• We performed RNA-seq on 6 BPDCN and 16 AML patient-derived xenografts (PDXs) and found higher BCL-2 expression in BPDCN (RPKM 48.2 vs 11.5, P=0.0005). (ashpublications.org)
  • All the differentiated cells within such a neoplasm produce the same whole immunoglobulin chain or chain fragment. (wordpress.com)
  • MicroRNAs (miRNAs) that exert function by posttranscriptional suppression have recently brought insight in our understanding of the role of non-protein-coding RNAs in carcinogenesis and metastasis. (nih.gov)
  • Circular RNAs (circRNAs) have emerged as important regulators in carcinogenesis and metastasis. (medscimonit.com)
  • RNA-binding proteins (RBPs) regulate many aspects of transcription and translation in a cell- and tissue-specific manner and are frequently dysregulated in malignancy. (confex.com)
  • To explore the mechanism of RBM39 dependence in AML, we performed proteomic analyses of RBM39 interacting proteins in MOLM-13 cells as well as transcriptome-wide analysis of RBM39 RNA binding by enhanced UV cross-linking and immunoprecipitation (eCLIP) in the same cells. (confex.com)
  • Furthermore, TGZ induced the expression of endogenous or exogenous p63 and p73 proteins and p63- or p73-directed short hairpin (si) RNAs inhibited the ability of TGZ to regulate expression of p21 in these cells. (osti.gov)
  • Analysis of truncated WT1 proteins demonstrated that three of four zinc fingers were necessary for RNA-protein interaction. (mendeley.com)
  • The class of non-coding RNAs-molecules that are generally not translated into proteins-are new cancer drivers and suppressors in all types of cancer. (mdpi.com)
  • We further find that treatment of cells with matrix metalloproteinase-3 (MMP-3), an inducer of EMT, interrupts a defined subset of cell contact-regulated genes, including genes encoding a variety of RNA splicing proteins known to regulate the expression of Rac1b, an activated splice isoform of Rac1 known to be a key mediator of MMP-3-induced EMT in breast, lung, and pancreas. (elsevier.com)
  • The U.S. Food and Drug Administration today approved Elzonris (tagraxofusp-erzs) infusion for the treatment of blastic plasmacytoid dendritic cell neoplasm in adults and in pediatric patients, two years of age and older. (news-medical.net)
  • Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive malignancy derived from precursors of plasmacytoid dendritic cells. (bloodjournal.org)
  • Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic disease, often presenting in the skin. (bloodjournal.org)
  • Blastic plasmacytoid dendritic cell neoplasm (BPDCN) can be an intense and largely incurable hematologic malignancy from plasmacytoid dendritic cells (pDCs). (antibodyassay.com)
  • Although a number of studies have characterized the DNA binding properties of the WT1 protein, recent evidence has suggested that WT1 may also have a role in RNA metabolism. (mendeley.com)
  • Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. (genecards.org)
  • Targeting Mcl-1 in these melanoma cell lines with specific small interfering RNA was sufficient to sensitize them to both anti-Fas mAb-induced apoptosis and activation of caspase-9. (aacrjournals.org)
  • RNA modifications impact numerous cellular processes such as pre-mRNA splicing and protein synthesis. (mendeley.com)
  • METHODOLOGY: The study tested the TiO2 and Ag+ bacteriostatic activity against S. aureus strains by MIC assays and S. aureus growth curves, lesion in the membranes by surface hydrophobicity tests, conductivity tests and measurements of DNA and RNA contents in S. aureus cultures, and investigated the inhibition of soluble protein and nucleic acid synthesis by measurements of soluble protein content, fluorescent intensity and nucleic acid content of living S. aureus. (bireme.br)
  • Composed of cytotoxic glycopeptide antibiotics, which appear to inhibit DNA synthesis, with some evidence of RNA and protein synthesis inhibition to a lesser degree. (medscape.com)
  • It works by inhibiting the synthesis of RNA and DNA of carcinoma cells. (wikipedia.org)
  • It is a competitive inhibitor of cell-free RNA and DNA synthesis, and blocks the action of DNase I. Anthramycin-methyl-ether (AME) forms a complex with DNA which blocks off synthesis by prohibiting DNA binding with proper enzymes. (wikipedia.org)
  • It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. (genecards.org)
  • glucocorticoids can inhibit mitosis, RNA synthesis, and protein synthesis in sensitive lymphocytes. (merckvetmanual.com)
  • Additionally, they have a higher rate of 5S RNA synthesis and probably contain more ribosomes as they contain more protein than do wild-type worms ( Frank and Roth, 1998 ). (biologists.org)
  • Folate is necessary for the production and maintenance of new cells , for DNA synthesis and RNA synthesis through methylation , and for preventing changes to DNA , thus for preventing cancer . (wikipedia.org)
  • Folate deficiency hinders DNA synthesis and cell division, affecting hematopoietic cells and neoplasms the most because of their greater frequency of cell division. (wikipedia.org)
