Loading...
  • vivo
  • Acetylation of the core histone N termini is a post-translational modification of chromatin that has been widely correlated with enhanced transcriptional activity in vivo ( 3 , 34 , 55 , 57 ). (asm.org)
  • Disruption of this interaction in vivo by using the E7 oncoprotein of human papillomavirus results in a marked increase in Pol III transcription. (hud.ac.uk)
  • synthesis
  • The origin of this energy demand is proposed to reside in a futile cycle of RNA synthesis and turnover that is enhanced by constitutive Pol III transcription. (pnas.org)
  • Metabolite profiling also confirms key predictions of the futile RNA cycle hypothesis by identifying changes in many metabolites involved in nucleotide synthesis and turnover. (pnas.org)
  • respectively
  • The 'A or G' sparing rule ('ΔG' or 'ΔA') as well as 'ΔU' and 'ΔC' rules are summarized at right with 'E', 'A' and 'B' to indicate whether the rule applies to each of the three domains of life (Eukaryotes, Archaea and Bacteria, respectively). (nih.gov)
  • fibroblasts
  • Pol III activity is also deregulated in fibroblasts derived from p107 p130 double knockout mice. (hud.ac.uk)
  • Function
  • Here, using targeted metabolomics, we find changes in the liver of fed and fasted Maf1 KO mice consistent with the function of mammalian Maf1 as a chronic Pol III repressor. (pnas.org)
  • The study cohort included 279 patients with SSc from the observational Oslo University Hospital cohort with complete data on (1) SSc-related autoantibodies, (2) paired, serial analyses of lung function and fibrosis by computed tomography, and (3) PH verified by right heart catheterization. (jrheum.org)
  • human
  • Further examination showed that both compounds are broad-spectrum inhibitors, displaying activity against RNA Pol III transcription systems derived from Candida albicans and human cells. (asm.org)
  • sequences
  • Bacteria use these stored spacer sequences as a template to express RNA to recognize and attack specific viruses if they are exposed again. (bio-protocol.org)
  • recognize
  • When combined with CRISPR-associated (Cas) proteins, CRISPR-Cas systems can recognize and cut foreign DNA or RNA, destroying the virus and protecting the host from repeated infections (Barrangou, 2013). (bio-protocol.org)
  • interactions
  • May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. (nih.gov)