopedia.com)
  • One ribozyme of this type is RNase P, which consists of one RNA chain and one or more proteins (depending on the organism). (encyclopedia.com)
  • Proteins are hypothesized to have evolved later, and as they evolved they took over functions previously performed by RNA molecules. (encyclopedia.com)
  • Since the first enzyme to be synthesized (by James Sumner in 1926) had turned out to be a protein, and since all of the hundreds of other cellular enzymes had also turned out to be proteins, Cech confidently began to search for the protein enzyme responsible for snipping introns from RNA molecules. (oup.com)
  • The concept of messenger RNA emerged during the late 1950s, and is associated with Crick's description of his "Central Dogma of Molecular Biology", which asserted that DNA led to the formation of RNA, which in turn led to the synthesis of proteins. (wikipedia.org)
  • gene
  • Mutation detection analysis of a region of 16S-like ribosomal RNA gene of Entamoeba histolytica, Entamoeba dispar and Entamoeba moshkovskii. (nih.gov)
  • In addition, high-throughput next-generation sequencing technologies (RNA-Seq) are used to analyze gene expression patterns (the transcriptome) during the developmental cycle. (yale.edu)
  • Here we describe the methods deployed to study mitochondrial gene transcription and RNA processing in Dictyostelium. (edu.au)
  • The common SINE family Alu probably originated from a 7SL RNA gene after deletion of a central sequence. (wikipedia.org)
  • Genome editing by clustered regularly interspaced short palindromic repeats (CRISPR), CRISPR-associated gene 9 (Cas9) is a transformative new technology [ 15 , 16 ] for precise cleavage of double-stranded DNA by a Cas9 nuclease with sequence-specificity determined by a single-guide RNA (sgRNA). (royalsocietypublishing.org)
  • Together with TBR5 and TBR17 it is a part of a tandemly repeated snoRNA gene cluster, located within the spliced leader RNA (SLA). (wikipedia.org)
  • 2008). Reconsideration of the Phylogenetic Position of Frontonia-related Peniculia (Ciliophora, Protozoa) Inferred from the Small Subunit Ribosomal RNA Gene Sequences. (wikipedia.org)
  • RNA editing through the addition and deletion of uracil has been found in kinetoplasts from the mitochondria of Trypanosoma brucei Because this may involve a large fraction of the sites in a gene, it is sometimes called "pan-editing" to distinguish it from topical editing of one or a few sites. (wikipedia.org)
  • bacterial
  • The gRNA consists of a 20-nucleotide (nt) guide (also known as protospacer) sequence, followed by an 82-nt chimeric sequence derived from the CRISPR RNA (crRNA) and the trans -activating RNAs (tracrRNAs) of the bacterial system. (asm.org)
  • The short-lived nature of bacterial RNAs, together with the highly complex nature of the cellular mRNA population, made the biochemical isolation of mRNA very challenging. (wikipedia.org)
  • Sequences
  • The regions near the 5'- and 3'-ends of the mammalian SRP RNA are similar to the dominant Alu family of middle repetitive sequences of the human genome. (wikipedia.org)
  • RNA interference has an important role in defending cells against parasitic nucleotide sequences - viruses and transposons. (wikipedia.org)
  • The insertions and deletions are mediated by short guide RNA (gRNAs) which encode the editing information in the form of complementary sequences (allowing GU as well as GC base pairs). (wikipedia.org)
  • yeast
  • Yeast, protozoan, and viral RTPases require a metal co-factor for their activity, which is most often either Mg2+ or Mn2+. (wikipedia.org)
  • Like yeast and human, protozoan protist Entamoeba histolytica : a primitive eukaryote adopted the same conserved secondary structure of U3 snoRNA. (wikipedia.org)
  • Rfam
  • Rfam has chosen to create Wikipedia entries for all of our RNA families and to open them up to community annotation. (rfam.org)
  • bacteria
  • citation needed] The 5'-end of the small (4.5S) SRP RNA of many bacteria is cleaved by RNase P.[citation needed] The ends of the Bacillus subtilis SRP RNA are processed by RNase III. (wikipedia.org)
  • double-stranded
  • Replication follows the double-stranded RNA virus replication model. (wikipedia.org)
  • These short double-stranded fragments are called small interfering RNAs (siRNAs). (wikipedia.org)
  • R2D2 carries tandem double-stranded RNA-binding domains to recognize the thermodynamically stable terminus of siRNA duplexes, whereas Dicer-2 the other less stable extremity. (wikipedia.org)
  • genome
  • The ribozyme then cleaves the long multimeric molecules into pieces that contain one genome copy, and fits that RNA piece into a virus particle. (encyclopedia.com)
  • Kolev
  • Kolev, N.G. and Ullu, E. SnoRNAs in Giardia lamblia: a novel role in RNA silencing? (yale.edu)
  • exons
  • In this case, an RNA chain is cleaved in two places and the middle piece (called the intron) is discarded, while the two flanking RNA pieces (called exons) are ligated together. (encyclopedia.com)