  • RNA transcription and subsequent protein synthesis are less affected by folate deficiency, as the mRNA can be recycled and used again (as opposed to DNA synthesis, where a new genomic copy must be created). (wikipedia.org)
  • IDIBELL Researchers of the Neuro-Oncology Unit of Bellvitge University Hospital - Catalan Institute of Oncology, led by Dr. Jordi Bruna, have successfully tested a new molecule capable of preventing the development of peripheral neuropathy induced by chemotherapy in cancer patients, especially in colon cancer cases, the third most common neoplasm in the world. (news-medical.net)
  • Additionally, a growing body of evidence supports the role of long non-coding RNAs (lncRNAs) in cancer development and progression. (mdpi.com)
  • We hypothesized that transcriptome sequencing (RNA-Seq) will enhance our understanding of the field of molecular injury in response to tobacco smoke exposure and lung cancer pathogenesis by identifying gene expression differences not interrogated or accurately measured by microarrays. (pubmedcentralcanada.ca)
  • The measurement of both coding and non-coding transcripts by RNA-Seq has the potential to help elucidate mechanisms of response to tobacco smoke and to identify additional biomarkers of lung cancer risk and novel targets for chemoprevention. (pubmedcentralcanada.ca)
  • HOXD antisense growth-associated long noncoding RNA (HOXD-AS1) was reported to be upregulated in various cancers, such as gastric cancer, hepatocellular carcinoma, colorectal cancer, and glioma. (dovepress.com)
  • Robert J KleinSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe used RNA sequencing to analyze the genomic signatures of prostate cancer that progressed after targeted alpha therapy. (medworm.com)
  • While cell behavior can be modulated by long non-coding RNAs (lncRNAs), the contributions of lncRNAs in progression and berberine effects on colorectal cancer are largely unknown. (medscimonit.com)
  • This invention relates to the use of tumor-derived or associated extracellular ribonucleic acid (RNA) found circulating in the plasma or serum fraction of blood for the detection, monitoring, or evaluation of cancer or premalignant conditions. (google.com.au)
  • Further, this invention allows the qualitative or quantitative detection of tumor-derived or associated extracellular RNA circulating in the plasma or serum of humans or animals with or without any prior knowledge of the presence of cancer or premalignant tissue. (google.com.au)
  • Encapsulated forms of the follicular variant with the absence of certain adverse features has led to another variant termed noninvasive follicular neoplasm with papillary-like nuclear features (NIFTP), which is currently considered to not be a cancer. (thyroid.org)
  • Rejin Kebudi* and Gul Nihal Ozdemir, "Secondary Neoplasms in Children Treated for Cancer", Current Pediatric Reviews (2017) 13: 34. (eurekaselect.com)
  • Compositions and methods for expanding CD34+ cells, performing research related to cancer stem cells, RNA-editing enzymes and for monitoring, diagnosing and treating, ameliorating and preventing diseases such as cancers or inflammatory diseases. (patents.com)
  • These findings provide the first evidence for the posttranscriptional regulation of ERalpha by a micro-RNA in the context of breast cancer. (labome.org)
  • Cancer known medically as a malignant neoplasm, is a broad group of diseases involving unregulated cell growth. (amrita.edu)
  • We also review research and potential clinical applications of RNA-Seq technology in inherited, chronic, neoplastic, and infectious diseases. (springer.com)
  • The quantitative analyses of MUC1, MUC5AC, S 100P, S100A11 and SHH are useful for differentiation between neoplasms and non-neoplastic lesions. (nii.ac.jp)
  • Recent studies suggest that myeloid leukemias with mutations in RNA splicing factors are sensitized to pharmacologic perturbation of RNA splicing. (confex.com)
  • Recurrent change-of-function mutations in RNA splicing factors are frequent in patients with myelodysplastic syndromes (MDS) and related myeloid neoplasms. (aamds.org)
  • Thermo Fisher Scientific's Ion Torrent Oncomine Myeloid Research Assay interrogates DNA mutations, RNA fusion transcripts and gene expression levels associated with myeloid cancers in a single run, yielding results in 2-3 days. (medindia.net)
  • Exploiting the selective vulnerability of splicing factor mutated myeloid neoplasms to further splicing inhibition has led to clinical development of drugs targeting. (aamds.org)
  • Histologically, BPDCN was initially thought as a lineage marker-negative plasmacytoid T cell lymphoma, and was later on categorized as "blastic NK-cell lymphoma" and/or "Compact disc4+Compact disc56+ hematodermic neoplasm" predicated on the manifestation from the NK marker Compact disc56. (antibodyassay.com)
  • Researchers have evaluated the presence of intratumoral vascularization in ovarian neoplasms by Color-flow Doppler ultrasound. (knowcancer.com)
