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  • viral
  • proposed to act as viral RNA sensor, signaling intermediate and transcriptional coactivator. (nih.gov)
  • Can bind to viral RNAs and via association with MAVS/IPS1 and DDX58/RIG-I is thought to induce signaling in early stages of infection. (nih.gov)
  • mRNA
  • Proposed to act prior to 43S ribosomal scanning and to locally destabilize these RNA structures to allow recognition of the mRNA cap or loading onto the 40S subunit. (nih.gov)
  • structures
  • RHs are a family of ATPases that rearrange the secondary structures of RNA and thus remodel ribonucleoprotein complexes. (frontiersin.org)
  • transcriptional
  • Importantly, this region of p68 lies outside the conserved helicase core and was previously shown by us to be essential for transcriptional regulation by p68. (biomedcentral.com)
  • We have also shown that p72, a helicase that is very highly related to p68 and that had previously been suggested to act in an analogous fashion to p68 [ 3 ], poorly coactivates ERĪ± in standard transcriptional coactivation assays, using ER-responsive promoters. (biomedcentral.com)
  • roles
  • DExD/H-box RHs are found in most organisms and play critical roles in a variety of RNA-involved cellular events. (frontiersin.org)