Rna precursors. Medical search. FAQ

Eukaryotic 5S rRNA is synthesized by RNA polymerase III , whereas other eukaryotic rRNAs are cleaved from a 45S precursor transcribed by RNA polymerase I . In Xenopus oocytes , it has been shown that fingers 4-7 of the nine- zinc finger transcription factor TFIIIA can bind to the central region of 5S RNA. (wikipedia.org)

Class 3 RNase III Class 3 RNases III include the Drosha family of enzymes known to function in maturation of precursors to miRNA. (wikipedia.org)

In bacteria and archaea , the large ribosomal subunit (LSU) itself is composed of two RNA moieties, the 5S rRNA and another larger RNA known as 23S rRNA , along with numerous associated proteins. (wikipedia.org)

The 5S ribosomal RNA ( 5S rRNA ) is an approximately 120 nucleotide-long ribosomal RNA molecule with a mass of 40 kDa . (wikipedia.org)
In prokaryotes, the 5S rRNA gene is typically located in the rRNA operons downstream of the small and the large subunit rRNA, and co-transcribed into a polycistronic precursor . (wikipedia.org)
Binding between 5S rRNA and TFIIIA serves to both repress further transcription of the 5S RNA gene and stabilize the 5S RNA transcript until it is required for ribosome assembly. (wikipedia.org)
The designation 5S refers to the molecule's sedimentation velocity in an ultracentrifuge, which is measured in Svedberg units (S). In prokaryotes, the 5S rRNA gene is typically located in rRNA operons downstream of the small and large subunit rRNA, and co-transcribed into a polycistronic precursor. (wikipedia.org)
When exactly 5S rRNA is integrated into the ribosome remains controversial, but it is generally accepted that 5S rRNA is incorporated into the 90S particle, which is a precursor to 60S particle, as part of a small ribosome-independent RNP complex formed by 5S rRNA and ribosomal protein L5. (wikipedia.org)
Interaction of 5S rRNA with the La protein prevents the RNA from degradation by exonucleases in the cell. (wikipedia.org)
La protein interacts with these RNAs (including the 5S rRNA) through their 3' oligo-uridine tract, aiding stability and folding of the RNA. (wikipedia.org)

They are ubiquitous compounds in the cell and play a major role in pathways such as RNA precursor synthesis, RNA Silencing, and the pnp autoregulatory mechanism. (wikipedia.org)

They process precursors to ribosomal RNA, small nuclear RNA (snRNA) and small nucleolar RNA (snoRNA). (wikipedia.org)
They process precursors to ribosomal RNA, small nuclear RNA (snRNA) and small nucleolar RNA (snoRNA) Yeast nucleases with the Class 2 RNase III domain: RNT1 (UniProtKB Q02555) - S. cerevisiae - this RNase III is involved in the transcription and processing of rDNA, the 3' end formation of U2 snRNA via cleavage of the terminal loop, cell wall stress response and degradation, and regulation of morphogenesis checkpoint genes. (wikipedia.org)

Class 4 RNase III Class 4 RNases III include the Dicer family of enzymes known to function in RNA interference (RNAi). (wikipedia.org)
Dicer enzymes process dsRNA subtrates into small RNA fragments of individual size ranging from 21-27 nucleotides in length. (wikipedia.org)

Ribonuclease III (RNase III or RNase C)(BRENDA 3.1.26.3) is a type of ribonuclease that recognizes dsRNA and cleaves it at specific targeted locations to transform them into mature RNAs. (wikipedia.org)

RNAs that are produced by Dicer act as guides for a sequence of particular silencing of cognate genes through RNAi and related pathways. (wikipedia.org)