  • In line with this, a recent systematic review of available data on the development of mammary neoplasms revealed weak evidence for risk reduction after neutering and an effect of age at neutering. (biomedcentral.com)
  • Steroid levels were not influenced by their corresponding receptor expression in mammary neoplasms, but increased PRL levels were negatively associated with low PRLR gene expression in malignant tumors. (biomedcentral.com)
  • Editorial Note: HTLV agents are retroviruses that have recently been associated with certain types of adult T-cell lymphoreticular neoplasms of man (6). (cdc.gov)
  • Prednisone and prednisolone are commonly used to treat lymphoreticular neoplasms in combination with other drugs. (merckvetmanual.com)
  • The only other gene that has so far been shown to negatively regulate RNA polymerase I and III transcription is ncl-1 (for abnormal nucleolus) from the soil nematode Caenorhabditis elegans . (biologists.org)
  • Background: Resistance to apoptosis is one of the hallmarks in hematological neoplasms, most typically via dysregulation of the intrinsic mitochondrial pathway. (bloodjournal.org)
  • Aim: To determine the gene expression levels of BCL2 , BCL2L1 and MCL1 across various hematological neoplasms in order to identify best candidates for pro-survival protein inhibitors. (bloodjournal.org)
  • Patients and Methods: 2239 patients with hematological neoplasms (Table1) were evaluated by whole transcriptome sequencing (WTS) and 64 cases without hematological neoplasms were analysed as controls. (bloodjournal.org)
  • Neoplasms of the mammary gland are among the most common diseases in female domestic dogs ( Canis familiaris ). (biomedcentral.com)
  • RAP30 and RAP74 produced in Escherichia coli can be used in place of natural human RAP30/74 to direct accurate transcription initiation by RNA polymerase II in vitro. (nih.gov)
  • 4 . The method of claim 1 , wherein cDNA is produced by reverse transcription of RNA. (google.com.au)
  • a. has σ factors to direct enzyme to promoters b. require a large set of transcriptional factors that assemble at the promoter with the RNA pol to initiate transcription c. must contend with nucleosomes and higher order chromatin packing d. (brainscape.com)
  • Classical Ewing sarcomas are pathognomonically characterized by fusions between a gene of the RNA-binding TET family ( EWSR1 or FUS ) with a gene of the ETS -transcription family ( FLI1, ERG, ETV1, ETV4 or FEV ). (springer.com)
  • RAP30/74 (also known as TFIIF, beta gamma and FC is one of several general factors required for initiation by RNA polymerase II. (nih.gov)
  • The small RAP30 subunit of RAP30/74 binds directly to polymerase and appears structurally and functionally homologous to bacterial sigma factors in their RNA polymerase-binding region. (nih.gov)
  • The elucidation of the mechanisms by which these modifications impact cellular processes necessitates the ability to both detect and quantify the presence of these modifications within RNA molecules. (mendeley.com)
  • What 3 identical but functionally different RNA molecules are transcribed from anti-sense (-) DNA (template strand)? (brainscape.com)
  • Aberrant expression of several miRNAs was found to be involved in a large variety of neoplasms, including hepatocellular carcinoma (HCC). (hindawi.com)
  • Circular RNA circ_0103552 promotes the invasion and migration of thyroid carcinoma cells by sponging miR-127. (medworm.com)
  • Retroviruses are ribonucleic acid (RNA) viruses containing the enzyme, reverse transcriptase, which allows production of a deoxyribonucleic acid (DNA) copy of their RNA genome. (cdc.gov)
  • RNA immunoprecipitation (RIP) assay was done to verify the interaction between lncRNA CASC2 and (AU-binding factor 1) AUF1, or AUF1 and B-cell CLL/lymphoma 2 (Bcl-2). (medscimonit.com)
  • Consistent with this, RNA-sequencing of AML cells following RBM39 deletion revealed significant effects of RBM39 loss on RNA splicing, most prominently causing increased cassette exon skipping ( Fig. F ). (confex.com)
  • A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often form a mass or lump, but may be distributed diffusely. (wikipedia.org)
  • We also show that brat mutant cells are larger, have larger nucleoli, and have more ribosomal RNA than wild-type cells. (biologists.org)
  • Furthermore, brat overexpressing cells contain less ribosomal RNA than control cells. (biologists.org)
  • 2014). Collectively, these research identified regular chromosomal deficits (5q, 12p13, 13q21, 6q23-ter, 9), R1626 inactivation of R1626 tumor suppressors (and locus ChIP-Seq songs for BRD4 (blue), RNA Pol2 (reddish) and TCF4 (green) are demonstrated for Cal-1 Rabbit polyclonal to APPBP2 cells. (antibodyassay.com)
  • Although much remains to be learned about how these mutations promote MDS development, recent results from our lab and others have demonstrated that cells expressing these mutations are preferentially sensitive to further alterations to the RNA splicing process. (aamds.org)